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Ample evidence suggests a substantial contribution of cellular and molecular changes in the spinal cord to the induction and persistence of chronic neuropathic pain conditions. While for a long time, proteases...
We recently showed that whereas inhibition of PI3K/akt or JAK/STAT pathway promoted retinal ganglion cell (RGC) survival after optic nerve (ON) injury in Fischer 344 (F344) rats, the same inhibition resulted i...
During speech production the planning of a description of several events requires, among other things, a verbal sequencing of these events. During this process, referred to as linearization during conceptualiz...
Prosaposin encodes, in tandem, four small acidic activator proteins (saposins) with specificities for glycosphingolipid (GSL) hydrolases in lysosomes. Extensive GSL storage occurs in various central nervous sy...
Parkinson's disease (PD) is a neurological disorder characterized by the degeneration of nigrostriatal dopaminergic systems. Free radicals induced by oxidative stress are involved in the mechanisms of cell dea...
Intrinsic apoptosis of neuronal somas is one aspect of neurodegenerative diseases that can be influenced by genetic background. Genes that affect this process may act as susceptibility alleles that contribute ...
Neurons require an elaborate system of intracellular transport to distribute cargo throughout axonal and dendritic projections. Active anterograde and retrograde transport of mitochondria serves in local energ...
Somatic Marker Hypothesis (SMH), based on clinical observations, delineates neuronal networks for interpreting consciousness generation and decision-making. The Iowa gambling task (IGT) was designed to verify ...
Human neural stem cells (hNSC) have the potential to provide novel cell-based therapies for neurodegenerative conditions such as multiple sclerosis and Parkinson's disease. In order to realise this goal, proto...
A crucial event in the development of the vertebrate neuromuscular junction (NMJ) is the postsynaptic enrichment of muscle acetylcholine (ACh) receptors (AChRs). This process involves two distinct steps: the l...
A verb's argument structure defines the number and relationships of participants needed for a complete event. One-argument (intransitive) verbs require only a subject to make a complete sentence, while two- an...
Multiple technologies have been brought to bear on understanding the three-dimensional morphology of individual neurons and glia within the brain, but little progress has been made on understanding the rules c...
Glutathione S-transferases (GSTs) play an important role in metabolizing anti-epileptic drugs (AEDs) in liver. Expressions of GSTs in brain, which may result in poor efficacy of AEDs, have not been well studie...
The Pleiades Promoter Project aims to improve gene therapy by designing human mini-promoters (< 4 kb) that drive gene expression in specific brain regions or cell-types of therapeutic interest. Our goal was to...
The mammalian auditory cortex can be subdivided into various fields characterized by neurophysiological and neuroarchitectural properties and by connections with different nuclei of the thalamus. Besides the p...
This article is part of a Supplement: Volume 9 Supplement 1
This article is part of a Supplement: Volume 9 Supplement 1
This article is part of a Supplement: Volume 9 Supplement 1
This article is part of a Supplement: Volume 9 Supplement 1
This article is part of a Supplement: Volume 9 Supplement 1
This article is part of a Supplement: Volume 9 Supplement 1
This article is part of a Supplement: Volume 9 Supplement 1
This article is part of a Supplement: Volume 9 Supplement 1
This article is part of a Supplement: Volume 9 Supplement 1
This article is part of a Supplement: Volume 9 Supplement 1
This article is part of a Supplement: Volume 9 Supplement 1
This article is part of a Supplement: Volume 9 Supplement 1
This article is part of a Supplement: Volume 9 Supplement 1
This article is part of a Supplement: Volume 9 Supplement 1
This article is part of a Supplement: Volume 9 Supplement 1
This article is part of a Supplement: Volume 9 Supplement 1
This article is part of a Supplement: Volume 9 Supplement 1
This article is part of a Supplement: Volume 9 Supplement 1
This article is part of a Supplement: Volume 9 Supplement 1
This article is part of a Supplement: Volume 9 Supplement 1
This article is part of a Supplement: Volume 9 Supplement 1
This article is part of a Supplement: Volume 9 Supplement 1
This article is part of a Supplement: Volume 9 Supplement 1
This article is part of a Supplement: Volume 9 Supplement 1
This article is part of a Supplement: Volume 9 Supplement 1
This article is part of a Supplement: Volume 9 Supplement 1
This article is part of a Supplement: Volume 9 Supplement 1
This article is part of a Supplement: Volume 9 Supplement 1
This article is part of a Supplement: Volume 9 Supplement 1
This article is part of a Supplement: Volume 9 Supplement 1
This article is part of a Supplement: Volume 9 Supplement 1
This article is part of a Supplement: Volume 9 Supplement 1
This article is part of a Supplement: Volume 9 Supplement 1
This article is part of a Supplement: Volume 9 Supplement 1
This article is part of a Supplement: Volume 9 Supplement 1
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