Articles

The effect of omega-3 fatty acids on central nervous system remyelination in fat-1 mice

There is a large body of experimental evidence suggesting that omega-3 (n-3) polyunsaturated fatty acids (PUFAs) are capable of modulating immune function. Some studies have shown that these PUFAs might have ...

Authors: Elise Siegert, Friedemann Paul, Michael Rothe and Karsten H. Weylandt

Application of hairless mouse strain to bioluminescence imaging of Arc expression in mouse brain

Bioluminescence imaging (BLI) is a powerful technique for monitoring the temporal and spatial dynamics of gene expression in the mouse brain. However, the black fur, skin pigmentation and hair regrowth after d...

Authors: Hironori Izumi, Tetsuya Ishimoto, Hiroshi Yamamoto and Hisashi Mori

Erratum to: High-fat diet-induced obesity exacerbates kainic acid-induced hippocampal cell death

Authors: Dong Ho Kang, Rok Won Heo, Chin-ok Yi, Hwajin Kim, Chang Hwa Choi and Gu Seob Roh

Erratum to: A mitochondrial division inhibitor, Mdivi-1, inhibits mitochondrial fragmentation and attenuates kainic acid-induced hippocampal cell death

Authors: Hwajin Kim, Jong Youl Lee, Keon Jae Park, Won-Ho Kim and Gu Seob Roh

Selenium suppresses glutamate-induced cell death and prevents mitochondrial morphological dynamic alterations in hippocampal HT22 neuronal cells

Previous studies have indicated that selenium supplementation may be beneficial in neuroprotection against glutamate-induced cell damage, in which mitochondrial dysfunction is considered a major pathogenic fea...

Authors: Yan-Mei Ma, Gordon Ibeanu, Li-Yao Wang, Jian-Zhong Zhang, Yue Chang, Jian-Da Dong, P. Andy Li and Li Jing

Poly(ADP-ribose) polymerase inhibitors activate the p53 signaling pathway in neural stem/progenitor cells

Poly(ADP-ribose) polymerase 1 (PARP-1), which catalyzes poly(ADP-ribosyl)ation of proteins by using NAD⁺ as a substrate, plays a key role in several nuclear events, including DNA repair, replication, and transcri...

Authors: Akiko Okuda, Suguru Kurokawa, Masanori Takehashi, Aika Maeda, Katsuya Fukuda, Yukari Kubo, Hyuma Nogusa, Tomoka Takatani-Nakase, Shujiro Okuda, Kunihiro Ueda and Seigo Tanaka

Brain metabolic pattern analysis using a magnetic resonance spectra classification software in experimental stroke

Magnetic resonance spectroscopy (MRS) provides non-invasive information about the metabolic pattern of the brain parenchyma in vivo. The SpectraClassifier software performs MRS pattern-recognition by determin...

Authors: Elena Jiménez-Xarrié, Myriam Davila, Ana Paula Candiota, Raquel Delgado-Mederos, Sandra Ortega-Martorell, Margarida Julià-Sapé, Carles Arús and Joan Martí-Fàbregas

Genistein protects against Aβ_25–35 induced apoptosis of PC12 cells through JNK signaling and modulation of Bcl-2 family messengers

Deposition of aggregated amyloid beta (Aβ) protein is hallmark of Alzheimer’s disease, leading to dysfunction and apoptosis of neurons. The isoflavone phytoestrogen compound genistein (Gen) exerts a significan...

Authors: Fuling You, Qiao Li, Guifang Jin, Yaojie Zheng, Jingrong Chen and Hong Yang

CX₃C chemokine receptor 1 deficiency modulates microglia morphology but does not affect lesion size and short-term deficits after experimental stroke

The fractalkine/CX₃C chemokine receptor 1 (CX₃CR1) pathway has been identified to play an essential role in the chemotaxis of microglia, leukocyte trafficking and microglia/macrophage recruitment. It has also bee...

Authors: Gerlinde van der Maten, Vivien Henck, Tadeusz Wieloch and Karsten Ruscher

Hemodynamic effects of intraoperative anesthetics administration in photothrombotic stroke model: a study using laser speckle imaging

Previous neuroimaging studies have shown the hemodynamic effect of either preconditioning or postconditioning anesthesia in ischemic stroke model. However, the anesthetic effect in hemodynamics during and imm...

