Cardenas-Roldan J, Rojas-Villarraga A, Anaya JM. How do autoimmune diseases cluster in families? A systematic review and meta-analysis. BMC Med. 2013;11:73.
Article
CAS
PubMed
PubMed Central
Google Scholar
Siriweera EH, Ratnatunga NV. Profile of Hashimoto’s thyroiditis in Sri Lankans: is there an increased risk of ancillary pathologies in Hashimoto’s thyroiditis? J Thyroid Res. 2010;2010:124264.
Article
PubMed
PubMed Central
Google Scholar
Kapila K, Sathar SA, Al-Rabah NA, Prahash A, Seshadri MS. Chronic lymphocytic (Hashimoto’s) thyroiditis in Kuwait diagnosed by fine needle aspirates. Ann Saudi Med. 1995;15:363–6.
Article
CAS
PubMed
Google Scholar
Carta MG, Hardoy MC, Carpiniello B, Murru A, Marci AR, Carbone F, et al. A case control study on psychiatric disorders in Hashimoto disease and Euthyroid Goitre: not only depressive but also anxiety disorders are associated with thyroid autoimmunity. Clin Pract Epidemiol Ment Health. 2005;1:23.
Article
PubMed
PubMed Central
Google Scholar
Mussig K, Kunle A, Sauberlich AL, Weinert C, Ethofer T, Saur R, et al. Thyroid peroxidase antibody positivity is associated with symptomatic distress in patients with Hashimoto’s thyroiditis. Brain Behav Immun. 2012;26:559–63.
Article
PubMed
CAS
Google Scholar
Giynas Ayhan M, Uguz F, Askin R, Gonen MS. The prevalence of depression and anxiety disorders in patients with euthyroid Hashimoto’s thyroiditis: a comparative study. Gen Hosp Psychiatry. 2014;36:95–8.
Article
PubMed
Google Scholar
Xu J, Zhu XY, Sun H, Xu XQ, Xu SA, Suo Y, et al. Low vitamin D levels are associated with cognitive impairment in patients with Hashimoto thyroiditis. BMC Endocr Disord. 2018;18:87.
Article
CAS
PubMed
PubMed Central
Google Scholar
Leyhe T, Mussig K. Cognitive and affective dysfunctions in autoimmune thyroiditis. Brain Behav Immun. 2014;41:261–6.
Article
CAS
PubMed
Google Scholar
Djurovic M, Pereira AM, Smit JWA, Vasovic O, Damjanovic S, Jemuovic Z, et al. Cognitive functioning and quality of life in patients with Hashimoto thyroiditis on long-term levothyroxine replacement. Endocrine. 2018;62:136–43.
Article
CAS
PubMed
Google Scholar
Leyhe T, Mussig K, Weinert C, Laske C, Haring HU, Saur R, et al. Increased occurrence of weaknesses in attention testing in patients with Hashimoto’s thyroiditis compared to patients with other thyroid illnesses. Psychoneuroendocrinology. 2008;33:1432–6.
Article
PubMed
Google Scholar
Leyhe T, Ethofer T, Bretscher J, Kunle A, Sauberlich AL, Klein R, et al. Low performance in attention testing is associated with reduced grey matter density of the left inferior frontal gyrus in euthyroid patients with Hashimoto’s thyroiditis. Brain Behav Immun. 2013;27:33–7.
Article
PubMed
Google Scholar
Wang N, Sun Y, Yang H, Xu Y, Cai Y, Liu T, et al. Hashimoto’s thyroiditis induces hippocampus-dependent cognitive alterations by impairing astrocytes in euthyroid mice. Thyroid. 2021;31:482–93.
Article
CAS
PubMed
Google Scholar
Cai YJ, Wang F, Chen ZX, Li L, Fan H, Wu ZB, et al. Hashimoto’s thyroiditis induces neuroinflammation and emotional alterations in euthyroid mice. J Neuroinflammation. 2018;15:299.
Article
CAS
PubMed
PubMed Central
Google Scholar
Ransohoff RM, Brown MA. Innate immunity in the central nervous system. J Clin Invest. 2012;122:1164–71.
Article
CAS
PubMed
PubMed Central
Google Scholar
Morganti-Kossmann MC, Semple BD, Hellewell SC, Bye N, Ziebell JM. The complexity of neuroinflammation consequent to traumatic brain injury: from research evidence to potential treatments. Acta Neuropathol. 2019;137:731–55.
