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Anorexia can occur as a serious complication of disease. Increasing evidence suggests that inflammation plays a major role, along with a hypothalamic dysregulation characterized by locally elevated serotonin l...
To get a broader view of global ischemia-induced cerebral disorders at the metabolic level, a nuclear magnetic resonance-based metabolomic study was performed to evaluate the metabolic profile changes on regio...
In contrast to the complexity found in mammals, only two Bcl-2 family genes have been found in Drosophila melanogaster including the pro-cell survival, human Bok-related orthologue, Buffy. The directed expression...
Brain network connectivity modeling is a crucial method for studying the brain’s cognitive functions. Meta-analyses can unearth reliable results from individual studies. Meta-analytic connectivity modeling is ...
Epilepsy is a common neurological disorder characterized by recurrent unprovoked seizures. Seizure-induced TLR4/MYD88 signaling plays a critical role in activating microglia and triggering neuron apoptosis. SA...
Red/near-infrared light therapy (R/NIR-LT) has been developed as a treatment for a range of conditions, including injury to the central nervous system (CNS). However, clinical trials have reported variable or ...
Patients with Parkinson’s disease (PD) often suffer from cognitive impairments, including set-shifting deficits, in addition to the characteristic motor symptoms. It is hypothesized that the striatal dopamine ...
We recently reported that poly-arginine peptides have neuroprotective properties both in vitro and in vivo. In cultured cortical neurons exposed to glutamic acid excitotoxicity, we demonstrated that neuroprote...
Deception can distort psychological tests on socially sensitive topics. Understanding the cerebral processes that are involved in such faking can be useful in detection and prevention of deception. Previous re...
Odor transduction, occurring in the chemosensory cilia of vertebrate olfactory sensory neurons, is triggered by guanosine triphosphate-coupled odor receptors and mediated by a cyclic adenosine monophosphate (c...
Regeneration of new myelin is impaired in persistent multiple sclerosis (MS) lesions, leaving neurons unable to function properly and subject to further degeneration. Current MS therapies attempt to ameliorate...
Glutamate carboxypeptidase II (GCPII) inactivates the peptide co-transmitter N-acetylaspartylglutamate following synaptic release. Inhibition of GCPII elevates extracellular levels of the peptide, inhibits glutam...
Circadian clocks are endogenous biochemical oscillators that control daily behavioral rhythms in all living organisms. In fruit fly, the circadian rhythms are typically studied using power spectra of multiday ...
Posttraumatic stress disorder (PTSD), an anxiety disorder that can develop after exposure to psychological trauma, impacts up to 20 % of soldiers returning from combat-related deployment. Advanced neuroimaging...
It has been demonstrated that the zebrafish model of pentylenetetrazole (PTZ)-evoked seizures and the well-established rodent models of epilepsy are similar pertaining to behavior, electrographic features, and c-
Prenatal maternal lipopolysaccharide (LPS) exposure leads to behavioral deficits such as depression, anxiety, and schizophrenia in the adult lives. LPS-exposure resulted in the production of cytokines and oxid...
Spinal cord edema is a serious complication and pathophysiological change after ischemia reperfusion (IR) injury. It has been demonstrated closely associated with bimodal disruption of blood–spinal cord barrie...
Smartphone use while walking is becoming a public concern owing to an increased risk of falling that can result from cognitive-motor interference. We evaluated prefrontal cortex (PFC) activity in participants ...
Speech-related disorders may refer to impairment of temporal analysis in the human auditory system. By the advance of non-invasive brain stimulation new forms of therapy arise. In the present study, we examine...
The decline of remyelination in chronic multiple sclerosis (MS) is in part attributed to inadequate oligodendrocyte precursor cell (OPC) migration, a process governed by the extracellular matrix (ECM). Elucida...
Bilateral subthalamic nucleus deep brain stimulation (STN-DBS) of parkinson’s disease (PD) patients has demonstrated to improve motor performance and to reduce dopa-induced dyskinesia. An association between t...
A major area of unmet need is the development of strategies to restore neuronal network systems and to recover brain function in patients with neurological disease. The use of cell-based therapies remains an a...
Depression is one of the most prevalent mood disorders, and is known to be associated with abnormal functional connectivity in neural networks of the brain. Interestingly, a significant proportion of patients ...
In highly complex social settings, an animal’s motivational drive to pursue an object depends not only on the intrinsic properties of the object, but also on whether the decision-making animal perceives an ob...
Periventricular leukomalacia (PVL) is the leading cause of neurological disabilities including motor and cognitive deficits in premature infants. Periventricular leukomalacia is characterized by damage to the ...
Nerve growth factor (NGF) is known not only as a major factor for neuronal plasticity but also as a pain stimulator. Although there have been several trials with NGF for its application in the regeneration or ...
Limb remote ischemic postconditioning (LRIP) can ameliorate cerebral ischemia–reperfusion injury (IRI), while the underlying mechanism remains elusive. Hypoxia-inducible factor 1α (HIF-1α) is an important tran...
WDR81 (WD repeat-containing protein 81) is associated with cerebellar ataxia, mental retardation and disequilibrium syndrome (CAMRQ2, [MIM 610185]). Human and mouse studies suggest tha...
Steady-state visual evoked potentials have been utilized widely in basic and applied research in recent years. These oscillatory responses of the visual cortex are elicited by flickering stimuli. They have th...
In neuroscience, experimental designs in which multiple measurements are collected in the same research object or treatment facility are common. Such designs result in clustered or nested data. When clusters i...
This article is part of a Supplement: Volume 16 Supplement 1
This article is part of a Supplement: Volume 16 Supplement 1
This article is part of a Supplement: Volume 16 Supplement 1
This article is part of a Supplement: Volume 16 Supplement 1
This article is part of a Supplement: Volume 16 Supplement 1
This article is part of a Supplement: Volume 16 Supplement 1
This article is part of a Supplement: Volume 16 Supplement 1
This article is part of a Supplement: Volume 16 Supplement 1
This article is part of a Supplement: Volume 16 Supplement 1
This article is part of a Supplement: Volume 16 Supplement 1
This article is part of a Supplement: Volume 16 Supplement 1
This article is part of a Supplement: Volume 16 Supplement 1
This article is part of a Supplement: Volume 16 Supplement 1
This article is part of a Supplement: Volume 16 Supplement 1
This article is part of a Supplement: Volume 16 Supplement 1
This article is part of a Supplement: Volume 16 Supplement 1
This article is part of a Supplement: Volume 16 Supplement 1
This article is part of a Supplement: Volume 16 Supplement 1
This article is part of a Supplement: Volume 16 Supplement 1
This article is part of a Supplement: Volume 16 Supplement 1
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