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  1. It is established that increasing the amplitude of a flutter stimulus increases its perceived intensity. Although many studies have examined this phenomenon with regard to the responding afferent population, t...

    Authors: Stephen B Simons, Vinay Tannan, Joannellyn Chiu, Oleg V Favorov, Barry L Whitsel and Mark Tommerdahl

    Citation: BMC Neuroscience 2005 6:43

    Content type: Research article

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  2. Brain-derived neurotrophic factor (BDNF), which is sorted into a regulated secretory pathway of neurons, is supposed to act retrogradely through dendrites on presynaptic neurons or anterogradely through axons ...

    Authors: Naoki Adachi, Keigo Kohara and Tadaharu Tsumoto

    Citation: BMC Neuroscience 2005 6:42

    Content type: Research article

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  3. In the laboratory, behavioral and physiological states of nocturnal rodents alternate, with a period near 24 h, between those appropriate for the night (e.g., elevated wheel-running activity and high melatonin...

    Authors: Sheila L Rosenthal, Martin M Vakili, Jennifer A Evans, Jeffrey A Elliott and Michael R Gorman

    Citation: BMC Neuroscience 2005 6:41

    Content type: Research article

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  4. HIV Associated Dementia (HAD) is a common complication of human immunodeficiency virus (HIV) infection that erodes the quality of life for patients and burdens health care providers. Intravenous drug use is a ...

    Authors: Sherie L Kendall, Caroline F Anderson, Avindra Nath, Jadwiga Turchan-Cholewo, Cantey L Land, Charles F Mactutus and Rosemarie M Booze

    Citation: BMC Neuroscience 2005 6:40

    Content type: Research article

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  5. The transcription factor AP-1 positively controls synaptic plasticity at the Drosophila neuromuscular junction. Although in motor neurons, JNK has been shown to activate AP-1, a positive regulator of growth and s...

    Authors: Paul D Etter, Radhakrishnan Narayanan, Zaneta Navratilova, Chirag Patel, Dirk Bohmann, Heinrich Jasper and Mani Ramaswami

    Citation: BMC Neuroscience 2005 6:39

    Content type: Research article

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  6. Animals must frequently make choices between alternative courses of action, seeking to maximize the benefit obtained. They must therefore evaluate the magnitude and the likelihood of the available outcomes. Li...

    Authors: Rudolf N Cardinal and Nathan J Howes

    Citation: BMC Neuroscience 2005 6:37

    Content type: Research article

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  7. Training of a repetitive synchronised movement of two limb muscles leads to short-term plastic changes in the primary motor cortex, which can be assessed by transcranial magnetic stimulation (TMS) mapping. We ...

    Authors: Peter Schwenkreis, Katja Witscher, Burkhard Pleger, Jean-Pierre Malin and Martin Tegenthoff

    Citation: BMC Neuroscience 2005 6:35

    Content type: Research article

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  8. High concentrations of glutamate can accumulate in the brain and may be involved in the pathogenesis of neurodegenerative disorders such as Alzheimer's disease. This form of neurotoxicity involves changes in t...

    Authors: Joel Perrella and Bhagu R Bhavnani

    Citation: BMC Neuroscience 2005 6:34

    Content type: Research article

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  9. ADAM22 is a member of the ADAM gene family, but the fact that it is expressed only in the nervous systems makes it unique. ADAM22's sequence similarity to other ADAMs suggests it to be an integrin binder and t...

    Authors: Koji Sagane, Kazuhiro Hayakawa, Junko Kai, Tomoko Hirohashi, Eiki Takahashi, Norimasa Miyamoto, Mitsuhiro Ino, Tohru Oki, Kazuto Yamazaki and Takeshi Nagasu

    Citation: BMC Neuroscience 2005 6:33

    Content type: Research article

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  10. The neocortical commissures have a fundamental role in functional integration across the cerebral hemispheres. We investigated whether commissural projections in prefrontal cortices are organized according to ...

    Authors: Helen Barbas, Claus C Hilgetag, Subhash Saha, Caterina R Dermon and Joanna L Suski

    Citation: BMC Neuroscience 2005 6:32

    Content type: Research article

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  11. Previous studies by our group suggest that extracellular dopamine (DA) and noradrenaline (NA) may be co-released from noradrenergic nerve terminals in the cerebral cortex. We recently demonstrated that the con...

