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  1. Content type: Research article

    Non-motor symptoms are common aspects of Parkinson’s disease (PD) occurring even at the prodromal stage of the disease and greatly affecting the quality of life. Here, we investigated whether non-motor symptom...

    Authors: Flavia Niccolini, Heather Wilson, Beniamino Giordano, Konstantinos Diamantopoulos, Gennaro Pagano, Kallol Ray Chaudhuri and Marios Politis

    Citation: BMC Neuroscience 2019 20:55

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  2. Content type: Research article

    The pathogenesis of medication overuse headache (MOH) involves hyperexcitability of cortical and trigeminal neurons. Derangement of the brainstem modulating system, especially raphe nuclei may contribute to th...

    Authors: Prangtip Potewiratnanond, Supang Maneesri le Grand, Anan Srikiatkhachorn and Weera Supronsinchai

    Citation: BMC Neuroscience 2019 20:54

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  3. Content type: Research article

    Neuroactive steroids seem to be implicated in a variety of neurophysiological and behavioral processes, such as sleep, learning, memory, stress, feeding and aging. Numerous studies have also addressed this imp...

    Authors: Jan Martin, Eva Plank, Bettina Jungwirth, Alexander Hapfelmeier, Armin Podtschaske and Simone M. Kagerbauer

    Citation: BMC Neuroscience 2019 20:53

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  4. Content type: Research article

    Neurological complications may occur in patients with acute or chronic renal failure; however, in cases of acute renal failure, the signs and symptoms are usually more pronounced, and progressed rapidly. Oxida...

    Authors: Fatemeh Sharifi, Parham Reisi and Maryam Malek

    Citation: BMC Neuroscience 2019 20:52

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  5. Content type: Research article

    We aimed to study the role of amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor (AMPAR) glutamate receptor 2 (GluR2) subunit trafficking, and activity changes in short-term neuroprotection provided b...

    Authors: Chenxu Wang, Ying Wei, Yuan Yuan, Yonghao Yu, Keliang Xie, Beibei Dong, Yuan Shi and Guolin Wang

    Citation: BMC Neuroscience 2019 20:51

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  6. Content type: Research article

    Movement performance depends on the synaptic interactions generated by coherent parallel sensorimotor cortical outputs to different downstream targets. The major outputs of the neocortex to subcortical structu...

    Authors: Rafael Olivares-Moreno, Mónica López-Hidalgo, Alain Altamirano-Espinoza, Adriana González-Gallardo, Anaid Antaramian, Verónica Lopez-Virgen and Gerardo Rojas-Piloni

    Citation: BMC Neuroscience 2019 20:50

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  7. Content type: Research article

    In animal research, authorities require a classification of anticipated pain levels and a perioperative analgesia protocol prior to approval of the experiments. However, data on this topic is rare and so is th...

    Authors: Irina Staib-Lasarzik, Nadine Nagel, Anne Sebastiani, Eva-Verena Griemert and Serge C. Thal

    Citation: BMC Neuroscience 2019 20:49

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  8. Content type: Research article

    Electrical stimulation is widely used in experimental pain research but it lacks selectivity towards small nociceptive fibers. When using standard surface patch electrodes and rectangular pulses, large fibers ...

    Authors: Rosa Hugosdottir, Carsten Dahl Mørch, Ole Kæseler Andersen, Thordur Helgason and Lars Arendt-Nielsen

    Citation: BMC Neuroscience 2019 20:48

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  9. Content type: Research article

    There is a need for new approaches to increase the knowledge of the membrane excitability of small nerve fibers both in healthy subjects, as well as during pathological conditions. Our research group has previ...

