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  1. Numerous studies have investigated the neural underpinnings of passive and active deviance and target detection in the well-known auditory oddball paradigm by means of event-related potentials (ERPs) or functiona...

    Authors: Christoph Justen and Cornelia Herbert
    Citation: BMC Neuroscience 2018 19:25
  2. Stroke is among the leading causes of death and disability. Although intense research efforts have provided promising treatment options in animals, most clinical trials in humans have failed and the therapeuti...

    Authors: Edvin Ingberg, Hua Dock, Elvar Theodorsson, Annette Theodorsson and Jakob O. Ström
    Citation: BMC Neuroscience 2018 19:24
  3. APOE ε4 allele is most common genetic risk factor for Alzheimer’s disease (AD) and cognitive decline. However, it remains poorly understood why only some carriers of APOE ε4 develop AD and how ethnic variabilitie...

    Authors: Vladimir N. Babenko, Dmitry A. Afonnikov, Elena V. Ignatieva, Anton V. Klimov, Fedor E. Gusev and Evgeny I. Rogaev
    Citation: BMC Neuroscience 2018 19(Suppl 1):16

    This article is part of a Supplement: Volume 19 Supplement 1

  4. Optogenetics has become widely recognized for its success in real-time control of brain neurons by utilizing non-mammalian photosensitive proteins to open or close membrane channels. Here we review a less well...

    Authors: Oksana Polesskaya, Ancha Baranova, Sarah Bui, Nikolai Kondratev, Evgeniya Kananykhina, Olga Nazarenko, Tatyana Shapiro, Frances Barg Nardia, Vladimir Kornienko, Vikas Chandhoke, Istvan Stadler, Raymond Lanzafame and Max Myakishev-Rempel
    Citation: BMC Neuroscience 2018 19(Suppl 1):12

    This article is part of a Supplement: Volume 19 Supplement 1

  5. Apoptotic changes after cerebral hemorrhage in brain samples of humans have been found. Caspase-cleaved cytokeratin (CCCK)-18 could be detected in the bloodstream during apoptosis. Higher circulating CCCK-18 l...

    Authors: Leonardo Lorente, María M. Martín, Antonia Pérez-Cejas, Luis Ramos, Mónica Argueso, Jordi Solé-Violán, Juan J. Cáceres, Alejandro Jiménez and Victor García-Marín
    Citation: BMC Neuroscience 2018 19:23
  6. Cerebrovascular reactivity (CVR) refers to the responsiveness of cerebral vasculature to vasoactive stimuli. CVR is an indicator of brain health and can be assessed using vasodilatory techniques and magnetic r...

    Authors: Sarah J. Catchlove, Andrew Pipingas, Matthew E. Hughes and Helen Macpherson
    Citation: BMC Neuroscience 2018 19:21
  7. Stroke is a leading cause of death and disability worldwide, yet there are limited treatments available. Intranasal administration is a novel non-invasive strategy to deliver cell therapy into the brain. Cell...

    Authors: Monica J. Chau, Todd C. Deveau, Xiaohuan Gu, Yo Sup Kim, Yun Xu, Shan Ping Yu and Ling Wei
    Citation: BMC Neuroscience 2018 19:20
  8. Autonomic nervous system (ANS) activity has been shown to vary with the state of brain arousal. In a previous study, this association of ANS activity with distinct states of brain arousal was demonstrated usin...

    Authors: Jue Huang, Christine Ulke, Christian Sander, Philippe Jawinski, Janek Spada, Ulrich Hegerl and Tilman Hensch
    Citation: BMC Neuroscience 2018 19:18
  9. Accumulation of the α-synuclein (α-syn) protein is a hallmark of a group of brain disorders collectively known as synucleinopathies. The mechanisms responsible for α-syn accumulation are not well understood. S...

