Articles

Quantitative genome-wide association analyses of receptive language in the Danish High Risk and Resilience Study

One of the most basic human traits is language. Linguistic ability, and disability, have been shown to have a strong genetic component in family and twin studies, but molecular genetic studies of language phen...

Authors: Ron Nudel, Camilla A. J. Christiani, Jessica Ohland, Md Jamal Uddin, Nicoline Hemager, Ditte Ellersgaard, Katrine S. Spang, Birgitte K. Burton, Aja N. Greve, Ditte L. Gantriis, Jonas Bybjerg-Grauholm, Jens Richardt M. Jepsen, Anne A. E. Thorup, Ole Mors, Thomas Werge and Merete Nordentoft

Neuroprotective effects of magnesium l-threonate in a hypoxic zebrafish model

Hypoxia inhibits the uptake of glutamate (a major neurotransmitter in the brain closely related to cognitive function) into brain cells, and the initial response of cells to cortical hypoxia depends on glutama...

Authors: Young-Sung Kim, Young Ju Won, Byung Gun Lim, Too Jae Min, Yeon-Hwa Kim and Il Ok Lee

NeuroConstruct-based implementation of structured-light stimulated retinal circuitry

Retinal circuitry provides a fundamental window to neural networks, featuring widely investigated visual phenomena ranging from direction selectivity to fast detection of approaching motion. As the divide betw...

Authors: Miriam Elbaz, Rachel Buterman and Elishai Ezra Tsur

Hcfc1a regulates neural precursor proliferation and asxl1 expression in the developing brain

Precise regulation of neural precursor cell (NPC) proliferation and differentiation is essential to ensure proper brain development and function. The HCFC1 gene encodes a transcriptional co-factor that regulates ...

Authors: Victoria L. Castro, Joel F. Reyes, Nayeli G. Reyes-Nava, David Paz and Anita M. Quintana

Anodal transcranial direct current stimulation reduces motor slowing in athletes and non-athletes

Motor fatigability describes a phenomenon that occurs when exhaustive exercise or physically demanding tasks are executed over an extended period of time. Concerning fast repetitive movements, it is noticeable...

Authors: Oliver Seidel-Marzi and Patrick Ragert

Repeated social defeat promotes persistent inflammatory changes in splenic myeloid cells; decreased expression of β-arrestin-2 (ARRB2) and increased expression of interleukin-6 (IL-6)

Previous studies suggest that persistent exposure to social stress in mammals may be associated with multiple physiological effects. Here, we examine the effects of social stress in rats, i.e. repeated social ...

Authors: Dhaksshaginy Rajalingam, Ingeborg Nymoen, Daniel Pitz Jacobsen, Mina Baarnes Eriksen, Erik Dissen, Morten Birkeland Nielsen, Ståle Valvatne Einarsen and Johannes Gjerstad

Dl-3-n-Butylphthalide promotes neovascularization and neurological recovery in a rat model of intracerebral hemorrhage

Cerebral stroke occurs following ischemic and hemorrhagic lesions in the brain. Survival and recovery of stroke patients depend on the severity of the initial injury but also the therapeutic approaches applied...

Authors: Ewen Tu, Qiong Chen, Li Tan and Yan Wang

Alexithymia and automatic processing of facial emotions: behavioral and neural findings

Alexithymia is a personality trait characterized by difficulties identifying and describing feelings, an externally oriented style of thinking, and a reduced inclination to imagination. Previous research has s...

Authors: Nicole Rosenberg, Klas Ihme, Vladimir Lichev, Julia Sacher, Michael Rufer, Hans Jörgen Grabe, Harald Kugel, André Pampel, Jöran Lepsien, Anette Kersting, Arno Villringer and Thomas Suslow

Resuscitation with macromolecular superoxide dismutase/catalase mimetic polynitroxylated PEGylated hemoglobin offers neuroprotection in guinea pigs after traumatic brain injury combined with hemorrhage shock

Polynitroxylated PEGylated hemoglobin (PNPH, aka SanFlow) possesses superoxide dismutase/catalase mimetic activities that may directly protect the brain from oxidative stress. Stabilization of PNPH with bound ...

Authors: Soichiro Seno, Jun Wang, Suyi Cao, Manda Saraswati, Sharon Park, Jan Simoni, Li Ma, Bohdan Soltys, Carleton J. C. Hsia, Raymond C. Koehler and Courtney L. Robertson

Cathodal tDCS exerts neuroprotective effect in rat brain after acute ischemic stroke

Transcranial direct current stimulation (tDCS) is a non-invasive brain modulation technique that has been proved to exert beneficial effects in the acute phase of stroke. To explore the underlying mechanism, w...

