Articles

Transcranial direct current stimulation for balance and gait in repetitive mild traumatic brain injury in rats

Balance impairment and lack of postural orientation are serious problems in patients with repetitive mild traumatic brain injury (mTBI).

Authors: Gahee Park, Jee Hyun Suh and Soo Jeong Han

N/OFQ modulates orofacial pain induced by tooth movement through CGRP-dependent pathways

Nociceptin/orphanin FQ (N/OFQ) has been revealed to play bidirectional roles in orofacial pain modulation. Calcitonin gene-related peptide (CGRP) is a well-known pro-nociceptive molecule that participates in t...

Authors: Xinyu Yan, Han Han, Shizhen Zhang, Yanzhu Lu, Linghuan Ren, Yufei Tang, Xiaolong Li, Fan Jian, Yan Wang, Hu Long and Wenli Lai

Behavioral sensitization induced by methamphetamine causes differential alterations in gene expression and histone acetylation of the prefrontal cortex in rats

Methamphetamine (METH) is one of the most widely abused illicit substances worldwide; unfortunately, its addiction mechanism remains unclear. Based on accumulating evidence, changes in gene expression and chro...

Authors: Hui Li, Jing-An Chen, Qian-Zhi Ding, Guan-Yi Lu, Ning Wu, Rui-Bin Su, Fei Li and Jin Li

Spinal reflexive movement follows general tau theory

Tau theory explains how both intrinsically and perceptually guided movements are controlled by the brain. According to general tau theory, voluntary, self-paced human movements are controlled by coupling the t...

Authors: Mehrdad Bahadori, Paola Cesari, Cathy Craig and Mehran Emadi Andani

Sex effects on clinical features in LRRK2 G2385R carriers and non-carriers in Parkinson's disease

Differences of genotypes between male and female have been studied in Parkinson’s disease (PD), but limited research has focused on the comparison between sexes with LRRK2 G2385 variant.

Authors: Shi-Shuang Cui, Rao Fu, Juan-Juan Du, Yi-Qi Lin, Pei Huang, Chao Gao, Hai-Yan Zhou and Sheng-Di Chen

Ammonia induced microglia activation was associated with limited effects on connexin 43 and aquaporin 4 expression in an astrocyte-microglia co-culture model

Hepatic encephalopathy (HE) is a neurological complication resulting from acute or chronic liver disease. Hyperammonemia leading to astrocyte swelling and cerebral edema in combination with neuroinflammation i...

Authors: Fatme Seval Ismail, Timo Jendrik Faustmann, Franco Corvace, Anamariya Tsvetanova, Zahra Moinfar and Pedro M. Faustmann

Association between the vertebrobasilar artery geometry and basilar artery plaques determined by high-resolution magnetic resonance imaging

Atherosclerotic plaques are often present in regions of arteries with complicated flow patterns. Vascular morphology plays important role in hemodynamics. In this study, we investigated the relationship betwee...

Authors: Jinmei Zheng, Bin Sun, Ruolan Lin, Yongqi Teng, Xihai Zhao and Yunjing Xue

Framing and self-responsibility modulate brain activities in decision escalation

Escalation of commitment is a common bias in human decision making. The present study examined (1) differences in neural recruitment for escalation and de-escalation decisions of prior investments, and (2) how...

Authors: Ting-Peng Liang, Yu-Wen Li, Nai-Shing Yen, Ofir Turel and Sen-Mou Hsu

SCN11A gene deletion causes sensorineural hearing loss by impairing the ribbon synapses and auditory nerves

The SCN11A gene, encoded Nav1.9 TTX resistant sodium channels, is a main effector in peripheral inflammation related pain in nociceptive neurons. The role of SCN11A gene in the auditory system has not been well c...

Authors: Mian Zu, Wei-Wei Guo, Tao Cong, Fei Ji, Shi-Li Zhang, Yue Zhang, Xin Song, Wei Sun, David Z. Z. He, Wei-Guo Shi and Shi-Ming Yang

The role of mGlu4 receptors within the nucleus accumbens in acquisition and expression of morphine-induced conditioned place preference in male rats

Several studies have shown that glutamate neurotransmission in the nucleus accumbens (NAc) is required for the development of morphine-induced conditional place preference (CPP). In addition, metabotropic glut...