    Authors: Rosa Hugosdottir, Carsten Dahl Mørch, Cecilia Klitgaard Jørgensen, Camilla Winther Nielsen, Mathias Vassard Olsen, Mads Jozwiak Pedersen and Jenny Tigerholm

    Citation: BMC Neuroscience 2019 20:47

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  10. Content type: Research article

    The Pde6brd1 (Rd1) mouse is widely used as a murine model for human retinitis pigmentosa. Understanding the spatio-temporal patterns of cone degeneration is important for evaluating potential treatments. In th...

    Authors: Daniel S. Narayan, Jack Ao, John P. M. Wood, Robert J. Casson and Glyn Chidlow

    Citation: BMC Neuroscience 2019 20:46

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  11. Content type: Research article

    Systemic inflammation is an important risk factor for neurodevelopmental impairments in preterm infants. Premyelinating oligodendrocytes are main building blocks of white matter in preterm infants and vulnerab...

    Authors: Seung Han Shin, Ee-Kyung Kim, Kyung-yup Lee and Han-Suk Kim

    Citation: BMC Neuroscience 2019 20:45

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  12. Content type: Research article

    Traumatic brain injury (TBI) is a widespread public health problem and a signature injury of our military in modern conflicts. Despite the long-term effects of even mild brain injuries, an effective treatment ...

    Authors: Whitney A. Ratliff, Jessica N. Saykally, Ronald F. Mervis, Xiaoyang Lin, Chuanhai Cao and Bruce A. Citron

    Citation: BMC Neuroscience 2019 20:44

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  13. Content type: Research article

    The aim of the present study was to evaluate the stability of brain arousal in adult attention-deficit/hyperactivity disorder (ADHD) outpatients with and without depressive symptomatology, and its association ...

    Authors: Jue Huang, Christine Ulke and Maria Strauss

    Citation: BMC Neuroscience 2019 20:43

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  14. Content type: Research article

    Parkinson's disease is a progressive degenerative nervous system disease. Recent studies have shown that secondary changes in the GABA system play directly affect the pathogenesis of PD. There is still much de...

    Authors: Lixuan Huang, Yande Ren, Zisan Zeng, Hao Ren, Shaojun Li, Shengnan He, Fan He and Xiangrong Li

    Citation: BMC Neuroscience 2019 20:42

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  15. Content type: Research article

    Oxidative stress and neuroinflammation are central pathogenic mechanisms common to many neurological diseases. Isoliquiritigenin (ISL) is a flavonoid in licorice with multiple pharmacological properties, inclu...

    Authors: Xiaobo Zhu, Jiankun Liu, Shaojie Chen, Jiang Xue, Shanying Huang, Yibiao Wang and Ou Chen

    Citation: BMC Neuroscience 2019 20:41

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  16. Content type: Research article

    Transcranial direct current stimulation (tDCS) is a noninvasive neural control technology that has become a research hotspot. To facilitate further research of tDCS, the biosafety of 500 μA cathodal tDCS, a co...

    Authors: Keying Zhang, Ling Guo, Junping Zhang, Guangzhou An, Yan Zhou, Jiajin Lin, Junling Xing, Mai Lu and Guirong Ding

    Citation: BMC Neuroscience 2019 20:40

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  17. Content type: Research article

    Amblyopia is generally considered a neurodevelopmental disorder that results from abnormal visual experiences in early childhood and may persist to adulthood. The neural basis of amblyopia has been a matter of...

    Authors: Minglong Liang, He Xiao, Bing Xie, Xuntao Yin, Jian Wang and Hong Yang

    Citation: BMC Neuroscience 2019 20:39

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  18. Content type: Research article

    In this study, nonlinear based time–frequency (TF) and time domain investigations are employed for the analysis of electroencephalogram (EEG) signals of mild cognitive impairment–Alzheimer’s disease (MCI–AD) p...

    Authors: T. Nimmy John, Puthankattil Subha Dharmapalan and N. Ramshekhar Menon

    Citation: BMC Neuroscience 2019 20:38

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  19. Content type: Research article

    Cardiovascular conditions contribute to brain volume loss, reduced cerebrovascular health, and increased dementia risk in aging adults. Altered hippocampal connectivity has also been observed in individuals wi...

