O'Collins VE, Macleod MR, Donnan GA, Horky LL, van der Worp BH, Howells DW: 1,026 experimental treatments in acute stroke. Ann Neurol. 2006, 59 (3): 467-477. 10.1002/ana.20741.
Article
PubMed
Google Scholar
Edvinsson L: Cerebrovascular endothelin receptor upregulation in cerebral ischemia. Curr Vasc Pharmacol. 2009, 7 (1): 26-33. 10.2174/157016109787354178.
Article
CAS
PubMed
Google Scholar
Viossat I, Duverger D, Chapelat M, Pirotzky E, Chabrier PE, Braquet P: Elevated tissue endothelin content during focal cerebral ischemia in the rat. J Cardiovasc Pharmacol. 1993, 22 (Suppl 8): S306-309.
Article
CAS
PubMed
Google Scholar
Lampl Y, Fleminger G, Gilad R, Galron R, Sarova-Pinhas I, Sokolovsky M: Endothelin in cerebrospinal fluid and plasma of patients in the early stage of ischemic stroke. Stroke. 1997, 28 (10): 1951-1955. 10.1161/01.STR.28.10.1951.
Article
CAS
PubMed
Google Scholar
Zervas NT: Vasospasm: an update. Clin Neurosurg. 1979, 26: 643-656.
CAS
PubMed
Google Scholar
Zervas NT, Lavyne MH, Negoro M: Neurotransmitters and the normal and ischemic cerebral circulation. N Engl J Med. 1975, 293 (16): 812-816. 10.1056/NEJM197510162931607.
Article
CAS
PubMed
Google Scholar
Saavedra JM, Benicky J, Zhou J: Mechanisms of the Anti-Ischemic Effect of Angiotensin II AT(1) Receptor Antagonists in the Brain. Cell Mol Neurobiol. 2006, 26 (7–8): 1099-1111.
CAS
PubMed
Google Scholar
Koudstaal PJ, Ciabattoni G, van Gijn J, Nieuwenhuis HK, de Groot PG, Sixma JJ, Patrono C: Increased thromboxane biosynthesis in patients with acute cerebral ischemia. Stroke. 1993, 24 (2): 219-223. 10.1161/01.STR.24.2.219.
Article
CAS
PubMed
Google Scholar
Saloheimo P, Juvela S, Riutta A, Pyhtinen J, Hillbom M: Thromboxane and prostacyclin biosynthesis in patients with acute spontaneous intracerebral hemorrhage. Thromb Res. 2005, 115 (5): 367-373. 10.1016/j.thromres.2004.08.026.
Article
CAS
PubMed
Google Scholar
Furuta H, Guo DF, Inagami T: Molecular cloning and sequencing of the gene encoding human angiotensin II type 1 receptor. Biochem Biophys Res Commun. 1992, 183 (1): 8-13. 10.1016/0006-291X(92)91600-U.
Article
CAS
PubMed
Google Scholar
Masaki T, Vane JR, Vanhoutte PM: International Union of Pharmacology nomenclature of endothelin receptors. Pharmacol Rev. 1994, 46 (2): 137-142.
CAS
PubMed
Google Scholar
Zimmermann M, Seifert V: Endothelin and subarachnoid hemorrhage: an overview. Neurosurgery. 1998, 43 (4): 863-875. 10.1097/00006123-199810000-00083. discussion 875-866
Article
CAS
PubMed
Google Scholar
Timmermans PB, Chiu AT, Herblin WF, Wong PC, Smith RD: Angiotensin II receptor subtypes. Am J Hypertens. 1992, 5 (6 Pt 1): 406-410. 10.1093/ajh/5.6.406.
Article
CAS
PubMed
Google Scholar
Chiu AT, Herblin WF, McCall DE, Ardecky RJ, Carini DJ, Duncia JV, Pease LJ, Wong PC, Wexler RR, Johnson AL: Identification of angiotensin II receptor subtypes. Biochem Biophys Res Commun. 1989, 165 (1): 196-203. 10.1016/0006-291X(89)91054-1.
Article
CAS
PubMed
Google Scholar
Coyle AT, Miggin SM, Kinsella BT: Characterization of the 5' untranslated region of alpha and beta isoforms of the human thromboxane A2 receptor (TP). Differential promoter utilization by the TP isoforms. Eur J Biochem. 2002, 269 (16): 4058-4073. 10.1046/j.1432-1033.2002.03098.x.
Article
CAS
PubMed
Google Scholar
Beg SA, Hansen-Schwartz JA, Vikman PJ, Xu CB, Edvinsson LI: ERK1/2 inhibition attenuates cerebral blood flow reduction and abolishes ET(B) and 5-HT(1B) receptor upregulation after subarachnoid hemorrhage in rat. J Cereb Blood Flow Metab. 2006, 26 (6): 846-856. 10.1038/sj.jcbfm.9600236.