Authors: Zahra Ebrahimi, Nazanin Kahvandi, Alireza Komaki, Seyed Asaad Karimi, Marzieh Naderishahab and Abdolrahman Sarihi

Correction to: Eye-tracking-aided characterization of saccades and antisaccades in SYNE1 ataxia patients: a pilot study

An amendment to this paper has been published and can be accessed via the original article.

Authors: Laszlo Szpisjak, Gabor Szaraz, Andras Salamon, Viola L. Nemeth, Noemi Szepfalusi, Gabor Veres, Balint Kincses, Zoltan Maroti, Tibor Kalmar, Malgorzata Rydzanicz, Rafal Ploski, Peter Klivenyi and Denes Zadori

Construction of competitive endogenous RNA network reveals regulatory role of long non-coding RNAs in intracranial aneurysm

Rupture of intracranial aneurysm (IA) is the main cause of devastating subarachnoid hemorrhage, which urges our understanding of the pathogenesis and regulatory mechanisms of IA. However, the regulatory roles ...

Authors: Yuan-Bo Pan, Jianan Lu, Biao Yang, Cameron Lenahan, Jianmin Zhang and Anwen Shao

Protective effects of intracerebroventricular adiponectin against olfactory impairments in an amyloid β_1–42 rat model

Alzheimer’s disease (AD) is characterized by cognitive impairment that eventually develops into dementia. Amyloid-beta (Aβ) accumulation is a widely described hallmark in AD, and has been reported to cause olf...

Authors: Mara A. Guzmán-Ruiz, Amor Herrera-González, Adriana Jiménez, Alan Candelas-Juárez, Crystal Quiroga-Lozano, Claudia Castillo-Díaz, Erika Orta-Salazar, Diana Organista-Juárez, Sofía Díaz-Cintra and Rosalinda Guevara-Guzmán

Homeostatic sleep regulation in the absence of the circadian sleep‐regulating component: effect of short light–dark cycles on sleep–wake stages and slow waves

Aside from the homeostatic and circadian components, light has itself an important, direct as well as indirect role in sleep regulation. Light exerts indirect sleep effect by modulating the circadian rhythms. ...

Authors: Örs Szalontai, Attila Tóth, Máté Pethő, Dóra Keserű, Tünde Hajnik and László Détári

Sex differences in neural responses to reward and the influences of individual reward and punishment sensitivity

Men and women show differences in sensitivity to reward and punishment, which may impact behavior in health and disease. However, the neural bases of these sex differences remain under-investigated. Here, by c...

Authors: Isha Dhingra, Sheng Zhang, Simon Zhornitsky, Wuyi Wang, Thang M. Le and Chiang-Shan R. Li

Neural basis underlying the trait of attachment anxiety and avoidance revealed by the amplitude of low-frequency fluctuations and resting-state functional connectivity

Attachment theory demonstrates that early attachment experience shapes internal working models with mental representations of self and close relationships, which affects personality traits and interpersonal re...

Authors: Min Deng, Xing Zhang, Xiaoyan Bi and Chunhai Gao

Cortical hemodynamics as a function of handgrip strength and cognitive performance: a cross-sectional fNIRS study in younger adults

There is growing evidence for a positive correlation between measures of muscular strength and cognitive abilities. However, the neurophysiological correlates of this relationship are not well understood so fa...

Authors: Fabian Herold, Tom Behrendt, Alexander Törpel, Dennis Hamacher, Notger G. Müller and Lutz Schega

Geranylgeranylacetone attenuates cerebral ischemia–reperfusion injury in rats through the augmentation of HSP 27 phosphorylation: a preliminary study

We previously reported that heat shock protein 27 (HSP27) phosphorylation plays an important role in the activation of glucose-6-phosphate dehydrogenase (G6PD), resulting in the upregulation of the pentose pho...

Authors: Kazuya Matsuo, Kohkichi Hosoda, Jun Tanaka, Yusuke Yamamoto, Taichiro Imahori, Tomoaki Nakai, Yasuhiro Irino, Masakazu Shinohara, Takashi Sasayama and Eiji Kohmura

Eosinophil-to-monocyte ratio is a potential biomarker in the prediction of functional outcome among patients with acute ischemic stroke

It has been shown that eosinophils are decreased and monocytes are elevated in patients with acute ischemic stroke (AIS), but the impact of eosinophil-to-monocyte ratio (EMR) on clinical outcomes among AIS pat...