    Authors: Paola Devoto, Giovanna Flore, Pierluigi Saba, Mauro Fà and Gian Luigi Gessa

    Citation: BMC Neuroscience 2005 6:31

    Content type: Research article

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  12. Gamma-aminobutyric acid type A receptors (GABAA-Rs) are the major inhibitory receptors in the mammalian brain and are modulated by a number of sedative/hypnotic drugs including benzodiazepines and anesthetics. Th...

    Authors: Dev Chandra, Esa R Korpi, Celia P Miralles, Angel L De Blas and Gregg E Homanics

    Citation: BMC Neuroscience 2005 6:30

    Content type: Research article

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  13. While SII cortex is considered to be the first cortical stage of the pathway that integrates tactile information arising from both sides of the body, SI cortex is generally not considered as a region in which ...

    Authors: Mark Tommerdahl, Stephen B Simons, Joannellyn S Chiu, Oleg Favorov and Barry Whitsel

    Citation: BMC Neuroscience 2005 6:29

    Content type: Research article

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  14. Neural stem cells (NSCs) can be isolated from the adult mammalian brain and expanded in culture, in the form of cellular aggregates called neurospheres. Neurospheres provide an in vitro model for studying NSC beh...

    Authors: Maria Sievertzon, Valtteri Wirta, Alex Mercer, Konstantinos Meletis, Rikard Erlandsson, Lilian Wikström, Jonas Frisén and Joakim Lundeberg

    Citation: BMC Neuroscience 2005 6:28

    Content type: Research article

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  15. The neuronal ceroid lipofuscinoses (NCLs) are a group of inherited neurodegenerative disorders characterized by accumulation of autofluorescent material in many tissues, especially in neurons. Mutations in the CL...

    Authors: Liina Lonka, Antti Aalto, Outi Kopra, Mervi Kuronen, Zaal Kokaia, Mart Saarma and Anna-Elina Lehesjoki

    Citation: BMC Neuroscience 2005 6:27

    Content type: Research article

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  16. The forebrain subventricular zone (SVZ)-olfactory bulb pathway and hippocampal subgranular zone (SGZ) generate neurons into adulthood in the mammalian brain. Neurogenesis increases after injury to the adult br...

    Authors: Maryam Faiz, Laia Acarin, Bernardo Castellano and Berta Gonzalez

    Citation: BMC Neuroscience 2005 6:26

    Content type: Research article

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  17. Annexin A7 is a member of the annexin protein family, which is characterized by its ability to interact with phospholipids in the presence of Ca2+-ions and which is thought to function in Ca2+-homeostasis. Result...

    Authors: Michaela Rick, Soraya I Ramos Garrido, Claudia Herr, Dietmar R Thal, Angelika A Noegel and Christoph S Clemen

    Citation: BMC Neuroscience 2005 6:25

    Content type: Research article

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  18. Neurite growth can be elicited by growth factors and interactions with extracellular matrix molecules like laminin. Among the targets of the signalling pathways activated by these stimuli are cytoskeletal elem...

    Authors: Kristy L Williams, Masuma Rahimtula and Karen M Mearow

    Citation: BMC Neuroscience 2005 6:24

    Content type: Research article

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  19. The sweet taste inhibitor lactisole acts on the human sweet taste receptor heteromer TAS1R2-TAS1R3 but not on its rodent counterpart. Recently, it was shown that the lactisole sensitivity of the human sweet ta...

    Authors: Marcel Winnig, Bernd Bufe and Wolfgang Meyerhof

    Citation: BMC Neuroscience 2005 6:22

    Content type: Research article

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  20. In mammals, the CNS vasculature is established during the postnatal period via active angiogenesis, providing different brain regions with capillary networks of various densities that locally supply adapted me...

    Authors: Gérard Alonso, Evelyne Galibert, Anne Duvoid-Guillou and Anne Vincent

    Citation: BMC Neuroscience 2005 6:20

    Content type: Research article

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  21. When spinal motor axons are injured, the nucleolus, nucleus and cell body of the injured cell transiently increase in size, the nucleus becomes more eccentrically placed, and the organization of polyribosomes ...