Authors: Hongyang Lu, Yao Li, Bin Bo, Lu Yuan, Xiaodan Lu, Hangdao Li and Shanbao Tong

Proteomic analyses of limbic regions in neonatal male, female and androgen receptor knockout mice

It is well-established that organizational effects of sex steroids during early development are fundamental for sex-typical displays of, for example, mating and aggressive behaviors in rodents and other specie...

Authors: Anna Zettergren, Sara Karlsson, Erik Studer, Anna Sarvimäki, Petronella Kettunen, Annika Thorsell, Carina Sihlbom and Lars Westberg

Suppression of experimental autoimmune encephalomyelitis by ultraviolet light is not mediated by isomerization of urocanic acid

Ultraviolet B irradiation confers strong resistance against experimental autoimmune encephalomyelitis, a model of multiple sclerosis. This protection by ultraviolet B is independent of vitamin D production but...

Authors: Amy A. Irving, Steven J. Marling, Lori A. Plum and Hector F. DeLuca

Immunization with neural derived peptides plus scar removal induces a permissive microenvironment, and improves locomotor recovery after chronic spinal cord injury

Immunization with neural derived peptides (INDP) as well as scar removal—separately—have shown to induce morphological and functional improvement after spinal cord injury (SCI). In the present study, we compar...

Authors: Roxana Rodríguez-Barrera, Adrián Flores-Romero, Ana María Fernández-Presas, Elisa García-Vences, Raúl Silva-García, Mina Konigsberg, Liliana Blancas-Espinoza, Vinnitsa Buzoianu-Anguiano, Karla Soria-Zavala, Paola Suárez-Meade and Antonio Ibarra

Important modifications by sugammadex, a modified γ-cyclodextrin, of ion currents in differentiated NSC-34 neuronal cells

Sugammadex (SGX) is a modified γ-cyclodextrin used for reversal of steroidal neuromuscular blocking agents during general anesthesia. Despite its application in clinical use, whether SGX treatment exerts any e...

Authors: Hung-Te Hsu, Yi-Ching Lo, Yan-Ming Huang, Yu-Ting Tseng and Sheng-Nan Wu

The variability of motor evoked potential latencies in neurosurgical motor mapping by preoperative navigated transcranial magnetic stimulation

Recording of motor evoked potentials (MEPs) is used during navigated transcranial magnetic stimulation (nTMS) motor mapping to locate motor function in the human brain. However, factors potentially underlying ...

Authors: Nico Sollmann, Lucia Bulubas, Noriko Tanigawa, Claus Zimmer, Bernhard Meyer and Sandro M. Krieg

Why does a cooled object feel heavier? Psychophysical investigations into the Weber’s Phenomenon

It has long been known that a concomitantly cooled stimulus is perceived as heavier than the same object at a neutral temperature—termed Weber’s Phenomenon (WP). In the current study, we re-examined this phenomen...

Authors: James S. Dunn, David A. Mahns and Saad S. Nagi

Yawning reduces facial temperature in the high-yawning subline of Sprague-Dawley rats

Yawning is a stereotyped behavior that enhances blood flow to the skull, and the resulting counterflow has been hypothesized as a mechanism for brain cooling. Studies have shown that yawns are strongly associa...

Authors: Jose R. Eguibar, Carlos A. Uribe, Carmen Cortes, Amando Bautista and Andrew C. Gallup

Expertise-related functional brain network efficiency in healthy older adults

In view of age-related brain changes, identifying factors that are associated with healthy aging are of great interest. In the present study, we compared the functional brain network characteristics of three g...

Authors: Julia C. Binder, Ladina Bezzola, Aurea I. S. Haueter, Carina Klein, Jürg Kühnis, Hansruedi Baetschmann and Lutz Jäncke

Neural hyperactivity in the amygdala induced by chronic treatment of rats with analgesics may elucidate the mechanisms underlying psychiatric comorbidities associated with medication-overuse headache

Patients with medication-overuse headache suffer not only from chronic headache, but often from psychiatric comorbidities, such as anxiety and depression. The mechanisms underlying these comorbidities are uncl...

Authors: Aree Wanasuntronwong, Ukkrit Jansri and Anan Srikiatkhachorn

Planar cell polarity genes Frizzled3a, Vangl2, and Scribble are required for spinal commissural axon guidance

A fundamental feature of early nervous system development is the guidance of axonal projections to their targets in order to assemble neural circuits that control behavior. Spinal commissural neurons are an at...

