Articles

Epileptiform activity in mouse hippocampal slices induced by moderate changes in extracellular Mg²⁺, Ca²⁺, and K⁺

Rodent brain slices—particularly hippocampal slices—are widely used in experimental investigations of epileptiform activity. Oxygenated artificial cerebrospinal fluid (ACSF) is used to maintain slices in vitro...

Authors: Haiyu Liu, Sai Zhang and Liang Zhang

In vivo oxygen measurement in cerebrospinal fluid of pigs to determine physiologic and pathophysiologic oxygen values during CNS infections

During infection and inflammation, a reduced oxygen level clearly affects cellular functions. Oxygen levels during CNS infections are unknown. Here we established and evaluated an in vivo measurement system to...

Authors: Nicole de Buhr, Alexander Martens, Marita Meurer, Marta C. Bonilla, Franz Söbbeler, Lara Twele, Stephan Neudeck, Michael Wendt, Andreas Beineke, Sabine Kästner and Maren von Köckritz-Blickwede

The neuroprotective effects of AMN082 on neuronal apoptosis in rats after traumatic brain injury

The aim of this study was to investigate whether AMN082 exerts its neuroprotective effect by attenuating glutamate receptor-associated neuronal apoptosis and improving functional outcomes after traumatic brain...

Authors: Chung-Che Lu, Tee-Tau Eric Nyam, Jinn-Rung Kuo, Yao-Lin Lee, Chung-Ching Chio and Che-Chuan Wang

Phenotypic overlap between atopic dermatitis and autism

Autism, a childhood behavioral disorder, belongs to a large suite of diseases, collectively referred to as autism spectrum disorders (ASD). Though multifactorial in etiology, approximately 10% of ASD are assoc...

Authors: Kyong-Oh Shin, Debra A. Crumrine, Sungeun Kim, Yerin Lee, Bogyeong Kim, Katrina Abuabara, Chaehyeong Park, Yoshikazu Uchida, Joan S. Wakefield, Jason M. Meyer, Sekyoo Jeong, Byeong Deog Park, Kyungho Park and Peter M. Elias

Brain size reductions associated with endothelin B receptor mutation, a cause of Hirschsprung’s disease

ET_B has been reported to regulate neurogenesis and vasoregulation in foetal development. Its dysfunction was known to cause HSCR, an aganglionic colonic disorder with syndromic forms reported to associate with bo...

Authors: Ko-Chin Chen, Zan-Min Song and Geoffrey D. Croaker

Memantine ameliorates cognitive deficit in AD mice via enhancement of entorhinal–CA1 projection

Memantine, a low- to moderate-affinity uncompetitive N-methyl-D-aspartate receptor antagonist, has been shown to improve cognitive functions in animal models of Alzheimer’s disease (AD). Here we treated APP/PS...

Authors: Peng Li, Jin Xu, Huanhuan Gu, Hua Peng, You Yin and Jianhua Zhuang

Retraction Note to: Differential regulation of wild-type and mutant alpha-synuclein binding to synaptic membranes by cytosolic factors

This article has been retracted. Please see the Retraction Notice for more detail: https://doi.org/10.1186/s12868-021-00644-1

Authors: Sabine Wislet-Gendebien, Naomi P. Visanji, Shawn N. Whitehead, Diana Marsilio, Weimin Hou, Daniel Figeys, Paul E. Fraser, Steffany A. L. Bennett and Anurag Tandon

MMP9 modulation improves specific neurobehavioral deficits in a mouse model of Alzheimer’s disease

Matrix metallopeptidase 9 (MMP9) has been implicated in a variety of neurological disorders, including Alzheimer’s disease (AD), where MMP9 levels are elevated in the brain and cerebrovasculature. Previously o...

Authors: Charis Ringland, Jonas Elias Schweig, Maxwell Eisenbaum, Daniel Paris, Ghania Ait-Ghezala, Michael Mullan, Fiona Crawford, Laila Abdullah and Corbin Bachmeier

Overexpression of the receptor for advanced glycation end-products in the auditory cortex of rats with noise-induced hearing loss

The receptor for advanced glycation end-products (RAGE) is involved in neuroinflammation. This study investigated the changes in RAGE expression following noise-induced hearing loss.

Authors: Chang Ho Lee, Kyung Woon Kim, Da-hye Lee, So Min Lee and So Young Kim

Causal relationship of CA3 back-projection to the dentate gyrus and its role in CA1 fast ripple generation

Pathophysiological evidence from temporal lobe epilepsy models highlights the hippocampus as the most affected structure due to its high degree of neuroplasticity and control of the dynamics of limbic structur...

