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  1. Circular RNAs (circRNAs) can act as microRNA (miRNA) sponges, thus regulating gene expression. The role of circRNAs in the process of oxygen-glucose deprivation/reoxygenation (OGD/R) is unclear. Here, we explo...

    Authors: Lei Yang, Hong Du, Xuejing Zhang, Bulang Gao, Dongliang Zhang, Zongrong Qiao, Xianhui Su, Tong Bao and Siqin Han
    Citation: BMC Neuroscience 2023 24:8
    Content type: Research Published on:

  2. Ischemic stroke is a major cause of death and disability worldwide. Translation into the clinical setting of neuroprotective agents showing promising results in pre-clinical studies has systematically failed. ...

    Authors: Laura Ramiro, Júlia Faura, Alba Simats, Paula García-Rodríguez, Feifei Ma, Luna Martín, Francesc Canals, Anna Rosell and Joan Montaner
    Citation: BMC Neuroscience 2023 24:7
    Content type: Research Published on:

  3. Multispectral fluorescence imaging coupled with linear unmixing is a form of image data collection and analysis that allows for measuring multiple molecular signals in a single biological sample. Multiple fluo...

    Authors: Vijay Sadashivaiah, Madhavi Tippani, Stephanie C. Page, Sang Ho Kwon, Svitlana V. Bach, Rahul A. Bharadwaj, Thomas M. Hyde, Joel E. Kleinman, Andrew E. Jaffe and Kristen R. Maynard
    Citation: BMC Neuroscience 2023 24:6
    Content type: Software Published on:

  4. Autism spectrum condition or ‘autism’ is associated with numerous genetic risk factors including the polygenic 16p11.2 microdeletion. The balance between excitatory and inhibitory neurons in the cerebral cortex i...

    Authors: Yifei Yang, Sam A. Booker, James M. Clegg, Idoia Quintana-Urzainqui, Anna Sumera, Zrinko Kozic, Owen Dando, Sandra Martin Lorenzo, Yann Herault, Peter C. Kind, David J. Price and Thomas Pratt
    Citation: BMC Neuroscience 2023 24:5
    Content type: Research Published on:

  5. A historically definitive marker for cholinergic neurons is choline acetyltransferase (ChAT), a synthesizing enzyme for acetylcholine, (ACh), which can be found in high concentrations in cholinergic neurons, b...

    Authors: Rashmi Gamage, Laszlo Zaborszky, Gerald Münch and Erika Gyengesi
    Citation: BMC Neuroscience 2023 24:4
    Content type: Research Published on:

  6. The release of various neurotransmitters and thereby the excitability of neuronal circuits are regulated by the endocannabinoid system in an activity-dependent manner. Hippocampal long-term potentiation (LTP) ...

    Authors: Masoumeh Nazari, Seyed Asaad Karimi, Somayeh Komaki, Masoumeh Kourosh Arami and Alireza Komaki
    Citation: BMC Neuroscience 2023 24:3
    Content type: Research Published on:

  7. The head-twitch response (HTR) in mice is considered a behavioral model for hallucinogens and serotonin 5-HT2A receptor function, as well as Tourette syndrome in humans. It is mediated by 5-HT2A receptor agonists...

    Authors: Yina Sun, Seetha Chebolu, Stone Skegrud, Setareh Kamali and Nissar A. Darmani
    Citation: BMC Neuroscience 2023 24:2
    Content type: Research Published on:

  9. Cataplexy is a loss of muscle tone that can lead to postural collapse, disturbing the daily life of narcolepsy patients; it is often triggered by positive emotions such as laughter in human patients. Narcoleps...

    Authors: Mayuko Yoshida, Koki Yamamoto and Tomoyuki Kuwaki
    Citation: BMC Neuroscience 2022 23:82
    Content type: Research Article Published on:

  10. Hearing loss is a major health problem and psychological burden in humans. Mouse models offer a possibility to elucidate genes involved in the underlying developmental and pathophysiological mechanisms of hear...

    Authors: Dominik Thalmeier, Gregor Miller, Elida Schneltzer, Anja Hurt, Martin Hrabě deAngelis, Lore Becker, Christian L. Müller and Holger Maier
    Citation: BMC Neuroscience 2022 23:81
    Content type: Research Published on:

  11. In the treatment of ischemic cerebral stroke (ICS), most conventional treatments, including carotid endarterectomy and carotid artery stenting, may cause cerebral ischemia-reperfusion injury (CIRI). For treate...

