Skip to main content



Page 1 of 92

  1. Content type: Research article

    Parkinson's disease is a progressive degenerative nervous system disease. Recent studies have shown that secondary changes in the GABA system play directly affect the pathogenesis of PD. There is still much de...

    Authors: Lixuan Huang, Yande Ren, Zisan Zeng, Hao Ren, Shaojun Li, Shengnan He, Fan He and Xiangrong Li

    Citation: BMC Neuroscience 2019 20:42

    Published on:

  2. Content type: Research article

    Oxidative stress and neuroinflammation are central pathogenic mechanisms common to many neurological diseases. Isoliquiritigenin (ISL) is a flavonoid in licorice with multiple pharmacological properties, inclu...

    Authors: Xiaobo Zhu, Jiankun Liu, Shaojie Chen, Jiang Xue, Shanying Huang, Yibiao Wang and Ou Chen

    Citation: BMC Neuroscience 2019 20:41

    Published on:

  3. Content type: Research article

    Transcranial direct current stimulation (tDCS) is a noninvasive neural control technology that has become a research hotspot. To facilitate further research of tDCS, the biosafety of 500 μA cathodal tDCS, a co...

    Authors: Keying Zhang, Ling Guo, Junping Zhang, Guangzhou An, Yan Zhou, Jiajin Lin, Junling Xing, Mai Lu and Guirong Ding

    Citation: BMC Neuroscience 2019 20:40

    Published on:

  4. Content type: Research article

    Amblyopia is generally considered a neurodevelopmental disorder that results from abnormal visual experiences in early childhood and may persist to adulthood. The neural basis of amblyopia has been a matter of...

    Authors: Minglong Liang, He Xiao, Bing Xie, Xuntao Yin, Jian Wang and Hong Yang

    Citation: BMC Neuroscience 2019 20:39

    Published on:

  5. Content type: Research article

    In this study, nonlinear based time–frequency (TF) and time domain investigations are employed for the analysis of electroencephalogram (EEG) signals of mild cognitive impairment–Alzheimer’s disease (MCI–AD) p...

    Authors: T. Nimmy John, Puthankattil Subha Dharmapalan and N. Ramshekhar Menon

    Citation: BMC Neuroscience 2019 20:38

    Published on:

  6. Content type: Research article

    Cardiovascular conditions contribute to brain volume loss, reduced cerebrovascular health, and increased dementia risk in aging adults. Altered hippocampal connectivity has also been observed in individuals wi...

    Authors: Liesel-Ann C. Meusel, Carol E. Greenwood, Andrea Maione, Ekaterina Tchistiakova, Bradley J. MacIntosh and Nicole D. Anderson

    Citation: BMC Neuroscience 2019 20:37

    Published on:

  7. Content type: Research article

    Postoperative pain (POP) is a severe acute pain encountered in patients suffering from an operation, and is less than adequately controlled by the currently available analgesics. Phosphatidylinositol 3-kinase ...

    Authors: Bing Xu, Cheng Mo, Chengmei Lv, Susu Liu, Jun Li, Jieying Chen, Yanhong Wei, Hongwei An, Li Ma and Xuehai Guan

    Citation: BMC Neuroscience 2019 20:36

    Published on:

  8. Content type: Research article

    The functional heterogeneity of the hippocampus along its longitudinal axis at the level of behavior is an established concept; however, the neurobiological mechanisms are still unknown. Diversifications in th...

    Authors: Andriana Koutsoumpa and Costas Papatheodoropoulos

    Citation: BMC Neuroscience 2019 20:35

    Published on:

  9. Content type: Research article

    Hypothalamic inflammation including astrogliosis and microglia activation occurs after intake of high fat diet (HFD) in rodent models or in obese individuals. However, the effect of chronic HFD feeding on olig...