Authors: Ke-Ying Zhang, Gang Rui, Jun-Ping Zhang, Ling Guo, Guang-Zhou An, Jia-Jin Lin, Wei He and Gui-Rong Ding

The impact of mental fatigue on brain activity: a comparative study both in resting state and task state using EEG

Mental fatigue is usually caused by long-term cognitive activities, mainly manifested as drowsiness, difficulty in concentrating, decreased alertness, disordered thinking, slow reaction, lethargy, reduced work...

Authors: Gang Li, Shan Huang, Wanxiu Xu, Weidong Jiao, Yonghua Jiang, Zhao Gao and Jianhua Zhang

Conformity-like behaviour in mice observing the freezing of other mice: a model of empathy

Empathy refers to the ability to recognise and share emotions with others. Several research groups have recognised observational fear in mice as a useful behavioural model for assessing their ability to empath...

Authors: Hiroshi Ueno, Shunsuke Suemitsu, Shinji Murakami, Naoya Kitamura, Kenta Wani, Yu Takahashi, Yosuke Matsumoto, Motoi Okamoto and Takeshi Ishihara

COX5A over-expression protects cortical neurons from hypoxic ischemic injury in neonatal rats associated with TPI up-regulation

Neonatal hypoxic-ischemic encephalopathy (HIE) represents as a major cause of neonatal morbidity and mortality. However, the underlying molecular mechanisms in brain damage are still not fully elucidated. This...

Authors: Ya Jiang, Xue Bai, Ting-Ting Li, Mohammed AL-Hawwas, Yuan Jin, Yu Zou, Yue Hu, Lin-Yi Liu, Ying Zhang, Qing Liu, Hao Yang, Jun Ma, Ting-Hua Wang, Jia Liu and Liu-Lin Xiong

Correction to: The role of C-afferents in mediating neurogenic vasodilatation in plantar skin after acute sciatic nerve injury in rats

An amendment to this paper has been published and can be accessed via the original article.

Authors: Tao Zhang, Jiahui Niu, Yaxian Wang, Junying Yan, Wen Hu and Daguo Mi

Noise exposure alters MMP9 and brevican expression in the rat primary auditory cortex

This study aimed to investigate the changes in molecules related to perineuronal nets (PNNs) and synaptic transporters in the primary auditory cortices of rats with noise-induced hearing loss. Female Sprague–D...

Authors: Sung-su Park, Da-hye Lee, So Min Lee, Chang Ho Lee and So Young Kim

The role of C-afferents in mediating neurogenic vasodilatation in plantar skin after acute sciatic nerve injury in rats

Vasomotor regulation of dermal blood vessels, which are critical in the function of the skin in thermoregulatory control, involves both neural and non-neural mechanisms. Whereas the role of sympathetic nerves ...

Authors: Tao Zhang, Jiahui Niu, Yaxian Wang, Junying Yan, Wen Hu and Daguo Mi

When gratitude and cooperation between friends affect inter-brain connectivity for EEG

Recently several studies in the psychological and social field have investigated the social function of gift exchange as a useful way for the consolidation of interpersonal and social relationships and the imp...

Authors: Michela Balconi, Giulia Fronda and Maria Elide Vanutelli

Intravenous methylprednisolone or immunoglobulin for anti-glutamic acid decarboxylase 65 antibody autoimmune encephalitis: which is better?

Patients positive for anti-glutamic acid decarboxylase 65 (GAD65) antibodies have attracted increasing attention. Their clinical manifestations are highly heterogeneous and can be comorbid with tumors. Current...

Authors: Tao-Ran Li, Yu-Di Zhang, Qun Wang, Xiao-Qiu Shao, Zhi-Mei Li and Rui-Juan Lv

Dopamine response gene pathways in dorsal striatum MSNs from a gene expression viewpoint: cAMP-mediated gene networks

Medium spiny neurons (MSNs) comprise the main body (95% in mouse) of the dorsal striatum neurons and represent dopaminoceptive GABAergic neurons. The cAMP (cyclic Adenosine MonoPhosphate)—mediated cascade of e...