Authors: Simon D. Sun, Ashley M. Purdy and Gregory S. Walsh

Investigating potentially salvageable penumbra tissue in an in vivo model of transient ischemic stroke using sodium, diffusion, and perfusion magnetic resonance imaging

Diffusion magnetic resonance imaging (MRI) is the current-state-of-the-art technique to clinically investigate acute (0–24 h) ischemic stroke tissue. However, reduced apparent diffusion coefficient (ADC)—cons...

Authors: Friedrich Wetterling, Eva Chatzikonstantinou, Laurent Tritschler, Stephen Meairs, Marc Fatar, Lothar R. Schad and Saema Ansar

Molar loss and powder diet leads to memory deficit and modifies the mRNA expression of brain-derived neurotrophic factor in the hippocampus of adult mice

It is known that tooth loss is known to be a risk factor for Alzheimer’s disease and soft diet feeding induces memory impairment. Recent studies have shown that brain-derived neurotrophic factor (BDNF) is asso...

Authors: Yosuke Takeda, Hiroshi Oue, Shinsuke Okada, Akira Kawano, Katsunori Koretake, Makoto Michikawa, Yasumasa Akagawa and Kazuhiro Tsuga

Bone morphogenetic protein-2-mediated pain and inflammation in a rat model of posterolateral arthrodesis

Bone morphogenetic protein-2 (BMP-2) is a pleiotropic, secreted molecule with diverse effects. The potent ability of BMP-2 to stimulate bone growth prompted its widespread clinical use for arthrodesis (spine f...

Authors: Kendall Mitchell, Jill P. Shah, Clifton L. Dalgard, Lyubov V. Tsytsikova, Ashley C. Tipton, Anton E. Dmitriev and Aviva J. Symes

Epigenetic evidence for involvement of the oxytocin receptor gene in obsessive–compulsive disorder

Obsessive–compulsive disorder (OCD) is a chronic neurodevelopmental disorder that affects up to 3% of the general population. Although epigenetic mechanisms play a role in neurodevelopment disorders, epigenet...

Authors: Carolina Cappi, Juliana Belo Diniz, Guaraci L. Requena, Tiaya Lourenço, Bianca Cristina Garcia Lisboa, Marcelo Camargo Batistuzzo, Andrea H. Marques, Marcelo Q. Hoexter, Carlos A. Pereira, Euripedes Constantino Miguel and Helena Brentani

CatWalk gait analysis in a rat model of multiple sclerosis

Myelin oligodendrocyte glycoprotein (MOG)-induced experimental autoimmune encephalomyelitis (EAE) is a widely used animal model for multiple sclerosis. The characteristic feature of the MOG-EAE model in Brown...

Authors: Sabine Herold, Prateek Kumar, Klaus Jung, Irina Graf, Henrike Menkhoff, Xenia Schulz, Mathias Bähr and Katharina Hein

Leucine-rich repeat kinase 2 (LRRK2) regulates α-synuclein clearance in microglia

α-Synuclein (αSYN) has been genetically implicated in familial and sporadic Parkinson’s disease (PD), and is associated with disease susceptibility, progression and pathology. Excess amounts of αSYN are toxic ...

Authors: Tatsunori Maekawa, Toshikuni Sasaoka, Sadahiro Azuma, Takafumi Ichikawa, Heather L. Melrose, Matthew J. Farrer and Fumiya Obata

Expression of Barhl2 and its relationship with Pax6 expression in the forebrain of the mouse embryo

The transcription factor Barhl2 is an antiproneural transcription factor with roles in neuronal differentiation. The functions of its homologue in Drosophila development are better understood than its functions i...

Authors: Elisa V. Parish, John O. Mason and David J. Price

Genotypic differences in intruder-evoked immediate early gene activation in male, but not female, vasopressin 1b receptor knockout mice

The neuropeptide arginine vasopressin (Avp) modulates social behaviors via its two centrally expressed receptors, the Avp 1a receptor and the Avp 1b receptor (Avpr1b). Recent work suggests that, at least in mi...

Authors: Shannah K. Witchey, Erica L. Stevenson and Heather K. Caldwell

Interleukin-1 receptor (IL-1R) mediates epilepsy-induced sleep disruption

Sleep disruptions are common in epilepsy patients. Our previous study demonstrates that homeostatic factors and circadian rhythm may mediate epilepsy-induced sleep disturbances when epilepsy occurs at differen...

Authors: Tzu-Rung Huang, Shuo-Bin Jou, Yu-Ju Chou, Pei-Lu Yi, Chun-Jen Chen and Fang-Chia Chang

mTOR and MAPK: from localized translation control to epilepsy

Epilepsy is one of the most common neurological diseases characterized by excessive hyperexcitability of neurons. Molecular mechanisms of epilepsy are diverse and not really understood. All in common is the mi...

