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  1. Meeting abstracts

    26th Annual Computational Neuroscience Meeting (CNS*2017): Part 2

    Leonid L. Rubchinsky, Sungwoo Ahn, Wouter Klijn, Ben Cumming, Stuart Yates, Vasileios Karakasis, Alexander Peyser, Marmaduke Woodman, Sandra Diaz-Pier, James Deraeve, Eliana Vassena, William Alexander, David Beeman, Pawel Kudela, Dana Boatman-Reich, William S. Anderson…

    BMC Neuroscience 2017 18(Suppl 1):59

    Published on: 18 August 2017

    This article is part of a Supplement: Volume 18 Supplement 1

  3. Meeting abstracts

    26th Annual Computational Neuroscience Meeting (CNS*2017): Part 3

    Adam J. H. Newton, Alexandra H. Seidenstein, Robert A. McDougal, Alberto Pérez-Cervera, Gemma Huguet, Tere M-Seara, Caroline Haimerl, David Angulo-Garcia, Alessandro Torcini, Rosa Cossart, Arnaud Malvache, Kaoutar Skiker, Mounir Maouene, Gianmarco Ragognetti, Letizia Lorusso, Andrea Viggiano…

    BMC Neuroscience 2017 18(Suppl 1):60

    Published on: 18 August 2017

    This article is part of a Supplement: Volume 18 Supplement 1

  4. Research article

    Musashi-1 is the candidate of the regulator of hair cell progenitors during inner ear regeneration

    Hair cell loss in the cochlea is caused by ototoxic drugs, aging, and environmental stresses and could potentially lead to devastating pathophysiological effects. In adult mammals, hair cell loss is irreversib...

    Takahiro Wakasaki, Hiroaki Niiro, Siamak Jabbarzadeh-Tabrizi, Mitsuru Ohashi, Takashi Kimitsuki, Takashi Nakagawa, Shizuo Komune and Koichi Akashi

    BMC Neuroscience 2017 18:64

    Published on: 16 August 2017

  5. Research article

    Specific ion channels contribute to key elements of pathology during secondary degeneration following neurotrauma

    Following partial injury to the central nervous system, cells beyond the initial injury site undergo secondary degeneration, exacerbating loss of neurons, compact myelin and function. Changes in Ca2+ flux are ass...

    Ryan L. O’Hare Doig, Wissam Chiha, Marcus K. Giacci, Nathanael J. Yates, Carole A. Bartlett, Nicole M. Smith, Stuart I. Hodgetts, Alan R. Harvey and Melinda Fitzgerald

    BMC Neuroscience 2017 18:62

    Published on: 14 August 2017

  7. Research article

    A CLCA regulatory protein present in the chemosensory cilia of olfactory sensory neurons induces a Ca2+-activated Cl− current when transfected into HEK293

    CLCA is a family of metalloproteases that regulate Ca2+-activated Cl− fluxes in epithelial tissues. In HEK293 cells, CLCA1 promotes membrane expression of an endogenous Anoctamin 1 (ANO1, also termed TMEM16A)-dep...

    Casilda V. Mura, Ricardo Delgado, María Graciela Delgado, Diego Restrepo and Juan Bacigalupo

    BMC Neuroscience 2017 18:61

    Published on: 11 August 2017

  9. Research article

    Neuroplasticity pathways and protein-interaction networks are modulated by vortioxetine in rodents

    The identification of biomarkers that predict susceptibility to major depressive disorder and treatment response to antidepressants is a major challenge. Vortioxetine is a novel multimodal antidepressant that ...

    Jessica A. Waller, Sara Holm Nygaard, Yan Li, Kristian Gaarn du Jardin, Joseph A. Tamm, Aicha Abdourahman, Betina Elfving, Alan L. Pehrson, Connie Sánchez and Rasmus Wernersson

    BMC Neuroscience 2017 18:56

    Published on: 4 August 2017

  10. Methodology article

    Immunocytochemistry and fluorescence imaging efficiently identify individual neurons with CRISPR/Cas9-mediated gene disruption in primary cortical cultures

    CRISPR/Cas9 system is a powerful method to investigate the role of genes by introducing a mutation selectively and efficiently to specific genome positions in cell and animal lines. However, in primary neuron...

