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  1. Alzheimer’s disease (AD) is characterized by the deposition of amyloid-β (Aβ) in brain parenchyma and cerebral blood vessels as cerebral amyloid angiopathy (CAA). Clusterin, a chaperon protein associated with ...

    Authors: Xue-Mei Qi, Cheng Wang, Xing-Kun Chu, Gen Li and Jian-Fang Ma

    Citation: BMC Neuroscience 2018 19:2

    Content type: Research article

    Published on:

  2. Activated microglia interact with astrocytes and neuronal cells to induce neuroinflammation, which can contribute to the pathogenesis and progression of Alzheimer’s and Parkinson’s disease. To identify the mos...

    Authors: Lalita Subedi, Oh Wook Kwon, Chaeho Pak, Goeun Lee, Kangwoo Lee, Hakwon Kim and Sun Yeou Kim

    Citation: BMC Neuroscience 2017 18:82

    Content type: Research article

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  3. Obesity induced brain inflammation is associated with cognitive disorders. We aimed to investigate the influence of vitamin D on hypothalamus and hippocampus inflammatory response in high-fat diet induced obes...

    Authors: Mahdieh Abbasalizad Farhangi, Mehran Mesgari-Abbasi, Ghazaleh Nameni, Ghazaleh Hajiluian and Parviz Shahabi

    Citation: BMC Neuroscience 2017 18:81

    Content type: Research article

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  4. Binocular disparity provides a powerful cue for depth perception in a stereoscopic environment. Despite increasing knowledge of the cortical areas that process disparity from neuroimaging studies, the neural m...

    Authors: Yuan Li, Chuncheng Zhang, Chunping Hou, Li Yao, Jiacai Zhang and Zhiying Long

    Citation: BMC Neuroscience 2017 18:80

    Content type: Research article

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  5. The hippocampus is a functionally heterogeneous brain structure and specializations of the intrinsic neuronal network may crucially support the functional segregation along the longitudinal axis of the hippoca...

    Authors: Vassilios Papaleonidopoulos, George Trompoukis, Andriana Koutsoumpa and Costas Papatheodoropoulos

    Citation: BMC Neuroscience 2017 18:79

    Content type: Research article

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  6. The formation of visuotopically-aligned projections in the brain is required for the generation of functional binocular circuits. The mechanisms which underlie this process are unknown. Ten-m3 is expressed in...

    Authors: Kelly A. Glendining, Sam C. Liu, Marvin Nguyen, Nuwan Dharmaratne, Rajini Nagarajah, Miguel A. Iglesias, Atomu Sawatari and Catherine A. Leamey

    Citation: BMC Neuroscience 2017 18:78

    Content type: Research Article

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  7. PDE4 cyclic nucleotide phosphodiesterases regulate 3′, 5′ cAMP abundance in the CNS and thereby regulate PKA activity and phosphorylation of CREB, which has been implicated in learning and memory, depression a...

    Authors: Susan L. Campbell, Thomas van Groen, Inga Kadish, Lisa High Mitchell Smoot and Graeme B. Bolger

    Citation: BMC Neuroscience 2017 18:77

    Content type: Research Article

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  8. In the mammalian superior olivary complex (SOC), synaptic inhibition contributes to the processing of binaural sound cues important for sound localization. Previous analyses demonstrated a tonotopic gradient f...

    Authors: Lena Ebbers, Maren Weber and Hans Gerd Nothwang

    Citation: BMC Neuroscience 2017 18:75

    Content type: Research article

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  9. In-vivo observations of neural processes during human aggressive behavior are difficult to obtain, limiting the number of studies in this area. To address this gap, the present study implemented a social react...

    Authors: Jonathan Repple, Christina M. Pawliczek, Bianca Voss, Steven Siegel, Frank Schneider, Nils Kohn and Ute Habel

    Citation: BMC Neuroscience 2017 18:73

    Content type: Research article

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  10. Intracellular calcium is an important ion involved in the regulation and modulation of many neuronal functions. From regulating cell cycle and proliferation to initiating signaling cascades and regulating pres...

