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  1. Permeability of the blood-brain barrier is one of the factors determining the bioavailability of therapeutic drugs and resistance to chemically different antiepileptic drugs is a consequence of decreased intra...

    Authors: Sanjay Awasthi, Kerri L Hallene, Vince Fazio, Sharad S Singhal, Luca Cucullo, Yogesh C Awasthi, Gabriele Dini and Damir Janigro

    Citation: BMC Neuroscience 2005 6:61

    Content type: Research article

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  2. Hydrochloric acid (HCl) is a potential threat to the integrity of the gastric mucosa and is known to contribute to upper abdominal pain. We have previously found that gastric mucosal challenge with excess HCl ...

    Authors: Peter Holzer, Evelin Painsipp and Rufina Schuligoi

    Citation: BMC Neuroscience 2005 6:60

    Content type: Research article

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  3. The fetal cortical neuroepithelium is a mosaic of distinct progenitor populations that elaborate diverse cellular fates. Ethanol induces apoptosis and interferes with the survival of differentiating neurons. H...

    Authors: Daniel R Santillano, Leena S Kumar, Terasa L Prock, Cynthia Camarillo, Joseph D Tingling and Rajesh C Miranda

    Citation: BMC Neuroscience 2005 6:59

    Content type: Research article

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  4. Estrogen suppresses microglial activation and extravasation of circulating monocytes in young animals, supporting an anti-inflammatory role for this hormone. However, the mechanisms underlying estrogen's anti-...

    Authors: Vanessa L Nordell, Danielle K Lewis, Shameena Bake and Farida Sohrabji

    Citation: BMC Neuroscience 2005 6:58

    Content type: Research article

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  5. After sub-total hemi-section of cervical cord at level C7/C8 in monkeys, the ipsilesional hand exhibited a paralysis for a couple of weeks, followed by incomplete recovery of manual dexterity, reaching a plate...

    Authors: Eric Schmidlin, Thierry Wannier, Jocelyne Bloch, Abderraouf Belhaj-Saif, Alexander F Wyss and Eric M Rouiller

    Citation: BMC Neuroscience 2005 6:56

    Content type: Research article

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  6. The recently discovered adult neural stem cells, which maintain continuous generation of new neuronal and glial cells throughout adulthood, are a promising and expandable source of cells for use in cell replac...

    Authors: Maria Sievertzon, Valtteri Wirta, Alex Mercer, Jonas Frisén and Joakim Lundeberg

    Citation: BMC Neuroscience 2005 6:55

    Content type: Research article

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  7. Epidemiological studies have associated estrogen replacement therapy with a lower risk of developing Alzheimer's disease, but a higher risk of developing breast cancer and certain cardiovascular disorders. The...

    Authors: Astrid Gutierrez-Zepeda, Ross Santell, Zhixin Wu, Marishka Brown, YanJue Wu, Ikhlas Khan, Christopher D Link, Baolu Zhao and Yuan Luo

    Citation: BMC Neuroscience 2005 6:54

    Content type: Research article

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  8. Plexins, known to date as receptors of semaphorins, are implicated in semaphorin-mediated axon repulsion and growth cone collapse. However, subtype-specific functions of the majority of the nine members of the...

    Authors: Christine Hartwig, Andres Veske, Sarka Krejcova, Georg Rosenberger and Ulrich Finckh

    Citation: BMC Neuroscience 2005 6:53

    Content type: Research article

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  9. Brevican is a member of the lectican family of aggregating extracellular matrix (ECM) proteoglycans that bear chondroitin sulfate (CS) chains. It is highly expressed in the central nervous system (CNS) and is ...

    Authors: Joanne Mayer, Michelle G Hamel and Paul E Gottschall

    Citation: BMC Neuroscience 2005 6:52

    Content type: Research article

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  10. While gelatinase (MMP-2 and -9) activity is increased after focal ischemia/reperfusion injury in the brain, the relative contribution of neutrophils to the MMP activity and to the development of hemorrhagic tr...

    Authors: Alex K Harris, Adviye Ergul, Anna Kozak, Livia S Machado, Maribeth H Johnson and Susan C Fagan

    Citation: BMC Neuroscience 2005 6:49

    Content type: Research article

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  11. Recently we reported that vibrotactile flutter stimulation of a skin locus at different amplitudes evokes an optical response confined to the same local region of the primary somatosensory cortex (SI), where i...

    Authors: Joannellyn S Chiu, Mark Tommerdahl, Barry L Whitsel and Oleg V Favorov

    Citation: BMC Neuroscience 2005 6:47

    Content type: Research article

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  12. Rag1 (Recombination activation gene-1) mediates genomic rearrangement and is essential for adaptive immunity in vertebrates. This gene is also expressed in the olfactory epithelium, but its function there is unkn...

    Authors: Bo Feng, Sarada Bulchand, Emre Yaksi, Rainer W Friedrich and Suresh Jesuthasan

    Citation: BMC Neuroscience 2005 6:46

    Content type: Research article

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  13. Notch signaling pathways are conserved across species and traditionally have been implicated in cell fate determination during embryonic development. Notch signaling components are also expressed postdevelopme...

