Feng D, Wang B, Wang L, Abraham N, Tao K, Huang L, Shi W, Dong Y, Qu Y. Pre-ischemia melatonin treatment alleviated acute neuronal injury after ischemic stroke by inhibiting endoplasmic reticulum stress-dependent autophagy via PERK and IRE1 signalings. J Pineal Res. 2017. https://doi.org/10.1111/jpi.12395.
Article
Google Scholar
Marciniec M, Sapko K, Kulczyński M, Popek-Marciniec S, Szczepańska-Szerej A, Rejdak K. Non-traumatic cervical artery dissection and ischemic stroke: a narrative review of recent research. Clin Neurol Neurosurg. 2019;187: 105561. https://doi.org/10.1016/j.clineuro.2019.105561.
Article
Google Scholar
Pan B, Sun J, Liu Z, Wang L, Huo H, Zhao Y, Tu P, Xiao W, Zheng J, Li J. Longxuetongluo capsule protects against cerebral ischemia/reperfusion injury through endoplasmic reticulum stress and MAPK-mediated mechanisms. J Adv Res. 2021;33:215–25. https://doi.org/10.1016/j.jare.2021.01.016.
Article
CAS
Google Scholar
Zhang Y, Li M, Li X, Zhang H, Wang L, Wu X, Zhang H, Luo Y. Catalytically inactive RIP1 and RIP3 deficiency protect against acute ischemic stroke by inhibiting necroptosis and neuroinflammation. Cell Death Dis. 2020;11(7):565. https://doi.org/10.1038/s41419-020-02770-w.
Article
CAS
Google Scholar
Bhaskar S, Stanwell P, Cordato D, Attia J, Levi C. Reperfusion therapy in acute ischemic stroke: dawn of a new era? BMC Neurol. 2018;18(1):8. https://doi.org/10.1186/s12883-017-1007-y.
Article
CAS
Google Scholar
Zhou Y, Liao J, Mei Z, Liu X, Ge J. Insight into crosstalk between ferroptosis and necroptosis: novel therapeutics in ischemic stroke. Oxid Med Cell Longev. 2021;2021:9991001. https://doi.org/10.1155/2021/9991001.
Article
CAS
Google Scholar
Wei K, Wan L, Liu J, Zhang B, Li X, Zhang Y, Zhang C, Yao W. Downregulation of TRB3 protects neurons against apoptosis induced by global cerebral ischemia and reperfusion injury in rats. Neuroscience. 2017;360:118–27. https://doi.org/10.1016/j.neuroscience.2017.07.062.
Article
CAS
Google Scholar
Luo L, Deng S, Yi J, Zhou S, She Y, Liu B. Buyang Huanwu decoction ameliorates poststroke depression via promoting neurotrophic pathway mediated neuroprotection and neurogenesis. Evid Based Complement Alternat Med. 2017;2017:4072658. https://doi.org/10.1155/2017/4072658.
Article
Google Scholar
Li H, Peng D, Zhang SJ, Zhang Y, Wang Q, Guan L. Buyang Huanwu Decoction promotes neurogenesis via sirtuin 1/autophagy pathway in a cerebral ischemia model. Mol Med Rep. 2021. https://doi.org/10.3892/mmr.2021.12431.
Article
Google Scholar
Li JH, Liu AJ, Li HQ, Wang Y, Shang HC, Zheng GQ. Buyang huanwu decoction for healthcare: evidence-based theoretical interpretations of treating different diseases with the same method and target of vascularity. Evid Based Complement Alternat Med. 2014;2014: 506783. https://doi.org/10.1155/2014/506783.
Article
Google Scholar
Zhang ZQ, Song JY, Jia YQ, Zhang YK. Buyanghuanwu decoction promotes angiogenesis after cerebral ischemia/reperfusion injury: mechanisms of brain tissue repair. Neural Regen Res. 2016;11(3):435–40. https://doi.org/10.4103/1673-5374.179055.
