Goedert M: Parkinson’s disease and other alpha-synucleinopathies. Clin Chem Lab Med. 2001, 39: 308-312.
Article
CAS
PubMed
Google Scholar
Ibanez P, Bonnet AM, Debarges B, Lohmann E, Tison F, Pollak P, Agid Y, Durr A, Brice A: Causal relation between alpha-synuclein gene duplication and familial Parkinson’s disease. Lancet. 2004, 364: 1169-1171. 10.1016/S0140-6736(04)17104-3.
Article
CAS
PubMed
Google Scholar
Chartier-Harlin MC, Kachergus J, Roumier C, Mouroux V, Douay X, Lincoln S, Levecque C, Larvor L, Andrieux J, Hulihan M, et al: Alpha-synuclein locus duplication as a cause of familial Parkinson’s disease. Lancet. 2004, 364: 1167-1169. 10.1016/S0140-6736(04)17103-1.
Article
CAS
PubMed
Google Scholar
Singleton AB, Farrer M, Johnson J, Singleton A, Hague S, Kachergus J, Hulihan M, Peuralinna T, Dutra A, Nussbaum R, et al: alpha-Synuclein locus triplication causes Parkinson’s disease. Science. 2003, 302: 841-10.1126/science.1090278.
Article
CAS
PubMed
Google Scholar
Masliah E, Rockenstein E, Veinbergs I, Mallory M, Hashimoto M, Takeda A, Sagara Y, Sisk A, Mucke L: Dopaminergic loss and inclusion body formation in alpha-synuclein mice: implications for neurodegenerative disorders. Science. 2000, 287: 1265-1269. 10.1126/science.287.5456.1265.
Article
CAS
PubMed
Google Scholar
Rockenstein E, Mallory M, Hashimoto M, Song D, Shults CW, Lang I, Masliah E: Differential neuropathological alterations in transgenic mice expressing alpha-synuclein from the platelet-derived growth factor and Thy-1 promoters. J Neurosci Res. 2002, 68: 568-578. 10.1002/jnr.10231.
Article
CAS
PubMed
Google Scholar
Hashimoto M, Rockenstein E, Masliah E: Transgenic models of alpha-synuclein pathology: past, present, and future. Ann N Y Acad Sci. 2003, 991: 171-188.
Article
CAS
PubMed
Google Scholar
Shults CW, Rockenstein E, Crews L, Adame A, Mante M, Larrea G, Hashimoto M, Song D, Iwatsubo T, Tsuboi K, et al: Neurological and neurodegenerative alterations in a transgenic mouse model expressing human alpha-synuclein under oligodendrocyte promoter: implications for multiple system atrophy. J Neurosci. 2005, 25: 10689-10699. 10.1523/JNEUROSCI.3527-05.2005.
Article
CAS
PubMed
Google Scholar
Yamakado H, Moriwaki Y, Yamasaki N, Miyakawa T, Kurisu J, Uemura K, Inoue H, Takahashi M, Takahashi R: alpha-Synuclein BAC transgenic mice as a model for Parkinson’s disease manifested decreased anxiety-like behavior and hyperlocomotion. Neurosci Res. 2012, 73: 173-177. 10.1016/j.neures.2012.03.010.
Article
CAS
PubMed
Google Scholar
Rieker C, Dev KK, Lehnhoff K, Barbieri S, Ksiazek I, Kauffmann S, Danner S, Schell H, Boden C, Ruegg MA, et al: Neuropathology in mice expressing mouse alpha-synuclein. PLoS One. 2011, 6: e24834-10.1371/journal.pone.0024834.
Article
PubMed Central
CAS
PubMed
Google Scholar
Nuber S, Petrasch-Parwez E, Winner B, Winkler J, von Horsten S, Schmidt T, Boy J, Kuhn M, Nguyen HP, Teismann P, et al: Neurodegeneration and motor dysfunction in a conditional model of Parkinson’s disease. J Neurosci. 2008, 28: 2471-2484. 10.1523/JNEUROSCI.3040-07.2008.
Article
CAS
PubMed
Google Scholar
Richfield EK, Thiruchelvam MJ, Cory-Slechta DA, Wuertzer C, Gainetdinov RR, Caron MG, Di Monte DA, Federoff HJ: Behavioral and neurochemical effects of wild-type and mutated human alpha-synuclein in transgenic mice. Exp Neurol. 2002, 175: 35-48. 10.1006/exnr.2002.7882.
Article
CAS
PubMed
Google Scholar
Morris R: Thy-1 in developing nervous tissue. Dev Neurosci. 1985, 7: 133-160. 10.1159/000112283.
