Blue light induces a neuroprotective gene expression program in Drosophila photoreceptors

Light exposure induces oxidative stress, which contributes to ocular diseases of aging. Blue light provides a model for light-induced oxidative stress, lipid peroxidation and retinal degeneration in Drosophila me...

Authors: Hana Hall, Jingqun Ma, Sudhanshu Shekhar, Walter D. Leon-Salas and Vikki M. Weake

Calcium currents in striatal fast-spiking interneurons: dopaminergic modulation of Ca_V1 channels

Striatal fast-spiking interneurons (FSI) are a subset of GABAergic cells that express calcium-binding protein parvalbumin (PV). They provide feed-forward inhibition to striatal projection neurons (SPNs), recei...

Authors: Ernesto Alberto Rendón-Ochoa, Teresa Hernández-Flores, Victor Hugo Avilés-Rosas, Verónica Alejandra Cáceres-Chávez, Mariana Duhne, Antonio Laville, Dagoberto Tapia, Elvira Galarraga and José Bargas

Juvenile stress induces behavioral change and affects perineuronal net formation in juvenile mice

Many neuropsychiatric disorders develop in early life. Although the mechanisms involved have not been elucidated, it is possible that functional abnormalities of parvalbumin-positive interneurons (PV neurons) ...

Authors: Hiroshi Ueno, Shunsuke Suemitsu, Shinji Murakami, Naoya Kitamura, Kenta Wani, Yosuke Matsumoto, Motoi Okamoto, Shozo Aoki and Takeshi Ishihara

Mapping visuospatial attention: the greyscales task in combination with repetitive navigated transcranial magnetic stimulation

Visuospatial attention is executed by the frontoparietal cortical areas of the brain. Damage to these areas can result in visual neglect. We therefore aimed to assess a combination of the greyscales task and r...

Authors: Katrin Giglhuber, Stefanie Maurer, Claus Zimmer, Bernhard Meyer and Sandro M. Krieg

A novel locus on mouse chromosome 7 that influences survival after infection with tick-borne encephalitis virus

Tick-borne encephalitis (TBE) is the main tick-borne viral infection in Eurasia. Its manifestations range from inapparent infections and fevers with complete recovery to debilitating or fatal encephalitis. Th...

Authors: Martin Palus, Yahya Sohrabi, Karl W. Broman, Hynek Strnad, Matyáš Šíma, Daniel Růžek, Valeriya Volkova, Martina Slapničková, Jarmila Vojtíšková, Lucie Mrázková, Jiří Salát and Marie Lipoldová

Melatonin ameliorates cognitive memory by regulation of cAMP-response element-binding protein expression and the anti-inflammatory response in a rat model of post-traumatic stress disorder

Post-traumatic stress disorder (PTSD) is an important psychological disease that can develop following the physical experience or witnessing of traumatic events. The psychopathological response to traumatic st...

Authors: Bombi Lee, Insop Shim, Hyejung Lee and Dae-Hyun Hahm

Late administration of high-frequency electrical stimulation increases nerve regeneration without aggravating neuropathic pain in a nerve crush injury

High-frequency transcutaneous neuromuscular electrical nerve stimulation (TENS) is currently used for the administration of electrical current in denervated muscle to alleviate muscle atrophy and enhance moto...

Authors: Hong-Lin Su, Chien-Yi Chiang, Zong-Han Lu, Fu-Chou Cheng, Chun-Jung Chen, Meei-Ling Sheu, Jason Sheehan and Hung-Chuan Pan

Higher levels of thyroxine may predict a favorable response to donepezil treatment in patients with Alzheimer disease: a prospective, case–control study

Cholinergic hypothesis has been advanced as an etiology of Alzheimer disease (AD) on the basis of the presynaptic deficit found in the diseased brains, and cholinesterase inhibitors (ChEIs) are the treatment o...

Authors: Yu San Chang, Yu Hsuan Wu, Chin Jen Wang, Shu Hui Tang and Hsiang Lan Chen

Neural correlates of free recall of “famous events” in a “hypermnestic” individual as compared to an age- and education-matched reference group

Memory performance of an individual (within the age range: 50–55 years old) showing superior memory abilities (protagonist PR) was compared to an age- and education-matched reference group in a historical fact...

Authors: Thorsten Fehr, Angelica Staniloiu, Hans J. Markowitsch, Peter Erhard and Manfred Herrmann

Modulation of long-term potentiation-like cortical plasticity in the healthy brain with low frequency-pulsed electromagnetic fields

Non-depolarizing magnetic fields, like low frequency-pulsed electromagnetic fields (LF-PEMFs) have shown the ability to modulate living structures, principally by influencing synaptic activity and ion channels...

Authors: Enrico Premi, Alberto Benussi, Antonio La Gatta, Stefano Visconti, Angelo Costa, Nicola Gilberti, Valentina Cantoni, Alessandro Padovani, Barbara Borroni and Mauro Magoni

Altered functional connectivity of the default mode network by glucose loading in young, healthy participants

The functional connectivity of the default mode network (DMN) decreases in patients with Alzheimer’s disease (AD) as well as in patients with type 2 diabetes mellitus (T2DM). Altered functional connectivity of...

Authors: Kenji Ishibashi, Keita Sakurai, Keigo Shimoji, Aya M. Tokumaru and Kenji Ishii

Extremely low frequency electromagnetic field exposure and restraint stress induce changes on the brain lipid profile of Wistar rats

Exposure to electromagnetic fields can affect human health, damaging tissues and cell homeostasis. Stress modulates neuronal responses and composition of brain lipids. The aim of this study was to evaluate the...

