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  1. Research article

    From provocation to aggression: the neural network

    In-vivo observations of neural processes during human aggressive behavior are difficult to obtain, limiting the number of studies in this area. To address this gap, the present study implemented a social react...

    Jonathan Repple, Christina M. Pawliczek, Bianca Voss, Steven Siegel, Frank Schneider, Nils Kohn and Ute Habel

    BMC Neuroscience 2017 18:73

    Published on: 17 October 2017

  2. Software

    PeakCaller: an automated graphical interface for the quantification of intracellular calcium obtained by high-content screening

    Intracellular calcium is an important ion involved in the regulation and modulation of many neuronal functions. From regulating cell cycle and proliferation to initiating signaling cascades and regulating pres...

    Elena Artimovich, Russell K. Jackson, Michaela B. C. Kilander, Yu-Chih Lin and Michael W. Nestor

    BMC Neuroscience 2017 18:72

    Published on: 16 October 2017

  3. Methodology

    A convenient UHPLC-MS/MS method for routine monitoring of plasma and brain levels of nicotine and cotinine as a tool to validate newly developed preclinical smoking model in mouse

    A sensitive, rapid and selective UHPLC–MS/MS method has been developed and validated for the quantification of Nicotine (NT) and Cotinine (CN) using Continine-d 3 as internal standard (...

    Mohammad A. Kaisar, Raja Reddy Kallem, Ravi K. Sajja, Ali Ehsan Sifat and Luca Cucullo

    BMC Neuroscience 2017 18:71

    Published on: 11 October 2017

  4. Research article

    PPARγ coactivator-1α (PGC-1α) protects neuroblastoma cells against amyloid-beta (Aβ) induced cell death and neuroinflammation via NF-κB pathway

    Alzheimer’s disease is characterized by the accumulation of amyloid beta (Aβ) and the formation of neurofibrillary tangles. Aβ is the main constituent of senile plaques and is largely involved in neuronal deat...

    Yuqin Zhang, Changchun Chen, Yanliu Jiang, Shupei Wang, Xiaoyu Wu and Kai Wang

    BMC Neuroscience 2017 18:69

    Published on: 25 September 2017

  5. Research article

    Why to cooperate is better than to compete: brain and personality components

    Cooperation and competition were compared in the present study. Brain correlates (electroencephalography, EEG frequency band, delta, theta, alpha, and beta) and hemodynamic measure of functional near-infrared...

    Michela Balconi, Davide Crivelli and Maria Elide Vanutelli

    BMC Neuroscience 2017 18:68

    Published on: 20 September 2017

  6. Research article

    Cerebral microvascular dysfunction in metabolic syndrome is exacerbated by ischemia–reperfusion injury

    Metabolic syndrome (MetS) is associated with an increased risk of cerebrovascular diseases, including cerebral ischemia. Microvascular dysfunction is an important feature underlying the pathophysiology of cere...

    Nathalie Obadia, Marcos Adriano Lessa, Anissa Daliry, Raquel Rangel Silvares, Fabiana Gomes, Eduardo Tibiriçá and Vanessa Estato

    BMC Neuroscience 2017 18:67

    Published on: 8 September 2017

  7. Research article

    The loss-of-function disease-mutation G301R in the Na+/K+-ATPase α2 isoform decreases lesion volume and improves functional outcome after acute spinal cord injury in mice

    The Na+/K+-ATPases are transmembrane ion pumps important for maintenance of ion gradients across the plasma membrane that serve to support multiple cellular functions, such as membrane potentials, regulation of c...

    Ditte Gry Ellman, Toke Jost Isaksen, Minna Christiansen Lund, Safinaz Dursun, Martin Wirenfeldt, Louise Helskov Jørgensen, Karin Lykke-Hartmann and Kate Lykke Lambertsen

    BMC Neuroscience 2017 18:66

    Published on: 8 September 2017

  8. Database

    Day2day: investigating daily variability of magnetic resonance imaging measures over half a year

    Most studies of brain structure and function, and their relationships to cognitive ability, have relied on inter-individual variability in magnetic resonance (MR) images. Intra-individual variability is often ign...

    Elisa Filevich, Nina Lisofsky, Maxi Becker, Oisin Butler, Martyna Lochstet, Johan Martensson, Elisabeth Wenger, Ulman Lindenberger and Simone Kühn

    BMC Neuroscience 2017 18:65

    Published on: 24 August 2017

  9. Meeting abstracts

    26th Annual Computational Neuroscience Meeting (CNS*2017): Part 2

    Leonid L. Rubchinsky, Sungwoo Ahn, Wouter Klijn, Ben Cumming, Stuart Yates, Vasileios Karakasis, Alexander Peyser, Marmaduke Woodman, Sandra Diaz-Pier, James Deraeve, Eliana Vassena, William Alexander, David Beeman, Pawel Kudela, Dana Boatman-Reich, William S. Anderson…

    BMC Neuroscience 2017 18(Suppl 1):59

    Published on: 18 August 2017

    This article is part of a Supplement: Volume 18 Supplement 1

  10. Meeting abstracts

    26th Annual Computational Neuroscience Meeting (CNS*2017): Part 3

    Adam J. H. Newton, Alexandra H. Seidenstein, Robert A. McDougal, Alberto Pérez-Cervera, Gemma Huguet, Tere M-Seara, Caroline Haimerl, David Angulo-Garcia, Alessandro Torcini, Rosa Cossart, Arnaud Malvache, Kaoutar Skiker, Mounir Maouene, Gianmarco Ragognetti, Letizia Lorusso, Andrea Viggiano…

    BMC Neuroscience 2017 18(Suppl 1):60

    Published on: 18 August 2017

    This article is part of a Supplement: Volume 18 Supplement 1

  11. Research article

    Musashi-1 is the candidate of the regulator of hair cell progenitors during inner ear regeneration

    Hair cell loss in the cochlea is caused by ototoxic drugs, aging, and environmental stresses and could potentially lead to devastating pathophysiological effects. In adult mammals, hair cell loss is irreversib...