    Authors: Elena Artimovich, Russell K. Jackson, Michaela B. C. Kilander, Yu-Chih Lin and Michael W. Nestor

    Citation: BMC Neuroscience 2017 18:72

    Content type: Software

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  11. A sensitive, rapid and selective UHPLC–MS/MS method has been developed and validated for the quantification of Nicotine (NT) and Cotinine (CN) using Continine-d 3 as internal standard (...

    Authors: Mohammad A. Kaisar, Raja Reddy Kallem, Ravi K. Sajja, Ali Ehsan Sifat and Luca Cucullo

    Citation: BMC Neuroscience 2017 18:71

    Content type: Methodology

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  12. Alzheimer’s disease is characterized by the accumulation of amyloid beta (Aβ) and the formation of neurofibrillary tangles. Aβ is the main constituent of senile plaques and is largely involved in neuronal deat...

    Authors: Yuqin Zhang, Changchun Chen, Yanliu Jiang, Shupei Wang, Xiaoyu Wu and Kai Wang

    Citation: BMC Neuroscience 2017 18:69

    Content type: Research article

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  13. Metabolic syndrome (MetS) is associated with an increased risk of cerebrovascular diseases, including cerebral ischemia. Microvascular dysfunction is an important feature underlying the pathophysiology of cere...

    Authors: Nathalie Obadia, Marcos Adriano Lessa, Anissa Daliry, Raquel Rangel Silvares, Fabiana Gomes, Eduardo Tibiriçá and Vanessa Estato

    Citation: BMC Neuroscience 2017 18:67

    Content type: Research article

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  14. The Na+/K+-ATPases are transmembrane ion pumps important for maintenance of ion gradients across the plasma membrane that serve to support multiple cellular functions, such as membrane potentials, regulation of c...

    Authors: Ditte Gry Ellman, Toke Jost Isaksen, Minna Christiansen Lund, Safinaz Dursun, Martin Wirenfeldt, Louise Helskov Jørgensen, Karin Lykke-Hartmann and Kate Lykke Lambertsen

    Citation: BMC Neuroscience 2017 18:66

    Content type: Research article

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  15. Most studies of brain structure and function, and their relationships to cognitive ability, have relied on inter-individual variability in magnetic resonance (MR) images. Intra-individual variability is often ign...

    Authors: Elisa Filevich, Nina Lisofsky, Maxi Becker, Oisin Butler, Martyna Lochstet, Johan Martensson, Elisabeth Wenger, Ulman Lindenberger and Simone Kühn

    Citation: BMC Neuroscience 2017 18:65

    Content type: Database

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  16. Authors: Adam J. H. Newton, Alexandra H. Seidenstein, Robert A. McDougal, Alberto Pérez-Cervera, Gemma Huguet, Tere M-Seara, Caroline Haimerl, David Angulo-Garcia, Alessandro Torcini, Rosa Cossart, Arnaud Malvache, Kaoutar Skiker, Mounir Maouene, Gianmarco Ragognetti, Letizia Lorusso, Andrea Viggiano…

    Citation: BMC Neuroscience 2017 18(Suppl 1):60

    Content type: Meeting abstracts

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    This article is part of a Supplement: Volume 18 Supplement 1

  17. Authors: Leonid L. Rubchinsky, Sungwoo Ahn, Wouter Klijn, Ben Cumming, Stuart Yates, Vasileios Karakasis, Alexander Peyser, Marmaduke Woodman, Sandra Diaz-Pier, James Deraeve, Eliana Vassena, William Alexander, David Beeman, Pawel Kudela, Dana Boatman-Reich, William S. Anderson…

    Citation: BMC Neuroscience 2017 18(Suppl 1):59

    Content type: Meeting abstracts

    Published on:

