Articles
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Citation: BMC Neuroscience 2023 24:31
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High frequencies (HF) repetitive transcranial magnetic stimulation (rTMS) increase motor coordination performances in volleyball players
It is widely demonstrated that high frequency (HF) repetitive transcranial magnetic stimulation (rTMS) has facilitative effects and is therefore capable to inducing changes in motor responses. One of the most ...
Citation: BMC Neuroscience 2023 24:30 -
Characterization of the planarian surface electroencephalogram
Despite large morphological differences between the nervous systems of lower animals and humans, striking functional similarities have been reported. However, little is known about how these functional similar...
Citation: BMC Neuroscience 2023 24:29 -
Effects of HDAC inhibitors on neuroblastoma SH-SY5Y cell differentiation into mature neurons via the Wnt signaling pathway
Histone deacetylase (HDAC) inhibitors affect cell homeostasis, gene expression, and cell cycle progression and promote cell terminal differentiation or apoptosis. However, the effect of HDAC inhibition on SH-S...
Citation: BMC Neuroscience 2023 24:28 -
Protective effect of resveratrol on mitochondrial biogenesis during hyperoxia-induced brain injury in neonatal pups
Neonatal hyperoxic brain injury is caused by exposure to hyperphysiological oxygen content during the period of incomplete development of the oxidative stress defence system, resulting in a large number of rea...
Citation: BMC Neuroscience 2023 24:27 -
Effects of gestational inflammation on age-related cognitive decline and hippocampal Gdnf-GFRα1 levels in F1 and F2 generations of CD-1 Mice
It has been reported that age-associated cognitive decline (AACD) accelerated by maternal lipopolysaccharide (LPS) insult during late pregnancy can be transmitted to the second generation in a sex-specificity ...
Citation: BMC Neuroscience 2023 24:26 -
Anodal tDCS over the left DLPFC but not M1 increases muscle activity and improves psychophysiological responses, cognitive function, and endurance performance in normobaric hypoxia: a randomized controlled trial
Transcranial direct current stimulation (tDCS) has been shown to have positive effects on exercise performance and cognitive function in the normal ambient condition. Hypoxia is deemed a stressful situation wi...
Citation: BMC Neuroscience 2023 24:25 -
Pinpointing the precise stimulation targets for brain rehabilitation in early-stage Parkinson’s disease
Transcranial magnetic stimulation (TMS) is increasingly used as a promising non-pharmacological treatment for Parkinson’s disease (PD). Scalp-to-cortex distance (SCD), as a key technical parameter of TMS, play...
Citation: BMC Neuroscience 2023 24:24 -
EDDSN-MRT: multiple rodent tracking based on ear detection and dual siamese network for rodent social behavior analysis
Rodent social behavior is a commonly used preclinical model to interrogate the mechanisms underpinning various human neurological conditions. To investigate the interplay between neural systems and social beha...
Citation: BMC Neuroscience 2023 24:23 -
A deep generative adversarial network capturing complex spiral waves in disinhibited circuits of the cerebral cortex
In the cerebral cortex, disinhibited activity is characterized by propagating waves that spread across neural tissue. In this pathological state, a widely reported form of activity are spiral waves that travel...
Citation: BMC Neuroscience 2023 24:22 -
Brain magnetic resonance imaging in the DE50-MD dog model of Duchenne muscular dystrophy reveals regional reductions in cerebral gray matter
Duchenne muscular dystrophy is a X-linked disease characterized by severe and progressive muscle weakness, alongside cognitive impairment and a range of neurobehavioral disorders secondary to brain dystrophin ...
Citation: BMC Neuroscience 2023 24:21 -
Neuroprotective effects of vinpocetine, as a phosphodiesterase 1 inhibitor, on long-term potentiation in a rat model of Alzheimer’s disease
Vinpocetine (Vin) is known as a phosphodiesterase 1 inhibitor (PDE1-I) drug with multilateral effects, including antioxidant and anti-inflammatory activity. In this research, we investigated the neuroprotectiv...
Citation: BMC Neuroscience 2023 24:20 -
EPO regulates neuronal differentiation of adult human neural-crest derived stem cells in a sex-specific manner
Sexual differences in the biology of human stem cells are increasingly recognized to influence their proliferation, differentiation and maturation. Especially in neurodegenerative diseases such as Alzheimers d...
