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Figure 5 | BMC Neuroscience

Figure 5

From: MAPK signaling pathway regulates cerebrovascular receptor expression in human cerebral arteries

Figure 5

A. Concentration response curves elicited by cumulative application of 5-CT in human cerebral arteries incubated for 48 h, human cerebral arteries incubated for 48 h with the MEK1/2 inhibitor U0126 (5 μM) and control human arteries. Data are expressed as mean ± s.e.m. B. Sections from the human cerebral artery showing 5-HT1B receptor immunoreactivity in the smooth muscle cell layer. C. Expression of 5-HT1B protein levels in human cerebral arteries incubated for 48 h with or without the MEK1/2 inhibitor U0126 (5 μM) and control human arteries. Data are expressed as percentage of fresh and given as mean ± s.e.m. *P<0.05, ** P<0.01.

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