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  1. Content type: Research article

    Hair cell loss in the cochlea is caused by ototoxic drugs, aging, and environmental stresses and could potentially lead to devastating pathophysiological effects. In adult mammals, hair cell loss is irreversib...

    Authors: Takahiro Wakasaki, Hiroaki Niiro, Siamak Jabbarzadeh-Tabrizi, Mitsuru Ohashi, Takashi Kimitsuki, Takashi Nakagawa, Shizuo Komune and Koichi Akashi

    Citation: BMC Neuroscience 2017 18:64

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  2. Content type: Research article

    Following partial injury to the central nervous system, cells beyond the initial injury site undergo secondary degeneration, exacerbating loss of neurons, compact myelin and function. Changes in Ca2+ flux are ass...

    Authors: Ryan L. O’Hare Doig, Wissam Chiha, Marcus K. Giacci, Nathanael J. Yates, Carole A. Bartlett, Nicole M. Smith, Stuart I. Hodgetts, Alan R. Harvey and Melinda Fitzgerald

    Citation: BMC Neuroscience 2017 18:62

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  3. Content type: Research article

    In Duchenne muscular dystrophy (DMD), the loss of the dystrophin component of the dystrophin-glycoprotein complex (DGC) compromises plasma membrane integrity in skeletal muscle, resulting in extensive muscle d...

    Authors: Azeez Aranmolate, Nathaniel Tse and Holly Colognato

    Citation: BMC Neuroscience 2017 18:63

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  4. Content type: Research article

    CLCA is a family of metalloproteases that regulate Ca2+-activated Cl fluxes in epithelial tissues. In HEK293 cells, CLCA1 promotes membrane expression of an endogenous Anoctamin 1 (ANO1, also termed TMEM16A)-dep...

    Authors: Casilda V. Mura, Ricardo Delgado, María Graciela Delgado, Diego Restrepo and Juan Bacigalupo

    Citation: BMC Neuroscience 2017 18:61

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  5. Content type: Research article

    Sesamin is a well-known antioxidant extracted from sesame seeds that exhibits various curative effects. The present study investigated whether sesamin would protect neuroblastoma SH-SY5Y cells against mechanic...

    Authors: Zhiming Xu, Yingliang Liu, Dianxu Yang, Fang Yuan, Jun Ding, Hao Chen and Hengli Tian

    Citation: BMC Neuroscience 2017 18:57

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  6. Content type: Research article

    The identification of biomarkers that predict susceptibility to major depressive disorder and treatment response to antidepressants is a major challenge. Vortioxetine is a novel multimodal antidepressant that ...

    Authors: Jessica A. Waller, Sara Holm Nygaard, Yan Li, Kristian Gaarn du Jardin, Joseph A. Tamm, Aicha Abdourahman, Betina Elfving, Alan L. Pehrson, Connie Sánchez and Rasmus Wernersson

    Citation: BMC Neuroscience 2017 18:56

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  7. Content type: Methodology article

    CRISPR/Cas9 system is a powerful method to investigate the role of genes by introducing a mutation selectively and efficiently to specific genome positions in cell and animal lines. However, in primary neuron...

    Authors: Hiroto Tsunematsu, Akiko Uyeda, Nobuhiko Yamamoto and Noriyuki Sugo

    Citation: BMC Neuroscience 2017 18:55

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  8. Content type: Research article

    It has been reported that internet gaming disorder (IGD) and smokers with nicotine dependence (SND) share clinical characteristics, such as over-engagement despite negative consequences and cravings. This stud...

    Authors: Xin Ge, Yawen Sun, Xu Han, Yao Wang, Weina Ding, Mengqiu Cao, Yasong Du, Jianrong Xu and Yan Zhou

    Citation: BMC Neuroscience 2017 18:54

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  9. Content type: Research article

    Delayed reconstruction of transection or laceration injuries of peripheral nerves is inflicted by a reduced regeneration capacity. Diabetic conditions, more frequently encountered in clinical practice, are kno...

