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The transmembrane presenilin (PSEN) proteins, PSEN1 and PSEN2, have been proposed to be the catalytic components of the γ-secretase protein complex, which is an intramembranous multimeric protease involved in ...
Previous studies have demonstrated that neonatal manipulation of oxytocin (OT) has effects on the expression of estrogen receptor α (ERα) and the central production of oxytocin observed in juveniles (at weanin...
Objects in our environment are often partly occluded, yet we effortlessly perceive them as whole and complete. This phenomenon is called visual amodal completion. Psychophysical investigations suggest that the...
In absence epilepsy, the neuronal hyper-excitation and hyper-synchronization, which induce spike and wave discharges in a cortico-thalamic loop are suspected to be due to an imbalance between GABA and glutamat...
Decision-making is a fundamental capacity which is crucial to many higher-order psychological functions. We recorded event-related potentials (ERPs) during a visual target-identification task that required go-...
Many studies have shown that mitochondrial dysfunction, complex I inhibition in particular, is involved in the pathogenesis of Parkinson's disease (PD). Rotenone, a specific inhibitor of mitochondrial complex ...
Visual, oculomotor, and – recently – cognitive functions of the superior colliculi (SC) have been documented in detail in non-human primates in the past. Evidence for corresponding functions of the SC in human...
Drosophila flies explore the environment very efficiently in order to colonize it. They explore collectively, not individually, so that when a few land on a food spot, they attract the others by signs. This behav...
The nasal cavity of all vertebrates houses multiple chemosensors, either innervated by the Ist (olfactory) or the Vth (trigeminal) cranial nerve. Various types of receptor cells are present, either segregated ...
The analysis of the role of genes in important brain functions like learning, memory and synaptic plasticity requires gene inactivation at the adult stage to exclude developmental effects, adaptive changes or ...
Sensory input is crucial to the initiation and modulation of swallowing. From a clinical point of view, oropharyngeal sensory deficits have been shown to be an important cause of dysphagia and aspiration in st...
Many commonly used chemotherapeutic agents, such as Cisplatin, are restricted in their potential anti-neoplastic effectiveness by their side effects, with one of the most problematic being induction of periphe...
Many sedative agents, including anesthetics, produce explicit memory impairment by largely unknown mechanisms. Sharp-wave ripple (SPW-R) complexes are network activity thought to represent the neuronal substra...
During the development of the Drosophila central nervous system the process of midline crossing is orchestrated by a number of guidance receptors and ligands. Many key axon guidance molecules have been identif...
Repeated execution of a tactile task enhances task performance. In the present study we sought to improve tactile performance with unattended activation-based learning processes (i.e., focused stimulation of d...
In hippocampal neurons, nuclear calcium signaling is important for learning- and neuronal survival-associated gene expression. However, it is unknown whether calcium signals generated by neuronal activity at t...
Sodium channel (NaCh) expressions change following nerve and inflammatory lesions and this change may contribute to the activation of pain pathways. In a previous study we found a dramatic increase in the size...
The involvement of different NMDA receptor (NMDAR) subunits has been implicated in several forms of synaptic plasticity. However, it is still controversial to what extent the involvement is specific, and littl...
Long-term use of non-steroidal anti-inflammatory drugs (NSAIDs) is associated with a reduced incidence of Alzheimer's disease (AD). We and others have shown that certain NSAIDs reduce secretion of Aβ42 in cell...
Extracellular signal-regulated kinase (ERK), one member of the mitogen-activated protein kinase (MAPK) family, has been suggested to regulate a diverse array of cellular functions, including cell growth, diffe...
The present study used event-related brain potentials to investigate semantic, phonological and syntactic processes in adult German dyslexic and normal readers in a word reading task. Pairs of German words wer...
The peptide CART is widely expressed in central and peripheral neurons, as well as in endocrine cells. Known peripheral sites of expression include the gastrointestinal (GI) tract, the pancreas, and the adrena...
Duchenne musclar dystrophy (DMD) is an X-linked recessive disease caused by mutations of dystrophin gene, there is no effective treatment for this disorder at present. Plasmid-mediated gene therapy is a promis...
This article is part of a Supplement: Volume 8 Supplement 2
This article is part of a Supplement: Volume 8 Supplement 2
This article is part of a Supplement: Volume 8 Supplement 2
This article is part of a Supplement: Volume 8 Supplement 2
This article is part of a Supplement: Volume 8 Supplement 2
This article is part of a Supplement: Volume 8 Supplement 2
This article is part of a Supplement: Volume 8 Supplement 2
This article is part of a Supplement: Volume 8 Supplement 2
This article is part of a Supplement: Volume 8 Supplement 2
This article is part of a Supplement: Volume 8 Supplement 2
This article is part of a Supplement: Volume 8 Supplement 2
This article is part of a Supplement: Volume 8 Supplement 2
This article is part of a Supplement: Volume 8 Supplement 2
This article is part of a Supplement: Volume 8 Supplement 2
This article is part of a Supplement: Volume 8 Supplement 2
This article is part of a Supplement: Volume 8 Supplement 2
This article is part of a Supplement: Volume 8 Supplement 2
This article is part of a Supplement: Volume 8 Supplement 2
This article is part of a Supplement: Volume 8 Supplement 2
This article is part of a Supplement: Volume 8 Supplement 2
This article is part of a Supplement: Volume 8 Supplement 2
This article is part of a Supplement: Volume 8 Supplement 2
This article is part of a Supplement: Volume 8 Supplement 2
This article is part of a Supplement: Volume 8 Supplement 2
This article is part of a Supplement: Volume 8 Supplement 2
This article is part of a Supplement: Volume 8 Supplement 2
This article is part of a Supplement: Volume 8 Supplement 2
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