    Authors: Liesel-Ann C. Meusel, Carol E. Greenwood, Andrea Maione, Ekaterina Tchistiakova, Bradley J. MacIntosh and Nicole D. Anderson

    Citation: BMC Neuroscience 2019 20:37

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  20. Content type: Research article

    Postoperative pain (POP) is a severe acute pain encountered in patients suffering from an operation, and is less than adequately controlled by the currently available analgesics. Phosphatidylinositol 3-kinase ...

    Authors: Bing Xu, Cheng Mo, Chengmei Lv, Susu Liu, Jun Li, Jieying Chen, Yanhong Wei, Hongwei An, Li Ma and Xuehai Guan

    Citation: BMC Neuroscience 2019 20:36

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  21. Content type: Research article

    The functional heterogeneity of the hippocampus along its longitudinal axis at the level of behavior is an established concept; however, the neurobiological mechanisms are still unknown. Diversifications in th...

    Authors: Andriana Koutsoumpa and Costas Papatheodoropoulos

    Citation: BMC Neuroscience 2019 20:35

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  23. Content type: Research article

    Hypothalamic inflammation including astrogliosis and microglia activation occurs after intake of high fat diet (HFD) in rodent models or in obese individuals. However, the effect of chronic HFD feeding on olig...

    Authors: Hui-Ting Huang, Sheng-Feng Tsai, Hung-Tsung Wu, Hsin-Ying Huang, Han-Hsueh Hsieh, Yu-Ming Kuo, Po-See Chen, Chung-Shi Yang and Shun-Fen Tzeng

    Citation: BMC Neuroscience 2019 20:33

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  24. Content type: Research article

    Three-dimensional (3D) reconstruction of human peripheral nerves, as a useful tool to understand the nerve internal information and functional basis, has become an important area of research in the peripheral ...

    Authors: Peng Luo, Jianghui Dong, Jian Qi, Yi Zhang, Xiaolin Liu, Yingchun Zhong, Cory J. Xian and Liping Wang

    Citation: BMC Neuroscience 2019 20:32

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  25. Content type: Research article

    Recently, the use of traditional Chinese medicine (TCM) has become more generally accepted, including by the Food and Drug Administration. To expand the use of TCM worldwide, it is important to study the molec...

    Authors: Jinyuan Yan, Zhongshan Yang, Ninghui Zhao, Zhiwei Li and Xia Cao

    Citation: BMC Neuroscience 2019 20:31

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  26. Content type: Research article

    Distinctive patterns of functional connectivity (FC) abnormalities in neural circuitry has been reported in patients with bipolar depression (BD) and unipolar depression (UD). However, it is unclear that wheth...

    Authors: Chang Liu, Weidan Pu, Guowei Wu, Jie Zhao and Zhimin Xue

    Citation: BMC Neuroscience 2019 20:30

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  28. Content type: Research article

    Neuropathic pain (NP) is a prevalent disease, which badly impairs the life quality of patients. The underlying mechanism of NP is still not fully understood. It has been reported that spinal Annexin A10 (ANXA1...

    Authors: LiHong Sun, Qi Xu, WenXin Zhang, CuiCui Jiao, Hui Wu and XinZhong Chen

    Citation: BMC Neuroscience 2019 20:28

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  29. Content type: Research article

    The mosquito Aedes aegypti has a wide variety of sensory pathways that have supported its success as a species as well as a highly competent vector of numerous debilitating infectious pathogens. Investigations in...

    Authors: Michelle Bui, Jennifer Shyong, Eleanor K. Lutz, Ting Yang, Ming Li, Kenneth Truong, Ryan Arvidson, Anna Buchman, Jeffrey A. Riffell and Omar S. Akbari

    Citation: BMC Neuroscience 2019 20:27

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  31. Content type: Research article

    Brain iron is an essential as well as a toxic redox active element. Physiological levels are not uniform among the different cell types. Besides the availability of quantitative methods, the knowledge about th...