Article
PubMed
Google Scholar
Sarlus H, Heneka MT. Microglia in Alzheimer’s disease. J Clin Invest. 2017;127:3240–9.
Article
PubMed
PubMed Central
Google Scholar
Yirmiya R, Rimmerman N, Reshef R. Depression as a microglial disease. Trends Neurosci. 2015;38:637–58.
Article
CAS
PubMed
Google Scholar
Hao S, Dey A, Yu X, Stranahan AM. Dietary obesity reversibly induces synaptic stripping by microglia and impairs hippocampal plasticity. Brain Behav Immun. 2016;51:230–9.
Article
PubMed
Google Scholar
Ben Achour S, Pascual O. Glia: the many ways to modulate synaptic plasticity. Neurochem Int. 2010;57:440–5.
Article
CAS
PubMed
Google Scholar
Meyer D, Bonhoeffer T, Scheuss V. Balance and stability of synaptic structures during synaptic plasticity. Neuron. 2014;82:430–43.
Article
CAS
PubMed
Google Scholar
Wake H, Moorhouse AJ, Jinno S, Kohsaka S, Nabekura J. Resting microglia directly monitor the functional state of synapses in vivo and determine the fate of ischemic terminals. J Neurosci. 2009;29:3974–80.
Article
CAS
PubMed
PubMed Central
Google Scholar
Wu Y, Dissing-Olesen L, MacVicar BA, Stevens B. Microglia: dynamic mediators of synapse development and plasticity. Trends Immunol. 2015;36:605–13.
Article
PubMed
PubMed Central
CAS
Google Scholar
Parkhurst CN, Yang G, Ninan I, Savas JN, Yates JR 3rd, Lafaille JJ, et al. Microglia promote learning-dependent synapse formation through brain-derived neurotrophic factor. Cell. 2013;155:1596–609.
Article
CAS
PubMed
PubMed Central
Google Scholar
Blinzinger K, Kreutzberg G. Displacement of synaptic terminals from regenerating motoneurons by microglial cells. Z Zellforsch Mikrosk Anat. 1968;85:145–57.
Article
CAS
PubMed
Google Scholar
Makwana M, Jones LL, Cuthill D, Heuer H, Bohatschek M, Hristova M, et al. Endogenous transforming growth factor beta 1 suppresses inflammation and promotes survival in adult CNS. J Neurosci. 2007;27:11201–13.
Article
CAS
PubMed
PubMed Central
Google Scholar
Trapp BD, Wujek JR, Criste GA, Jalabi W, Yin X, Kidd GJ, et al. Evidence for synaptic stripping by cortical microglia. Glia. 2007;55:360–8.
Article
PubMed
Google Scholar
Damotte D, Colomb E, Cailleau C, Brousse N, Charreire J, Carnaud C. Analysis of susceptibility of NOD mice to spontaneous and experimentally induced thyroiditis. Eur J Immunol. 1997;27:2854–62.
Article
CAS
PubMed
Google Scholar
Pearce EN, Farwell AP, Braverman LE. Thyroiditis. N Engl J Med. 2003;348:2646–55.
Article
PubMed
Google Scholar
Kari S, Flynn JC, Zulfiqar M, Snower DP, Elliott BE, Kong YC. Enhanced autoimmunity associated with induction of tumor immunity in thyroiditis-susceptible mice. Thyroid. 2013;23:1590–9.
Article
CAS
PubMed
PubMed Central
Google Scholar
Kolypetri P, Randell E, Van Vliet BN, Carayanniotis G. High salt intake does not exacerbate murine autoimmune thyroiditis. Clin Exp Immunol. 2014;176:336–40.
Article
CAS
PubMed
PubMed Central
Google Scholar
Vecchiatti SM, Guzzo ML, Caldini EG, Bisi H, Longatto-Filho A, Lin CJ. Iodine increases and predicts incidence of thyroiditis in NOD mice: histopathological and ultrastructural study. Exp Ther Med. 2013;5:603–7.
Article
PubMed
Google Scholar
Yu Z, Han Y, Shen R, Huang K, Xu YY, Wang QN, et al. Gestational di-(2-ethylhexyl) phthalate exposure causes fetal intrauterine growth restriction through disturbing placental thyroid hormone receptor signaling. Toxicol Lett. 2018;294:1–10.