    Authors: Jared Schommer, Gurdeep Marwarha, Trevor Schommer, Travis Flick, Jonah Lund and Othman Ghribi
    Citation: BMC Neuroscience 2018 19:17
  10. Chronic opioid therapy for non-malignant pain conditions has significantly increased over the last 15 years. Recently, the correlation between opioid analgesics and alternations in brain structure, such as leu...

    Authors: Ruping Fan, Lisa M. Schrott, Thomas Arnold, Stephen Snelling, Meghana Rao, Derrel Graham, Angela Cornelius and Nadejda L. Korneeva
    Citation: BMC Neuroscience 2018 19:15
  11. Amyotrophic lateral sclerosis (ALS) is a clinically and histopathologically heterogeneous neurodegenerative disorder, in which therapy is hindered by the rapid progression of disease and lack of biomarkers. Ma...

    Authors: Menuka Pallebage-Gamarallage, Sean Foxley, Ricarda A. L. Menke, Istvan N. Huszar, Mark Jenkinson, Benjamin C. Tendler, Chaoyue Wang, Saad Jbabdi, Martin R. Turner, Karla L. Miller and Olaf Ansorge
    Citation: BMC Neuroscience 2018 19:11
  12. Sleep deprivation impairs learning, causes stress, and can lead to death. Notch and JNK-1 pathways impact C. elegans sleep in complex ways; these have been hypothesized to involve compensatory sleep. C. elegans D...

    Authors: Heather L. Bennett, Yulia Khoruzhik, Dustin Hayden, Huiyan Huang, Jarred Sanders, Melissa B. Walsh, David Biron and Anne C. Hart
    Citation: BMC Neuroscience 2018 19:10
  13. Labor subjects the fetus to an hypoxic episode and concomitant adrenomodullary catecholamine surge that may provide protection against the hypoxic insult. The beta1-adrenergic agonist dobutamine protects again...

    Authors: Tina Markus, David Ley, Stefan R. Hansson, Tadeusz Wieloch and Karsten Ruscher
    Citation: BMC Neuroscience 2018 19:9
  14. Quantification of axon regeneration in spinal cord tissue sections is a fundamental step to adequately determine if an applied treatment leads to an anatomical benefit following spinal cord injury. Recent adva...

    Authors: Akash Patel, Zhongzhi Li, Philip Canete, Hans Strobl, Jennifer Dulin, Ken Kadoya, Dan Gibbs and Gunnar H. D. Poplawski
    Citation: BMC Neuroscience 2018 19:8
  15. Understanding the process of relapse to abused drugs and ultimately developing treatments that can reduce the incidence of relapse remains the primary goal for the study of substance dependence. Therefore, exp...

    Authors: Tingting Ning, Changlong Leng, Lin Chen, Baomiao Ma and Xiaokang Gong
    Citation: BMC Neuroscience 2018 19:4
  16. Neuroinflammation and the presence of amyloid beta protein (Aβ) and neurofibrillary tangles are key pathologies in Alzheimer’s disease (AD). As a potent anti-amyloid and anti-inflammatory natural polyphenol, c...

    Authors: Panchanan Maiti, Leela Paladugu and Gary L. Dunbar
    Citation: BMC Neuroscience 2018 19:7
  17. Brain pericytes ensheathe the endothelium and contribute to formation and maintenance of the blood–brain-barrier. Additionally, pericytes are involved in several aspects of the CNS immune response including sc...

    Authors: Justin Rustenhoven, Leon C. Smyth, Deidre Jansson, Patrick Schweder, Miranda Aalderink, Emma L. Scotter, Edward W. Mee, Richard L. M. Faull, Thomas I.-H. Park and Mike Dragunow
    Citation: BMC Neuroscience 2018 19:6
  18. The recent Zika virus (ZIKV) outbreak has linked ZIKV with microcephaly and other central nervous system pathologies in humans. Astrocytes are among the first cells to respond to ZIKV infection in the brain an...