    Authors: Hui-Ting Huang, Sheng-Feng Tsai, Hung-Tsung Wu, Hsin-Ying Huang, Han-Hsueh Hsieh, Yu-Ming Kuo, Po-See Chen, Chung-Shi Yang and Shun-Fen Tzeng

    Citation: BMC Neuroscience 2019 20:33

    Published on:

  10. Content type: Research article

    Three-dimensional (3D) reconstruction of human peripheral nerves, as a useful tool to understand the nerve internal information and functional basis, has become an important area of research in the peripheral ...

    Authors: Peng Luo, Jianghui Dong, Jian Qi, Yi Zhang, Xiaolin Liu, Yingchun Zhong, Cory J. Xian and Liping Wang

    Citation: BMC Neuroscience 2019 20:32

    Published on:

  11. Content type: Research article

    Recently, the use of traditional Chinese medicine (TCM) has become more generally accepted, including by the Food and Drug Administration. To expand the use of TCM worldwide, it is important to study the molec...

    Authors: Jinyuan Yan, Zhongshan Yang, Ninghui Zhao, Zhiwei Li and Xia Cao

    Citation: BMC Neuroscience 2019 20:31

    Published on:

  12. Content type: Research article

    Distinctive patterns of functional connectivity (FC) abnormalities in neural circuitry has been reported in patients with bipolar depression (BD) and unipolar depression (UD). However, it is unclear that wheth...

    Authors: Chang Liu, Weidan Pu, Guowei Wu, Jie Zhao and Zhimin Xue

    Citation: BMC Neuroscience 2019 20:30

    Published on:

  13. Content type: Research article

    Neuropathic pain (NP) is a prevalent disease, which badly impairs the life quality of patients. The underlying mechanism of NP is still not fully understood. It has been reported that spinal Annexin A10 (ANXA1...

    Authors: LiHong Sun, Qi Xu, WenXin Zhang, CuiCui Jiao, Hui Wu and XinZhong Chen

    Citation: BMC Neuroscience 2019 20:28

    Published on:

  14. Content type: Research article

    The mosquito Aedes aegypti has a wide variety of sensory pathways that have supported its success as a species as well as a highly competent vector of numerous debilitating infectious pathogens. Investigations in...

    Authors: Michelle Bui, Jennifer Shyong, Eleanor K. Lutz, Ting Yang, Ming Li, Kenneth Truong, Ryan Arvidson, Anna Buchman, Jeffrey A. Riffell and Omar S. Akbari

    Citation: BMC Neuroscience 2019 20:27

    Published on:

  15. Content type: Research article

    Brain iron is an essential as well as a toxic redox active element. Physiological levels are not uniform among the different cell types. Besides the availability of quantitative methods, the knowledge about th...

    Authors: Anja Reinert, Markus Morawski, Johannes Seeger, Thomas Arendt and Tilo Reinert

    Citation: BMC Neuroscience 2019 20:25

    Published on:

  16. Content type: Research article

    Mutants which carry mutations in genes encoding mitochondrial ligases MUL1 and PARKIN are convenient Drosophila models of Parkinson’s disease (PD). In several studies it has been shown that in Parkinson’s disease...

    Authors: Bartosz Doktór, Milena Damulewicz and Elżbieta Pyza

    Citation: BMC Neuroscience 2019 20:24

    Published on:

  17. Content type: Research article

    Patients with Parkinson’s disease (PD) have elevated levels of brain iron, especially in the nigrostriatal dopaminergic system. The purpose of this study was to evaluate the iron deposition in the substantia n...

    Authors: Qiqi Chen, Yiting Chen, Yue Zhang, Furu Wang, Hongchang Yu, Caiyuan Zhang, Zhen Jiang and Weifeng Luo

    Citation: BMC Neuroscience 2019 20:23

    Published on:

  18. Content type: Research article

    Prepulse inhibition (PPI) of the acoustic startle response, a measurement of sensorimotor gaiting, is modulated by monoaminergic, presumably dopaminergic neurotransmission. Disturbances of the dopaminergic sys...