Authors: Miguel A. Núñez-Ochoa, Gustavo A. Chiprés-Tinajero, Nadia P. González-Domínguez and Laura Medina-Ceja

Inhibitory control training reveals a common neurofunctional basis for generic executive functions and language switching in bilinguals

The neural networks underpinning language control and domain-general executive functions overlap in bilinguals, but existing evidence is mainly correlative. Here, we present the first neurofunctional evidence ...

Authors: Yan Jing Wu, Mo Chen, Guillaume Thierry, Yongben Fu, Junjie Wu and Taomei Guo

Impairments in brain perfusion, executive control network, topological characteristics, and neurocognition in adult patients with asymptomatic Moyamoya disease

Asymptomatic Moyamoya disease (MMD) impairs hemodynamic and cognitive function. The relationship between these changes, cerebral blood flow (CBF), and network connectivity remains largely unknown. The aim of t...

Authors: Shihao He, Ziqi Liu, Yanchang Wei, Ran Duan, Zongsheng Xu, Cai Zhang, Li Yuan, Tian Li, Ning Ma, Xin Lou, Xiaoyuan Liu and Rong Wang

Time spent on the smartphone does not relate to manual dexterity in young adults

The Grooved Pegboard Test (GPT) is widely adopted to evaluate manual dexterity, it presents normative data but the test is influenced by different factors. The influence of time spent on smartphones has not be...

Authors: Luca Petrigna, Milda Treigienė, Ewan Thomas, Diba Mani, Simona Pajaujiene, Patrik Drid, Gioacchino Lavanco, Antonio Palma and Antonino Bianco

Comparative analysis of spreading depolarizations in brain slices exposed to osmotic or metabolic stress

Recurrent spreading depolarizations (SDs) occur in stroke and traumatic brain injury and are considered as a hallmark of injury progression. The complexity of conditions associated with SD in the living brain ...

Authors: Rita Frank, Ferenc Bari, Ákos Menyhárt and Eszter Farkas

Oxytocin ameliorates impaired social behavior in a Chd8 haploinsufficiency mouse model of autism

Autism spectrum disorder (ASD) is characterized by the core symptoms of impaired social interactions. Increasing evidence suggests that ASD has a strong genetic link with mutations in chromodomain helicase DNA...

Authors: Stanislav M. Cherepanov, Maria Gerasimenko, Teruko Yuhi, Kazumi Furuhara, Chiharu Tsuji, Shigeru Yokoyama, Keiichi I. Nakayama, Masaaki Nishiyama and Haruhiro Higashida

Lung-protective ventilation increases cerebral metabolism and non-inflammatory brain injury in porcine experimental sepsis

Protective ventilation with lower tidal volumes reduces systemic and organ-specific inflammation. In sepsis-induced encephalopathy or acute brain injury the use of protective ventilation has not been widely in...

Authors: Axel Nyberg, Erik Gremo, Jonas Blixt, Jesper Sperber, Anders Larsson, Miklós Lipcsey, Andreas Pikwer and Markus Castegren

A short-term musical training affects implicit emotion regulation only in behaviour but not in brain activity

In everyday life, negative emotions can be implicitly regulated by positive stimuli, without any conscious cognitive engagement; however, the effects of such implicit regulation on mood and related neuro-mecha...

Authors: M. Berthold-Losleben, S. Papalini, U. Habel, K. Losleben, F. Schneider, K. Amunts and N. Kohn

Concentrations of estradiol, progesterone and testosterone in serum and cerebrospinal fluid of patients with aneurysmal subarachnoid hemorrhage correlate weakly with transcranial Doppler flow velocities

The implication of the steroids estradiol, progesterone and testosterone in cerebral vasospasm after aneurysmal subarachnoid hemorrhage (aSAH) has not been comprehensively assessed. In rodents, studies suggest...

Authors: Jan Martin, Eva Plank, Bernhard Ulm, Jens Gempt, Maria Wostrack, Bettina Jungwirth and Simone M. Kagerbauer

Early postnatal irradiation‐induced age‐dependent changes in adult mouse brain: MRI based characterization

Brain radiation exposure, in particular, radiotherapy, can induce cognitive impairment in patients, with significant effects persisting for the rest of their life. However, the main mechanisms leading to this ...

Authors: Bo Xu Ren, Isaac Huen, Zi Jun Wu, Hong Wang, Meng Yun Duan, Ilonka Guenther, K. N. Bhanu Prakash and Feng Ru Tang

Correction to: Protective effects of intracerebroventricular adiponectin against olfactory impairments in an amyloid β_1–42 rat model

An amendment to this paper has been published and can be accessed via the original article.