    Authors: Lena Stenberg, Maria Stößel, Giulia Ronchi, Stefano Geuna, Yaobin Yin, Susanne Mommert, Lisa Mårtensson, Jennifer Metzen, Claudia Grothe, Lars B. Dahlin and Kirsten Haastert-Talini

    Citation: BMC Neuroscience 2017 18:53

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  10. Content type: Review

    In the recent decade, iron oxide nanoparticles (IONPs) have been proposed for several applications in the central nervous system (CNS), including targeting amyloid beta (Aβ) in the arteries, inhibiting the mic...

    Authors: Zahra Yarjanli, Kamran Ghaedi, Abolghasem Esmaeili, Soheila Rahgozar and Ali Zarrabi

    Citation: BMC Neuroscience 2017 18:51

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  11. Content type: Research article

    The brain is continuously targeted by a wealth of stimuli with complex spatio-temporal patterns and has presumably evolved in order to cope with those inputs in an optimal way. Previous studies investigating t...

    Authors: Francesca Scarsi, Jacopo Tessadori, Michela Chiappalone and Valentina Pasquale

    Citation: BMC Neuroscience 2017 18:49

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  12. Content type: Research article

    Learning algorithms come in three orders of complexity: zeroth-order (perturbation), first-order (gradient descent), and second-order (e.g., quasi-Newton). But which of these are used in the brain? We trained ...

    Authors: John Kim, Fariya Mostafa and Douglas Blair Tweed

    Citation: BMC Neuroscience 2017 18:50

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  13. Content type: Research article

    Systemic inflammation and white matter (WM) alterations have been noted as effects of Parkinson’s disease (PD). This study sought to evaluate WM integrity in PD patients using diffusion tensor imaging (DTI) an...

    Authors: Pi-Ling Chiang, Hsiu-Ling Chen, Cheng-Hsien Lu, Pei-Chin Chen, Meng-Hsiang Chen, I.-Hsiao Yang, Nai-Wen Tsai and Wei-Che Lin

    Citation: BMC Neuroscience 2017 18:48

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  14. Content type: Research article

    We studied whether regulation of Cdca7 (Cell division cycle associated 7) expression by transcription factor Pax6 contributes to Pax6’s cellular actions during corticogenesis. The function of Cdca7 in mediating P...

    Authors: Yu-Ting Huang, John O. Mason and David J. Price

    Citation: BMC Neuroscience 2017 18:47

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  15. Content type: Research article

    Sirtuins (SIRTs) are NAD+ dependent lysine deacetylases which are conserved from bacteria to humans and have been associated with longevity and lifespan extension. SIRT1, the best studied mammalian SIRT is invol...

    Authors: Preeti Singh, Peter S. Hanson and Christopher M. Morris

    Citation: BMC Neuroscience 2017 18:46

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  16. Content type: Research article

    Mice lacking Kalirin-7 (Kal7KO), a Rho GDP/GTP exchange factor, self-administer cocaine at a higher rate than wildtype mice, and show an exaggerated locomotor response to experimenter-administered cocaine. Kal7, ...

    Authors: Taylor P. LaRese, Yan Yan, Betty A. Eipper and Richard E. Mains

    Citation: BMC Neuroscience 2017 18:45

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  17. Content type: Research article

    The GluN2B subunit of the N-methyl-d-aspartate receptor (NMDAr) modulates many physiological processes including learning, memory, and pain. Excessive increase in NMDAr/GluN2B activity has been associated with va...

    Authors: Edwin A. Reyes-Guzman, Nohora Vega-Castro, Edgar A. Reyes-Montaño and Esperanza Recio-Pinto

    Citation: BMC Neuroscience 2017 18:44

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  18. Content type: Research article

    Impaired reaction time in patients suffering from hypoxia during sleep, caused by sleep breathing disorders, is a well-described phenomenon. High altitude sleep is known to induce periodic breathing with centr...