Article
CAS
Google Scholar
Zhang WW, Xu F, Wang D, Ye J, Cai SQ. Buyang Huanwu decoction ameliorates ischemic stroke by modulating multiple targets with multiple components: in vitro evidences. Chin J Nat Med. 2018;16(3):194–202. https://doi.org/10.1016/s1875-5364(18)30047-5.
Article
CAS
Google Scholar
She Y, Shao L, Zhang Y, Hao Y, Cai Y, Cheng Z, Deng C, Liu X. Neuroprotective effect of glycosides in Buyang Huanwu decoction on pyroptosis following cerebral ischemia-reperfusion injury in rats. J Ethnopharmacol. 2019;242: 112051. https://doi.org/10.1016/j.jep.2019.112051.
Article
CAS
Google Scholar
Gao Q, Tian D, Han Z, Lin J, Chang Z, Zhang D, Ma D. Network pharmacology and molecular docking analysis on molecular targets and mechanisms of buyang huanwu decoction in the treatment of ischemic stroke. Evid Based Complement Alternat Med. 2021;2021:8815447. https://doi.org/10.1155/2021/8815447.
Article
Google Scholar
Yan X, Wang S, Yu A, Shen X, Zheng H, Wang L. Cell chromatography-based screening of the active components in buyang huanwu decoction promoting axonal regeneration. Biomed Res Int. 2019;2019:6970198. https://doi.org/10.1155/2019/6970198.
Article
CAS
Google Scholar
Chen ZZ, Gong X, Guo Q, Zhao H, Wang L. Bu Yang Huan Wu decoction prevents reperfusion injury following ischemic stroke in rats via inhibition of HIF-1 α, VEGF and promotion β-ENaC expression. J Ethnopharmacol. 2019;228:70–81. https://doi.org/10.1016/j.jep.2018.09.017.
Article
Google Scholar
Sun T, Wang J, Huang LH, Cao YX. Antihypertensive effect of formononetin through regulating the expressions of eNOS, 5-HT2A/1B receptors and α1-adrenoceptors in spontaneously rat arteries. Eur J Pharmacol. 2013;699(1–3):241–9. https://doi.org/10.1016/j.ejphar.2012.10.031.
Article
CAS
Google Scholar
Li L, Wang Y, Wang X, Tao Y, Bao K, Hua Y, Jiang G, Hong M. Formononetin attenuated allergic diseases through inhibition of epithelial-derived cytokines by regulating E-cadherin. Clin Immunol. 2018;195:67–76. https://doi.org/10.1016/j.clim.2018.07.018.
Article
CAS
Google Scholar
Mu H, Bai YH, Wang ST, Zhu ZM, Zhang YW. Research on antioxidant effects and estrogenic effect of formononetin from Trifolium pratense (red clover). Phytomedicine. 2009;16(4):314–9. https://doi.org/10.1016/j.phymed.2008.07.005.
Article
CAS
Google Scholar
Tian Z, Liu SB, Wang YC, Li XQ, Zheng LH, Zhao MG. Neuroprotective effects of formononetin against NMDA-induced apoptosis in cortical neurons. Phytother Res. 2013;27(12):1770–5. https://doi.org/10.1002/ptr.4928.
Article
CAS
Google Scholar
Tay KC, Tan LT, Chan CK, Hong SL, Chan KG, Yap WH, Pusparajah P, Lee LH, Goh BH. Formononetin: a review of its anticancer potentials and mechanisms. Front Pharmacol. 2019;10:820. https://doi.org/10.3389/fphar.2019.00820.
Article
CAS
Google Scholar
Ong SKL, Shanmugam MK, Fan L, Fraser SE, Arfuso F, Ahn KS, Sethi G, Bishayee A. Focus on formononetin: anticancer potential and molecular targets. Cancers. 2019. https://doi.org/10.3390/cancers11050611.
Article
Google Scholar
Zhang S, Tang X, Tian J, Li C, Zhang G, Jiang W, Zhang Z. Cardioprotective effect of sulphonated formononetin on acute myocardial infarction in rats. Basic Clin Pharmacol Toxicol. 2011;108(6):390–5. https://doi.org/10.1111/j.1742-7843.2011.00676.x.