Article
CAS
PubMed
Google Scholar
Koutcherov Y, Mai JK, Paxinos G. Hypothalamus of the human fetus. J Chem Neuroanat. 2003;26:253–70.
Article
CAS
PubMed
Google Scholar
Wang F, Wu Z, Zha X, Cai Y, Wu B, Jia X, et al. Concurrent administration of thyroxine and donepezil induces plastic changes in the prefrontal cortex of adult hypothyroid rats. Mol Med Rep. 2017;16:3233–41.
Article
CAS
PubMed
PubMed Central
Google Scholar
Alonso-Nanclares L, Gonzalez-Soriano J, Rodriguez JR, DeFelipe J. Gender differences in human cortical synaptic density. Proc Natl Acad Sci U S A. 2008;105:14615–9.
Article
CAS
PubMed
PubMed Central
Google Scholar
Xu X, Liu X, Zhang Q, Zhang G, Lu Y, Ruan Q, et al. Sex-specific effects of bisphenol-A on memory and synaptic structural modification in hippocampus of adult mice. Horm Behav. 2013;63:766–75.
Article
CAS
PubMed
Google Scholar
Hong S, Beja-Glasser VF, Nfonoyim BM, Frouin A, Li S, Ramakrishnan S, et al. Complement and microglia mediate early synapse loss in Alzheimer mouse models. Science. 2016;352:712–6.
Article
CAS
PubMed
PubMed Central
Google Scholar
Desmond NL, Levy WB. Changes in the numerical density of synaptic contacts with long-term potentiation in the hippocampal dentate gyrus. J Comp Neurol. 1986;253:466–75.
Article
CAS
PubMed
Google Scholar
Bian C, Huang Y, Zhu H, Zhao Y, Zhao J, Zhang J. Steroid receptor coactivator-1 knockdown decreases synaptic plasticity and impairs spatial memory in the hippocampus of mice. Neuroscience. 2018;377:114–25.
Article
CAS
PubMed
Google Scholar
Jones DG, Devon RM. An ultrastructural study into the effects of pentobarbitone on synaptic organization. Brain Res. 1978;147:47–63.
Article
CAS
PubMed
Google Scholar
Sanagi T, Yuasa S, Nakamura Y, Suzuki E, Aoki M, Warita H, et al. Appearance of phagocytic microglia adjacent to motoneurons in spinal cord tissue from a presymptomatic transgenic rat model of amyotrophic lateral sclerosis. J Neurosci Res. 2010;88:2736–46.
CAS
PubMed
Google Scholar
Gao X, Deng P, Xu ZC, Chen J. Moderate traumatic brain injury causes acute dendritic and synaptic degeneration in the hippocampal dentate gyrus. PLoS ONE. 2011;6:e24566.
Article
CAS
PubMed
PubMed Central
Google Scholar
Chugh D, Nilsson P, Afjei SA, Bakochi A, Ekdahl CT. Brain inflammation induces post-synaptic changes during early synapse formation in adult-born hippocampal neurons. Exp Neurol. 2013;250:176–88.
Article
CAS
PubMed
Google Scholar
Avdic U, Chugh D, Osman H, Chapman K, Jackson J, Ekdahl CT. Absence of interleukin-1 receptor 1 increases excitatory and inhibitory scaffolding protein expression and microglial activation in the adult mouse hippocampus. Cell Mol Immunol. 2015;12:645–7.
Article
CAS
PubMed
Google Scholar
Kim HJ, Cho MH, Shim WH, Kim JK, Jeon EY, Kim DH, et al. Deficient autophagy in microglia impairs synaptic pruning and causes social behavioral defects. Mol Psychiatry. 2017;22:1576–84.
Article
CAS
PubMed
Google Scholar
Salvesen L, Winge K, Brudek T, Agander TK, Lokkegaard A, Pakkenberg B. Neocortical neuronal loss in patients with multiple system atrophy: a stereological study. Cereb Cortex. 2017;27:400–10.
PubMed
Google Scholar
Bolton JL, Marinero S, Hassanzadeh T, Natesan D, Le D, Belliveau C, et al. Gestational exposure to air pollution alters cortical volume, microglial morphology, and microglia-neuron interactions in a sex-specific manner. Front Synaptic Neurosci. 2017;9:10.
