Fig. 2

Mouse models of euthyroid HT. a Gross inspection of thyroids from HT and Con Mice. Note the enlarged thyroids in HT mice. b Representative thyroid sections stained with H & E showing monocyte infiltration between the groups (arrow). The control mice had intact thyroid follicles with an even distribution, and monocyte infiltration was hardly found in thyroid tissues. In contrast, HT mice displayed disorderly and destroyed thyroid follicles, and monocyte infiltration was evident in thyroid tissues. c Quantitation of monocyte infiltration. d–h Serum levels of the indicated thyroid-related parameters. Data are the mean ± SEM (Con group, n = 10 mice; HT group, n = 11 mice); ns, no significant difference; *p < 0.01, **p < 0.01, and ***p < 0.001. Scale bars: = 100 μm