    This article is part of a Supplement: Volume 18 Supplement 1

  18. Authors: Sue Denham, Panayiota Poirazi, Erik De Schutter, Karl Friston, Ho Ka Chan, Thomas Nowotny, Dongqi Han, Sungho Hong, Sophie Rosay, Tanja Wernle, Alessandro Treves, Sarah Goethals, Romain Brette, Tomas Van Pottelbergh, Rodolphe Sepulchre, Alex D. Bird…

    Citation: BMC Neuroscience 2017 18(Suppl 1):58

    Content type: Meeting abstracts

    Published on:

    This article is part of a Supplement: Volume 18 Supplement 1

  19. Hair cell loss in the cochlea is caused by ototoxic drugs, aging, and environmental stresses and could potentially lead to devastating pathophysiological effects. In adult mammals, hair cell loss is irreversib...

    Authors: Takahiro Wakasaki, Hiroaki Niiro, Siamak Jabbarzadeh-Tabrizi, Mitsuru Ohashi, Takashi Kimitsuki, Takashi Nakagawa, Shizuo Komune and Koichi Akashi

    Citation: BMC Neuroscience 2017 18:64

    Content type: Research article

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  20. In Duchenne muscular dystrophy (DMD), the loss of the dystrophin component of the dystrophin-glycoprotein complex (DGC) compromises plasma membrane integrity in skeletal muscle, resulting in extensive muscle d...

    Authors: Azeez Aranmolate, Nathaniel Tse and Holly Colognato

    Citation: BMC Neuroscience 2017 18:63

    Content type: Research article

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  21. Following partial injury to the central nervous system, cells beyond the initial injury site undergo secondary degeneration, exacerbating loss of neurons, compact myelin and function. Changes in Ca2+ flux are ass...

    Authors: Ryan L. O’Hare Doig, Wissam Chiha, Marcus K. Giacci, Nathanael J. Yates, Carole A. Bartlett, Nicole M. Smith, Stuart I. Hodgetts, Alan R. Harvey and Melinda Fitzgerald

    Citation: BMC Neuroscience 2017 18:62

    Content type: Research article

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  22. CLCA is a family of metalloproteases that regulate Ca2+-activated Cl fluxes in epithelial tissues. In HEK293 cells, CLCA1 promotes membrane expression of an endogenous Anoctamin 1 (ANO1, also termed TMEM16A)-dep...

    Authors: Casilda V. Mura, Ricardo Delgado, María Graciela Delgado, Diego Restrepo and Juan Bacigalupo

    Citation: BMC Neuroscience 2017 18:61

    Content type: Research article

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  23. Sesamin is a well-known antioxidant extracted from sesame seeds that exhibits various curative effects. The present study investigated whether sesamin would protect neuroblastoma SH-SY5Y cells against mechanic...

    Authors: Zhiming Xu, Yingliang Liu, Dianxu Yang, Fang Yuan, Jun Ding, Hao Chen and Hengli Tian

    Citation: BMC Neuroscience 2017 18:57

    Content type: Research article

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  24. The identification of biomarkers that predict susceptibility to major depressive disorder and treatment response to antidepressants is a major challenge. Vortioxetine is a novel multimodal antidepressant that ...

    Authors: Jessica A. Waller, Sara Holm Nygaard, Yan Li, Kristian Gaarn du Jardin, Joseph A. Tamm, Aicha Abdourahman, Betina Elfving, Alan L. Pehrson, Connie Sánchez and Rasmus Wernersson

    Citation: BMC Neuroscience 2017 18:56

    Content type: Research article

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  25. CRISPR/Cas9 system is a powerful method to investigate the role of genes by introducing a mutation selectively and efficiently to specific genome positions in cell and animal lines. However, in primary neuron...

    Authors: Hiroto Tsunematsu, Akiko Uyeda, Nobuhiko Yamamoto and Noriyuki Sugo

    Citation: BMC Neuroscience 2017 18:55

    Content type: Methodology article

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  26. It has been reported that internet gaming disorder (IGD) and smokers with nicotine dependence (SND) share clinical characteristics, such as over-engagement despite negative consequences and cravings. This stud...