Citation: BMC Neuroscience 2023 24:19 -
Pharmacologic antagonism of CB1 receptors improves electrophysiological alterations in Purkinje cells exposed to 3-AP
Although ataxia is associated with cerebellar dysfunction, little is known about the effects of 3-AP exposure on Purkinje cell electrophysiological properties. Here, we evaluated these parameters in cerebellar...
Citation: BMC Neuroscience 2023 24:18 -
KDM4A, involved in the inflammatory and oxidative stress caused by traumatic brain injury-hemorrhagic shock, partly through the regulation of the microglia M1 polarization
Microglial polarization and the subsequent neuroinflammatory response and oxidative stress are contributing factors for traumatic brain injury (TBI) plus hemorrhagic shock (HS) induced brain injury. In the pre...
Citation: BMC Neuroscience 2023 24:17 -
Retraction Note: Solid lipid curcumin particles provide greater anti-amyloid, anti-inflammatory and neuroprotective effects than curcumin in the 5xFAD mouse model of Alzheimer’s disease
Citation: BMC Neuroscience 2023 24:16 -
Similar cortical morphometry trajectories from 5 to 9 years in children with perinatal HIV who started treatment before age 2 years and uninfected controls
Life-long early ART (started before age 2 years), often with periods of treatment interruption, is now the standard of care in pediatric HIV infection. Although cross-sectional studies have investigated HIV-re...
Citation: BMC Neuroscience 2023 24:15 -
Activation of the IL-17/TRAF6/NF-κB pathway is implicated in Aβ-induced neurotoxicity
Neuroinflammation plays a critical role in Amyloid-β (Aβ) pathophysiology. The cytokine, interleukin-17A (IL-17) is involved in the learning and memory process in the central nervous system and its level was r...
Citation: BMC Neuroscience 2023 24:14 -
Detection of neuronal OFF periods as low amplitude neural activity segments
During non-rapid eye movement sleep (NREM), alternating periods of synchronised high (ON period) and low (OFF period) neuronal activity are associated with high amplitude delta band (0.5–4 Hz) oscillations in ...
Citation: BMC Neuroscience 2023 24:13 -
Non-conscious processing of fear faces: a function of the implicit self-concept of anxiety
Trait anxiety refers to a stable tendency to experience fears and worries across many situations. High trait anxiety is a vulnerability factor for the development of psychopathologies. Self-reported trait anxi...
Citation: BMC Neuroscience 2023 24:12 -
Correction: Trait anxiety is related to Nx4’s efficacy on stress-induced changes in amygdala-centered resting state functional connectivity: a placebo-controlled cross-over trial in mildly to moderately stressed healthy volunteers
Citation: BMC Neuroscience 2023 24:11 -
Cudraflavone B induces human glioblastoma cells apoptosis via ER stress-induced autophagy
Glioblastoma (GBM) is the most common malignant intracranial tumor with a low survival rate. However, only few drugs responsible for GBM therpies, hence new drug development for it is highly required. The natu...
Citation: BMC Neuroscience 2023 24:10 -
Activation of autophagy inhibits the activation of NLRP3 inflammasome and alleviates sevoflurane-induced cognitive dysfunction in elderly rats
As a common complication in elderly patients after surgery/anesthesia, postoperative cognitive dysfunction (POCD) is mainly characterized by memory, attention, motor, and intellectual retardation. Neuroinflamm...
Citation: BMC Neuroscience 2023 24:9 -
Circ VRK1/microRNA-17/PTEN axis modulates the angiogenesis of human brain microvascular endothelial cells to affect injury induced by oxygen-glucose deprivation/reperfusion
Circular RNAs (circRNAs) can act as microRNA (miRNA) sponges, thus regulating gene expression. The role of circRNAs in the process of oxygen-glucose deprivation/reoxygenation (OGD/R) is unclear. Here, we explo...
Citation: BMC Neuroscience 2023 24:8 -
Influence of sex, age and diabetes on brain transcriptome and proteome modifications following cerebral ischemia
Ischemic stroke is a major cause of death and disability worldwide. Translation into the clinical setting of neuroprotective agents showing promising results in pre-clinical studies has systematically failed. ...
Citation: BMC Neuroscience 2023 24:7 -
SUFI: an automated approach to spectral unmixing of fluorescent multiplex images captured in mouse and post-mortem human brain tissues
Multispectral fluorescence imaging coupled with linear unmixing is a form of image data collection and analysis that allows for measuring multiple molecular signals in a single biological sample. Multiple fluo...