Authors: Helena F. Pernice, Rico Schieweck, Michael A. Kiebler and Bastian Popper

TfAP-2 is required for night sleep in Drosophila

The AP-2 transcription factor APTF-1 is crucially required for developmentally controlled sleep behavior in Caenorhabditis elegans larvae. Its human ortholog, TFAP-2beta, causes Char disease and has also been lin...

Authors: Mariya M. Kucherenko, Vinodh Ilangovan, Bettina Herzig, Halyna R. Shcherbata and Henrik Bringmann

A method for isolation of cone photoreceptors from adult zebrafish retinae

Cone photoreceptors are specialised sensory retinal neurons responsible for photopic vision, colour perception and visual acuity. Retinal degenerative diseases are a heterogeneous group of eye diseases in whic...

Authors: Antonino Glaviano, Andrew J. Smith, Alfonso Blanco, Sarah McLoughlin, Maria L. Cederlund, Theresa Heffernan, Beata Sapetto-Rebow, Yolanda Alvarez, Jun Yin and Breandán N. Kennedy

‘Proactive’ use of cue-context congruence for building reinforcement learning’s reward function

Reinforcement learning is a fundamental form of learning that may be formalized using the Bellman equation. Accordingly an agent determines the state value as the sum of immediate reward and of the discounted ...

Authors: Judit Zsuga, Klara Biro, Gabor Tajti, Magdolna Emma Szilasi, Csaba Papp, Bela Juhasz and Rudolf Gesztelyi

Severe respiratory changes at end stage in a FUS-induced disease state in adult rats

Fused in sarcoma (FUS) is an RNA-binding protein associated with the neurodegenerative diseases amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration. ALS manifests in patients as a progres...

Authors: Kasey L. Jackson, Hemangini A. Dhaibar, Robert D. Dayton, Sergio G. Cananzi, William G. Mayhan, Edward Glasscock and Ronald L. Klein

Simultaneous acoustic stimulation of human primary and secondary somatosensory cortices using transcranial focused ultrasound

Transcranial focused ultrasound (FUS) is gaining momentum as a novel non-invasive brain stimulation method, with promising potential for superior spatial resolution and depth penetration compared to transcrani...

Authors: Wonhye Lee, Yong An Chung, Yujin Jung, In-Uk Song and Seung-Schik Yoo

Results on the spatial resolution of repetitive transcranial magnetic stimulation for cortical language mapping during object naming in healthy subjects

The spatial resolution of repetitive navigated transcranial magnetic stimulation (rTMS) for language mapping is largely unknown. Thus, to determine a minimum spatial resolution of rTMS for language mapping, we...

Authors: Nico Sollmann, Theresa Hauck, Lorena Tussis, Sebastian Ille, Stefanie Maurer, Tobias Boeckh-Behrens, Florian Ringel, Bernhard Meyer and Sandro M. Krieg

Neuroprotective effects of HTR1A antagonist WAY-100635 on scopolamine-induced delirium in rats and underlying molecular mechanisms

Limited surveys have assessed the performance of 5-hydroxytreptamine receptor 1A and its antagonist WAY-100635 in pharmacological manipulations targeting delirium therapies. The purpose of this paper was to as...

Authors: Yimin Qiu, Dongmei Chen, Xiaojing Huang, Lina Huang, Liang Tang, Jihong Jiang, Lianhua Chen and Shitong Li

Cortical processes of speech illusions in the general population

There is evidence that experimentally elicited auditory illusions in the general population index risk for psychotic symptoms. As little is known about underlying cortical mechanisms of auditory illusions, an ...

Authors: E. Schepers, L. Bodar, J. van Os and R. Lousberg

Hypertonic saline alleviates experimentally induced cerebral oedema through suppression of vascular endothelial growth factor and its receptor VEGFR2 expression in astrocytes

Cerebral oedema is closely related to the permeability of blood–brain barrier, vascular endothelial growth factor (VEGF) and its receptor vascular endothelial growth factor receptor 2 (VEGFR2) all of which are...

Authors: Linqiang Huang, Wei Cao, Yiyu Deng, Gaofeng Zhu, Yongli Han and Hongke Zeng

Identification of environmental stressors and validation of light preference as a measure of anxiety in larval zebrafish

Larval zebrafish, with a simple and transparent vertebrate brain composed of ~100 K neurons, is well suited for deciphering entire neural circuit activity underlying behavior. Moreover, their small body size (...