    Authors: Michal Stefanik, Petra Formanova, Tomas Bily, Marie Vancova, Ludek Eyer, Martin Palus, Jiri Salat, Carla Torres Braconi, Paolo M. de A. Zanotto, Ernest A. Gould and Daniel Ruzek
    Citation: BMC Neuroscience 2018 19:5
  19. Real-time reverse transcription quantitative polymerase chain reaction (RT-qPCR) is a critical tool for evaluating the levels of mRNA transcribed from genes. Reliable RT-qPCR results largely depend on normaliz...

    Authors: Yingbo Kang, Zhuomin Wu, De Cai and Binger Lu
    Citation: BMC Neuroscience 2018 19:3
  20. Alzheimer’s disease (AD) is characterized by the deposition of amyloid-β (Aβ) in brain parenchyma and cerebral blood vessels as cerebral amyloid angiopathy (CAA). Clusterin, a chaperon protein associated with ...

    Authors: Xue-Mei Qi, Cheng Wang, Xing-Kun Chu, Gen Li and Jian-Fang Ma
    Citation: BMC Neuroscience 2018 19:2
  21. Activated microglia interact with astrocytes and neuronal cells to induce neuroinflammation, which can contribute to the pathogenesis and progression of Alzheimer’s and Parkinson’s disease. To identify the mos...

    Authors: Lalita Subedi, Oh Wook Kwon, Chaeho Pak, Goeun Lee, Kangwoo Lee, Hakwon Kim and Sun Yeou Kim
    Citation: BMC Neuroscience 2017 18:82
  22. Obesity induced brain inflammation is associated with cognitive disorders. We aimed to investigate the influence of vitamin D on hypothalamus and hippocampus inflammatory response in high-fat diet induced obes...

    Authors: Mahdieh Abbasalizad Farhangi, Mehran Mesgari-Abbasi, Ghazaleh Nameni, Ghazaleh Hajiluian and Parviz Shahabi
    Citation: BMC Neuroscience 2017 18:81
  23. Binocular disparity provides a powerful cue for depth perception in a stereoscopic environment. Despite increasing knowledge of the cortical areas that process disparity from neuroimaging studies, the neural m...

    Authors: Yuan Li, Chuncheng Zhang, Chunping Hou, Li Yao, Jiacai Zhang and Zhiying Long
    Citation: BMC Neuroscience 2017 18:80
  24. The hippocampus is a functionally heterogeneous brain structure and specializations of the intrinsic neuronal network may crucially support the functional segregation along the longitudinal axis of the hippoca...

    Authors: Vassilios Papaleonidopoulos, George Trompoukis, Andriana Koutsoumpa and Costas Papatheodoropoulos
    Citation: BMC Neuroscience 2017 18:79
  25. The formation of visuotopically-aligned projections in the brain is required for the generation of functional binocular circuits. The mechanisms which underlie this process are unknown. Ten-m3 is expressed in...

    Authors: Kelly A. Glendining, Sam C. Liu, Marvin Nguyen, Nuwan Dharmaratne, Rajini Nagarajah, Miguel A. Iglesias, Atomu Sawatari and Catherine A. Leamey
    Citation: BMC Neuroscience 2017 18:78
  26. PDE4 cyclic nucleotide phosphodiesterases regulate 3′, 5′ cAMP abundance in the CNS and thereby regulate PKA activity and phosphorylation of CREB, which has been implicated in learning and memory, depression a...

    Authors: Susan L. Campbell, Thomas van Groen, Inga Kadish, Lisa High Mitchell Smoot and Graeme B. Bolger
    Citation: BMC Neuroscience 2017 18:77
  27. In the mammalian superior olivary complex (SOC), synaptic inhibition contributes to the processing of binaural sound cues important for sound localization. Previous analyses demonstrated a tonotopic gradient f...