    Authors: Patricia Panther, Maria Kuehne, Jürgen Voges, Sven Nullmeier, Jörn Kaufmann, Janet Hausmann, Daniel Bittner, Imke Galazky, Hans-Jochen Heinze, Andreas Kupsch and Tino Zaehle

    Citation: BMC Neuroscience 2019 20:20

    Published on:

  19. Content type: Research article

    To determine whether photobiomodulation (PBM) rescued the disruption of Na+/Ca2+ homeostasis and mitochondrial membrane potential by ouabain; the Na, K-ATPase inhibitor. For PBM in this study, a 660 nm LED array ...

    Authors: Yun-Hee Rhee, Jeong Hwan Moon, Jae Yun Jung, Connie Oh, Jin-Chul Ahn and Phil-Sang Chung

    Citation: BMC Neuroscience 2019 20:19

    Published on:

  20. Content type: Research article

    Despite increasing evidence that lipopolysaccharide (LPS) affects the biological active substances of dorsal root ganglia (DRG) we have limited knowledge of the influence of a single low dose of LPS, which doe...

    Authors: Anita Mikołajczyk and Dagmara Złotkowska

    Citation: BMC Neuroscience 2019 20:18

    Published on:

  21. Content type: Research article

    Reports show that stressful events before injury exacerbates post-injury pain. The mechanism underlying stress-induced heightened thermal pain is unclear. Here, we examined the effects of chronic intermittent ...

    Authors: Natasha M. Sosanya, Thomas H. Garza, Winfred Stacey, Stephen L. Crimmins, Robert J. Christy and Bopaiah P. Cheppudira

    Citation: BMC Neuroscience 2019 20:17

    Published on:

  22. Content type: Research article

    Chronic neuropathic pain is often associated with anxiety, depressive symptoms, and cognitive impairment with relevant impact on patients` health related quality of life. To investigate the influence of a pro-...

    Authors: Franziska Karl, Maria B. Nandini Colaço, Annemarie Schulte, Claudia Sommer and Nurcan Üçeyler

    Citation: BMC Neuroscience 2019 20:16

    Published on:

  23. Content type: Research article

    Smoking (TS) and recently e-cigarettes (EC) vaping, have been associated with vascular endothelial dysfunction primarily relevant to oxidative stress, exposure to nicotine, and smoking-induced inflammation. It...

    Authors: Farzane Sivandzade and Luca Cucullo

    Citation: BMC Neuroscience 2019 20:15

    Published on:

  24. Content type: Research article

    Previous data show that serotonin 2C (5-HT2C) and cannabinoid 1 (CB1) receptors have a role in the modulation of sleep–wake cycle. Namely, antagonists on these receptors promoted wakefulness and inhibited rapid e...

    Authors: Emese Bogáthy, Noémi Papp, Laszló Tóthfalusi, Szilvia Vas and György Bagdy

    Citation: BMC Neuroscience 2019 20:14

    Published on:

  25. Content type: Research article

    Knock-in (KI) mouse models of Alzheimer’s disease (AD) that endogenously overproduce Aβ without non-physiological overexpression of amyloid precursor protein (APP) provide important insights into the pathogeni...

    Authors: Yasufumi Sakakibara, Michiko Sekiya, Takashi Saito, Takaomi C. Saido and Koichi M. Iijima

    Citation: BMC Neuroscience 2019 20:13

    Published on:

  26. Content type: Research article

    Transcranial focused ultrasound (tFUS) attracts wide attention in neuroscience as an effective noninvasive approach to modulate brain circuits. In spite of this, the effects of tFUS on the brain is still uncle...

    Authors: Evgenii Kim, Eloise Anguluan, Sangyeon Youn, Jihun Kim, Jae Youn Hwang and Jae Gwan Kim

    Citation: BMC Neuroscience 2019 20:12

    Published on:

  27. Content type: Research article

    Pre-treatment with the corticotropin-releasing factor antagonist α-helical CRF9-41 prevents inhibition of gastric emptying by cocaine-and amphetamine-regulated transcript peptide at a dorsal hindbrain level, b...

