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Cerebellar timing and negative patterning

Experimental studies suggest that the rabbit cerebellum is able to show negative patterning (exclusive or), a paradigm in which the rabbit eyelid is conditioned to respond to two individual stimuli, but not to both stimuli presented together. The paradigm, however, works only for interstimulus intervals (ISIs) longer than 800 ms. In this study we use a large scale simulation of the cerebellum to investigate the dynamics between cerebellar timing and the negative patterning paradigm at shorter ISIs. Since the simulation is not able to learn negative patterning with the standard paradigm we design a modified negative patterning training paradigm which is able to produce the standard results. The training mechanism induced by the new paradigm suggests that cerebellar timing and the negative patterning paradigm are mutually exclusive for ISIs shorter than 800 ms.

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Correspondence to Horatiu Voicu.

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Open Access This article is published under license to BioMed Central Ltd. This is an Open Access article is distributed under the terms of the Creative Commons Attribution 2.0 International License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Voicu, H. Cerebellar timing and negative patterning. BMC Neurosci 9 (Suppl 1), P1 (2008).

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