Article
CAS
PubMed
Google Scholar
Beg SS, Hansen-Schwartz JA, Vikman PJ, Xu CB, Edvinsson LI: Protein kinase C inhibition prevents upregulation of vascular ET(B) and 5-HT(1B) receptors and reverses cerebral blood flow reduction after subarachnoid haemorrhage in rats. J Cereb Blood Flow Metab. 2007, 27 (1): 21-32. 10.1038/sj.jcbfm.9600313.
Article
CAS
PubMed
Google Scholar
Vikman P, Beg S, Khurana T, Hansen-Schwartz J, Edvinsson L: Gene expression and molecular changes in cerebral arteries following subarachnoid hemorrhage in the rat. J Neurosurg. 2006, 105 (3): 438-444. 10.3171/jns.2006.105.3.438.
Article
CAS
PubMed
Google Scholar
Hansen-Schwartz J, Hoel NL, Zhou M, Xu CB, Svendgaard NA, Edvinsson L: Subarachnoid hemorrhage enhances endothelin receptor expression and function in rat cerebral arteries. Neurosurgery. 2003, 52 (5): 1188-1194. 10.1227/01.NEU.0000058467.82442.64. 1194-1185
Article
PubMed
Google Scholar
Hansen-Schwartz J, Hoel NL, Xu CB, Svendgaard NA, Edvinsson L: Subarachnoid hemorrhage-induced upregulation of the 5-HT1B receptor in cerebral arteries in rats. J Neurosurg. 2003, 99 (1): 115-120. 10.3171/jns.2003.99.1.0115.
Article
CAS
PubMed
Google Scholar
Ansar S, Vikman P, Nielsen M, Edvinsson L: Cerebrovascular ETB, 5-HT1B, and AT1 receptor upregulation correlates with reduction in regional CBF after subarachnoid hemorrhage. Am J Physiol Heart Circ Physiol. 2007, 293 (6): H3750-3758. 10.1152/ajpheart.00857.2007.
Article
CAS
PubMed
Google Scholar
Stenman E, Edvinsson L: Cerebral ischemia enhances vascular angiotensin AT1 receptor-mediated contraction in rats. Stroke. 2004, 35 (4): 970-974. 10.1161/01.STR.0000121642.53822.58.
Article
CAS
PubMed
Google Scholar
Stenman E, Malmsjo M, Uddman E, Gido G, Wieloch T, Edvinsson L: Cerebral ischemia upregulates vascular endothelin ET(B) receptors in rat. Stroke. 2002, 33 (9): 2311-2316. 10.1161/01.STR.0000028183.04277.32.
Article
CAS
PubMed
Google Scholar
Ansar S, Larsen C, Maddahi A, Edvinsson L: Subarachnoid hemorrhage induces enhanced expression of thromboxane A2 receptors in rat cerebral arteries. Brain Res. 2010, 1316: 163-172.
Article
CAS
PubMed
Google Scholar
Ansar S, Edvinsson L: Subtype activation and interaction of protein kinase C and mitogen-activated protein kinase controlling receptor expression in cerebral arteries and microvessels after subarachnoid hemorrhage. Stroke. 2008, 39 (1): 185-190. 10.1161/STROKEAHA.107.487827.
Article
CAS
PubMed
Google Scholar
Namura S, Iihara K, Takami S, Nagata I, Kikuchi H, Matsushita K, Moskowitz MA, Bonventre JV, Alessandrini A: Intravenous administration of MEK inhibitor U0126 affords brain protection against forebrain ischemia and focal cerebral ischemia. Proc Natl Acad Sci USA. 2001, 98 (20): 11569-11574. 10.1073/pnas.181213498.
Article
PubMed Central
CAS
PubMed
Google Scholar
Henriksson M, Stenman E, Vikman P, Edvinsson L: MEK1/2 inhibition attenuates vascular ETA and ETB receptor alterations after cerebral ischaemia. Exp Brain Res. 2007, 178 (4): 470-476. 10.1007/s00221-006-0753-7.
Article
CAS
PubMed
Google Scholar
Irving EA, Bamford M: Role of mitogen- and stress-activated kinases in ischemic injury. J Cereb Blood Flow Metab. 2002, 22 (6): 631-647.
Article
CAS
PubMed
Google Scholar
Sandhu H, Ansar S, Edvinsson L: Comparison of MEK/ERK pathway inhibitors on the upregulation of vascular G-protein coupled receptors in rat cerebral arteries. Eur J Pharmacol. 2010, 644 (1–3): 128-137.
Article
CAS
PubMed
Google Scholar
Ansar S, Maddahi A, Edvinsson L: Inhibition of cerebrovascular raf activation attenuates cerebral blood flow and prevents upregulation of contractile receptors after subarachnoid hemorrhage. BMC Neurosci. 2011, 12: 107-10.1186/1471-2202-12-107.