Authors: Shuhong Yu, Yi Luo, Tan Zhang, Chenrong Huang, Yu Fu, Qiang Zhang, Fangyue Zeng, Hao Huang, Chunyuan Zhang and Zhiliang Guo

Eye-tracking-aided characterization of saccades and antisaccades in SYNE1 ataxia patients: a pilot study

SYNE1 ataxia is an autosomal recessive hereditary condition, the main characteristic features of which are gait and limb ataxia and cerebellar dysarthria. Reports have revealed that the clinical phenotype of SYNE...

Authors: Laszlo Szpisjak, Gabor Szaraz, Andras Salamon, Viola L. Nemeth, Noemi Szepfalusi, Gabor Veres, Balint Kincses, Zoltan Maroti, Tibor Kalmar, Malgorzata Rydzanicz, Rafal Ploski, Peter Klivenyi and Denes Zadori

The inflammatory profile of cerebrospinal fluid, plasma, and saliva from patients with severe neuropathic pain and healthy controls-a pilot study

Neuropathic pain (NeuP) is a complex, debilitating condition of the somatosensory system, where dysregulation between pro- and anti-inflammatory cytokines and chemokines are believed to play a pivotal role. As...

Authors: Mika Jönsson, Björn Gerdle, Bijar Ghafouri and Emmanuel Bäckryd

 Knockout of the circadian gene, Per2, disrupts corticosterone secretion and results in depressive‐like behaviors and deficits in startle responses

The Period Circadian Regulator 2 (Per2) gene is important for the modulation of circadian rhythms that influence biological processes. Circadian control of the hypothalamus-pituitary-adrenal (HPA) axis is critica...

Authors: Ashley L. Russell, Lauren Miller, Hannah Yi, Rita Keil, Robert J. Handa and T. John Wu

Docosahexaenoic fatty acid reduces the pro‐inflammatory response induced by IL-1β in astrocytes through inhibition of NF-κB and AP-1 transcription factor activation

Astrocytes are responsible for a broad range of functions that maintain homeostasis in the brain. However, their response to the pro-inflammatory cytokines released by activated microglia in various neurologic...

Authors: Emilia Zgórzyńska, Dawid Stulczewski, Barbara Dziedzic, Kuan-Pin Su and Anna Walczewska

Association between circle of Willis and ischemic stroke: a systematic review and meta-analysis

Circle of Willis is the main structure that provides constant and regular blood flow to the brain, protects the brain from ischemia. Stroke has remained the second leading cause of death globally in the last f...

Authors: Mohammed Oumer, Mekuriaw Alemayehu and Abebe Muche

Post-status epilepticus treatment with the Fyn inhibitor, saracatinib, improves cognitive function in mice

Status epilepticus (SE) is a life-threatening neurological disorder. The hippocampus, as an important area of the brain that regulates cognitive function, is usually damaged after SE, and cognitive deficits of...

Authors: Xin-Ming Luo, Jing Zhao, Wen-Yue Wu, Jie Fu, Zheng-Yu Li, Ming Zhang and Jie Lu

A dimension reduction technique applied to regression on high dimension, low sample size neurophysiological data sets

A common problem in neurophysiological signal processing is the extraction of meaningful information from high dimension, low sample size data (HDLSS). We present RoLDSIS (regression on low-dimension spanned i...

Authors: Adrielle C. Santana, Adriano V. Barbosa, Hani C. Yehia and Rafael Laboissière

29th Annual Computational Neuroscience Meeting: CNS*2020

Authors:

Distraction by a cognitive task has a higher impact on electrophysiological measures compared with conditioned pain modulation

Conditioned pain modulation (CPM) evaluates the effect of a painful conditioning stimulus (CS) on a painful test stimulus (TS). Using painful cutaneous electrical stimulation (PCES) as TS and painful cold wate...

Authors: A. T. L. Do, E. K. Enax-Krumova, Ö. Özgül, L. B. Eitner, S. Heba, M. Tegenthoff, C. Maier and O. Höffken

Target detection in healthy 4-week old piglets from a passive two-tone auditory oddball paradigm

Passive auditory oddball tests are effort independent assessments that evaluate auditory processing and are suitable for paediatric patient groups. Our goal was to develop a two-tone auditory oddball test pro...