Authors: Jesús Martínez-Sámano, Alan Flores-Poblano, Leticia Verdugo-Díaz, Marco Antonio Juárez-Oropeza and Patricia V. Torres-Durán

Limited effects of dysfunctional macroautophagy on the accumulation of extracellularly derived α-synuclein in oligodendroglia: implications for MSA pathogenesis

The progressive neurodegenerative disorder multiple system atrophy (MSA) is characterized by α-synuclein-positive (oligodendro-) glial cytoplasmic inclusions (GCIs). A connection between the abnormal accumulat...

Authors: Lisa Fellner, Edith Buchinger, Dominik Brueck, Regina Irschick, Gregor K. Wenning and Nadia Stefanova

A method for estimating relative changes in the synaptic density in Drosophila central nervous system

Synapse density is an essential indicator of development and functioning of the central nervous system. It is estimated indirectly through the accumulation of pre and postsynaptic proteins in tissue sections. ...

Authors: Dipti Rai, Swagata Dey and Krishanu Ray

Zinc and linoleic acid pre-treatment attenuates biochemical and histological changes in the midbrain of rats with rotenone-induced Parkinsonism

Studies have suggested the supplementation of Zinc and Linoleic acid in the management of neurodegenerative disorders but none has investigated the combined effects. Little is known about the neuroprotective e...

Authors: Ngala Elvis Mbiydzenyuy, Herbert Izo Ninsiima, Miriela Betancourt Valladares and Constant Anatole Pieme

Mice lacking galectin-3 (Lgals3) function have decreased home cage movement

Galectins are a large family of proteins evolved to recognize specific carbohydrate moieties. Given the importance of pattern recognition processes for multiple biological tasks, including CNS development and ...

Authors: Tammy R. Chaudoin and Stephen J. Bonasera

Cochlear morphology in the developing inner ear of the porcine model of spontaneous deafness

Auditory function and cochlear morphology have previously been described in a porcine model with spontaneous WS2-like phenotype. In the present study, cochlear histopathology was further investigated in the in...

Authors: Wei Chen, Qing-Qing Hao, Li–Li Ren, Wei Ren, Hui-sang Lin, Wei-Wei Guo and Shi-Ming Yang

Clinical features and risk factors of neurological involvement in Sjögren’s syndrome

To investigated distinct manifestations of Sjögren’s syndrome (SS) patients with neurological complications and the potential risk factors associated with neurological complications in SS, and to produce a dis...

Authors: Wenjing Ye, Siyan Chen, Xinshi Huang, Wei Qin, Ting Zhang, Xiaofang Zhu, Xiaochun Zhu, Chongxiang Lin and Xiaobing Wang

Optogenetic regulation of transcription

Optogenetics has become widely recognized for its success in real-time control of brain neurons by utilizing non-mammalian photosensitive proteins to open or close membrane channels. Here we review a less well...

Authors: Oksana Polesskaya, Ancha Baranova, Sarah Bui, Nikolai Kondratev, Evgeniya Kananykhina, Olga Nazarenko, Tatyana Shapiro, Frances Barg Nardia, Vladimir Kornienko, Vikas Chandhoke, Istvan Stadler, Raymond Lanzafame and Max Myakishev-Rempel

Haplotype analysis of APOE intragenic SNPs

APOE ε4 allele is most common genetic risk factor for Alzheimer’s disease (AD) and cognitive decline. However, it remains poorly understood why only some carriers of APOE ε4 develop AD and how ethnic variabilitie...

Authors: Vladimir N. Babenko, Dmitry A. Afonnikov, Elena V. Ignatieva, Anton V. Klimov, Fedor E. Gusev and Evgeny I. Rogaev

Effect of laser Doppler flowmetry and occlusion time on outcome variability and mortality in rat middle cerebral artery occlusion: inconclusive results

Stroke is among the leading causes of death and disability. Although intense research efforts have provided promising treatment options in animals, most clinical trials in humans have failed and the therapeuti...

Authors: Edvin Ingberg, Hua Dock, Elvar Theodorsson, Annette Theodorsson and Jakob O. Ström

The spatio-temporal dynamics of deviance and target detection in the passive and active auditory oddball paradigm: a sLORETA study

Numerous studies have investigated the neural underpinnings of passive and active deviance and target detection in the well-known auditory oddball paradigm by means of event-related potentials (ERPs) or functiona...

Authors: Christoph Justen and Cornelia Herbert

Modulation of the expression of genes related to the system of amyloid-beta metabolism in the brain as a novel mechanism of ceftriaxone neuroprotective properties

The dominant hypothesis about the pathogenesis of Alzheimer’s disease (AD) is the “amyloid cascade” concept and modulating the expression of proteins involved in the metabolism of amyloid-beta (Aβ) is propose...

Authors: Maria A. Tikhonova, Tamara G. Amstislavskaya, Victor M. Belichenko, Larisa A. Fedoseeva, Sergey P. Kovalenko, Ekaterina E. Pisareva, Alla S. Avdeeva, Nataliya G. Kolosova, Nikolai D. Belyaev and Lyubomir I. Aftanas

Novel functional variants at the GWAS-implicated loci might confer risk to major depressive disorder, bipolar affective disorder and schizophrenia

A challenge of understanding the mechanisms underlying cognition including neurodevelopmental and neuropsychiatric disorders is mainly given by the potential severity of cognitive disorders for the quality of ...

Authors: Leonid O. Bryzgalov, Elena E. Korbolina, Ilja I. Brusentsov, Elena Y. Leberfarb, Natalia P. Bondar and Tatiana I. Merkulova

Neuroscience researches at Belyaev conference-2017

Authors: Yuriy L. Orlov, Leonid L. Moroz and Ancha V. Baranova