    Authors: Anja Reinert, Markus Morawski, Johannes Seeger, Thomas Arendt and Tilo Reinert

    Citation: BMC Neuroscience 2019 20:25

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  32. Content type: Research article

    Mutants which carry mutations in genes encoding mitochondrial ligases MUL1 and PARKIN are convenient Drosophila models of Parkinson’s disease (PD). In several studies it has been shown that in Parkinson’s disease...

    Authors: Bartosz Doktór, Milena Damulewicz and Elżbieta Pyza

    Citation: BMC Neuroscience 2019 20:24

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  33. Content type: Research article

    Patients with Parkinson’s disease (PD) have elevated levels of brain iron, especially in the nigrostriatal dopaminergic system. The purpose of this study was to evaluate the iron deposition in the substantia n...

    Authors: Qiqi Chen, Yiting Chen, Yue Zhang, Furu Wang, Hongchang Yu, Caiyuan Zhang, Zhen Jiang and Weifeng Luo

    Citation: BMC Neuroscience 2019 20:23

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  36. Content type: Research article

    Prepulse inhibition (PPI) of the acoustic startle response, a measurement of sensorimotor gaiting, is modulated by monoaminergic, presumably dopaminergic neurotransmission. Disturbances of the dopaminergic sys...

    Authors: Patricia Panther, Maria Kuehne, Jürgen Voges, Sven Nullmeier, Jörn Kaufmann, Janet Hausmann, Daniel Bittner, Imke Galazky, Hans-Jochen Heinze, Andreas Kupsch and Tino Zaehle

    Citation: BMC Neuroscience 2019 20:20

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  37. Content type: Research article

    To determine whether photobiomodulation (PBM) rescued the disruption of Na+/Ca2+ homeostasis and mitochondrial membrane potential by ouabain; the Na, K-ATPase inhibitor. For PBM in this study, a 660 nm LED array ...

    Authors: Yun-Hee Rhee, Jeong Hwan Moon, Jae Yun Jung, Connie Oh, Jin-Chul Ahn and Phil-Sang Chung

    Citation: BMC Neuroscience 2019 20:19

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  38. Content type: Research article

    Despite increasing evidence that lipopolysaccharide (LPS) affects the biological active substances of dorsal root ganglia (DRG) we have limited knowledge of the influence of a single low dose of LPS, which doe...

    Authors: Anita Mikołajczyk and Dagmara Złotkowska

    Citation: BMC Neuroscience 2019 20:18

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  39. Content type: Research article

    Reports show that stressful events before injury exacerbates post-injury pain. The mechanism underlying stress-induced heightened thermal pain is unclear. Here, we examined the effects of chronic intermittent ...

    Authors: Natasha M. Sosanya, Thomas H. Garza, Winfred Stacey, Stephen L. Crimmins, Robert J. Christy and Bopaiah P. Cheppudira

    Citation: BMC Neuroscience 2019 20:17

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  40. Content type: Research article

    Chronic neuropathic pain is often associated with anxiety, depressive symptoms, and cognitive impairment with relevant impact on patients` health related quality of life. To investigate the influence of a pro-...

    Authors: Franziska Karl, Maria B. Nandini Colaço, Annemarie Schulte, Claudia Sommer and Nurcan Üçeyler

    Citation: BMC Neuroscience 2019 20:16

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  41. Content type: Research article

    Smoking (TS) and recently e-cigarettes (EC) vaping, have been associated with vascular endothelial dysfunction primarily relevant to oxidative stress, exposure to nicotine, and smoking-induced inflammation. It...

    Authors: Farzane Sivandzade and Luca Cucullo

    Citation: BMC Neuroscience 2019 20:15

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  42. Content type: Research article

    Previous data show that serotonin 2C (5-HT2C) and cannabinoid 1 (CB1) receptors have a role in the modulation of sleep–wake cycle. Namely, antagonists on these receptors promoted wakefulness and inhibited rapid e...

