- Poster presentation
- Open Access
GABAergic control of backpropagating action potentials in striatal medium spiny neurons
© Hjorth et al; licensee BioMed Central Ltd. 2008
- Published: 11 July 2008
- Feedback Inhibition
- Medium Spiny Neuron
- GABAergic Inhibition
- Distal Dendrite
- Sodium Conductance
Experiments have demonstrated the ability of action potentials to actively backpropagate in striatal medium spiny (MS) neurons, affecting the calcium levels in the dendrites [1–3]. Increased calcium levels trigger changes in plasticity [4, 5], which is important for learning and other functions . Studies in the hippocampus have shown that GABAergic input can modulate the backpropagation of action potentials from the soma to the distal dendrites . The MS neurons receive both proximal feedforward GABAergic inhibition from fast spiking interneurons (FS), and distal feedback inhibition from other neighbouring MS neurons. In the present study the effect of these GABAergic inputs on the dendritic calcium dynamics is investigated.
A previously published MS model  was reimplemented in GENESIS. The dendritic axial resistance and sodium conductances have been modified to better fit experimental results [1–3]. For example, in the modified model, backpropagation of dendritic action potentials requires sodium channel activation, and fails if those channels are blocked . The MS neuron was activated by simulated AMPA/NMDA and GABAergic synaptic inputs , or by somatic current injections.
In this study we compare the effect of FS and MS synaptic inhibition on the backpropagation of action potentials in the MS model. Preliminary results suggest that GABAerigic inputs in distal dendrites can decrease the backpropagating action potential, and thus can reduce dendritic calcium levels, even though the cell is still spiking in the soma. These findings might suggest that feedback inhibition can control how prone the neighbouring MS neurons will be to plastic changes.
- Kerr JND, Plenz D: Dendritic calcium encodes striatal neuron output during up-states. J Neurosci. 2002, 22 (5): 1499-1512.PubMedGoogle Scholar
- Carter AG, Sabatini BL: State-dependent calcium signaling in dendritic spines of striatal medium spiny neurons. Neuron. 2004, 44: 483-493. 10.1016/j.neuron.2004.10.013.View ArticlePubMedGoogle Scholar
- Kerr JND, Plenz D: Action potential timing determines dendritic calcium during striatal up-states. J Neurosci. 2004, 24 (4): 877-885. 10.1523/JNEUROSCI.4475-03.2004.View ArticlePubMedGoogle Scholar
- Stuart GJ, Hausser M: Dendritic coincidence detection of EPSPs and action potentials. Nat Neurosci. 2001, 4 (1): 63-71. 10.1038/82910.View ArticlePubMedGoogle Scholar
- Sjöström PJ, Nelson SB: Spike timing, calcium signals and synaptic plasticity. Curr Opin Neurobiol. 2002, 12 (3): 305-314. 10.1016/S0959-4388(02)00325-2.View ArticlePubMedGoogle Scholar
- Dan Y, Poo MM: Spike timing-dependent plasticity: from synapse to perception. Physiol Rev. 2006, 86 (3): 1033-1048. 10.1152/physrev.00030.2005.View ArticlePubMedGoogle Scholar
- Tsukobawa H, Ross WN: IPSPs modulate spike backpropagation and associated [Ca2+]i changes in the dendrites of hippocampal CA1 pyramidal neurons. J Neurophysiol. 1996, 76 (5): 2896-2906.Google Scholar
- Wolf JA, Moyer JT, Lazarewicz MT, Contreras D, Benoit-Marand M, O'Donnell P, Finkel LH: NMDA/AMPA ratio impacts state transitions and entrainment to oscillations in a computational model of the nucleus accumbens medium spiny projection neuron. J Neurosci. 2005, 25 (40): 9080-9095. 10.1523/JNEUROSCI.2220-05.2005.View ArticlePubMedGoogle Scholar
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