Authors: Mara A. Guzmán-Ruiz, Amor Herrera-González, Adriana Jiménez, Alan Candelas-Juárez, Crystal Quiroga-Lozano, Claudia Castillo-Díaz, Erika Orta-Salazar, Diana Organista-Juárez, Sofía Díaz-Cintra and Rosalinda Guevara-Guzmán

Transcranial direct current stimulation for balance and gait in repetitive mild traumatic brain injury in rats

Balance impairment and lack of postural orientation are serious problems in patients with repetitive mild traumatic brain injury (mTBI).

Authors: Gahee Park, Jee Hyun Suh and Soo Jeong Han

N/OFQ modulates orofacial pain induced by tooth movement through CGRP-dependent pathways

Nociceptin/orphanin FQ (N/OFQ) has been revealed to play bidirectional roles in orofacial pain modulation. Calcitonin gene-related peptide (CGRP) is a well-known pro-nociceptive molecule that participates in t...

Authors: Xinyu Yan, Han Han, Shizhen Zhang, Yanzhu Lu, Linghuan Ren, Yufei Tang, Xiaolong Li, Fan Jian, Yan Wang, Hu Long and Wenli Lai

Behavioral sensitization induced by methamphetamine causes differential alterations in gene expression and histone acetylation of the prefrontal cortex in rats

Methamphetamine (METH) is one of the most widely abused illicit substances worldwide; unfortunately, its addiction mechanism remains unclear. Based on accumulating evidence, changes in gene expression and chro...

Authors: Hui Li, Jing-An Chen, Qian-Zhi Ding, Guan-Yi Lu, Ning Wu, Rui-Bin Su, Fei Li and Jin Li

Spinal reflexive movement follows general tau theory

Tau theory explains how both intrinsically and perceptually guided movements are controlled by the brain. According to general tau theory, voluntary, self-paced human movements are controlled by coupling the t...

Authors: Mehrdad Bahadori, Paola Cesari, Cathy Craig and Mehran Emadi Andani

Sex effects on clinical features in LRRK2 G2385R carriers and non-carriers in Parkinson's disease

Differences of genotypes between male and female have been studied in Parkinson’s disease (PD), but limited research has focused on the comparison between sexes with LRRK2 G2385 variant.

Authors: Shi-Shuang Cui, Rao Fu, Juan-Juan Du, Yi-Qi Lin, Pei Huang, Chao Gao, Hai-Yan Zhou and Sheng-Di Chen

Ammonia induced microglia activation was associated with limited effects on connexin 43 and aquaporin 4 expression in an astrocyte-microglia co-culture model

Hepatic encephalopathy (HE) is a neurological complication resulting from acute or chronic liver disease. Hyperammonemia leading to astrocyte swelling and cerebral edema in combination with neuroinflammation i...

Authors: Fatme Seval Ismail, Timo Jendrik Faustmann, Franco Corvace, Anamariya Tsvetanova, Zahra Moinfar and Pedro M. Faustmann

Association between the vertebrobasilar artery geometry and basilar artery plaques determined by high-resolution magnetic resonance imaging

Atherosclerotic plaques are often present in regions of arteries with complicated flow patterns. Vascular morphology plays important role in hemodynamics. In this study, we investigated the relationship betwee...

Authors: Jinmei Zheng, Bin Sun, Ruolan Lin, Yongqi Teng, Xihai Zhao and Yunjing Xue

Framing and self-responsibility modulate brain activities in decision escalation

Escalation of commitment is a common bias in human decision making. The present study examined (1) differences in neural recruitment for escalation and de-escalation decisions of prior investments, and (2) how...

Authors: Ting-Peng Liang, Yu-Wen Li, Nai-Shing Yen, Ofir Turel and Sen-Mou Hsu

SCN11A gene deletion causes sensorineural hearing loss by impairing the ribbon synapses and auditory nerves

The SCN11A gene, encoded Nav1.9 TTX resistant sodium channels, is a main effector in peripheral inflammation related pain in nociceptive neurons. The role of SCN11A gene in the auditory system has not been well c...

Authors: Mian Zu, Wei-Wei Guo, Tao Cong, Fei Ji, Shi-Li Zhang, Yue Zhang, Xin Song, Wei Sun, David Z. Z. He, Wei-Guo Shi and Shi-Ming Yang

The role of mGlu4 receptors within the nucleus accumbens in acquisition and expression of morphine-induced conditioned place preference in male rats

Several studies have shown that glutamate neurotransmission in the nucleus accumbens (NAc) is required for the development of morphine-induced conditional place preference (CPP). In addition, metabotropic glut...