    Authors: Emese Bogáthy, Noémi Papp, Laszló Tóthfalusi, Szilvia Vas and György Bagdy

    Citation: BMC Neuroscience 2019 20:14

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  43. Content type: Research article

    Knock-in (KI) mouse models of Alzheimer’s disease (AD) that endogenously overproduce Aβ without non-physiological overexpression of amyloid precursor protein (APP) provide important insights into the pathogeni...

    Authors: Yasufumi Sakakibara, Michiko Sekiya, Takashi Saito, Takaomi C. Saido and Koichi M. Iijima

    Citation: BMC Neuroscience 2019 20:13

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  44. Content type: Research article

    Transcranial focused ultrasound (tFUS) attracts wide attention in neuroscience as an effective noninvasive approach to modulate brain circuits. In spite of this, the effects of tFUS on the brain is still uncle...

    Authors: Evgenii Kim, Eloise Anguluan, Sangyeon Youn, Jihun Kim, Jae Youn Hwang and Jae Gwan Kim

    Citation: BMC Neuroscience 2019 20:12

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  45. Content type: Research article

    Pre-treatment with the corticotropin-releasing factor antagonist α-helical CRF9-41 prevents inhibition of gastric emptying by cocaine-and amphetamine-regulated transcript peptide at a dorsal hindbrain level, b...

    Authors: Ulrika Smedh, Karen A. Scott and Timothy H. Moran

    Citation: BMC Neuroscience 2019 20:11

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  46. Content type: Research article

    The spinal cord is limited in its capacity to repair after damage caused by injury or disease. However, propriospinal (PS) neurons in the spinal cord have demonstrated a propensity for axonal regeneration afte...

    Authors: Kristen Swieck, Amanda Conta-Steencken, Frank A. Middleton, Justin R. Siebert, Donna J. Osterhout and Dennis J. Stelzner

    Citation: BMC Neuroscience 2019 20:10

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  47. Content type: Research article

    The recovery of neurophysiological parameters at various time intervals following fatiguing exercise has been investigated previously. However, the repetition of neuromuscular assessments during the recovery p...

    Authors: Saied Jalal Aboodarda, Selina Fan, Kyla Coates and Guillaume Y. Millet

    Citation: BMC Neuroscience 2019 20:9

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  48. Content type: Methodology article

    The electroencephalogram (EEG) is a widely used laboratory technique in rodent models of epilepsy, traumatic brain injury (TBI), and other neurological diseases accompanied by seizures. Obtaining prolonged con...

    Authors: Yasser Medlej, Rita Asdikian, Lara Wadi, Houssein Salah, Laura Dosh, Rabih Hashash, Nabil Karnib, Mohammad Medlej, Hala Darwish, Firas Kobeissy and Makram Obeid

    Citation: BMC Neuroscience 2019 20:8

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  49. Content type: Research article

    Gulf War Illness (GWI) affects 30% of veterans from the 1991 Gulf War and has no known cause. Everyday symptoms include pain, fatigue, migraines, and dyscognition. A striking syndromic feature is post-exertion...

    Authors: Rakib U. Rayhan, Stuart D. Washington, Richard Garner, Kristina Zajur, Florencia Martinez Addiego, John W. VanMeter and James N. Baraniuk

    Citation: BMC Neuroscience 2019 20:7

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  50. Content type: Research article

    Epidemiologic studies strongly suggest that the pathophysiology of late-onset Alzheimer disease (AD) versus early-onset AD has environmental rather than genetic causes, thus revealing potentially novel therape...

    Authors: Zein Al-Atrache, Danielle B. Lopez, Susan T. Hingley and Denah M. Appelt

    Citation: BMC Neuroscience 2019 20:6

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