    Authors: Lena Ebbers, Maren Weber and Hans Gerd Nothwang
    Citation: BMC Neuroscience 2017 18:75
  28. In-vivo observations of neural processes during human aggressive behavior are difficult to obtain, limiting the number of studies in this area. To address this gap, the present study implemented a social react...

    Authors: Jonathan Repple, Christina M. Pawliczek, Bianca Voss, Steven Siegel, Frank Schneider, Nils Kohn and Ute Habel
    Citation: BMC Neuroscience 2017 18:73
  29. Intracellular calcium is an important ion involved in the regulation and modulation of many neuronal functions. From regulating cell cycle and proliferation to initiating signaling cascades and regulating pres...

    Authors: Elena Artimovich, Russell K. Jackson, Michaela B. C. Kilander, Yu-Chih Lin and Michael W. Nestor
    Citation: BMC Neuroscience 2017 18:72
  30. A sensitive, rapid and selective UHPLC–MS/MS method has been developed and validated for the quantification of Nicotine (NT) and Cotinine (CN) using Continine-d 3 as internal standard (...

    Authors: Mohammad A. Kaisar, Raja Reddy Kallem, Ravi K. Sajja, Ali Ehsan Sifat and Luca Cucullo
    Citation: BMC Neuroscience 2017 18:71
  31. Alzheimer’s disease is characterized by the accumulation of amyloid beta (Aβ) and the formation of neurofibrillary tangles. Aβ is the main constituent of senile plaques and is largely involved in neuronal deat...

    Authors: Yuqin Zhang, Changchun Chen, Yanliu Jiang, Shupei Wang, Xiaoyu Wu and Kai Wang
    Citation: BMC Neuroscience 2017 18:69
  32. Metabolic syndrome (MetS) is associated with an increased risk of cerebrovascular diseases, including cerebral ischemia. Microvascular dysfunction is an important feature underlying the pathophysiology of cere...

    Authors: Nathalie Obadia, Marcos Adriano Lessa, Anissa Daliry, Raquel Rangel Silvares, Fabiana Gomes, Eduardo Tibiriçá and Vanessa Estato
    Citation: BMC Neuroscience 2017 18:67
  33. The Na+/K+-ATPases are transmembrane ion pumps important for maintenance of ion gradients across the plasma membrane that serve to support multiple cellular functions, such as membrane potentials, regulation of c...

    Authors: Ditte Gry Ellman, Toke Jost Isaksen, Minna Christiansen Lund, Safinaz Dursun, Martin Wirenfeldt, Louise Helskov Jørgensen, Karin Lykke-Hartmann and Kate Lykke Lambertsen
    Citation: BMC Neuroscience 2017 18:66
  34. Most studies of brain structure and function, and their relationships to cognitive ability, have relied on inter-individual variability in magnetic resonance (MR) images. Intra-individual variability is often ign...

    Authors: Elisa Filevich, Nina Lisofsky, Maxi Becker, Oisin Butler, Martyna Lochstet, Johan Martensson, Elisabeth Wenger, Ulman Lindenberger and Simone Kühn
    Citation: BMC Neuroscience 2017 18:65
  35. Authors: Adam J. H. Newton, Alexandra H. Seidenstein, Robert A. McDougal, Alberto Pérez-Cervera, Gemma Huguet, Tere M-Seara, Caroline Haimerl, David Angulo-Garcia, Alessandro Torcini, Rosa Cossart, Arnaud Malvache, Kaoutar Skiker, Mounir Maouene, Gianmarco Ragognetti, Letizia Lorusso, Andrea Viggiano…
    Citation: BMC Neuroscience 2017 18(Suppl 1):60

    This article is part of a Supplement: Volume 18 Supplement 1

  36. Authors: Leonid L. Rubchinsky, Sungwoo Ahn, Wouter Klijn, Ben Cumming, Stuart Yates, Vasileios Karakasis, Alexander Peyser, Marmaduke Woodman, Sandra Diaz-Pier, James Deraeve, Eliana Vassena, William Alexander, David Beeman, Pawel Kudela, Dana Boatman-Reich, William S. Anderson…
    Citation: BMC Neuroscience 2017 18(Suppl 1):59