    Hiroto Tsunematsu, Akiko Uyeda, Nobuhiko Yamamoto and Noriyuki Sugo

    BMC Neuroscience 2017 18:55

    Published on: 1 August 2017

  11. Research article

    Difference in the functional connectivity of the dorsolateral prefrontal cortex between smokers with nicotine dependence and individuals with internet gaming disorder

    It has been reported that internet gaming disorder (IGD) and smokers with nicotine dependence (SND) share clinical characteristics, such as over-engagement despite negative consequences and cravings. This stud...

    Xin Ge, Yawen Sun, Xu Han, Yao Wang, Weina Ding, Mengqiu Cao, Yasong Du, Jianrong Xu and Yan Zhou

    BMC Neuroscience 2017 18:54

    Published on: 27 July 2017

  12. Research article

    Regeneration of long-distance peripheral nerve defects after delayed reconstruction in healthy and diabetic rats is supported by immunomodulatory chitosan nerve guides

    Delayed reconstruction of transection or laceration injuries of peripheral nerves is inflicted by a reduced regeneration capacity. Diabetic conditions, more frequently encountered in clinical practice, are kno...

    Lena Stenberg, Maria Stößel, Giulia Ronchi, Stefano Geuna, Yaobin Yin, Susanne Mommert, Lisa Mårtensson, Jennifer Metzen, Claudia Grothe, Lars B. Dahlin and Kirsten Haastert-Talini

    BMC Neuroscience 2017 18:53

    Published on: 18 July 2017

  14. Review

    Iron oxide nanoparticles may damage to the neural tissue through iron accumulation, oxidative stress, and protein aggregation

    In the recent decade, iron oxide nanoparticles (IONPs) have been proposed for several applications in the central nervous system (CNS), including targeting amyloid beta (Aβ) in the arteries, inhibiting the mic...

    Zahra Yarjanli, Kamran Ghaedi, Abolghasem Esmaeili, Soheila Rahgozar and Ali Zarrabi

    BMC Neuroscience 2017 18:51

    Published on: 26 June 2017

  16. Research article

    The order of complexity of visuomotor learning

    Learning algorithms come in three orders of complexity: zeroth-order (perturbation), first-order (gradient descent), and second-order (e.g., quasi-Newton). But which of these are used in the brain? We trained ...

    John Kim, Fariya Mostafa and Douglas Blair Tweed

    BMC Neuroscience 2017 18:50

    Published on: 12 June 2017

  17. Research article

    White matter damage and systemic inflammation in Parkinson’s disease

    Systemic inflammation and white matter (WM) alterations have been noted as effects of Parkinson’s disease (PD). This study sought to evaluate WM integrity in PD patients using diffusion tensor imaging (DTI) an...

    Pi-Ling Chiang, Hsiu-Ling Chen, Cheng-Hsien Lu, Pei-Chin Chen, Meng-Hsiang Chen, I.-Hsiao Yang, Nai-Wen Tsai and Wei-Che Lin

    BMC Neuroscience 2017 18:48

    Published on: 8 June 2017

  21. Research article

    Antagonistic action on NMDA/GluN2B mediated currents of two peptides that were conantokin-G structure-based designed

    The GluN2B subunit of the N-methyl-d-aspartate receptor (NMDAr) modulates many physiological processes including learning, memory, and pain. Excessive increase in NMDAr/GluN2B activity has been associated with va...

    Edwin A. Reyes-Guzman, Nohora Vega-Castro, Edgar A. Reyes-Montaño and Esperanza Recio-Pinto

    BMC Neuroscience 2017 18:44

    Published on: 16 May 2017

  22. Research article

    Normobaric hypoxia overnight impairs cognitive reaction time

    Impaired reaction time in patients suffering from hypoxia during sleep, caused by sleep breathing disorders, is a well-described phenomenon. High altitude sleep is known to induce periodic breathing with centr...

    Stephan Pramsohler, Stefan Wimmer, Martin Kopp, Hannes Gatterer, Martin Faulhaber, Martin Burtscher and Nikolaus Cristoph Netzer

    BMC Neuroscience 2017 18:43

    Published on: 15 May 2017

  23. Research article

    Astaxanthin protects astrocytes against trauma-induced apoptosis through inhibition of NKCC1 expression via the NF-κB signaling pathway

    Astaxanthin (ATX) is a carotenoid pigment with pleiotropic pharmacological properties that is seen as a possible drug for treating cerebral ischemic injury and subarachnoid hemorrhage. Na+–K+–2Cl− co-transporter-...

    Mingkun Zhang, Zhenwen Cui, Hua Cui, Yong Wang and Chunlong Zhong

    BMC Neuroscience 2017 18:42

    Published on: 10 May 2017

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