Article
PubMed
PubMed Central
CAS
Google Scholar
Gellrich MM, Gellrich NC. Quantitative relations in the retinal ganglion cell layer of the rat: neurons, glia and capillaries before and after optic nerve section. Graefes Arch Clin Exp Ophthalmol. 1996;234:315–23.
Article
CAS
PubMed
Google Scholar
Gramlich OW, Joachim SC, Gottschling PF, Laspas P, Cuny CS, Pfeiffer N, et al. Ophthalmopathology in rats with MBP-induced experimental autoimmune encephalomyelitis. Graefes Arch Clin Exp Ophthalmol. 2011;249:1009–20.
Article
PubMed
Google Scholar
Ge JF, Peng YY, Qi CC, Chen FH, Zhou JN. Depression-like behavior in subclinical hypothyroidism rat induced by hemi-thyroid electrocauterization. Endocrine. 2014;45:430–8.
Article
CAS
PubMed
Google Scholar
Bellesi M, de Vivo L, Chini M, Gilli F, Tononi G, Cirelli C. Sleep loss promotes astrocytic phagocytosis and microglial activation in mouse cerebral cortex. J Neurosci. 2017;37:5263–73.
Article
CAS
PubMed
PubMed Central
Google Scholar
Emirandetti A, Simoes GF, Zanon RG, Oliveira AL. Spinal motoneuron synaptic plasticity after axotomy in the absence of inducible nitric oxide synthase. J Neuroinflammation. 2010;7:31.
Article
PubMed
PubMed Central
CAS
Google Scholar
Chen Z, Jalabi W, Shpargel KB, Farabaugh KT, Dutta R, Yin X, et al. Lipopolysaccharide-induced microglial activation and neuroprotection against experimental brain injury is independent of hematogenous TLR4. J Neurosci. 2012;32:11706–15.
Article
CAS
PubMed
PubMed Central
Google Scholar
Fields RD, Stevens-Graham B. New insights into neuron-glia communication. Science. 2002;298:556–62.
Article
CAS
PubMed
PubMed Central
Google Scholar
Klauck TM, Scott JD. The postsynaptic density: a subcellular anchor for signal transduction enzymes. Cell Signal. 1995;7:747–57.
Article
CAS
PubMed
Google Scholar
Xiao Y, Fu H, Han X, Hu X, Gu H, Chen Y, et al. Role of synaptic structural plasticity in impairments of spatial learning and memory induced by developmental lead exposure in Wistar rats. PLoS ONE. 2014;9:e115556.
Article
PubMed
PubMed Central
CAS
Google Scholar
Cortes C, Eugenin E, Aliaga E, Carreno LJ, Bueno SM, Gonzalez PA, et al. Hypothyroidism in the adult rat causes incremental changes in brain-derived neurotrophic factor, neuronal and astrocyte apoptosis, gliosis, and deterioration of postsynaptic density. Thyroid. 2012;22:951–63.
Article
CAS
PubMed
PubMed Central
Google Scholar
Strobl MJ, Freeman D, Patel J, Poulsen R, Wendler CC, Rivkees SA, et al. Opposing effects of maternal hypo- and hyperthyroidism on the stability of thalamocortical synapses in the visual cortex of adult offspring. Cereb Cortex. 2017;27:3015–27.
PubMed
Google Scholar
Wang F, Zeng X, Zhu Y, Ning D, Liu J, Liu C, et al. Effects of thyroxine and donepezil on hippocampal acetylcholine content, acetylcholinesterase activity, synaptotagmin-1 and SNAP-25 expression in hypothyroid adult rats. Mol Med Rep. 2015;11:775–82.
Article
CAS
PubMed
Google Scholar
Wishart TM, Parson SH, Gillingwater TH. Synaptic vulnerability in neurodegenerative disease. J Neuropathol Exp Neurol. 2006;65:733–9.
Article
CAS
PubMed
Google Scholar
Erturk A, Wang Y, Sheng M. Local pruning of dendrites and spines by caspase-3-dependent and proteasome-limited mechanisms. J Neurosci. 2014;34:1672–88.
Article
CAS
PubMed
PubMed Central
Google Scholar
Vasek MJ, Garber C, Dorsey D, Durrant DM, Bollman B, Soung A, et al. A complement-microglial axis drives synapse loss during virus-induced memory impairment. Nature. 2016;534:538–43.