Authors: R. Anna Oeur and Susan S. Margulies

Sex-dimorphic neuroestradiol regulation of ventromedial hypothalamic nucleus glucoregulatory transmitter and glycogen metabolism enzyme protein expression in the rat

Ventromedial hypothalamic nucleus (VMN) gluco-regulatory transmission is subject to sex-specific control by estradiol. The VMN is characterized by high levels of aromatase expression.

Authors: Md. Main Uddin, Mostafa M. H. Ibrahim and Karen P. Briski

Enriched environment ameliorates adult hippocampal neurogenesis deficits in Tcf4 haploinsufficient mice

Transcription factor 4 (TCF4) has been linked to human neurodevelopmental disorders such as intellectual disability, Pitt-Hopkins Syndrome (PTHS), autism, and schizophrenia. Recent work demonstrated that TCF4 par...

Authors: Katharina Braun, Benjamin M. Häberle, Marie-Theres Wittmann and D. Chichung Lie

Autistic traits are associated with the functional connectivity of between—but not within—attention systems in the general population

Previous studies have demonstrated that individuals with autism spectrum disorder (ASD) exhibit dysfunction in the three attention systems (i.e., alerting, orienting, and executive control) as well as atypical re...

Authors: Sayaka Yoshimura, Kei Kobayashi, Tsukasa Ueno, Takashi Miyagi, Naoya Oishi, Toshiya Murai and Hironobu Fujiwara

Occipital repetitive transcranial magnetic stimulation does not affect multifocal visual evoked potentials

To identify mechanisms of cortical plasticity of the visual cortex and to quantify their significance, sensitive parameters are warranted. In this context, multifocal visual evoked potentials (mfVEPs) can make...

Authors: Robert Kolbe, Aykut Aytulun, Ann-Kristin Müller, Marius Ringelstein, Orhan Aktas, Alfons Schnitzler, Hans-Peter Hartung, Stefan Jun Groiss and Philipp Albrecht

Emotion regulation through bifocal processing of fear inducing and disgust inducing stimuli

We present first-time evidence for the immediate neural and behavioral effects of bifocal emotional processing via visualized tapping for two different types of negative emotions (fear and disgust) in a sample...

Authors: Dina Wittfoth, Antonia Pfeiffer, Michael Bohne, Heinrich Lanfermann and Matthias Wittfoth

Crossed cerebellar diaschisis after stroke detected noninvasively by arterial spin-labeling MR imaging

As a noninvasive perfusion-weighted MRI technique, arterial spin-labeling (ASL) was becoming increasingly used to evaluate cerebral hemodynamics in many studies. The relation between ASL-MRI and crossed cerebe...

Authors: Juan Wang, Li-Jun Pan, Bin Zhou, Jin-Yan Zu, Yi-Xu Zhao, Yang Li, Wan-Qiu Zhu, Lei Li, Jian-Rong Xu and Zeng-Ai Chen

Effect of acute noise trauma on the gene expression profile of the hippocampus

This study aimed to investigate the changes in the expression of hippocampal genes upon acute noise exposure.

Authors: Chang Ho Lee, Kyung Woon Kim, So Min Lee and So Young Kim

Correction to: Gender differences in nerve regeneration after sciatic nerve injury and repair in healthy and in type 2 diabetic Goto-Kakizaki rats

An amendment to this paper has been published and can be accessed via the original article.

Authors: Lena Stenberg and Lars B. Dahlin

Neurologic effects of short-term treatment with a soluble epoxide hydrolase inhibitor after cardiac arrest in pediatric swine

Cardiac arrest (CA) is the most common cause of acute neurologic insult in children. Many survivors have significant neurocognitive deficits at 1 year of recovery. Epoxyeicosatrienoic acids (EETs) are multifun...

Authors: Caitlin E. O’Brien, Polan T. Santos, Ewa Kulikowicz, Jennifer K. Lee, Raymond C. Koehler and Lee J. Martin

Does conserved domain SOD1 mutation has any role in ALS severity and therapeutic outcome?

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative fatal disease that can affect the neurons of brain and spinal cord. ALS genetics has identified various genes to be associated with diseas...

Authors: Surinder Pal, Abha Tiwari, Kaushal Sharma and Suresh Kumar Sharma

Sensory gating and suppression of subjective peripheral sensations during voluntary muscle contraction

During voluntary muscle contraction, sensory information induced by electrostimulation of the nerves supplying the contracting muscle is inhibited and the somatosensory evoked potentials (SEPs) amplitude decre...