    Authors: Lu Yin, Tengfei Yu, Linggang Cheng, Xinyao Liu, Wei Zhang, Hongxia Zhang, Lijuan Du and Wen He
    Citation: BMC Neuroscience 2022 23:80
    Content type: Research Article Published on:

  12. Infant emotional stimuli can preferentially engage adults’ attention and provide valuable information essential for successful interaction between adults and infants. Exploring the neural processes of recogniz...

    Authors: Kaihua Zhang, Xiaoyu Du, Xianling Liu, Wei Su, Zhenhua Sun, Mengxing Wang and Xiaoxia Du
    Citation: BMC Neuroscience 2022 23:79
    Content type: Research Published on:

  13. Electromagnetic induction has recently been considered as an important factor affecting the activity of neurons. However, as an important form of intervention in epilepsy treatment, few people have linked the ...

    Authors: Yuqin Sun, Yuting Chen, Hudong Zhang and Yuan Chai
    Citation: BMC Neuroscience 2022 23:78
    Content type: Research Article Published on:

  14. Succinic semialdehyde dehydrogenase deficiency (SSADH-D) is an autosomal recessive gamma-aminobutyric acid (GABA) metabolism disorder that can arise due to ALDH5A1 mutations, resulting in severe, progressive, unt...

    Authors: Xiaodan Chen, Minzhi Peng, Yanna Cai, Chengcheng Zhou and Li Liu
    Citation: BMC Neuroscience 2022 23:77
    Content type: Research Published on:

  16. Intraluminal monofilament model of middle cerebral artery occlusion (MCAO) is widely adopted for ischemic stroke; and Sprague–Dawley (SD) rats are commonly used rodents for preclinical research. Due to the pau...

    Authors: I. J. Biose, W. H. Chastain, H. Wang, B. Ouvrier and G. J. Bix
    Citation: BMC Neuroscience 2022 23:75
    Content type: Research Published on:

  17. Sodium formononetin-3ʹ-sulphonate (Sul-F) may alleviate I/R injury in vivo with uncertain mechanism. Endoplasmic reticulum (ER) stress-mediated apoptosis participates in the process of cerebral ischemia‐reperf...

    Authors: Yue Bai, Zhiwei He, Weisong Duan, He Gu, Kefeng Wu, Wei Yuan, Wenkang Liu, Huaipeng Huang and Yanan Li
    Citation: BMC Neuroscience 2022 23:74
    Content type: Research Published on:

  18. In the military, constant physiological and psychological stress encountered by Soldiers can lead to development of the combat and operational stress reaction (COSR), which can effect pain management. Similar ...

    Authors: Misty M. Strain, Sirima Tongkhuya, Nathan Wienandt, Farah Alsadoon, Roger Chavez, Jamar Daniels, Thomas Garza, Alex V. Trevino, Kenney Wells, Thomas Stark, John Clifford and Natasha M. Sosanya
    Citation: BMC Neuroscience 2022 23:73
    Content type: Research Published on:

  19. To explore the feasibility of diffusion-weighted imaging (DWI) metrics to predict the histologic subtypes and genetic status of gliomas (e.g., IDH, MGMT, and TERT) noninvasively.

    Authors: Sirui Liu, Yiwei Zhang, Ziren Kong, Chendan Jiang, Yu Wang, Dachun Zhao, Hui You, Wenbin Ma and Feng Feng
    Citation: BMC Neuroscience 2022 23:72
    Content type: Research article Published on:

  20. Calcium imaging is a powerful technique for recording cellular activity across large populations of neurons. However, analysis methods capable of single-cell resolution in cultured neurons, especially for cult...

    Authors: Madhavi Tippani, Elizabeth A. Pattie, Brittany A. Davis, Claudia V. Nguyen, Yanhong Wang, Srinidhi Rao Sripathy, Brady J. Maher, Keri Martinowich, Andrew E. Jaffe and Stephanie Cerceo Page
    Citation: BMC Neuroscience 2022 23:71
    Content type: Software Published on:

  21. Obstructive sleep apnea (OSA) is mainly characterized by sleep fragmentation and chronic intermittent hypoxia (CIH), the latter one being associated with multiple organ injury. Recently, OSA-induced cognition ...