    Authors: Ulrika Smedh, Karen A. Scott and Timothy H. Moran

    Citation: BMC Neuroscience 2019 20:11

    Published on:

  28. Content type: Research article

    The spinal cord is limited in its capacity to repair after damage caused by injury or disease. However, propriospinal (PS) neurons in the spinal cord have demonstrated a propensity for axonal regeneration afte...

    Authors: Kristen Swieck, Amanda Conta-Steencken, Frank A. Middleton, Justin R. Siebert, Donna J. Osterhout and Dennis J. Stelzner

    Citation: BMC Neuroscience 2019 20:10

    Published on:

  29. Content type: Research article

    The recovery of neurophysiological parameters at various time intervals following fatiguing exercise has been investigated previously. However, the repetition of neuromuscular assessments during the recovery p...

    Authors: Saied Jalal Aboodarda, Selina Fan, Kyla Coates and Guillaume Y. Millet

    Citation: BMC Neuroscience 2019 20:9

    Published on:

  30. Content type: Methodology article

    The electroencephalogram (EEG) is a widely used laboratory technique in rodent models of epilepsy, traumatic brain injury (TBI), and other neurological diseases accompanied by seizures. Obtaining prolonged con...

    Authors: Yasser Medlej, Rita Asdikian, Lara Wadi, Houssein Salah, Laura Dosh, Rabih Hashash, Nabil Karnib, Mohammad Medlej, Hala Darwish, Firas Kobeissy and Makram Obeid

    Citation: BMC Neuroscience 2019 20:8

    Published on:

  31. Content type: Research article

    Gulf War Illness (GWI) affects 30% of veterans from the 1991 Gulf War and has no known cause. Everyday symptoms include pain, fatigue, migraines, and dyscognition. A striking syndromic feature is post-exertion...

    Authors: Rakib U. Rayhan, Stuart D. Washington, Richard Garner, Kristina Zajur, Florencia Martinez Addiego, John W. VanMeter and James N. Baraniuk

    Citation: BMC Neuroscience 2019 20:7

    Published on:

  32. Content type: Research article

    Epidemiologic studies strongly suggest that the pathophysiology of late-onset Alzheimer disease (AD) versus early-onset AD has environmental rather than genetic causes, thus revealing potentially novel therape...

    Authors: Zein Al-Atrache, Danielle B. Lopez, Susan T. Hingley and Denah M. Appelt

    Citation: BMC Neuroscience 2019 20:6

    Published on:

  33. Content type: Research article

    Accurately assessing promising therapeutic interventions for human diseases depends, in part, on the reproducibility of preclinical disease models. With the development of transgenic mice, the rapid adaptation...

    Authors: Peggy Rentsch, Sandy Stayte, Gary P. Morris and Bryce Vissel

    Citation: BMC Neuroscience 2019 20:5

    Published on:

  34. Content type: Correction

    Following the publication of the original article [1], it was highlighted that an old version of the text for abstract P252 was published, thereby causing the text to no longer correspond with Fig. 1.

    Authors: James Bennett and Thomas Nowotny

    Citation: BMC Neuroscience 2019 20:4

    Published on:

    The original article was published in BMC Neuroscience 2018 19:65

  35. Content type: Research article

    Transcranial ultrasonic stimulation is a novel noninvasive tool for neuromodulation, and has high spatial resolution and deep penetration. Although it can increase excitation of neurons, its effects on neuron ...

    Authors: Kun Cui, Shuai Zhang, Jinyao Sun, Xueying Zhang, Chong Ding and Guizhi Xu

    Citation: BMC Neuroscience 2019 20:3

    Published on:

  36. Content type: Research article

    To prevent and control dementia, many scholars have focused on the transition stage between normal ageing and dementia, mild cognitive impairment (MCI) which is a key interventional target for dementia. Studie...