Citation: BMC Neuroscience 2023 24:6 -
Identifying foetal forebrain interneurons as a target for monogenic autism risk factors and the polygenic 16p11.2 microdeletion
Autism spectrum condition or ‘autism’ is associated with numerous genetic risk factors including the polygenic 16p11.2 microdeletion. The balance between excitatory and inhibitory neurons in the cerebral cortex i...
Citation: BMC Neuroscience 2023 24:5 -
Evaluation of eGFP expression in the ChAT-eGFP transgenic mouse brain
A historically definitive marker for cholinergic neurons is choline acetyltransferase (ChAT), a synthesizing enzyme for acetylcholine, (ACh), which can be found in high concentrations in cholinergic neurons, b...
Citation: BMC Neuroscience 2023 24:4 -
Underlying mechanisms of long-term potentiation during the inhibition of the cannabinoid CB1 and GABAB receptors in the dentate gyrus of hippocampus
The release of various neurotransmitters and thereby the excitability of neuronal circuits are regulated by the endocannabinoid system in an activity-dependent manner. Hippocampal long-term potentiation (LTP) ...
Citation: BMC Neuroscience 2023 24:3 -
Effects of low-doses of methamphetamine on d-fenfluramine-induced head-twitch response (HTR) in mice during ageing and c-fos expression in the prefrontal cortex
The head-twitch response (HTR) in mice is considered a behavioral model for hallucinogens and serotonin 5-HT2A receptor function, as well as Tourette syndrome in humans. It is mediated by 5-HT2A receptor agonists...
Citation: BMC Neuroscience 2023 24:2 -
Cytokine expression profiles in white blood cells of patients with small fiber neuropathy
The role of cytokines in the pathophysiology, diagnosis, and prognosis of small fiber neuropathy (SFN) is incompletely understood. We studied expression profiles of selected pro- and anti-inflammatory cytokine...
Citation: BMC Neuroscience 2023 24:1 -
Positive memory increases cataplexy-like behaviors in narcolepsy mice as revealed using conditioned place preference test
Cataplexy is a loss of muscle tone that can lead to postural collapse, disturbing the daily life of narcolepsy patients; it is often triggered by positive emotions such as laughter in human patients. Narcoleps...
Citation: BMC Neuroscience 2022 23:82 -
Objective hearing threshold identification from auditory brainstem response measurements using supervised and self-supervised approaches
Hearing loss is a major health problem and psychological burden in humans. Mouse models offer a possibility to elucidate genes involved in the underlying developmental and pathophysiological mechanisms of hear...
Citation: BMC Neuroscience 2022 23:81 -
Laser speckle contrast imaging for blood flow monitoring in predicting outcomes after cerebral ischemia-reperfusion injury in mice
In the treatment of ischemic cerebral stroke (ICS), most conventional treatments, including carotid endarterectomy and carotid artery stenting, may cause cerebral ischemia-reperfusion injury (CIRI). For treate...
Citation: BMC Neuroscience 2022 23:80 -
Gender differences in brain response to infant emotional faces
Infant emotional stimuli can preferentially engage adults’ attention and provide valuable information essential for successful interaction between adults and infants. Exploring the neural processes of recogniz...
Citation: BMC Neuroscience 2022 23:79 -
Dynamic effect of electromagnetic induction on epileptic waveform
Electromagnetic induction has recently been considered as an important factor affecting the activity of neurons. However, as an important form of intervention in epilepsy treatment, few people have linked the ...
Citation: BMC Neuroscience 2022 23:78 -
Human iPSC-derived neural stem cells with ALDH5A1 mutation as a model of succinic semialdehyde dehydrogenase deficiency
Succinic semialdehyde dehydrogenase deficiency (SSADH-D) is an autosomal recessive gamma-aminobutyric acid (GABA) metabolism disorder that can arise due to ALDH5A1 mutations, resulting in severe, progressive, unt...
Citation: BMC Neuroscience 2022 23:77 -
Transcranial direct current stimulation combined with amantadine in repetitive mild traumatic brain injury in rats
Balance and memory deficits are common in patients with repetitive mild traumatic brain injury (mTBI).