    Authors: Michael Y Chao, Jonah Larkins-Ford, Tim M Tucey and Anne C Hart

    Citation: BMC Neuroscience 2005 6:45

    Content type: Research article

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  14. It is established that increasing the amplitude of a flutter stimulus increases its perceived intensity. Although many studies have examined this phenomenon with regard to the responding afferent population, t...

    Authors: Stephen B Simons, Vinay Tannan, Joannellyn Chiu, Oleg V Favorov, Barry L Whitsel and Mark Tommerdahl

    Citation: BMC Neuroscience 2005 6:43

    Content type: Research article

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  15. Brain-derived neurotrophic factor (BDNF), which is sorted into a regulated secretory pathway of neurons, is supposed to act retrogradely through dendrites on presynaptic neurons or anterogradely through axons ...

    Authors: Naoki Adachi, Keigo Kohara and Tadaharu Tsumoto

    Citation: BMC Neuroscience 2005 6:42

    Content type: Research article

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  16. In the laboratory, behavioral and physiological states of nocturnal rodents alternate, with a period near 24 h, between those appropriate for the night (e.g., elevated wheel-running activity and high melatonin...

    Authors: Sheila L Rosenthal, Martin M Vakili, Jennifer A Evans, Jeffrey A Elliott and Michael R Gorman

    Citation: BMC Neuroscience 2005 6:41

    Content type: Research article

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  17. HIV Associated Dementia (HAD) is a common complication of human immunodeficiency virus (HIV) infection that erodes the quality of life for patients and burdens health care providers. Intravenous drug use is a ...

    Authors: Sherie L Kendall, Caroline F Anderson, Avindra Nath, Jadwiga Turchan-Cholewo, Cantey L Land, Charles F Mactutus and Rosemarie M Booze

    Citation: BMC Neuroscience 2005 6:40

    Content type: Research article

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  18. The transcription factor AP-1 positively controls synaptic plasticity at the Drosophila neuromuscular junction. Although in motor neurons, JNK has been shown to activate AP-1, a positive regulator of growth and s...

    Authors: Paul D Etter, Radhakrishnan Narayanan, Zaneta Navratilova, Chirag Patel, Dirk Bohmann, Heinrich Jasper and Mani Ramaswami

    Citation: BMC Neuroscience 2005 6:39

    Content type: Research article

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  19. Animals must frequently make choices between alternative courses of action, seeking to maximize the benefit obtained. They must therefore evaluate the magnitude and the likelihood of the available outcomes. Li...

    Authors: Rudolf N Cardinal and Nathan J Howes

    Citation: BMC Neuroscience 2005 6:37

    Content type: Research article

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  20. Training of a repetitive synchronised movement of two limb muscles leads to short-term plastic changes in the primary motor cortex, which can be assessed by transcranial magnetic stimulation (TMS) mapping. We ...

    Authors: Peter Schwenkreis, Katja Witscher, Burkhard Pleger, Jean-Pierre Malin and Martin Tegenthoff

    Citation: BMC Neuroscience 2005 6:35

    Content type: Research article

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  21. High concentrations of glutamate can accumulate in the brain and may be involved in the pathogenesis of neurodegenerative disorders such as Alzheimer's disease. This form of neurotoxicity involves changes in t...

    Authors: Joel Perrella and Bhagu R Bhavnani

    Citation: BMC Neuroscience 2005 6:34

    Content type: Research article

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  22. ADAM22 is a member of the ADAM gene family, but the fact that it is expressed only in the nervous systems makes it unique. ADAM22's sequence similarity to other ADAMs suggests it to be an integrin binder and t...

    Authors: Koji Sagane, Kazuhiro Hayakawa, Junko Kai, Tomoko Hirohashi, Eiki Takahashi, Norimasa Miyamoto, Mitsuhiro Ino, Tohru Oki, Kazuto Yamazaki and Takeshi Nagasu

    Citation: BMC Neuroscience 2005 6:33

    Content type: Research article

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  23. The neocortical commissures have a fundamental role in functional integration across the cerebral hemispheres. We investigated whether commissural projections in prefrontal cortices are organized according to ...

    Authors: Helen Barbas, Claus C Hilgetag, Subhash Saha, Caterina R Dermon and Joanna L Suski

    Citation: BMC Neuroscience 2005 6:32

    Content type: Research article

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  24. Previous studies by our group suggest that extracellular dopamine (DA) and noradrenaline (NA) may be co-released from noradrenergic nerve terminals in the cerebral cortex. We recently demonstrated that the con...

    Authors: Paola Devoto, Giovanna Flore, Pierluigi Saba, Mauro Fà and Gian Luigi Gessa

    Citation: BMC Neuroscience 2005 6:31

    Content type: Research article

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  25. Gamma-aminobutyric acid type A receptors (GABAA-Rs) are the major inhibitory receptors in the mammalian brain and are modulated by a number of sedative/hypnotic drugs including benzodiazepines and anesthetics. Th...

    Authors: Dev Chandra, Esa R Korpi, Celia P Miralles, Angel L De Blas and Gregg E Homanics

    Citation: BMC Neuroscience 2005 6:30

    Content type: Research article

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  26. While SII cortex is considered to be the first cortical stage of the pathway that integrates tactile information arising from both sides of the body, SI cortex is generally not considered as a region in which ...