Article
PubMed Central
CAS
PubMed
Google Scholar
Adner M, Cantera L, Ehlert F, Nilsson L, Edvinsson L: Plasticity of contractile endothelin-B receptors in human arteries after organ culture. Br J Pharmacol. 1996, 119 (6): 1159-1166. 10.1111/j.1476-5381.1996.tb16018.x.
Article
PubMed Central
CAS
PubMed
Google Scholar
Henriksson M, Xu CB, Edvinsson L: Importance of ERK1/2 in upregulation of endothelin type B receptors in cerebral arteries. Br J Pharmacol. 2004, 142 (7): 1155-1161. 10.1038/sj.bjp.0705803.
Article
PubMed Central
CAS
PubMed
Google Scholar
Mulvany MJ, Halpern W: Contractile properties of small arterial resistance vessels in spontaneously hypertensive and normotensive rats. Circ Res. 1977, 41 (1): 19-26. 10.1161/01.RES.41.1.19.
Article
CAS
PubMed
Google Scholar
Hogestatt ED, Andersson KE, Edvinsson L: Mechanical properties of rat cerebral arteries as studied by a sensitive device for recording of mechanical activity in isolated small blood vessels. Acta Physiol Scand. 1983, 117 (1): 49-61. 10.1111/j.1748-1716.1983.tb07178.x.
Article
CAS
PubMed
Google Scholar
Hansen-Schwartz J, Nordstrom CH, Edvinsson L: Human endothelin subtype A receptor enhancement during tissue culture via de novo transcription. Neurosurgery. 2002, 50 (1): 127-133. discussion 133-125
PubMed
Google Scholar
Edvinsson LI, Povlsen GK: Vascular plasticity in cerebrovascular disorders. J Cereb Blood Flow Metab. 2011, 31 (7): 1554-1571. 10.1038/jcbfm.2011.70.
Article
PubMed Central
CAS
PubMed
Google Scholar
Povlsen GK, Waldsee R, Ahnstedt H, Kristiansen KA, Johansen FF, Edvinsson L: In vivo experimental stroke and in vitro organ culture induce similar changes in vasoconstrictor receptors and intracellular calcium handling in rat cerebral arteries. Exp Brain Res. 2012, 219 (4): 507-520. 10.1007/s00221-012-3108-6.
Article
CAS
PubMed
Google Scholar
Vikman P, Edvinsson L: Gene expression profiling in the human middle cerebral artery after cerebral ischemia. Eur J Neurol. 2006, 13 (12): 1324-1332. 10.1111/j.1468-1331.2006.01496.x.
Article
CAS
PubMed
Google Scholar
Johansson S, Povlsen GK, Edvinsson L: Expressional changes in cerebrovascular receptors after experimental transient forebrain ischemia. PLoS One. 2012, 7 (7): e41852-10.1371/journal.pone.0041852.
Article
PubMed Central
CAS
PubMed
Google Scholar
Prehn JH, Welsch M, Backhauss C, Nuglisch J, Ausmeier F, Karkoutly C, Krieglstein J: Effects of serotonergic drugs in experimental brain ischemia: evidence for a protective role of serotonin in cerebral ischemia. Brain Res. 1993, 630 (1–2): 10-20.
Article
CAS
PubMed
Google Scholar
Guilbert F, Lainee P, Dubreuil B, McCort G, O'Connor SE, Janiak P, Herbert JM: Serotonin aggravates exercise-induced cardiac ischemia in the dog: effect of serotonin receptor antagonists. Eur J Pharmacol. 2004, 497 (1): 55-63. 10.1016/j.ejphar.2004.06.024.
Article
CAS
PubMed
Google Scholar
Maddahi A, Edvinsson L: Enhanced expressions of microvascular smooth muscle receptors after focal cerebral ischemia occur via the MAPK MEK/ERK pathway. BMC Neurosci. 2008, 9: 85-10.1186/1471-2202-9-85.
Article
PubMed Central
PubMed
Google Scholar
Zubkov AY, Nanda A, Zhang JH: Signal transduction pathways in cerebral vasospasm. Pathophysiology. 2003, 9 (2): 47-61. 10.1016/S0928-4680(02)00055-X.
Article
CAS
PubMed
Google Scholar
Vajkoczy P, Meyer B, Weidauer S, Raabe A, Thome C, Ringel F, Breu V, Schmiedek P: Clazosentan (AXV-034343), a selective endothelin A receptor antagonist, in the prevention of cerebral vasospasm following severe aneurysmal subarachnoid hemorrhage: results of a randomized, double-blind, placebo-controlled, multicenter phase IIa study. J Neurosurg. 2005, 103 (1): 9-17. 10.3171/jns.2005.103.1.0009.
Article
CAS
PubMed
Google Scholar