    Authors: Ningning She, Yewen Shi, Yani Feng, Lina Ma, Yuqi Yuan, Yitong Zhang, Zine Cao, Xi Chen, Bingjie Zhao, Haiqin Liu and Xiaoyong Ren
    Citation: BMC Neuroscience 2022 23:70
    Content type: Research Published on:

  22. Arginine-Vasopressin (AVP) is a nonapeptide that exerts multiple functions within the central nervous system and in the blood circulation that might contribute to outcome in critically ill patients. Sex differ...

    Authors: A. H. Podtschaske, J. Martin, B. Ulm, B. Jungwirth and S. M. Kagerbauer
    Citation: BMC Neuroscience 2022 23:69
    Content type: Research Published on:

  23. The multicomponent drug Neurexan (Nx4) was shown to reduce the neural stress network activation. We now investigated its effects on stress-induced resting state functional connectivity (RSFC) in dependence of ...

    Authors: Melanni Nanni-Zepeda, Sarah Alizadeh, Tara Chand, Vanessa Kasties, Yan Fan, Johan van der Meer, Luisa Herrmann, Johannes C. Vester, Myron Schulz, Britta Naschold and Martin Walter
    Citation: BMC Neuroscience 2022 23:68
    Content type: Research Published on:

  25. Esketamine upregulates Zn2+-dependent matrix metalloproteinase 9 (MMP9) and increases the neuronal apoptosis in retinal ganglion cell layer during the early development. We aimed to test whether albumin can allev...

    Authors: Kan Zhang, Ruijing Ma, Luping Feng, Peiwen Liu, Shuang Cai, Chaoyang Tong and Jijian Zheng
    Citation: BMC Neuroscience 2022 23:66
    Content type: Research Published on:

  26. One of the most serious nervous system diseases is spinal cord injury(SCI), which is increasing for various reasons. Although no definitive treatment has yet been identified for SCI, one possible treatment is ...

    Authors: Arvin Naeimi, Arash Zaminy, Naser Amini, Raziye Balabandi and Zoleikha Golipoor
    Citation: BMC Neuroscience 2022 23:65
    Content type: Research Published on:

  27. The pathogenesis of neuropathic pain (NP) has not been fully elucidated. Gene changes in dorsal root ganglia (DRG) may contribute to the development of NP. Circular RNAs (circRNAs) are a class of endogenous no...

    Authors: Wanxia Xiong, Min Wei, Li Zhang, Jie Wang, Fan Liu and Zhiyao Wang
    Citation: BMC Neuroscience 2022 23:64
    Content type: Research Published on:

  28. Retinal ganglion cells (RGCs) are important retinal neurons that connect visual receptors to the brain, and lysine-specific demethylase 1 (LSD1) is implicated in the development of RGCs. This study expounded t...

    Authors: Xiuling Yu, Tongtong Niu and Chi Liu
    Citation: BMC Neuroscience 2022 23:63
    Content type: Research Published on:

  29. Inflammation and glutamate (GLU) are widely thought to participate in the pathogenesis of depression, and current evidence suggests that the development of depression is associated with the activation of the k...

    Authors: Xingying Wu, Bowen Chen, Zhong Di, Shuo Jiang, Haipeng Xu, Mengting Shi, Rong Hu, Shaopeng Sun, Zhujin Song, Jiapeng Liu, Ruijie Ma and Qin Guo
    Citation: BMC Neuroscience 2022 23:62
    Content type: Research Published on:

  30. In brain, microvascular endothelial cells are exposed to various forces, including shear stress (SS). However, little is known about the effects of high shear stress (HSS) on human brain microvascular endothel...

    Authors: Zhe Li, Jia-Nan Li, Qiang Li, Chun Liu, Lin-Hua Zhou, Qi Zhang and Yi Xu
    Citation: BMC Neuroscience 2022 23:61
    Content type: Research Published on:

  31. Chondroitinase ABC (chABC) is an enzyme could improve regeneration and thereby improving functional recovery of spinal cord injury (SCI) in rodent models. Degradation of the active enzyme and diffusion away fr...

    Authors: Atousa Sharifi, Ali Zandieh, Zahra Behroozi, Michael R. Hamblin, Sara Mayahi, Mahmoud Yousefifard and Fatemeh Ramezani
    Citation: BMC Neuroscience 2022 23:60
    Content type: Research Published on:

  32. The hooded seal (Cystophora cristata) exhibits impressive diving skills and can tolerate extended durations of asphyxia, hypoxia and oxidative stress, without suffering from irreversible neuronal damage. Thus, wh...