Authors: Zahra Ebrahimi, Nazanin Kahvandi, Alireza Komaki, Seyed Asaad Karimi, Marzieh Naderishahab and Abdolrahman Sarihi

Correction to: Eye-tracking-aided characterization of saccades and antisaccades in SYNE1 ataxia patients: a pilot study

An amendment to this paper has been published and can be accessed via the original article.

Authors: Laszlo Szpisjak, Gabor Szaraz, Andras Salamon, Viola L. Nemeth, Noemi Szepfalusi, Gabor Veres, Balint Kincses, Zoltan Maroti, Tibor Kalmar, Malgorzata Rydzanicz, Rafal Ploski, Peter Klivenyi and Denes Zadori

Construction of competitive endogenous RNA network reveals regulatory role of long non-coding RNAs in intracranial aneurysm

Rupture of intracranial aneurysm (IA) is the main cause of devastating subarachnoid hemorrhage, which urges our understanding of the pathogenesis and regulatory mechanisms of IA. However, the regulatory roles ...

Authors: Yuan-Bo Pan, Jianan Lu, Biao Yang, Cameron Lenahan, Jianmin Zhang and Anwen Shao

Protective effects of intracerebroventricular adiponectin against olfactory impairments in an amyloid β_1–42 rat model

Alzheimer’s disease (AD) is characterized by cognitive impairment that eventually develops into dementia. Amyloid-beta (Aβ) accumulation is a widely described hallmark in AD, and has been reported to cause olf...

Authors: Mara A. Guzmán-Ruiz, Amor Herrera-González, Adriana Jiménez, Alan Candelas-Juárez, Crystal Quiroga-Lozano, Claudia Castillo-Díaz, Erika Orta-Salazar, Diana Organista-Juárez, Sofía Díaz-Cintra and Rosalinda Guevara-Guzmán

Homeostatic sleep regulation in the absence of the circadian sleep‐regulating component: effect of short light–dark cycles on sleep–wake stages and slow waves

Aside from the homeostatic and circadian components, light has itself an important, direct as well as indirect role in sleep regulation. Light exerts indirect sleep effect by modulating the circadian rhythms. ...

Authors: Örs Szalontai, Attila Tóth, Máté Pethő, Dóra Keserű, Tünde Hajnik and László Détári

Sex differences in neural responses to reward and the influences of individual reward and punishment sensitivity

Men and women show differences in sensitivity to reward and punishment, which may impact behavior in health and disease. However, the neural bases of these sex differences remain under-investigated. Here, by c...

Authors: Isha Dhingra, Sheng Zhang, Simon Zhornitsky, Wuyi Wang, Thang M. Le and Chiang-Shan R. Li

Neural basis underlying the trait of attachment anxiety and avoidance revealed by the amplitude of low-frequency fluctuations and resting-state functional connectivity

Attachment theory demonstrates that early attachment experience shapes internal working models with mental representations of self and close relationships, which affects personality traits and interpersonal re...

Authors: Min Deng, Xing Zhang, Xiaoyan Bi and Chunhai Gao

Cortical hemodynamics as a function of handgrip strength and cognitive performance: a cross-sectional fNIRS study in younger adults

There is growing evidence for a positive correlation between measures of muscular strength and cognitive abilities. However, the neurophysiological correlates of this relationship are not well understood so fa...

Authors: Fabian Herold, Tom Behrendt, Alexander Törpel, Dennis Hamacher, Notger G. Müller and Lutz Schega

Geranylgeranylacetone attenuates cerebral ischemia–reperfusion injury in rats through the augmentation of HSP 27 phosphorylation: a preliminary study

We previously reported that heat shock protein 27 (HSP27) phosphorylation plays an important role in the activation of glucose-6-phosphate dehydrogenase (G6PD), resulting in the upregulation of the pentose pho...

Authors: Kazuya Matsuo, Kohkichi Hosoda, Jun Tanaka, Yusuke Yamamoto, Taichiro Imahori, Tomoaki Nakai, Yasuhiro Irino, Masakazu Shinohara, Takashi Sasayama and Eiji Kohmura

Eosinophil-to-monocyte ratio is a potential biomarker in the prediction of functional outcome among patients with acute ischemic stroke

It has been shown that eosinophils are decreased and monocytes are elevated in patients with acute ischemic stroke (AIS), but the impact of eosinophil-to-monocyte ratio (EMR) on clinical outcomes among AIS pat...