Citation: BMC Neuroscience 2022 23:76 -
Optimizing intraluminal monofilament model of ischemic stroke in middle-aged Sprague–Dawley rats
Intraluminal monofilament model of middle cerebral artery occlusion (MCAO) is widely adopted for ischemic stroke; and Sprague–Dawley (SD) rats are commonly used rodents for preclinical research. Due to the pau...
Citation: BMC Neuroscience 2022 23:75 -
Sodium formononetin-3'-sulphonate alleviates cerebral ischemia–reperfusion injury in rats via suppressing endoplasmic reticulum stress-mediated apoptosis
Sodium formononetin-3ʹ-sulphonate (Sul-F) may alleviate I/R injury in vivo with uncertain mechanism. Endoplasmic reticulum (ER) stress-mediated apoptosis participates in the process of cerebral ischemia‐reperf...
Citation: BMC Neuroscience 2022 23:74 -
Exploring combat stress exposure effects on burn pain in a female rodent model
In the military, constant physiological and psychological stress encountered by Soldiers can lead to development of the combat and operational stress reaction (COSR), which can effect pain management. Similar ...
Citation: BMC Neuroscience 2022 23:73 -
Feasibility of evaluating the histologic and genetic subtypes of WHO grade II-IV gliomas by diffusion-weighted imaging
To explore the feasibility of diffusion-weighted imaging (DWI) metrics to predict the histologic subtypes and genetic status of gliomas (e.g., IDH, MGMT, and TERT) noninvasively.
Citation: BMC Neuroscience 2022 23:72 -
CaPTure: Calcium PeakToolbox for analysis of in vitro calcium imaging data
Calcium imaging is a powerful technique for recording cellular activity across large populations of neurons. However, analysis methods capable of single-cell resolution in cultured neurons, especially for cult...
Citation: BMC Neuroscience 2022 23:71 -
NLRP3 inflammasome regulates astrocyte transformation in brain injury induced by chronic intermittent hypoxia
Obstructive sleep apnea (OSA) is mainly characterized by sleep fragmentation and chronic intermittent hypoxia (CIH), the latter one being associated with multiple organ injury. Recently, OSA-induced cognition ...
Citation: BMC Neuroscience 2022 23:70 -
Sex-specific issues of central and peripheral arginine-vasopressin concentrations in neurocritical care patients
Arginine-Vasopressin (AVP) is a nonapeptide that exerts multiple functions within the central nervous system and in the blood circulation that might contribute to outcome in critically ill patients. Sex differ...
Citation: BMC Neuroscience 2022 23:69 -
Trait anxiety is related to Nx4’s efficacy on stress-induced changes in amygdala-centered resting state functional connectivity: a placebo-controlled cross-over trial in mildly to moderately stressed healthy volunteers
The multicomponent drug Neurexan (Nx4) was shown to reduce the neural stress network activation. We now investigated its effects on stress-induced resting state functional connectivity (RSFC) in dependence of ...
Citation: BMC Neuroscience 2022 23:68 -
CXCL1/CXCR2 is involved in white matter injury in neonatal rats via the gut–brain axis
This study aimed to investigate whether CXCL1/CXCR2 mediates intestinal injury or white matter injury by delivering inflammatory mediators through the gut–brain regulation axis.
Citation: BMC Neuroscience 2022 23:67 -
Albumin alleviated esketamine-induced neuronal apoptosis of rat retina through downregulation of Zn2+-dependent matrix metalloproteinase 9 during the early development
Esketamine upregulates Zn2+-dependent matrix metalloproteinase 9 (MMP9) and increases the neuronal apoptosis in retinal ganglion cell layer during the early development. We aimed to test whether albumin can allev...
Citation: BMC Neuroscience 2022 23:66 -
Effects of melatonin-pretreated adipose-derived mesenchymal stem cells (MSC) in an animal model of spinal cord injury
One of the most serious nervous system diseases is spinal cord injury(SCI), which is increasing for various reasons. Although no definitive treatment has yet been identified for SCI, one possible treatment is ...
Citation: BMC Neuroscience 2022 23:65 -
Chronic constriction injury-induced changes in circular RNA expression profiling of the dorsal root ganglion in a rat model of neuropathic pain
The pathogenesis of neuropathic pain (NP) has not been fully elucidated. Gene changes in dorsal root ganglia (DRG) may contribute to the development of NP. Circular RNAs (circRNAs) are a class of endogenous no...
Citation: BMC Neuroscience 2022 23:64
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