Article
CAS
PubMed
PubMed Central
Google Scholar
Albert M, Barrantes-Freer A, Lohrberg M, Antel JP, Prineas JW, Palkovits M, et al. Synaptic pathology in the cerebellar dentate nucleus in chronic multiple sclerosis. Brain Pathol. 2017;27:737–47.
Article
PubMed
PubMed Central
Google Scholar
Bialas AR, Presumey J, Das A, van der Poel CE, Lapchak PH, Mesin L, et al. Microglia-dependent synapse loss in type I interferon-mediated lupus. Nature. 2017;546:539–43.
Article
CAS
PubMed
Google Scholar
Prinz M, Erny D, Hagemeyer N. Ontogeny and homeostasis of CNS myeloid cells. Nat Immunol. 2017;18:385–92.
Article
CAS
PubMed
Google Scholar
Milligan CE, Webster L, Piros ET, Evans CJ, Cunningham TJ, Levitt P. Induction of opioid receptor-mediated macrophage chemotactic activity after neonatal brain injury. J Immunol. 1995;154:6571–81.
CAS
PubMed
Google Scholar
Stevens B, Allen NJ, Vazquez LE, Howell GR, Christopherson KS, Nouri N, et al. The classical complement cascade mediates CNS synapse elimination. Cell. 2007;131:1164–78.
Article
CAS
PubMed
Google Scholar
Peterson JW, Bo L, Mork S, Chang A, Trapp BD. Transected neurites, apoptotic neurons, and reduced inflammation in cortical multiple sclerosis lesions. Ann Neurol. 2001;50:389–400.
Article
CAS
PubMed
Google Scholar
Haga S, Akai K, Ishii T. Demonstration of microglial cells in and around senile (neuritic) plaques in the Alzheimer brain. An immunohistochemical study using a novel monoclonal antibody. Acta Neuropathol. 1989;77:569–75.
Article
CAS
PubMed
Google Scholar
Tremblay ME, Lowery RL, Majewska AK. Microglial interactions with synapses are modulated by visual experience. PLoS Biol. 2010;8:e1000527.
Article
PubMed
PubMed Central
CAS
Google Scholar
Rajendran L, Paolicelli RC. Microglia-mediated synapse loss in Alzheimer’s disease. J Neurosci. 2018;38:2911–9.
Article
CAS
PubMed
PubMed Central
Google Scholar
Wang WY, Tan MS, Yu JT, Tan L. Role of pro-inflammatory cytokines released from microglia in Alzheimer’s disease. Ann Transl Med. 2015;3:136.
PubMed
PubMed Central
Google Scholar
Li Y, Liu L, Barger SW, Griffin WS. Interleukin-1 mediates pathological effects of microglia on tau phosphorylation and on synaptophysin synthesis in cortical neurons through a p38-MAPK pathway. J Neurosci. 2003;23:1605–11.
Article
CAS
PubMed
PubMed Central
Google Scholar
Sofroniew MV, Vinters HV. Astrocytes: biology and pathology. Acta Neuropathol. 2010;119:7–35.
Article
PubMed
Google Scholar
Clarke LE, Barres BA. Emerging roles of astrocytes in neural circuit development. Nat Rev Neurosci. 2013;14:311–21.
Article
CAS
PubMed
PubMed Central
Google Scholar
Chung WS, Clarke LE, Wang GX, Stafford BK, Sher A, Chakraborty C, et al. Astrocytes mediate synapse elimination through MEGF10 and MERTK pathways. Nature. 2013;504:394–400.
Article
CAS
PubMed
PubMed Central
Google Scholar
Liddelow S, Barres B. SnapShot: astrocytes in health and disease. Cell. 2015;162:1170–270.
Article
CAS
PubMed
Google Scholar
Liddelow SA, Guttenplan KA, Clarke LE, Bennett FC, Bohlen CJ, Schirmer L, et al. Neurotoxic reactive astrocytes are induced by activated microglia. Nature. 2017;541:481–7.
Article
CAS
PubMed
PubMed Central
Google Scholar
Chung WS, Allen NJ, Eroglu C. Astrocytes control synapse formation, function, and elimination. Cold Spring Harb Perspect Biol. 2015;7:a020370.
Article
PubMed
PubMed Central
Google Scholar