    Authors: Stephan Pramsohler, Stefan Wimmer, Martin Kopp, Hannes Gatterer, Martin Faulhaber, Martin Burtscher and Nikolaus Cristoph Netzer

    Citation: BMC Neuroscience 2017 18:43

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  19. Content type: Research article

    Astaxanthin (ATX) is a carotenoid pigment with pleiotropic pharmacological properties that is seen as a possible drug for treating cerebral ischemic injury and subarachnoid hemorrhage. Na+–K+–2Cl co-transporter-...

    Authors: Mingkun Zhang, Zhenwen Cui, Hua Cui, Yong Wang and Chunlong Zhong

    Citation: BMC Neuroscience 2017 18:42

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  20. Content type: Research article

    Recent studies have suggested that the activation of mammalian target of rapamycin (mTOR) signaling may be related to antidepressant action. Therefore, the present study evaluated whether antidepressant drugs ...

    Authors: Mi Kyoung Seo, Cheol Min Choi, Roger S. McIntyre, Hye Yeon Cho, Chan Hong Lee, Rodrigo B. Mansur, Yena Lee, Jae-Hon Lee, Young Hoon Kim, Sung Woo Park and Jung Goo Lee

    Citation: BMC Neuroscience 2017 18:39

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  21. Content type: Review

    In this paper we present a mechanistic model that integrates subneuronal structures, namely ion channels, membrane fatty acids, lipid rafts, G proteins and the cytoskeleton in a dynamic system that is finely t...

    Authors: Massimo Cocchi, Chiara Minuto, Lucio Tonello, Fabio Gabrielli, Gustav Bernroider, Jack A. Tuszynski, Francesco Cappello and Mark Rasenick

    Citation: BMC Neuroscience 2017 18:38

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  22. Content type: Research article

    The mechanisms of steroids actions in the brain mainly involve the binding and nuclear translocation of specific cytoplasmic receptors. These receptors can act as transcription factors and regulate gene expres...

    Authors: Marcin Piechota, Michał Korostynski, Slawomir Golda, Joanna Ficek, Danuta Jantas, Ziolkowska Barbara and Ryszard Przewlocki

    Citation: BMC Neuroscience 2017 18:37

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  23. Content type: Research article

    Systemic inflammation is known to induce sickness behaviors, including decreased social interaction and pain. We have reported increased serum inflammatory cytokines in a rat model of repetitive strain injury ...

    Authors: D. L. Xin, J. Hadrévi, M. E. Elliott, M. Amin, M. Y. Harris, A. E. Barr-Gillespie and M. F. Barbe

    Citation: BMC Neuroscience 2017 18:36

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  24. Content type: Research article

    Recent rodent and human studies provide evidence in support of the fact that CD157, well known as bone marrow stromal cell antigen-1 (BST-1) and a risk factor in Parkinson’s disease, also meaningfully acts in ...

    Authors: Haruhiro Higashida, Mingkun Liang, Toru Yoshihara, Shirin Akther, Azam Fakhrul, Cherepanov Stanislav, Tae-Sik Nam, Uh-Hyun Kim, Satoka Kasai, Tomoko Nishimura, Naila Al Mahmuda, Shigeru Yokoyama, Katsuhiko Ishihara, Maria Gerasimenko, Alla Salmina, Jing Zhong…

    Citation: BMC Neuroscience 2017 18:35

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  25. Content type: Research article

    Oddball paradigms are frequently used to study auditory discrimination by comparing event-related potential (ERP) responses from a standard, high probability sound and to a deviant, low probability sound. Prev...

    Authors: Phillip M. Gilley, Kristin Uhler, Kaylee Watson and Christine Yoshinaga-Itano

    Citation: BMC Neuroscience 2017 18:34

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  26. Content type: Research article

    Ischemic stroke is a major disease that threatens human health in ageing population. Increasing evidence has shown that neuroinflammatory mediators play crucial roles in the pathophysiology of cerebral ischemi...