    Authors: Gerrit A. Martens, Cornelia Geßner, Carina Osterhof, Thomas Hankeln and Thorsten Burmester
    Citation: BMC Neuroscience 2022 23:59
    Content type: Research Published on:

  33. Opioids are among the most effective and commonly prescribed analgesics for the treatment of acute pain after spinal cord injury (SCI). However, morphine administration in the early phase of SCI undermines loc...

    Authors: Mabel N. Terminel, Carla Bassil, Josephina Rau, Amanda Trevino, Cristina Ruiz, Robert Alaniz and Michelle A. Hook
    Citation: BMC Neuroscience 2022 23:58
    Content type: Research Published on:

  34. Auditory steady-state responses (ASSRs) are periodic evoked responses to constant periodic auditory stimuli, such as click trains, and are suggested to be associated with higher cognitive functions in humans. ...

    Authors: Tomoya Nakamura, Trong Ha Dinh, Makoto Asai, Hiroshi Nishimaru, Jumpei Matsumoto, Tsuyoshi Setogawa, Hiroyuki Ichijo, Sokichi Honda, Hiroshi Yamada, Takuma Mihara and Hisao Nishijo
    Citation: BMC Neuroscience 2022 23:57
    Content type: Research Published on:

  35. Dysregulation of long noncoding RNA (lncRNA) expression is related to aging and age-associated neurodegenerative diseases, and the lncRNA expression profile in the aging hippocampus is not well characterized. ...

    Authors: Li Qi, Xiao Li, Shi-min Liu, Dan-li Jiao, Dan Hu, Xin-yao Ju, Shu-yu Zhao, Shu-han Si, Li Hu, Guo-na Li, Bing-zhe Ma, Shuang Zhou and Chen Zhao
    Citation: BMC Neuroscience 2022 23:56
    Content type: Research Published on:

  36. Neuronal injury induced in young rats by cerebral ischemia reperfusion (CIR) is known to differ substantially from that in adult rats. In the present study, we investigated the specific differences in neuronal...

    Authors: Jie Wang, Zihao Xia, Peng Sheng, Mengmeng Shen, Lidong Ding, Dezhi Liu and Bing Chun Yan
    Citation: BMC Neuroscience 2022 23:55
    Content type: Research Published on:

  37. Exercise boosts the health of some brain parts, such as the hippocampus and hypothalamus. Several studies show that long-term exercise improves spatial learning and memory, enhances hypothalamic leptin sensiti...

    Authors: Shu-Jing Liu, Tong-Hui Cai, Chun-Lu Fang, Shao-Zhang Lin, Wen-Qi Yang, Yuan Wei, Fu Zhou, Ling Liu, Yuan Luo, Zi-Yi Guo, Ge Zhao, Ya-Ping Li and Liang-Ming Li
    Citation: BMC Neuroscience 2022 23:54
    Content type: Research Published on:

  38. Glioblastoma (GBM) is an aggressive and malignant brain tumor with extremely poor prognosis. Despite advances in treatment, the pathogenesis of GBM remains elusive. Mounting studies have revealed the critical ...

    Authors: Qingjiu Zhou, Mahati Shaya, Yalikun Kugeluke, Qiang Fu, Shaoshan Li and Yisireyili Dilimulati
    Citation: BMC Neuroscience 2022 23:53
    Content type: Research Published on:

  39. Paraoxonase 2 (PON2) is an intracellular antioxidant enzyme located at the inner mitochondrial membrane. Previous studies have found PON2 to be an important antioxidant in a variety of cellular systems, such a...

    Authors: Jacqueline M. Garrick, Khoi Dao, Lucio G. Costa, Judit Marsillach and Clement E. Furlong
    Citation: BMC Neuroscience 2022 23:52
    Content type: Research Published on:

  40. Spinal cord injury (SCI) is a common trauma in clinical practices. Subacute SCI is mainly characterized by neuronal apoptosis, axonal demyelination, Wallerian degeneration, axonal remodeling, and glial scar fo...

    Authors: Lei Yan, Jiawei Fu, Xiong Dong, Baishen Chen, Hongxiang Hong and Zhiming Cui
    Citation: BMC Neuroscience 2022 23:51
    Content type: Research Published on:

  41. Evidences indicate that inflammasome compounds participate in amyotrophic lateral sclerosis (ALS), a fatal progressive motoneuron degenerative disease. Researchers have observed the expressions of nucleotide o...