    Authors: David L McIlwain and Victoria B Hoke

    Citation: BMC Neuroscience 2005 6:19

    Content type: Research article

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  22. Recent discoveries suggest that arealization of the mammalian cortical sheet develops in a manner consonant with principles established for embryonic patterning of the body. Signaling centers release morphogen...

    Authors: David C Airey, Alicia I Robbins, Katherine M Enzinger, Fangbai Wu and Christine E Collins

    Citation: BMC Neuroscience 2005 6:18

    Content type: Research article

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  23. Mechanisms that affect recovery from fetal and neonatal hypoxic-ischemic (H-I) brain injury have not been fully elucidated. The incidence of intrapartum asphyxia is approximately 2.5%, but the occurrence of ad...

    Authors: John Bartley, Thomas Soltau, Hereward Wimborne, Sunjun Kim, Angeline Martin-Studdard, David Hess, William Hill, Jennifer Waller and James Carroll

    Citation: BMC Neuroscience 2005 6:15

    Content type: Research article

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  24. Physiological and morphological evidence suggests that activation of the ventromedial preoptic area of the hypothalamus (VMPO) is an essential component of an intravenous LPS-dependent fever. In response to th...

    Authors: Heather J Ranels and John D Griffin

    Citation: BMC Neuroscience 2005 6:14

    Content type: Research article

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  25. Apoptosis plays a key role in cell death observed in neurodegenerative diseases marked by a progressive loss of neurons as seen in Alzheimer's disease. Although the exact cause of apoptosis is not known, a num...

    Authors: YueMei Zhang and Bhagu R Bhavnani

    Citation: BMC Neuroscience 2005 6:13

    Content type: Research article

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  26. A distinctive property of SII is that it is the first cortical stage of the somatosensory projection pathway that integrates information arising from both sides of the body. However, there is very little known...

    Authors: Mark Tommerdahl, Stephen B Simons, Joannellyn S Chiu, Vinay Tannan, Oleg Favorov and Barry Whitsel

    Citation: BMC Neuroscience 2005 6:11

    Content type: Research article

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  27. The blood brain barrier (BBB) is the first line of defence of the central nervous system (CNS) against circulating pathogens, such as HIV. The cytotoxic HIV protein, gp120, damages endothelial cells of the BBB...

    Authors: Dianne Langford, Rosemary Hurford, Makoto Hashimoto, Murat Digicaylioglu and Eliezer Masliah

    Citation: BMC Neuroscience 2005 6:8

    Content type: Research article

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  28. The pathology of Alzheimer's disease (AD) is comprised of extracellular amyloid plaques, intracellular tau tangles, dystrophic neurites and neurodegeneration. The mechanisms by which these various pathological...

    Authors: Chad A Dickey, Marcia N Gordon, Donna M Wilcock, Donna L Herber, Melissa J Freeman and Dave Morgan

    Citation: BMC Neuroscience 2005 6:7

    Content type: Research article

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  29. The progressive nature of Wallerian degeneration has long been controversial. Conflicting reports that distal stumps of injured axons degenerate anterogradely, retrogradely, or simultaneously are based on stat...

    Authors: Bogdan Beirowski, Robert Adalbert, Diana Wagner, Daniela S Grumme, Klaus Addicks, Richard R Ribchester and Michael P Coleman

    Citation: BMC Neuroscience 2005 6:6

    Content type: Research article

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  30. In Leber's congenital amaurosis (LCA), affected individuals are blind, or nearly so, from birth. This early onset suggests abnormal development of the neural retina. Mutations in genes that affect the developm...

    Authors: Eric M Morrow, Takahisa Furukawa, Elio Raviola and Constance L Cepko

    Citation: BMC Neuroscience 2005 6:5

    Content type: Research article

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  31. Nerve growth factor (NGF), glial cell line-derived neurotrophic factor (GDNF) and brain-derived neurotrophic factor (BDNF) all play important roles in the development of the peripheral sensory nervous system. ...