Authors: Vladimir N. Babenko, Anna G. Galyamina, Igor B. Rogozin, Dmitry A. Smagin and Natalia N. Kudryavtseva

Neuropathological changes in dorsal root ganglia induced by pyridoxine in dogs

Pyridoxine (PDX; vitamin B₆), is an essential vitamin. PDX deficiency induces various symptoms, and when PDX is misused it acts as a neurotoxicant, inducing severe sensory neuropathy.

Authors: Sumin Yun, Woosuk Kim, Min Soo Kang, Tae Hyeong Kim, Yoonhwan Kim, Jin-Ok Ahn, Jung Hoon Choi, In Koo Hwang and Jin-Young Chung

Correction to: Wnt3a induces exosome secretion from primary cultured rat microglia

Following the publication of this article [1], it has been noted by the authors that an image of the same cell nuclei has been used in error twice, in Fig. 8, parts A and B. These images are redundant in this ...

Authors: Claudie Hooper, Ricardo Sainz-Fuertes, Steven Lynham, Abdul Hye, Richard Killick, Alice Warley, Cecilia Bolondi, Jennifer Pocock and Simon Lovestone

Neuromyelitis optica: a pilot study of clinical presentation and status of serological biomarker AQP4 among patients admitted to a tertiary centre in NCNS, Sudan

Neuromyelitis optica (NMO) is a demyelinating disease primarily affecting the optic nerves and spinal cord. It is distinguished from other demyelinating conditions by the presence of AQP4-IgG and serum aquapor...

Authors: Etedal Ahmed AbuElbasher Ibrahim, Fatima Gammer and Alsadig Gassoum

Suppression of behavioral activity and hippocampal noradrenaline caused by surgical stress in type 2 diabetes model mice

There has been much discussion recently about the occurrence of neuropsychological complications during the perioperative period. Diabetes is known to be one of the metabolic risk factors. Although the number ...

Authors: Momoka Nishimura, Yuki Nomura, Moritoki Egi, Norihiko Obata, Makoto Tsunoda and Satoshi Mizobuchi

Identifying the pulsed neuron networks’ structures by a nonlinear Granger causality method

It is a crucial task of brain science researches to explore functional connective maps of Biological Neural Networks (BNN). The maps help to deeply study the dominant relationship between the structures of the...

Authors: Mei-jia Zhu, Chao-yi Dong, Xiao-yan Chen, Jing-wen Ren and Xiao-yi Zhao

Proximity ligation assay reveals both pre- and postsynaptic localization of the APP-processing enzymes ADAM10 and BACE1 in rat and human adult brain

Synaptic degeneration and accumulation of amyloid β-peptides (Aβ) are hallmarks of the Alzheimer diseased brain. Aβ is synaptotoxic and produced by sequential cleavage of the amyloid precursor protein (APP) by...

Authors: Jolanta L. Lundgren, Lina Vandermeulen, Anna Sandebring-Matton, Saheeb Ahmed, Bengt Winblad, Monica Di Luca, Lars O. Tjernberg, Elena Marcello and Susanne Frykman

Sexual dimorphism following in vitro ischemia in the response to neurosteroids and mechanisms of injury

Cerebral ischemic stroke is a significant cause of morbidity and mortality. Sex differences exist following stroke in terms of incidence, symptoms, outcomes and response to some treatments. Importantly, molecu...

Authors: Raeed Altaee and Claire L. Gibson

Carbonyl-protein content increases in brain and blood of female rats after chronic oxycodone treatment

Opioids are the most effective drugs commonly prescribed to treat pain. Due to their addictive nature, opioid pain relievers are now second to marijuana, ahead of cocaine with respect to dependence. Ours and o...

Authors: Ruping Fan, Lisa M. Schrott, Stephen Snelling, John Felty, Derrel Graham, Patrick L. McGauly, Thomas Arnold and Nadejda L. Korneeva

Capturing multiple interaction effects in L1 and L2 object-naming reaction times in healthy bilinguals: a mixed-effects multiple regression analysis

It is difficult to set up a balanced higher-order full-factorial experiment that can capture multiple intricate interactions between cognitive and psycholinguistic factors underlying bilingual speech productio...

Authors: Severin Schramm, Noriko Tanigawa, Lorena Tussis, Bernhard Meyer, Nico Sollmann and Sandro M. Krieg

Proteomics profiling and pathway analysis of hippocampal aging in rhesus monkeys

Aged rhesus monkeys exhibit deficits in memory mediated by the hippocampus. Although extensive research has been carried out on the characteristics of human hippocampal aging, there is still very little scient...