    Authors: Haoyun Zhang, Hao Li, Bingkun Huang, Shaoye Wang, Ying Gao, Fandi Meng, Yanchun Chen, Fenghua Zhou, Yingjun Guan and Xin Wang
    Citation: BMC Neuroscience 2022 23:50
    Content type: Research Published on:

  42. Microglia assume opposite phenotypes in response to ischemic brain injury, exerting neurotoxic and neuroprotective effects under different ischemic stages. Modulating M1/M2 polarization is a potential therapy ...

    Authors: Ye Hong, Jinfeng Lyu, Lin Zhu, Xixi Wang, Mengna Peng, Xiangliang Chen, Qiwen Deng, Jie Gao, Zhenhua Yuan, Di Wang, Gelin Xu and Mengyi Xu
    Citation: BMC Neuroscience 2022 23:49
    Content type: Research Published on:

  43. During neurodegenerative diseases, the brain undergoes morphological and pathological changes; Iron deposits are one of the causes of pathological changes in the brain. The Quantitative susceptibility mapping ...

    Authors: Farzaneh Nikparast, Zohreh Ganji and Hoda Zare
    Citation: BMC Neuroscience 2022 23:48
    Content type: Research Published on:

  44. Stem cell-based therapy has received considerable attention as a potential candidate in the treatment of ischemic stroke; however, employing an appropriate type of stem cells and an effective delivery route ar...

    Authors: Seyedeh Maryam Mousavi, Bijan Akbarpour, Saeideh Karimi-Haghighi, Sareh Pandamooz, Ivaldo Jesus Almeida Belém-Filho, Marianella Masís-Calvo, Haniye Salimi, Ramin Lashanizadegan, Alireza Pouramini, Maryam Owjfard, Etrat Hooshmandi, Mahnaz Bayat, Seyedeh Shaghayegh Zafarmand, Mehdi Dianatpour, Mohammad Saied Salehi and Afshin Borhani-Haghighi
    Citation: BMC Neuroscience 2022 23:47
    Content type: Research Published on:

  45. Following one mild traumatic brain injury (mTBI), there is a window of vulnerability during which subsequent mTBIs can cause substantially exacerbated impairments. Currently, there are no known methods to moni...

    Authors: Prashanth S. Velayudhan, Jordan J. Mak, Lisa M. Gazdzinski and Anne L. Wheeler
    Citation: BMC Neuroscience 2022 23:46
    Content type: Research article Published on:

  46. Physical exercise and neurorehabilitation involve repetitive training that can induce changes in motor performance arising from neuroplasticity. Retention of these motor changes occurs via an encoding process,...

    Authors: Martin V. Sale and Anastasiia Kuzovina
    Citation: BMC Neuroscience 2022 23:45
    Content type: Research Published on:

  47. Following Spinal Cord Injury (SCI), innumerable inflammatory and degenerative fluctuations appear in the injured site, and even remotely in manifold areas of the brain. Howbeit, inflammatory, degenerative, and...

    Authors: Ahad Karimzadeh Kalkhoran, Mohammad Reza Alipour, Mohsen Jafarzadehgharehziaaddin, Hamid Soltani Zangbar and Parviz Shahabi
    Citation: BMC Neuroscience 2022 23:44
    Content type: Research Published on:

  48. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is highly contagious, and the neurological symptoms of SARS-CoV-2 infection have already been reported. However, the mechanisms underlying the effec...

    Authors: Rui-Cheng Yang, Kun Huang, Hui-Peng Zhang, Liang Li, Chen Tan, Huan-Chun Chen, Mei-Lin Jin and Xiang-Ru Wang
    Citation: BMC Neuroscience 2022 23:43
    Content type: Research Published on:

  49. Cervical spondylotic myelopathy (CSM) is a clinically symptomatic condition due to spinal cord compression, leading to spinal cord dysfunction. Surgical decompression is the main treatment of CSM, but the mech...

    Authors: Peisheng Liu, Xiaofeng Li, Jing Liu, Hengjia Zhang, Zhitao You and Jianfeng Zhang
    Citation: BMC Neuroscience 2022 23:42
    Content type: Research Published on:

  50. Exercise could prevent physical and psychological deteriorations, especially during pandemic times of lock-down scenarios and social isolation. But to meet both, the common exercise protocols require optimizat...

    Authors: V. Abeln, E. Fomina, J. Popova, L. Braunsmann, J. Koschate, F. Möller, S. O. Fedyay, G. Y. Vassilieva, S. Schneider, H. K. Strüder and T. Klein
    Citation: BMC Neuroscience 2022 23:41
    Content type: Research Published on:
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BMC Neuroscience

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