Authors: Yiming Bai, Harrison Liu, Bo Huang, Mahendra Wagle and Su Guo

Reserve and Reserve-building activities research: key challenges and future directions

The concept of Cognitive Reserve has great appeal and has led to an interesting and important body of research. We believe, however, that it is unnecessarily limited by ‘habits’ of measurement, nomenclature, a...

Authors: Carolyn E. Schwartz, Bruce D. Rapkin and Brian C. Healy

Increased pro-inflammatory cytokines, glial activation and oxidative stress in the hippocampus after short-term bilateral adrenalectomy

Bilateral adrenalectomy has been shown to damage the hippocampal neurons. Although the effects of long-term adrenalectomy have been studied extensively there are few publications on the effects of short-term a...

Authors: Naserddine Hamadi, Azimullah Sheikh, Nather Madjid, Loai Lubbad, Naheed Amir, Safa Al-Deen Saudi Shehab, Fatima Khelifi-Touhami and Abdu Adem

Astaxanthin alleviates cerebral edema by modulating NKCC1 and AQP4 expression after traumatic brain injury in mice

Astaxanthin is a carotenoid pigment that possesses potent antioxidative, anti-inflammatory, antitumor, and immunomodulatory activities. Previous studies have demonstrated that astaxanthin displays potential ne...

Authors: Mingkun Zhang, Zhenwen Cui, Hua Cui, Yang Cao, Yong Wang and Chunlong Zhong

Cerebral blood perfusion changes in amputees with myoelectric hands after rehabilitation: a SPECT computer-aided analysis

Rehabilitation, which is essential for amputees with myoelectric hands, can improve the quality of daily life by remodeling the neuron network. In our study, we aim to develop a cerebral blood perfusion (CBF) ...

Authors: Qiufang Liu, Xiujuan Zheng, Panli Li, Lian Xu, Longwen He, Zhao Mei, Yinyan Zhu, Gang Huang, Chunlong Zhong and Shaoli Song

Neuroprotective effect of nerolidol against neuroinflammation and oxidative stress induced by rotenone

Parkinson disease (PD) is a movement disorder affecting 1 % of people over the age of 60. The etiology of the disease is unknown; however, accumulating evidence suggests that mitochondrial defects, oxidative s...

Authors: Hayate Javed, Sheikh Azimullah, Salema B. Abul Khair, Shreesh Ojha and M. Emdadul Haque

25th Annual Computational Neuroscience Meeting: CNS-2016

A1 Functional advantages of cell-type heterogeneity in neural circuits

Authors: Tatyana O. Sharpee, Alain Destexhe, Mitsuo Kawato, Vladislav Sekulić, Frances K. Skinner, Daniel K. Wójcik, Chaitanya Chintaluri, Dorottya Cserpán, Zoltán Somogyvári, Jae Kyoung Kim, Zachary P. Kilpatrick, Matthew R. Bennett, Kresimir Josić, Irene Elices, David Arroyo, Rafael Levi…

Hysteretic behavior of bladder afferent neurons in response to changes in bladder pressure

Mechanosensitive afferents innervating the bladder increase their firing rate as the bladder fills and pressure rises. However, the relationship between afferent firing rates and intravesical pressure is not a...

Authors: Shani E. Ross, Zachariah J. Sperry, Colin M. Mahar and Tim M. Bruns

MicroRNA-34b mediates hippocampal astrocyte apoptosis in a rat model of recurrent seizures

Recurrent convulsions can cause irreversible astrocyte death, impede neuron regeneration, and further aggravate brain damage. MicroRNAs have been revealed as players in the progression of numerous diseases inc...

Authors: Liqun Liu, Lingjuan Liu, Jiayun Shi, Menglin Tan, Jie Xiong, Xingfang Li, Qingpeng Hu, Zhuwen Yi and Ding’an Mao

Olfactory perception of chemically diverse molecules

Understanding the relationship between a stimulus and how it is perceived reveals fundamental principles about the mechanisms of sensory perception. While this stimulus-percept problem is mostly understood for...

Authors: Andreas Keller and Leslie B. Vosshall

The influence of postsynaptic structure on missing quanta at the Drosophila neuromuscular junction

Synaptic transmission requires both pre- and post-synaptic elements for neural communication. The postsynaptic structure contributes to the ability of synaptic currents to induce voltage changes in postsynapti...

Authors: Christine T. Nguyen and Bryan A. Stewart