Article
CAS
Google Scholar
Dong Z, Shi Y, Zhao H, Li N, Ye L, Zhang S, Zhu H. Sulphonated formononetin induces angiogenesis through vascular endothelial growth factor/camp response element-binding protein/early growth response 3/vascular cell adhesion molecule 1 and Wnt/β-catenin signaling pathway. Pharmacology. 2018;101(1–2):76–85. https://doi.org/10.1159/000480662.
Article
Google Scholar
Sun Y, Liu N, Wang J, Chen L, Qian X, Chen L, Han Z, Sun J. Effect of formononetin on blood brain barrier integrity after cerebral ischemia reperfusion. Tianjin Pharmacy. 2021;33(01):1–3.
CAS
Google Scholar
Zhu H, Zou L, Tian J, Lin F, He J, Hou J. Protective effects of sulphonated formononetin in a rat model of cerebral ischemia and reperfusion injury. Planta Med. 2014;80(4):262–8. https://doi.org/10.1055/s-0033-1360340.
Article
CAS
Google Scholar
Gong L, Tang Y, An R, Lin M, Chen L, Du J. RTN1-C mediates cerebral ischemia/reperfusion injury via ER stress and mitochondria-associated apoptosis pathways. Cell Death Dis. 2017;8(10): e3080. https://doi.org/10.1038/cddis.2017.465.
Article
Google Scholar
Sun X, Liu H, Sun Z, Zhang B, Wang X, Liu T, Pan T, Gao Y, Jiang X, Li H. Acupuncture protects against cerebral ischemia-reperfusion injury via suppressing endoplasmic reticulum stress-mediated autophagy and apoptosis. Mol Med. 2020;26(1):105. https://doi.org/10.1186/s10020-020-00236-5.
Article
CAS
Google Scholar
Guo MM, Qu SB, Lu HL, Wang WB, He ML, Su JL, Chen J, Wang Y. Biochanin a alleviates cerebral ischemia/reperfusion injury by suppressing endoplasmic reticulum stress-induced apoptosis and p38mapk signaling pathway in vivo and in vitro. Front Endocrinol. 2021;12: 646720. https://doi.org/10.3389/fendo.2021.646720.
Article
Google Scholar
White A, Parekh RU, Theobald D, Pakala P, Myers AL, Van Dross R, Sriramula S. Kinin B1R activation induces endoplasmic reticulum stress in primary hypothalamic neurons. Front Pharmacol. 2022;13: 841068. https://doi.org/10.3389/fphar.2022.841068.
Article
CAS
Google Scholar
Qi Z, Chen L. Endoplasmic reticulum stress and autophagy. Adv Exp Med Biol. 2019;1206:167–77. https://doi.org/10.1007/978-981-15-0602-4_8.
Article
CAS
Google Scholar
Lin YW, Chen TY, Hung CY, Tai SH, Huang SY, Chang CC, Hung HY, Lee EJ. Melatonin protects brain against ischemia/reperfusion injury by attenuating endoplasmic reticulum stress. Int J Mol Med. 2018;42(1):182–92. https://doi.org/10.3892/ijmm.2018.3607.
Article
CAS
Google Scholar
Li HQ, Xia SN, Xu SY, Liu PY, Gu Y, Bao XY, Xu Y, Cao X. γ-glutamylcysteine alleviates ischemic stroke-induced neuronal apoptosis by inhibiting ros-mediated endoplasmic reticulum stress. Oxid Med Cell Longev. 2021;2021:2961079. https://doi.org/10.1155/2021/2961079.
Article
CAS
Google Scholar
Lv Z, Liu C, Zhai M, Zhang Q, Li J, Zheng F, Peng M. LPS Pretreatment attenuates cerebral ischaemia/reperfusion injury by inhibiting inflammation and apoptosis. Cell Physiol Biochem. 2018;45(6):2246–56. https://doi.org/10.1159/000488170.