Authors: Shu Meng, Wenchao Xia, Meng Pan, Yangjie Jia, Zhanlong He and Wei Ge

Folic acid ameliorates depression-like behaviour in a rat model of chronic unpredictable mild stress

Depression is characterized by significant and low mood. Classical antidepressants are still not adequate in treating depression because of undesirable side effects. Folic acid, a member of the vitamin B compl...

Authors: Yue Zhou, Yu Cong and Huan Liu

Altered functional connectivity of the nucleus accumbens subdivisions in amphetamine-type stimulant abusers: a resting-state fMRI study

The growing abuse of amphetamine-type stimulants leads to new challenges to human health. A possible addiction mechanism has been proposed by altered functional architecture of the nucleus accumbens (NAc) duri...

Authors: Yun Wang, Kai-Juan Yan, Chen-Xiao Fan, Xiao-Nian Luo and Yuan Zhou

The Bdnf and Npas4 genes are targets of HDAC3-mediated transcriptional repression

Histone deacetylase-3 (HDAC3) promotes neurodegeneration in various cell culture and in vivo models of neurodegeneration but the mechanism by which HDAC3 exerts neurotoxicity is not known. HDAC3 is known to be...

Authors: Anto Sam Crosslee Louis Sam Titus, Dharmendra Sharma, Min Soo Kim and Santosh R. D’Mello

Lipopolysaccharide worsens the prognosis of experimental cerebral ischemia via interferon gamma-induced protein 10 recruit in the acute stage

Infection is an important clinical complication facing stroke-patients and triples the risk of death within 30 days post-stroke via mechanisms which are poorly understood.

Authors: Ping Wang, Jiaqi Zhang, Feifei Guo, Shuang Wang, Yi Zhang, Defeng Li, Haiyu Xu and Hongjun Yang

Inhibition of autophagy triggers melatonin-induced apoptosis in glioblastoma cells

Autophagy is considered to be another restorative focus for the treatment of brain tumors. Although several research have demonstrated that melatonin induces autophagy in colon cancer and hepatoma cells, there...

Authors: Nan Zhou, Zi Xuan Wei and Zeng Xin Qi

Amiodarone exacerbates brain injuries after hypoxic–ischemic insult in mice

Sodium ion transportation plays a crucial role in the pathogenesis of hypoxic–ischemic brain injury. Amiodarone, a Vaughan-Williams class III antiarrhythmic drug, has been widely used to treat life-threatening...

Authors: Masakazu Kotoda, Sohei Hishiyama, Tadahiko Ishiyama, Kazuha Mitsui and Takashi Matsukawa

Chondroitinase ABC reduces dopaminergic nigral cell death and striatal terminal loss in a 6-hydroxydopamine partial lesion mouse model of Parkinson’s disease

Parkinson’s disease (PD) is characterised by dopaminergic cell loss within the substantia nigra pars compacta (SNc) that leads to reduced striatal dopamine content and resulting motor deficits. Identifying new...

Authors: Edward J. R. Fletcher, Lawrence D. F. Moon and Susan Duty

Ketamine affects the integration of developmentally generated granule neurons in the adult stage

Ketamine has been reported to cause neonatal neurotoxicity in a variety of developing animal models. Various studies have been conducted to study the mechanism of neurotoxicity for general anesthetic use durin...

Authors: Zhanqiang Zhao, Bing Li, Yuqing Wu, Xujun Chen, Yan Guo, Yang Shen and He Huang

LPS immune challenge reduces arcuate nucleus TSHR and CART mRNA and elevates plasma CART peptides

The aim was to examine the impact of lipopolysaccharide-induced systemic inflammation on expression of mRNA for cocaine- and amphetamine-regulated transcript (CART) and the thyrotropin receptor (TSHR) and its ...

Authors: Jonathan R. Burgos, Britt-Marie Iresjö, Linda Olsson and Ulrika Smedh

Diazepam and ethanol differently modulate neuronal activity in organotypic cortical cultures

The pharmacodynamic results of diazepam and ethanol administration are similar, in that each can mediate amnestic and sedative-hypnotic effects. Although each of these molecules effectively reduce the activity...

Authors: Matthias Kreuzer, Paul S. García, Verena Brucklacher-Waldert, Rebecca Claassen, Gerhard Schneider, Bernd Antkowiak and Berthold Drexler

Localization of phosphotyrosine adaptor protein ShcD/SHC4 in the adult rat central nervous system

Mammalian Shc (Src homology and collagen) proteins comprise a family of four phosphotyrosine adaptor molecules which exhibit varied spatiotemporal expression and signaling functions. ShcD is the most recently ...