    Takahiro Wakasaki, Hiroaki Niiro, Siamak Jabbarzadeh-Tabrizi, Mitsuru Ohashi, Takashi Kimitsuki, Takashi Nakagawa, Shizuo Komune and Koichi Akashi

    BMC Neuroscience 2017 18:64

    Published on: 16 August 2017

  12. Research article

    Specific ion channels contribute to key elements of pathology during secondary degeneration following neurotrauma

    Following partial injury to the central nervous system, cells beyond the initial injury site undergo secondary degeneration, exacerbating loss of neurons, compact myelin and function. Changes in Ca2+ flux are ass...

    Ryan L. O’Hare Doig, Wissam Chiha, Marcus K. Giacci, Nathanael J. Yates, Carole A. Bartlett, Nicole M. Smith, Stuart I. Hodgetts, Alan R. Harvey and Melinda Fitzgerald

    BMC Neuroscience 2017 18:62

    Published on: 14 August 2017

  13. Research article

    A CLCA regulatory protein present in the chemosensory cilia of olfactory sensory neurons induces a Ca2+-activated Cl current when transfected into HEK293

    CLCA is a family of metalloproteases that regulate Ca2+-activated Cl fluxes in epithelial tissues. In HEK293 cells, CLCA1 promotes membrane expression of an endogenous Anoctamin 1 (ANO1, also termed TMEM16A)-dep...

    Casilda V. Mura, Ricardo Delgado, María Graciela Delgado, Diego Restrepo and Juan Bacigalupo

    BMC Neuroscience 2017 18:61

    Published on: 11 August 2017

  14. Research article

    Neuroplasticity pathways and protein-interaction networks are modulated by vortioxetine in rodents

    The identification of biomarkers that predict susceptibility to major depressive disorder and treatment response to antidepressants is a major challenge. Vortioxetine is a novel multimodal antidepressant that ...

    Jessica A. Waller, Sara Holm Nygaard, Yan Li, Kristian Gaarn du Jardin, Joseph A. Tamm, Aicha Abdourahman, Betina Elfving, Alan L. Pehrson, Connie Sánchez and Rasmus Wernersson

    BMC Neuroscience 2017 18:56

    Published on: 4 August 2017

  15. Methodology article

    Immunocytochemistry and fluorescence imaging efficiently identify individual neurons with CRISPR/Cas9-mediated gene disruption in primary cortical cultures

    CRISPR/Cas9 system is a powerful method to investigate the role of genes by introducing a mutation selectively and efficiently to specific genome positions in cell and animal lines. However, in primary neuron...

    Hiroto Tsunematsu, Akiko Uyeda, Nobuhiko Yamamoto and Noriyuki Sugo

    BMC Neuroscience 2017 18:55

    Published on: 1 August 2017

  16. Research article

    Difference in the functional connectivity of the dorsolateral prefrontal cortex between smokers with nicotine dependence and individuals with internet gaming disorder

    It has been reported that internet gaming disorder (IGD) and smokers with nicotine dependence (SND) share clinical characteristics, such as over-engagement despite negative consequences and cravings. This stud...

    Xin Ge, Yawen Sun, Xu Han, Yao Wang, Weina Ding, Mengqiu Cao, Yasong Du, Jianrong Xu and Yan Zhou

    BMC Neuroscience 2017 18:54

    Published on: 27 July 2017

  17. Research article

    Regeneration of long-distance peripheral nerve defects after delayed reconstruction in healthy and diabetic rats is supported by immunomodulatory chitosan nerve guides

    Delayed reconstruction of transection or laceration injuries of peripheral nerves is inflicted by a reduced regeneration capacity. Diabetic conditions, more frequently encountered in clinical practice, are kno...

    Lena Stenberg, Maria Stößel, Giulia Ronchi, Stefano Geuna, Yaobin Yin, Susanne Mommert, Lisa Mårtensson, Jennifer Metzen, Claudia Grothe, Lars B. Dahlin and Kirsten Haastert-Talini

    BMC Neuroscience 2017 18:53

    Published on: 18 July 2017

  18. Review

    Iron oxide nanoparticles may damage to the neural tissue through iron accumulation, oxidative stress, and protein aggregation

    In the recent decade, iron oxide nanoparticles (IONPs) have been proposed for several applications in the central nervous system (CNS), including targeting amyloid beta (Aβ) in the arteries, inhibiting the mic...

    Zahra Yarjanli, Kamran Ghaedi, Abolghasem Esmaeili, Soheila Rahgozar and Ali Zarrabi

    BMC Neuroscience 2017 18:51

    Published on: 26 June 2017

  19. Research article

    The order of complexity of visuomotor learning

    Learning algorithms come in three orders of complexity: zeroth-order (perturbation), first-order (gradient descent), and second-order (e.g., quasi-Newton). But which of these are used in the brain? We trained ...

    John Kim, Fariya Mostafa and Douglas Blair Tweed

    BMC Neuroscience 2017 18:50

    Published on: 12 June 2017

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