    Authors: Ying Xu, Zhijie Qiu, Jingfang Zhu, Jiao Liu, Jingsong Wu, Jing Tao and Lidian Chen

    Citation: BMC Neuroscience 2019 20:2

    Published on:

  37. Content type: Research article

    Peripheral diabetic neuropathy can be painful and its symptoms include hyperalgesia, allodynia and spontaneous pain. Hydrogen sulfide (H2S) is involved in diabetes-induced hyperalgesia and allodynia. However, the...

    Authors: José Eduardo Roa-Coria, Jorge Baruch Pineda-Farias, Paulino Barragán-Iglesias, Geovanna Nallely Quiñonez-Bastidas, Ángel Zúñiga-Romero, Juan Carlos Huerta-Cruz, Juan Gerardo Reyes-García, Francisco Javier Flores-Murrieta, Vinicio Granados-Soto and Héctor Isaac Rocha-González

    Citation: BMC Neuroscience 2019 20:1

    Published on:

  38. Content type: Research article

    Cobalt chloride (CoCl2) induces chemical hypoxia through activation of hypoxia-inducible factor-1 alpha (HIF-1α). Mammalian target of rapamycin (mTOR) is a multifaceted protein capable of regulating cell growth, ...

    Authors: Mary A. Zimmerman, Christan D. Biggers and P. Andy Li

    Citation: BMC Neuroscience 2018 19:82

    Published on:

  39. Content type: Research article

    Acute subdural hemorrhage (ASDH) is a severe consequence of traumatic brain injury. The occurrence of subdural blood increases the lethality of these patients independent of the amount of blood or elevated int...

    Authors: Tobias J. Krämer, Wasim Sakas, Daniel Jussen, Harald Krenzlin, Oliver Kempski and Beat Alessandri

    Citation: BMC Neuroscience 2018 19:81

    Published on:

  40. Content type: Research article

    Development of anxiety- and depression-like states under chronic social defeat stress in mice has been shown by many experimental studies. In this article, the differentially expressed Slc25* family genes encodin...

    Authors: Vladimir N. Babenko, Dmitry A. Smagin, Anna G. Galyamina, Irina L. Kovalenko and Natalia N. Kudryavtseva

    Citation: BMC Neuroscience 2018 19:79

    Published on:

  41. Content type: Research article

    Low-intensity pulsed ultrasound stimulation (LIPUS) has been proven to be a noninvasive method with high spatial resolution and deep penetration. Previous studies have qualitatively demonstrated that the elect...

    Authors: Yi Yuan, Xingran Wang, Jiaqing Yan and Xiaoli Li

    Citation: BMC Neuroscience 2018 19:78

    Published on:

  42. Content type: Research article

    The treatment of Parkinson’s disease is often complicated by levodopa-induced dyskinesia (LID). Nicotinic acetylcholine receptor agonists can alleviate LID in animal models but may be less effective in conditi...

    Authors: Sakari Leino, Samuel Kohtala, Tomi Rantamäki, Sini K. Koski, Saara Rannanpää and Outi Salminen

    Citation: BMC Neuroscience 2018 19:77

    Published on:

  43. Content type: Research article

    Global cerebral ischemia triggers neurodegeneration in the hippocampal CA1 region, but the mechanism of neuronal death remains elusive. The epsilon isoform of protein kinase C (PKCε) has recently been identifi...

    Authors: Varun Kumar, Yi-Chinn Weng, Yu-Chieh Wu, Yu-Ting Huang and Wen-Hai Chou

    Citation: BMC Neuroscience 2018 19:76

    Published on:

  44. Content type: Research article

    Traumatic brain injury (TBI) is a complex condition and remains a prominent public and medical health issue in individuals of all ages. A rapid increase in extracellular glutamate occurs after TBI, leading to ...

    Authors: Wenbo Wu, Siyi Xu, Jialin Wang, Kuiming Zhang, Mingkun Zhang, Yang Cao, Hongqing Ren, Deyou Zheng and Chunlong Zhong

    Citation: BMC Neuroscience 2018 19:75

    Published on:

Featured videos

View featured videos from across the BMC-series journals