Article
CAS
Google Scholar
Zhao X, Zhu L, Liu D, Chi T, Ji X, Liu P, Yang X, Tian X, Zou L. Sigma-1 receptor protects against endoplasmic reticulum stress-mediated apoptosis in mice with cerebral ischemia/reperfusion injury. Apoptosis. 2019;24(1–2):157–67. https://doi.org/10.1007/s10495-018-1495-2.
Article
Google Scholar
Xu F, Ma R, Zhang G, Wang S, Yin J, Wang E, Xiong E, Zhang Q, Li Y. Estrogen and propofol combination therapy inhibits endoplasmic reticulum stress and remarkably attenuates cerebral ischemia-reperfusion injury and OGD injury in hippocampus. Biomed Pharmacother. 2018;108:1596–606. https://doi.org/10.1016/j.biopha.2018.09.167.
Article
CAS
Google Scholar
Zheng Y, Hou J, Liu J, Yao M, Li L, Zhang B, Zhu H, Wang Z. Inhibition of autophagy contributes to melatonin-mediated neuroprotection against transient focal cerebral ischemia in rats. J Pharmacol Sci. 2014;124(3):354–64. https://doi.org/10.1254/jphs.13220fp.
Article
CAS
Google Scholar
Uzdensky AB. Apoptosis regulation in the penumbra after ischemic stroke: expression of pro- and antiapoptotic proteins. Apoptosis. 2019;24(9–10):687–702. https://doi.org/10.1007/s10495-019-01556-6.
Article
CAS
Google Scholar
Demyanenko S, Uzdensky A. Profiling of signaling proteins in penumbra after focal photothrombotic infarct in the rat brain cortex. Mol Neurobiol. 2017;54(9):6839–56. https://doi.org/10.1007/s12035-016-0191-x.
Article
CAS
Google Scholar
Zeng M, Zhou H, He Y, Wang Z, Shao C, Yin J, Du H, Yang J, Wan H. Danhong injection alleviates cerebral ischemia/reperfusion injury by improving intracellular energy metabolism coupling in the ischemic penumbra. Biomed Pharmacother. 2021;140: 111771. https://doi.org/10.1016/j.biopha.2021.111771.
Article
CAS
Google Scholar
Hou Y, Wang K, Wan W, Cheng Y, Pu X, Ye X. Resveratrol provides neuroprotection by regulating the JAK2/STAT3/PI3K/AKT/mTOR pathway after stroke in rats. Genes Dis. 2018;5(3):245–55. https://doi.org/10.1016/j.gendis.2018.06.001.
Article
CAS
Google Scholar
Deng Y, Tan R, Li F, Liu Y, Shi J, Gong Q. Isorhynchophylline ameliorates cerebral ischemia/reperfusion injury by inhibiting CX3CR1-mediated microglial activation and neuroinflammation. Front Pharmacol. 2021;12: 574793. https://doi.org/10.3389/fphar.2021.574793.
Article
CAS
Google Scholar
Yihao D, Tao G, Zhiyuan W, Xiaoming Z, Lingling D, Hongyun H. Ginkgo biloba leaf extract (EGb-761) elicits neuroprotection against cerebral ischemia/reperfusion injury by enhancement of autophagy flux in neurons in the penumbra. Iran J Basic Med Sci. 2021;24(8):1138–45. https://doi.org/10.22038/ijbms.2021.46318.10694.
Article
Google Scholar
Fluri F, Schuhmann MK, Kleinschnitz C. Animal models of ischemic stroke and their application in clinical research. Drug Des Devel Ther. 2015;9:3445–54. https://doi.org/10.2147/dddt.S56071.
Article
CAS
Google Scholar
Zhai M, Liu C, Li Y, Zhang P, Yu Z, Zhu H, Zhang L, Zhang Q, Wang J, Wang J. Dexmedetomidine inhibits neuronal apoptosis by inducing Sigma-1 receptor signaling in cerebral ischemia-reperfusion injury. Aging. 2019;11(21):9556–68. https://doi.org/10.18632/aging.102404.