    Authors: Wen-Xin Zeng, Yong-Li Han, Gao-Feng Zhu, Lin-Qiang Huang, Yi-Yu Deng, Qiao-Sheng Wang, Wen-Qiang Jiang, Miao-Yun Wen, Qian-Peng Han, Di Xie and Hong-Ke Zeng

    Citation: BMC Neuroscience 2017 18:32

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  27. Content type: Research article

    Increased motor activity or social interactions through enriched environment are strong stimulators of grey and white matter plasticity in the adult rodent brain. In the present study we evaluated whether spe...

    Authors: Silke Keiner, Fanny Niv, Susanne Neumann, Tanja Steinbach, Christian Schmeer, Katrin Hornung, Yvonne Schlenker, Martin Förster, Otto W. Witte and Christoph Redecker

    Citation: BMC Neuroscience 2017 18:31

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  28. Content type: Research article

    The possibility of using deep brain stimulation (DBS) for memory enhancement has recently been reported, but the precise underlying mechanisms of its effects remain unknown. Our previous study suggested that s...

    Authors: Da Un Jeong, Jihyeon Lee, Won Seok Chang and Jin Woo Chang

    Citation: BMC Neuroscience 2017 18:29

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  29. Content type: Research article

    Wallerian degeneration (WD) in injured peripheral nerves is associated with a large number of up- or down-regulated genes, but the effects of these changes are poorly understood. In our previous studies, we re...

    Authors: Xingyu Liu, Yuhua Sun, Huaiqin Li, Yuting Li, Meiyuan Li, Ying Yuan, Shusen Cui and Dengbing Yao

    Citation: BMC Neuroscience 2017 18:30

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  30. Content type: Research article

    EEG studies investigating the neural networks that facilitate action observation (AO) and kinaesthetic motor imagery (KMI) have shown reduced, or desynchronized, power in the alpha (8–12 Hz) and beta (13–30 Hz...

    Authors: Paula M. Di Nota, Julie M. Chartrand, Gabriella R. Levkov, Rodrigo Montefusco-Siegmund and Joseph F. X. DeSouza

    Citation: BMC Neuroscience 2017 18:28

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  31. Content type: Research article

    Primary open angle glaucoma is a heterogeneous group of optic neuropathies that results in optic nerve degeneration and a loss of retinal ganglion cells (RGCs) ultimately causing blindness if allowed to progre...

    Authors: Nolan R. McGrady, Alena Z. Minton, Dorota L. Stankowska, Shaoqing He, Hayden B. Jefferies and Raghu R. Krishnamoorthy

    Citation: BMC Neuroscience 2017 18:27

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  32. Content type: Research article

    The study investigates oscillatory brain activity during working memory (WM) tasks. The tasks employed varied in two dimensions. First, they differed in complexity from average to highly demanding. Second, we ...

    Authors: Yuri G. Pavlov and Boris Kotchoubey

    Citation: BMC Neuroscience 2017 18:26

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  33. Content type: Research article

    The role of the piriform cortex (PC) in olfactory information processing remains largely unknown. The anterior part of the piriform cortex (APC) has been the focus of cortical-level studies of olfactory codin...

    Authors: Junli Yang, Gerhard Litscher, Zhongren Sun, Qiang Tang, Kiyoshi Kishi, Satoko Oda, Masaaki Takayanagi, Zemin Sheng, Yang Liu, Wenhai Guo, Ting Zhang, Lu Wang, Ingrid Gaischek, Daniela Litscher, Irmgard Th. Lippe and Masaru Kuroda

    Citation: BMC Neuroscience 2017 18:25

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  34. Content type: Research article

    Synucleinopathies such as Parkinson’s disease or multiple system atrophy are characterized by Lewy bodies in distinct brain areas. These aggregates are mainly formed by α-synuclein inclusions, a protein crucia...

    Authors: R. Rabl, C. Breitschaedel, S. Flunkert, S. Duller, D. Amschl, J. Neddens, V. Niederkofler, E. Rockenstein, E. Masliah, H. Roemer and B. Hutter-Paier

    Citation: BMC Neuroscience 2017 18:22

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  35. Content type: Methodology

    Cation-chloride cotransporters (CCCs) are indispensable for maintaining chloride homeostasis in multiple cell types, but K–Cl cotransporter KCC2 is the only CCC member with an exclusively neuronal expression i...