    This article is part of a Supplement: Volume 18 Supplement 1

  37. Authors: Sue Denham, Panayiota Poirazi, Erik De Schutter, Karl Friston, Ho Ka Chan, Thomas Nowotny, Dongqi Han, Sungho Hong, Sophie Rosay, Tanja Wernle, Alessandro Treves, Sarah Goethals, Romain Brette, Tomas Van Pottelbergh, Rodolphe Sepulchre, Alex D. Bird…
    Citation: BMC Neuroscience 2017 18(Suppl 1):58

    This article is part of a Supplement: Volume 18 Supplement 1

  38. Hair cell loss in the cochlea is caused by ototoxic drugs, aging, and environmental stresses and could potentially lead to devastating pathophysiological effects. In adult mammals, hair cell loss is irreversib...

    Authors: Takahiro Wakasaki, Hiroaki Niiro, Siamak Jabbarzadeh-Tabrizi, Mitsuru Ohashi, Takashi Kimitsuki, Takashi Nakagawa, Shizuo Komune and Koichi Akashi
    Citation: BMC Neuroscience 2017 18:64
  39. In Duchenne muscular dystrophy (DMD), the loss of the dystrophin component of the dystrophin-glycoprotein complex (DGC) compromises plasma membrane integrity in skeletal muscle, resulting in extensive muscle d...

    Authors: Azeez Aranmolate, Nathaniel Tse and Holly Colognato
    Citation: BMC Neuroscience 2017 18:63
  40. Following partial injury to the central nervous system, cells beyond the initial injury site undergo secondary degeneration, exacerbating loss of neurons, compact myelin and function. Changes in Ca2+ flux are ass...

    Authors: Ryan L. O’Hare Doig, Wissam Chiha, Marcus K. Giacci, Nathanael J. Yates, Carole A. Bartlett, Nicole M. Smith, Stuart I. Hodgetts, Alan R. Harvey and Melinda Fitzgerald
    Citation: BMC Neuroscience 2017 18:62
  41. CLCA is a family of metalloproteases that regulate Ca2+-activated Cl fluxes in epithelial tissues. In HEK293 cells, CLCA1 promotes membrane expression of an endogenous Anoctamin 1 (ANO1, also termed TMEM16A)-dep...

    Authors: Casilda V. Mura, Ricardo Delgado, María Graciela Delgado, Diego Restrepo and Juan Bacigalupo
    Citation: BMC Neuroscience 2017 18:61
  42. Sesamin is a well-known antioxidant extracted from sesame seeds that exhibits various curative effects. The present study investigated whether sesamin would protect neuroblastoma SH-SY5Y cells against mechanic...

    Authors: Zhiming Xu, Yingliang Liu, Dianxu Yang, Fang Yuan, Jun Ding, Hao Chen and Hengli Tian
    Citation: BMC Neuroscience 2017 18:57
  43. The identification of biomarkers that predict susceptibility to major depressive disorder and treatment response to antidepressants is a major challenge. Vortioxetine is a novel multimodal antidepressant that ...

    Authors: Jessica A. Waller, Sara Holm Nygaard, Yan Li, Kristian Gaarn du Jardin, Joseph A. Tamm, Aicha Abdourahman, Betina Elfving, Alan L. Pehrson, Connie Sánchez and Rasmus Wernersson
    Citation: BMC Neuroscience 2017 18:56
  44. CRISPR/Cas9 system is a powerful method to investigate the role of genes by introducing a mutation selectively and efficiently to specific genome positions in cell and animal lines. However, in primary neuron...

    Authors: Hiroto Tsunematsu, Akiko Uyeda, Nobuhiko Yamamoto and Noriyuki Sugo
    Citation: BMC Neuroscience 2017 18:55

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