Article
CAS
Google Scholar
Zhao L, Li H, Gao Q, Xu J, Zhu Y, Zhai M, Zhang P, Shen N, Di Y, Wang J, et al. Berberine attenuates cerebral ischemia-reperfusion injury induced neuronal apoptosis by down-regulating the CNPY2 signaling pathway. Front Pharmacol. 2021;12: 609693. https://doi.org/10.3389/fphar.2021.609693.
Article
CAS
Google Scholar
Campanella M, Sciorati C, Tarozzo G, Beltramo M. Flow cytometric analysis of inflammatory cells in ischemic rat brain. Stroke. 2002;33(2):586–92. https://doi.org/10.1161/hs0202.103399.
Article
Google Scholar
Wasserman JK, Yang H, Schlichter LC. Glial responses, neuron death and lesion resolution after intracerebral hemorrhage in young vs aged rats. Eur J Neurosci. 2008;28(7):1316–28. https://doi.org/10.1111/j.1460-9568.2008.06442.x.
Article
Google Scholar
Caso JR, Moro MA, Lorenzo P, Lizasoain I, Leza JC. Involvement of IL-1beta in acute stress-induced worsening of cerebral ischaemia in rats. Eur Neuropsychopharmacol. 2007;17(9):600–7. https://doi.org/10.1016/j.euroneuro.2007.02.009.
Article
CAS
Google Scholar
Suzuki S, Tanaka K, Suzuki N. Ambivalent aspects of interleukin-6 in cerebral ischemia: inflammatory versus neurotrophic aspects. J Cereb Blood Flow Metab. 2009;29(3):464–79. https://doi.org/10.1038/jcbfm.2008.141.
Article
CAS
Google Scholar
Maddahi A, Kruse LS, Chen QW, Edvinsson L. The role of tumor necrosis factor-α and TNF-α receptors in cerebral arteries following cerebral ischemia in rat. J Neuroinflammation. 2011;8:107. https://doi.org/10.1186/1742-2094-8-107.
Article
CAS
Google Scholar
Xie W, Zhu T, Dong X, Nan F, Meng X, Zhou P, Sun G, Sun X. HMGB1-triggered inflammation inhibition of notoginseng leaf triterpenes against cerebral ischemia and reperfusion injury via MAPK and NF-κB signaling pathways. Biomolecules. 2019. https://doi.org/10.3390/biom9100512.
Article
Google Scholar
Yang Y, Li X, Zhang L, Liu L, Jing G, Cai H. Ginsenoside Rg1 suppressed inflammation and neuron apoptosis by activating PPARγ/HO-1 in hippocampus in rat model of cerebral ischemia-reperfusion injury. Int J Clin Exp Pathol. 2015;8(3):2484–94.
Google Scholar
Wang L, Zhao H, Zhai ZZ, Qu LX. Protective effect and mechanism of ginsenoside Rg1 in cerebral ischaemia-reperfusion injury in mice. Biomed Pharmacother. 2018;99:876–82. https://doi.org/10.1016/j.biopha.2018.01.136.
Article
CAS
Google Scholar
Sprenkle NT, Sims SG, Sánchez CL, Meares GP. Endoplasmic reticulum stress and inflammation in the central nervous system. Mol Neurodegener. 2017;12(1):42. https://doi.org/10.1186/s13024-017-0183-y.
Article
CAS
Google Scholar
Zhang K, Kaufman RJ. From endoplasmic-reticulum stress to the inflammatory response. Nature. 2008;454(7203):455–62. https://doi.org/10.1038/nature07203.
Article
CAS
Google Scholar
Wada T, Yasunaga H, Inokuchi R, Horiguchi H, Fushimi K, Matsubara T, Nakajima S, Yahagi N. Effects of edaravone on early outcomes in acute ischemic stroke patients treated with recombinant tissue plasminogen activator. J Neurol Sci. 2014;345(1–2):106–11. https://doi.org/10.1016/j.jns.2014.07.018.
Article
CAS
Google Scholar
Edaravone Acute Infarction Study Group. Effect of a novel free radical scavenger, edaravone (MCI-186), on acute brain infarction Randomized, placebo-controlled, double-blind study at multicenters. Cerebrovasc Dis. 2003;15(3):222–9. https://doi.org/10.1159/000069318.