    Authors: Xin Ge, Yawen Sun, Xu Han, Yao Wang, Weina Ding, Mengqiu Cao, Yasong Du, Jianrong Xu and Yan Zhou

    Citation: BMC Neuroscience 2017 18:54

    Content type: Research article

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  27. Delayed reconstruction of transection or laceration injuries of peripheral nerves is inflicted by a reduced regeneration capacity. Diabetic conditions, more frequently encountered in clinical practice, are kno...

    Authors: Lena Stenberg, Maria Stößel, Giulia Ronchi, Stefano Geuna, Yaobin Yin, Susanne Mommert, Lisa Mårtensson, Jennifer Metzen, Claudia Grothe, Lars B. Dahlin and Kirsten Haastert-Talini

    Citation: BMC Neuroscience 2017 18:53

    Content type: Research article

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  28. In the recent decade, iron oxide nanoparticles (IONPs) have been proposed for several applications in the central nervous system (CNS), including targeting amyloid beta (Aβ) in the arteries, inhibiting the mic...

    Authors: Zahra Yarjanli, Kamran Ghaedi, Abolghasem Esmaeili, Soheila Rahgozar and Ali Zarrabi

    Citation: BMC Neuroscience 2017 18:51

    Content type: Review

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  29. Learning algorithms come in three orders of complexity: zeroth-order (perturbation), first-order (gradient descent), and second-order (e.g., quasi-Newton). But which of these are used in the brain? We trained ...

    Authors: John Kim, Fariya Mostafa and Douglas Blair Tweed

    Citation: BMC Neuroscience 2017 18:50

    Content type: Research article

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  30. The brain is continuously targeted by a wealth of stimuli with complex spatio-temporal patterns and has presumably evolved in order to cope with those inputs in an optimal way. Previous studies investigating t...

    Authors: Francesca Scarsi, Jacopo Tessadori, Michela Chiappalone and Valentina Pasquale

    Citation: BMC Neuroscience 2017 18:49

    Content type: Research article

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  31. Systemic inflammation and white matter (WM) alterations have been noted as effects of Parkinson’s disease (PD). This study sought to evaluate WM integrity in PD patients using diffusion tensor imaging (DTI) an...

    Authors: Pi-Ling Chiang, Hsiu-Ling Chen, Cheng-Hsien Lu, Pei-Chin Chen, Meng-Hsiang Chen, I.-Hsiao Yang, Nai-Wen Tsai and Wei-Che Lin

    Citation: BMC Neuroscience 2017 18:48

    Content type: Research article

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  32. We studied whether regulation of Cdca7 (Cell division cycle associated 7) expression by transcription factor Pax6 contributes to Pax6’s cellular actions during corticogenesis. The function of Cdca7 in mediating P...

    Authors: Yu-Ting Huang, John O. Mason and David J. Price

    Citation: BMC Neuroscience 2017 18:47

    Content type: Research article

    Published on:

  33. Sirtuins (SIRTs) are NAD+ dependent lysine deacetylases which are conserved from bacteria to humans and have been associated with longevity and lifespan extension. SIRT1, the best studied mammalian SIRT is invol...

    Authors: Preeti Singh, Peter S. Hanson and Christopher M. Morris

    Citation: BMC Neuroscience 2017 18:46

    Content type: Research article

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  34. Mice lacking Kalirin-7 (Kal7KO), a Rho GDP/GTP exchange factor, self-administer cocaine at a higher rate than wildtype mice, and show an exaggerated locomotor response to experimenter-administered cocaine. Kal7, ...

    Authors: Taylor P. LaRese, Yan Yan, Betty A. Eipper and Richard E. Mains

    Citation: BMC Neuroscience 2017 18:45

    Content type: Research article

    Published on:

  35. The GluN2B subunit of the N-methyl-d-aspartate receptor (NMDAr) modulates many physiological processes including learning, memory, and pain. Excessive increase in NMDAr/GluN2B activity has been associated with va...