    Authors: Mark Tommerdahl, Stephen B Simons, Joannellyn S Chiu, Oleg Favorov and Barry Whitsel

    Citation: BMC Neuroscience 2005 6:29

    Content type: Research article

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  27. Neural stem cells (NSCs) can be isolated from the adult mammalian brain and expanded in culture, in the form of cellular aggregates called neurospheres. Neurospheres provide an in vitro model for studying NSC beh...

    Authors: Maria Sievertzon, Valtteri Wirta, Alex Mercer, Konstantinos Meletis, Rikard Erlandsson, Lilian Wikström, Jonas Frisén and Joakim Lundeberg

    Citation: BMC Neuroscience 2005 6:28

    Content type: Research article

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  28. The neuronal ceroid lipofuscinoses (NCLs) are a group of inherited neurodegenerative disorders characterized by accumulation of autofluorescent material in many tissues, especially in neurons. Mutations in the CL...

    Authors: Liina Lonka, Antti Aalto, Outi Kopra, Mervi Kuronen, Zaal Kokaia, Mart Saarma and Anna-Elina Lehesjoki

    Citation: BMC Neuroscience 2005 6:27

    Content type: Research article

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  29. The forebrain subventricular zone (SVZ)-olfactory bulb pathway and hippocampal subgranular zone (SGZ) generate neurons into adulthood in the mammalian brain. Neurogenesis increases after injury to the adult br...

    Authors: Maryam Faiz, Laia Acarin, Bernardo Castellano and Berta Gonzalez

    Citation: BMC Neuroscience 2005 6:26

    Content type: Research article

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  30. Annexin A7 is a member of the annexin protein family, which is characterized by its ability to interact with phospholipids in the presence of Ca2+-ions and which is thought to function in Ca2+-homeostasis. Result...

    Authors: Michaela Rick, Soraya I Ramos Garrido, Claudia Herr, Dietmar R Thal, Angelika A Noegel and Christoph S Clemen

    Citation: BMC Neuroscience 2005 6:25

    Content type: Research article

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  31. Neurite growth can be elicited by growth factors and interactions with extracellular matrix molecules like laminin. Among the targets of the signalling pathways activated by these stimuli are cytoskeletal elem...

    Authors: Kristy L Williams, Masuma Rahimtula and Karen M Mearow

    Citation: BMC Neuroscience 2005 6:24

    Content type: Research article

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  32. The sweet taste inhibitor lactisole acts on the human sweet taste receptor heteromer TAS1R2-TAS1R3 but not on its rodent counterpart. Recently, it was shown that the lactisole sensitivity of the human sweet ta...

    Authors: Marcel Winnig, Bernd Bufe and Wolfgang Meyerhof

    Citation: BMC Neuroscience 2005 6:22

    Content type: Research article

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  33. In mammals, the CNS vasculature is established during the postnatal period via active angiogenesis, providing different brain regions with capillary networks of various densities that locally supply adapted me...

    Authors: Gérard Alonso, Evelyne Galibert, Anne Duvoid-Guillou and Anne Vincent

    Citation: BMC Neuroscience 2005 6:20

    Content type: Research article

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  34. When spinal motor axons are injured, the nucleolus, nucleus and cell body of the injured cell transiently increase in size, the nucleus becomes more eccentrically placed, and the organization of polyribosomes ...

    Authors: David L McIlwain and Victoria B Hoke

    Citation: BMC Neuroscience 2005 6:19

    Content type: Research article

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  35. Recent discoveries suggest that arealization of the mammalian cortical sheet develops in a manner consonant with principles established for embryonic patterning of the body. Signaling centers release morphogen...

    Authors: David C Airey, Alicia I Robbins, Katherine M Enzinger, Fangbai Wu and Christine E Collins

    Citation: BMC Neuroscience 2005 6:18

    Content type: Research article

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  36. Mechanisms that affect recovery from fetal and neonatal hypoxic-ischemic (H-I) brain injury have not been fully elucidated. The incidence of intrapartum asphyxia is approximately 2.5%, but the occurrence of ad...

    Authors: John Bartley, Thomas Soltau, Hereward Wimborne, Sunjun Kim, Angeline Martin-Studdard, David Hess, William Hill, Jennifer Waller and James Carroll

    Citation: BMC Neuroscience 2005 6:15

    Content type: Research article

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  37. Physiological and morphological evidence suggests that activation of the ventromedial preoptic area of the hypothalamus (VMPO) is an essential component of an intravenous LPS-dependent fever. In response to th...

    Authors: Heather J Ranels and John D Griffin

    Citation: BMC Neuroscience 2005 6:14

    Content type: Research article

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  38. Apoptosis plays a key role in cell death observed in neurodegenerative diseases marked by a progressive loss of neurons as seen in Alzheimer's disease. Although the exact cause of apoptosis is not known, a num...

    Authors: YueMei Zhang and Bhagu R Bhavnani

    Citation: BMC Neuroscience 2005 6:13

    Content type: Research article

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