Authors: Hannah N. Robeson, Hayley R. Lau, Laura A. New, Jasmin Lalonde, John N. Armstrong and Nina Jones

28th Annual Computational Neuroscience Meeting: CNS*2019

Authors:

Sleep disturbances and gastrointestinal dysfunction are associated with thalamic atrophy in Parkinson’s disease

Non-motor symptoms are common aspects of Parkinson’s disease (PD) occurring even at the prodromal stage of the disease and greatly affecting the quality of life. Here, we investigated whether non-motor symptom...

Authors: Flavia Niccolini, Heather Wilson, Beniamino Giordano, Konstantinos Diamantopoulos, Gennaro Pagano, Kallol Ray Chaudhuri and Marios Politis

Altered activity in the nucleus raphe magnus underlies cortical hyperexcitability and facilitates trigeminal nociception in a rat model of medication overuse headache

The pathogenesis of medication overuse headache (MOH) involves hyperexcitability of cortical and trigeminal neurons. Derangement of the brainstem modulating system, especially raphe nuclei may contribute to th...

Authors: Prangtip Potewiratnanond, Supang Maneesri le Grand, Anan Srikiatkhachorn and Weera Supronsinchai

Weak correlations between serum and cerebrospinal fluid levels of estradiol, progesterone and testosterone in males

Neuroactive steroids seem to be implicated in a variety of neurophysiological and behavioral processes, such as sleep, learning, memory, stress, feeding and aging. Numerous studies have also addressed this imp...

Authors: Jan Martin, Eva Plank, Bettina Jungwirth, Alexander Hapfelmeier, Armin Podtschaske and Simone M. Kagerbauer

Synaptic plasticity in hippocampal CA1 neurons and learning behavior in acute kidney injury, and estradiol replacement in ovariectomized rats

Neurological complications may occur in patients with acute or chronic renal failure; however, in cases of acute renal failure, the signs and symptoms are usually more pronounced, and progressed rapidly. Oxida...

Authors: Fatemeh Sharifi, Parham Reisi and Maryam Malek

The role of PI3K-mediated AMPA receptor changes in post-conditioning of propofol in brain protection

We aimed to study the role of amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor (AMPAR) glutamate receptor 2 (GluR2) subunit trafficking, and activity changes in short-term neuroprotection provided b...

Authors: Chenxu Wang, Ying Wei, Yuan Yuan, Yonghao Yu, Keliang Xie, Beibei Dong, Yuan Shi and Guolin Wang

Mouse corticospinal system comprises different functional neuronal ensembles depending on their hodology

Movement performance depends on the synaptic interactions generated by coherent parallel sensorimotor cortical outputs to different downstream targets. The major outputs of the neocortex to subcortical structu...

Authors: Rafael Olivares-Moreno, Mónica López-Hidalgo, Alain Altamirano-Espinoza, Adriana González-Gallardo, Anaid Antaramian, Verónica Lopez-Virgen and Gerardo Rojas-Piloni

Analgesic treatment limits surrogate parameters for early stress and pain response after experimental subarachnoid hemorrhage

In animal research, authorities require a classification of anticipated pain levels and a perioperative analgesia protocol prior to approval of the experiments. However, data on this topic is rare and so is th...

Authors: Irina Staib-Lasarzik, Nadine Nagel, Anne Sebastiani, Eva-Verena Griemert and Serge C. Thal

Preferential activation of small cutaneous fibers through small pin electrode also depends on the shape of a long duration electrical current

Electrical stimulation is widely used in experimental pain research but it lacks selectivity towards small nociceptive fibers. When using standard surface patch electrodes and rectangular pulses, large fibers ...

Authors: Rosa Hugosdottir, Carsten Dahl Mørch, Ole Kæseler Andersen, Thordur Helgason and Lars Arendt-Nielsen

Altered excitability of small cutaneous nerve fibers during cooling assessed with the perception threshold tracking technique

There is a need for new approaches to increase the knowledge of the membrane excitability of small nerve fibers both in healthy subjects, as well as during pathological conditions. Our research group has previ...

Authors: Rosa Hugosdottir, Carsten Dahl Mørch, Cecilia Klitgaard Jørgensen, Camilla Winther Nielsen, Mathias Vassard Olsen, Mads Jozwiak Pedersen and Jenny Tigerholm