    Authors: Edwin A. Reyes-Guzman, Nohora Vega-Castro, Edgar A. Reyes-Montaño and Esperanza Recio-Pinto

    Citation: BMC Neuroscience 2017 18:44

    Content type: Research article

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  36. Impaired reaction time in patients suffering from hypoxia during sleep, caused by sleep breathing disorders, is a well-described phenomenon. High altitude sleep is known to induce periodic breathing with centr...

    Authors: Stephan Pramsohler, Stefan Wimmer, Martin Kopp, Hannes Gatterer, Martin Faulhaber, Martin Burtscher and Nikolaus Cristoph Netzer

    Citation: BMC Neuroscience 2017 18:43

    Content type: Research article

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  37. Astaxanthin (ATX) is a carotenoid pigment with pleiotropic pharmacological properties that is seen as a possible drug for treating cerebral ischemic injury and subarachnoid hemorrhage. Na+–K+–2Cl co-transporter-...

    Authors: Mingkun Zhang, Zhenwen Cui, Hua Cui, Yong Wang and Chunlong Zhong

    Citation: BMC Neuroscience 2017 18:42

    Content type: Research article

    Published on:

  38. Recent studies have suggested that the activation of mammalian target of rapamycin (mTOR) signaling may be related to antidepressant action. Therefore, the present study evaluated whether antidepressant drugs ...

    Authors: Mi Kyoung Seo, Cheol Min Choi, Roger S. McIntyre, Hye Yeon Cho, Chan Hong Lee, Rodrigo B. Mansur, Yena Lee, Jae-Hon Lee, Young Hoon Kim, Sung Woo Park and Jung Goo Lee

    Citation: BMC Neuroscience 2017 18:39

    Content type: Research article

    Published on:

  39. In this paper we present a mechanistic model that integrates subneuronal structures, namely ion channels, membrane fatty acids, lipid rafts, G proteins and the cytoskeleton in a dynamic system that is finely t...

    Authors: Massimo Cocchi, Chiara Minuto, Lucio Tonello, Fabio Gabrielli, Gustav Bernroider, Jack A. Tuszynski, Francesco Cappello and Mark Rasenick

    Citation: BMC Neuroscience 2017 18:38

    Content type: Review

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  40. The mechanisms of steroids actions in the brain mainly involve the binding and nuclear translocation of specific cytoplasmic receptors. These receptors can act as transcription factors and regulate gene expres...

    Authors: Marcin Piechota, Michał Korostynski, Slawomir Golda, Joanna Ficek, Danuta Jantas, Ziolkowska Barbara and Ryszard Przewlocki

    Citation: BMC Neuroscience 2017 18:37

    Content type: Research article

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  41. Systemic inflammation is known to induce sickness behaviors, including decreased social interaction and pain. We have reported increased serum inflammatory cytokines in a rat model of repetitive strain injury ...

    Authors: D. L. Xin, J. Hadrévi, M. E. Elliott, M. Amin, M. Y. Harris, A. E. Barr-Gillespie and M. F. Barbe

    Citation: BMC Neuroscience 2017 18:36

    Content type: Research article

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  42. Recent rodent and human studies provide evidence in support of the fact that CD157, well known as bone marrow stromal cell antigen-1 (BST-1) and a risk factor in Parkinson’s disease, also meaningfully acts in ...

    Authors: Haruhiro Higashida, Mingkun Liang, Toru Yoshihara, Shirin Akther, Azam Fakhrul, Cherepanov Stanislav, Tae-Sik Nam, Uh-Hyun Kim, Satoka Kasai, Tomoko Nishimura, Naila Al Mahmuda, Shigeru Yokoyama, Katsuhiko Ishihara, Maria Gerasimenko, Alla Salmina, Jing Zhong…

    Citation: BMC Neuroscience 2017 18:35

    Content type: Research article

    Published on:

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