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Table 1 Contractile effects of ET-1, U46619, Ang II and 5-CT in human cerebral arteries

From: MAPK signaling pathway regulates cerebrovascular receptor expression in human cerebral arteries

 

N

K+mean ± s.e.m

Emax(%) ± s.e.m

pEC50± s.e.m

ET-1

    

Control

6

6.76 ± 1.32

107 ± 12a

7.20 ± 0.89

Organ Culture

6

4.37 ± 1.21

143 ± 22 a,b

8.74 ± 0.25

Organ Culture + U0126

7

3.53 ± 0,90

57 ± 8 b

8.49 ± 0,10

U46619

    

Control

7

8.26 ± 1.98

102 ± 15a

7.35 ± 0.74

Organ Culture

7

5.10 ± 1.60

141 ± 11a,b

7.18 ± 0.18

Organ Culture + U0126

4

3.65 ± 1.89

76 ± 40b

6.64 ± 0.10

Ang II

    

Control

6

1.67 ± 0.54

12 ± 2a

 

Organ Culture

5

4.44 ± 1.92

43 ± 12a,b

9.15 ± 0.82

Organ Culture + U0126

4

4.46 ± 2.41

1 ± 1b

9.05 ± 1.13

5-CT

    

Control

6

6.76 ± 1.36

50 ± 8

7.45 ± 0.66

Organ Culture

4

3.90 ± 1.59

17 ± 5b

7.35 ± 1.21

Organ Culture + U0126

7

3.53 ± 0.90

2 ± 1b

7.38 ± 0.73

  1. Responses were characterized by Emax values, expressed as percent of 63 mM K+ -induced contraction, and pEC50 values (negative logarithm of the molar concentration that produces half maximum contraction). Values are represented as mean ± s.e.m and n represents number of patients. a = significant difference between organ culture and control groups, b = significant difference between organ culture and organ culture treated with U0126.