- Poster presentation
- Open Access
A model of learning temporal delays, representative of adaptive myelination
- Meenakshi Asokan1,
- Karishma Chhabria2 and
- V Srinivasa Chakravarthy2Email author
https://doi.org/10.1186/1471-2202-16-S1-P29
© Asokan and Chakravarthy 2015
- Published: 18 December 2015
Keywords
- Spike Train
- Dyslexia
- Temporal Delay
- Hebbian Learning
- Post Synaptic Activity
Learning and plasticity in the brain has been generally attributed to the synaptic activity in a neuronal network. However, recent studies [1] propose that the changes in conduction velocity of action potentials could affect the synchrony of spike arrival timings at the synapse, thereby modulating plasticity. This is attributed to adaptive myelination brought about by the oligodendrocytes (a class of glia that myelinate the axons in the central nervous system). We propose that the temporal delays in a neuronal network could be trained in addition to the training solely synaptic weights, in response to dynamic input spike patterns. These temporal delays are trained using the Spike Timing Dependent Plasticity (STDP) kernel, which is a temporally asymmetric variant of Hebbian learning. This paradigm of modeling is motivated from a study which describes that in addition to the pre-synaptic activity, oligodendrocytes can sense the post synaptic activity relayed through the astrocyte activity [2].
A. Network architecture B. Pictorial representation of the input patterns (first layer) C. Output of the SOM (second layer) corresponding to each input pattern D. Processed second layer output is fed to the third layer to train the delays (τ) and the weights (w).
Authors’ Affiliations
References
- Fields RD: Oligodendrocytes changing the rules: action potentials in glia and oligodendrocytes controlling action potentials. Neuroscientist. 2008, 14 (6): 540-543.PubMedPubMed CentralView ArticleGoogle Scholar
- Ishibashi T, Dakin KA, Stevens B, Lee PR, Kozlov SV, Stewart CL, Fields RD: Astrocytes promote myelination in response to electrical impulses. Neuron. 2006, 49 (6): 823-832.PubMedPubMed CentralView ArticleGoogle Scholar
- Pajevic S, Basser PJ, Fields RD: Role of myelin plasticity in oscillations and synchrony of neuronal activity. Neuroscience. 2014, 276: 135-147.PubMedPubMed CentralView ArticleGoogle Scholar
Copyright
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.