Article
CAS
Google Scholar
Wang Y, Liu M, Pu C. Chinese guidelines for secondary prevention of ischemic stroke and transient ischemic attack. Int J Stroke. 2017;12(3):302–20. https://doi.org/10.1177/1747493017694391.
Article
Google Scholar
Shinohara Y, Yanagihara T, Abe K, Yoshimine T, Fujinaka T, Chuma T, Ochi F, Nagayama M, Ogawa A, Suzuki N, et al. Cerebral infarction/transient ischemic attack (TIA). J Stroke Cerebrovasc Dis. 2011;20(4):31–73. https://doi.org/10.1016/j.jstrokecerebrovasdis.2011.05.004.
Article
Google Scholar
Cheng B, Guo Y, Li C, Ji B, Pan Y, Chen J, Bai B. Edaravone protected PC12 cells against MPP(+)-cytoxicity via inhibiting oxidative stress and up-regulating heme oxygenase-1 expression. J Neurol Sci. 2014;343(1–2):115–9. https://doi.org/10.1016/j.jns.2014.05.051.
Article
CAS
Google Scholar
Srinivasan K, Sharma SS. Edaravone offers neuroprotection in a diabetic stroke model via inhibition of endoplasmic reticulum stress. Basic Clin Pharmacol Toxicol. 2012;110(2):133–40. https://doi.org/10.1111/j.1742-7843.2011.00763.x.
Article
CAS
Google Scholar
Ono H, Nishijima Y, Adachi N, Tachibana S, Chitoku S, Mukaihara S, Sakamoto M, Kudo Y, Nakazawa J, Kaneko K, et al. Improved brain MRI indices in the acute brain stem infarct sites treated with hydroxyl radical scavengers, Edaravone and hydrogen, as compared to Edaravone alone a non-controlled study. Med Gas Res. 2011;1(1):12. https://doi.org/10.1186/2045-9912-1-12.
Article
CAS
Google Scholar
Li G, Yang M, Hao X, Li C, Gao Y, Tao J. Acute toxicity of sodium formononetin-3’-sulphonate (Sul-F) in sprague-dawley rats and beagle dogs. Regul Toxicol Pharmacol. 2015;73(2):629–33. https://doi.org/10.1016/j.yrtph.2015.09.010.
Article
CAS
Google Scholar
Huang G, Zang J, He L, Zhu H, Huang J, Yuan Z, Chen T, Xu A. Bioactive nanoenzyme reverses oxidative damage and endoplasmic reticulum stress in neurons under ischemic stroke. ACS Nano. 2021. https://doi.org/10.1021/acsnano.1c07205.
Article
Google Scholar
Wei J, Wu X, Luo P, Yue K, Yu Y, Pu J, Zhang L, Dai S, Han D, Fei Z. Homer1a attenuates endoplasmic reticulum stress-induced mitochondrial stress after ischemic reperfusion injury by inhibiting the PERK pathway. Front Cell Neurosci. 2019;13:101. https://doi.org/10.3389/fncel.2019.00101.
Article
CAS
Google Scholar
Rozpedek W, Pytel D, Mucha B, Leszczynska H, Diehl JA, Majsterek I. The Role of the PERK/eIF2α/ATF4/CHOP signaling pathway in tumor progression during endoplasmic reticulum stress. Curr Mol Med. 2016;16(6):533–44. https://doi.org/10.2174/1566524016666160523143937.
Article
CAS
Google Scholar
Yang W, Paschen W. Unfolded protein response in brain ischemia: A timely update. J Cereb Blood Flow Metab. 2016;36(12):2044–50. https://doi.org/10.1177/0271678x16674488.
Article
CAS
Google Scholar
Shi R, Weng J, Zhao L, Li XM, Gao TM, Kong J. Excessive autophagy contributes to neuron death in cerebral ischemia. CNS Neurosci Ther. 2012;18(3):250–60. https://doi.org/10.1111/j.1755-5949.2012.00295.x.
Article
CAS
Google Scholar