Authors: Shuhong Yu, Yi Luo, Tan Zhang, Chenrong Huang, Yu Fu, Qiang Zhang, Fangyue Zeng, Hao Huang, Chunyuan Zhang and Zhiliang Guo

Eye-tracking-aided characterization of saccades and antisaccades in SYNE1 ataxia patients: a pilot study

SYNE1 ataxia is an autosomal recessive hereditary condition, the main characteristic features of which are gait and limb ataxia and cerebellar dysarthria. Reports have revealed that the clinical phenotype of SYNE...

Authors: Laszlo Szpisjak, Gabor Szaraz, Andras Salamon, Viola L. Nemeth, Noemi Szepfalusi, Gabor Veres, Balint Kincses, Zoltan Maroti, Tibor Kalmar, Malgorzata Rydzanicz, Rafal Ploski, Peter Klivenyi and Denes Zadori

The inflammatory profile of cerebrospinal fluid, plasma, and saliva from patients with severe neuropathic pain and healthy controls-a pilot study

Neuropathic pain (NeuP) is a complex, debilitating condition of the somatosensory system, where dysregulation between pro- and anti-inflammatory cytokines and chemokines are believed to play a pivotal role. As...

Authors: Mika Jönsson, Björn Gerdle, Bijar Ghafouri and Emmanuel Bäckryd

 Knockout of the circadian gene, Per2, disrupts corticosterone secretion and results in depressive‐like behaviors and deficits in startle responses

The Period Circadian Regulator 2 (Per2) gene is important for the modulation of circadian rhythms that influence biological processes. Circadian control of the hypothalamus-pituitary-adrenal (HPA) axis is critica...

Authors: Ashley L. Russell, Lauren Miller, Hannah Yi, Rita Keil, Robert J. Handa and T. John Wu

Docosahexaenoic fatty acid reduces the pro‐inflammatory response induced by IL-1β in astrocytes through inhibition of NF-κB and AP-1 transcription factor activation

Astrocytes are responsible for a broad range of functions that maintain homeostasis in the brain. However, their response to the pro-inflammatory cytokines released by activated microglia in various neurologic...

Authors: Emilia Zgórzyńska, Dawid Stulczewski, Barbara Dziedzic, Kuan-Pin Su and Anna Walczewska

Association between circle of Willis and ischemic stroke: a systematic review and meta-analysis

Circle of Willis is the main structure that provides constant and regular blood flow to the brain, protects the brain from ischemia. Stroke has remained the second leading cause of death globally in the last f...

Authors: Mohammed Oumer, Mekuriaw Alemayehu and Abebe Muche

Post-status epilepticus treatment with the Fyn inhibitor, saracatinib, improves cognitive function in mice

Status epilepticus (SE) is a life-threatening neurological disorder. The hippocampus, as an important area of the brain that regulates cognitive function, is usually damaged after SE, and cognitive deficits of...

Authors: Xin-Ming Luo, Jing Zhao, Wen-Yue Wu, Jie Fu, Zheng-Yu Li, Ming Zhang and Jie Lu

A dimension reduction technique applied to regression on high dimension, low sample size neurophysiological data sets

A common problem in neurophysiological signal processing is the extraction of meaningful information from high dimension, low sample size data (HDLSS). We present RoLDSIS (regression on low-dimension spanned i...

Authors: Adrielle C. Santana, Adriano V. Barbosa, Hani C. Yehia and Rafael Laboissière

29th Annual Computational Neuroscience Meeting: CNS*2020

Authors:

Distraction by a cognitive task has a higher impact on electrophysiological measures compared with conditioned pain modulation

Conditioned pain modulation (CPM) evaluates the effect of a painful conditioning stimulus (CS) on a painful test stimulus (TS). Using painful cutaneous electrical stimulation (PCES) as TS and painful cold wate...

Authors: A. T. L. Do, E. K. Enax-Krumova, Ö. Özgül, L. B. Eitner, S. Heba, M. Tegenthoff, C. Maier and O. Höffken

Target detection in healthy 4-week old piglets from a passive two-tone auditory oddball paradigm

Passive auditory oddball tests are effort independent assessments that evaluate auditory processing and are suitable for paediatric patient groups. Our goal was to develop a two-tone auditory oddball test pro...

Authors: R. Anna Oeur and Susan S. Margulies

Sex-dimorphic neuroestradiol regulation of ventromedial hypothalamic nucleus glucoregulatory transmitter and glycogen metabolism enzyme protein expression in the rat

Ventromedial hypothalamic nucleus (VMN) gluco-regulatory transmission is subject to sex-specific control by estradiol. The VMN is characterized by high levels of aromatase expression.

Authors: Md. Main Uddin, Mostafa M. H. Ibrahim and Karen P. Briski