    Authors: Anastasia Ludwig, Claudio Rivera and Pavel Uvarov

    Citation: BMC Neuroscience 2017 18:23

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  36. Content type: Research article

    TDP-43 aggregates accumulate in individuals affected by amyotrophic lateral sclerosis (ALS) and other neurodegenerative diseases, representing potential diagnostic and therapeutic targets. Using an atomic forc...

    Authors: Stephanie M. Williams, Galam Khan, Brent T. Harris, John Ravits and Michael R. Sierks

    Citation: BMC Neuroscience 2017 18:20

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  37. Content type: Research article

    Previous studies compared evoked potentials (EPs) between several sleep stages but only one uniform wake state. However, using electroencephalography (EEG), several arousal states can be distinguished before s...

    Authors: Jue Huang, Tilman Hensch, Christine Ulke, Christian Sander, Janek Spada, Philippe Jawinski and Ulrich Hegerl

    Citation: BMC Neuroscience 2017 18:21

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  38. Content type: Research Article

    There is a large body of experimental evidence suggesting that omega-3 (n-3) polyunsaturated fatty acids (PUFAs) are capable of modulating immune function. Some studies have shown that these PUFAs might have ...

    Authors: Elise Siegert, Friedemann Paul, Michael Rothe and Karsten H. Weylandt

    Citation: BMC Neuroscience 2017 18:19

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  39. Content type: methodology article

    Bioluminescence imaging (BLI) is a powerful technique for monitoring the temporal and spatial dynamics of gene expression in the mouse brain. However, the black fur, skin pigmentation and hair regrowth after d...

    Authors: Hironori Izumi, Tetsuya Ishimoto, Hiroshi Yamamoto and Hisashi Mori

    Citation: BMC Neuroscience 2017 18:18

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  40. Content type: Research article

    Previous studies have indicated that selenium supplementation may be beneficial in neuroprotection against glutamate-induced cell damage, in which mitochondrial dysfunction is considered a major pathogenic fea...

    Authors: Yan-Mei Ma, Gordon Ibeanu, Li-Yao Wang, Jian-Zhong Zhang, Yue Chang, Jian-Da Dong, P. Andy Li and Li Jing

    Citation: BMC Neuroscience 2017 18:15

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  41. Content type: Research Article

    Poly(ADP-ribose) polymerase 1 (PARP-1), which catalyzes poly(ADP-ribosyl)ation of proteins by using NAD+ as a substrate, plays a key role in several nuclear events, including DNA repair, replication, and transcri...

    Authors: Akiko Okuda, Suguru Kurokawa, Masanori Takehashi, Aika Maeda, Katsuya Fukuda, Yukari Kubo, Hyuma Nogusa, Tomoka Takatani-Nakase, Shujiro Okuda, Kunihiro Ueda and Seigo Tanaka

    Citation: BMC Neuroscience 2017 18:14

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  42. Content type: Research article

    Magnetic resonance spectroscopy (MRS) provides non-invasive information about the metabolic pattern of the brain parenchyma in vivo. The SpectraClassifier software performs MRS pattern-recognition by determin...

    Authors: Elena Jiménez-Xarrié, Myriam Davila, Ana Paula Candiota, Raquel Delgado-Mederos, Sandra Ortega-Martorell, Margarida Julià-Sapé, Carles Arús and Joan Martí-Fàbregas

    Citation: BMC Neuroscience 2017 18:13

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  43. Content type: Research article

    Deposition of aggregated amyloid beta (Aβ) protein is hallmark of Alzheimer’s disease, leading to dysfunction and apoptosis of neurons. The isoflavone phytoestrogen compound genistein (Gen) exerts a significan...

    Authors: Fuling You, Qiao Li, Guifang Jin, Yaojie Zheng, Jingrong Chen and Hong Yang

    Citation: BMC Neuroscience 2017 18:12

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