Authors: Terumasa Takahara, Hidetaka Yamaguchi, Kazutoshi Seki and Sho Onodera

Autoreceptor control of serotonin dynamics

Serotonin is a neurotransmitter that has been linked to a wide variety of behaviors including feeding and body-weight regulation, social hierarchies, aggression and suicidality, obsessive compulsive disorder, ...

Authors: Janet Best, William Duncan, Farrah Sadre-Marandi, Parastoo Hashemi, H. Frederik Nijhout and Michael Reed

Aberrant functional connectivity in resting state networks of ADHD patients revealed by independent component analysis

ADHD is one of the most common psychiatric disorders in children and adolescents. Altered functional connectivity has been associated with ADHD symptoms. This study aimed to investigate abnormal changes in the...

Authors: Huayu Zhang, Yue Zhao, Weifang Cao, Dong Cui, Qing Jiao, Weizhao Lu, Hongyu Li and Jianfeng Qiu

NGF receptors and PI3K/AKT pathway involved in glucose fluctuation-induced damage to neurons and α-lipoic acid treatment

Glucose fluctuation promotes neuronal apoptosis, which plays a central role in diabetic encephalopathy (DE). Nerve growth factor (NGF), and its interaction with high-affinity (TrkA) and low-affinity (p75NTR) r...

Authors: Ting Yan, Zhihui Zhang and Danqing Li

Distributed causality in resting-state network connectivity in the acute and remitting phases of RRMS

Although previous studies have shown that intra-network abnormalities in brain functional networks are correlated with clinical/cognitive impairment in multiple sclerosis (MS), there is little information rega...

Authors: Lin Wu, Muhua Huang, Fuqing Zhou, Xianjun Zeng and Honghan Gong

Isolation and characterization of antibody fragments selective for human FTD brain derived TDP-43 variants

Frontotemporal dementia (FTD) is the second leading cause of early onset dementia following Alzheimer’s disease. It involves atrophy of the frontal and temporal regions of the brain affecting language, memory,...

Authors: Lalitha Venkataraman, Ping He, Galam Khan, Brent T. Harris and Michael R. Sierks

Inter-scanner reproducibility of brain volumetry: influence of automated brain segmentation software

The inter-scanner reproducibility of brain volumetry is important in multi-site neuroimaging studies, where the reliability of automated brain segmentation (ABS) tools plays an important role. This study aimed...

Authors: Sirui Liu, Bo Hou, Yiwei Zhang, Tianye Lin, Xiaoyuan Fan, Hui You and Feng Feng

Median nerve conduction studies in rabbits

When planning nerve conduction studies using animal models, the sciatic nerve is often used and the upper extremity nerves are not preferred due to the size of laboratory animals. This study aimed to present t...

Authors: Basak Mansiz-Kaplan, Secil Pervane-Vural, Koray Gursoy and Baris Nacir

MicroRNA-138 promotes neuroblastoma SH-SY5Y cell apoptosis by directly targeting DEK in Alzheimer’s disease cell model

Alzheimer’s disease (AD) is a progressive neuro-degenerative disease with a major manifestation of dementia. MicroRNAs were reported to regulate the transcript expression in patients with Alzheimer’s disease (...

Authors: Jin Miao, Jin Jing, Yixiang Shao and Huaichang Sun

Opposing effects of antibiotics and germ-free status on neuropeptide systems involved in social behaviour and pain regulation

Recent research has revealed that the community of microorganisms inhabiting the gut affects brain development, function and behaviour. In particular, disruption of the gut microbiome during critical developme...

Authors: Katerina V. A. Johnson and Philip W. J. Burnet

Genome-wide epigenetic analyses in Japanese immigrant plantation workers with Parkinson’s disease and exposure to organochlorines reveal possible involvement of glial genes and pathways involved in neurotoxicity

Parkinson’s disease (PD) is a disease of the central nervous system that progressively affects the motor system. Epidemiological studies have provided evidence that exposure to agriculture-related occupations ...

Authors: Rodney C. P. Go, Michael J. Corley, G. Webster Ross, Helen Petrovitch, Kamal H. Masaki, Alika K. Maunakea, Qimei He and Maarit I. Tiirikainen