    Authors: Theodore J Price, Michael D Louria, Damaries Candelario-Soto, Gregory O Dussor, Nathanial A Jeske, Amol M Patwardhan, Anibal Diogenes, Amanda A Trott, Kenneth M Hargreaves and Christopher M Flores

    Citation: BMC Neuroscience 2005 6:4

    Content type: Research article

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  32. Iron is necessary for neuronal function but in excess generates neurodegeneration. Although most of the components of the iron homeostasis machinery have been described in neurons, little is known about the pa...

    Authors: Pabla Aguirre, Natalia Mena, Victoria Tapia, Miguel Arredondo and Marco T Núñez

    Citation: BMC Neuroscience 2005 6:3

    Content type: Research article

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  33. Nicotinic acetylcholine receptors (nAChRs) are pentameric proteins that are important drug targets for a variety of diseases including Alzheimer's, schizophrenia and various forms of epilepsy. One of the most ...

    Authors: Steven D Buckingham, Luanda Pym, Andrew K Jones, Laurence Brown, Mark SP Sansom, David B Sattelle and Philip C Biggin

    Citation: BMC Neuroscience 2005 6:2

    Content type: Database

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  34. Huntington's disease (HD) is an inherited neurodegenerative disorder triggered by an expanded polyglutamine tract in huntingtin that is thought to confer a new conformational property on this large protein. Th...

    Authors: Jin Wang, Silvia Gines, Marcy E MacDonald and James F Gusella

    Citation: BMC Neuroscience 2005 6:1

    Content type: Research article

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  35. Define covariates of cerebrospinal corticotropin-releasing hormone (CRH) levels in normal humans. CRHCSF was measured in 9 normal subjects as part of an intensive study of physiological responses stressors in chr...

    Authors: James N Baraniuk, Hilda Maibach, Gail Whalen and Daniel J Clauw

    Citation: BMC Neuroscience 2004 5:58

    Content type: Research article

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  36. JNCL is a recessively inherited, childhood-onset neurodegenerative disease most-commonly caused by a ~1 kb CLN3 mutation. The resulting loss of battenin activity leads to deposition of mitochondrial ATP synthase,...

    Authors: Elisa Fossale, Pavlina Wolf, Janice A Espinola, Tanya Lubicz-Nawrocka, Allison M Teed, Hanlin Gao, Dorotea Rigamonti, Elena Cattaneo, Marcy E MacDonald and Susan L Cotman

    Citation: BMC Neuroscience 2004 5:57

    Content type: Research article

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  37. Sign-language comprehension activates the auditory cortex in deaf subjects. It is not known whether this functional plasticity in the temporal cortex is age dependent. We conducted functional magnetic-resonanc...

    Authors: Norihiro Sadato, Hiroki Yamada, Tomohisa Okada, Masaki Yoshida, Takehiro Hasegawa, Ken-Ichi Matsuki, Yoshiharu Yonekura and Harumi Itoh

    Citation: BMC Neuroscience 2004 5:56

    Content type: Research article

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  38. The neuroprotective effect of xenon has been demonstrated for glutamatergic neurons. In the present study it is investigated if dopaminergic neurons, i.e. nerve-growth-factor differentiated PC-12 cells, are pr...

    Authors: Christian Petzelt, Per Blom, Wolfgang Schmehl, Jana Müller and Wolfgang J Kox

    Citation: BMC Neuroscience 2004 5:55

    Content type: Research article

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  39. Leptin and insulin are long-term regulators of body weight. They act in hypothalamic centres to modulate the function of specific neuronal subtypes, by altering transcriptional control of releasable peptides a...

    Authors: Shirin Mirshamsi, Hilary A Laidlaw, Ke Ning, Erin Anderson, Laura A Burgess, Alexander Gray, Calum Sutherland and Michael LJ Ashford

    Citation: BMC Neuroscience 2004 5:54

    Content type: Research article

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  40. GABAergic inhibition and effects of intracellular chloride ions on calcium channel activity have been proposed to regulate neurotransmission from photoreceptors. To assess the impact of these and other chlorid...

    Authors: Wallace B Thoreson and Eric J Bryson

    Citation: BMC Neuroscience 2004 5:53

    Content type: Research article

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