Article
CAS
PubMed
Google Scholar
Crews L, Spencer B, Desplats P, Patrick C, Paulino A, Rockenstein E, Hansen L, Adame A, Galasko D, Masliah E: Selective molecular alterations in the autophagy pathway in patients with Lewy body disease and in models of alpha-synucleinopathy. PLoS One. 2010, 5: e9313-10.1371/journal.pone.0009313.
Article
PubMed Central
PubMed
Google Scholar
Price DL, Rockenstein E, Ubhi K, Phung V, MacLean-Lewis N, Askay D, Cartier A, Spencer B, Patrick C, Desplats P, et al: Alterations in mGluR5 expression and signaling in Lewy body disease and in transgenic models of alpha-synucleinopathy–implications for excitotoxicity. PLoS One. 2010, 5: e14020-10.1371/journal.pone.0014020.
Article
PubMed Central
PubMed
Google Scholar
Dufty BM, Warner LR, Hou ST, Jiang SX, Gomez-Isla T, Leenhouts KM, Oxford JT, Feany MB, Masliah E, Rohn TT: Calpain-cleavage of alpha-synuclein: connecting proteolytic processing to disease-linked aggregation. Am J Pathol. 2007, 170: 1725-1738. 10.2353/ajpath.2007.061232.
Article
PubMed Central
CAS
PubMed
Google Scholar
Spencer B, Potkar R, Trejo M, Rockenstein E, Patrick C, Gindi R, Adame A, Wyss-Coray T, Masliah E: Beclin 1 gene transfer activates autophagy and ameliorates the neurodegenerative pathology in alpha-synuclein models of Parkinson’s and Lewy body diseases. J Neurosci. 2009, 29: 13578-13588. 10.1523/JNEUROSCI.4390-09.2009.
Article
PubMed Central
CAS
PubMed
Google Scholar
Spencer B, Michael S, Shen J, Kosberg K, Rockenstein E, Patrick C, Adame A, Masliah E: Lentivirus Mediated Delivery of Neurosin Promotes Clearance of Wild-type alpha-Synuclein and Reduces the Pathology in an alpha-Synuclein Model of LBD. Mol Ther. 2012
Google Scholar
Yacoubian TA, Slone SR, Harrington AJ, Hamamichi S, Schieltz JM, Caldwell KA, Caldwell GA, Standaert DG: Differential neuroprotective effects of 14-3-3 proteins in models of Parkinson’s disease. Cell Death Dis. 2010, 1: e2-10.1038/cddis.2009.4.
Article
PubMed Central
CAS
PubMed
Google Scholar
Clark J, Clore EL, Zheng K, Adame A, Masliah E, Simon DK: Oral N-acetyl-cysteine attenuates loss of dopaminergic terminals in alpha-synuclein overexpressing mice. PLoS One. 2010, 5: e12333-10.1371/journal.pone.0012333.
Article
PubMed Central
PubMed
Google Scholar
Koob AO, Ubhi K, Paulsson JF, Kelly J, Rockenstein E, Mante M, Adame A, Masliah E: Lovastatin ameliorates alpha-synuclein accumulation and oxidation in transgenic mouse models of alpha-synucleinopathies. Exp Neurol. 2010, 221: 267-274. 10.1016/j.expneurol.2009.11.015.
Article
PubMed Central
CAS
PubMed
Google Scholar
Masliah E, Rockenstein E, Mante M, Crews L, Spencer B, Adame A, Patrick C, Trejo M, Ubhi K, Rohn TT, et al: Passive immunization reduces behavioral and neuropathological deficits in an alpha-synuclein transgenic model of Lewy body disease. PLoS One. 2011, 6: e19338-10.1371/journal.pone.0019338.
Article
PubMed Central
CAS
PubMed
Google Scholar
Abeliovich A, Schmitz Y, Farinas I, Choi-Lundberg D, Ho WH, Castillo PE, Shinsky N, Verdugo JM, Armanini M, Ryan A, et al: Mice lacking alpha-synuclein display functional deficits in the nigrostriatal dopamine system. Neuron. 2000, 25: 239-252. 10.1016/S0896-6273(00)80886-7.
Article
CAS
PubMed
Google Scholar
Maroteaux L, Campanelli JT, Scheller RH: Synuclein: a neuron-specific protein localized to the nucleus and presynaptic nerve terminal. J Neurosci. 1988, 8: 2804-2815.
CAS
PubMed
Google Scholar
Anderson JP, Walker DE, Goldstein JM, de Laat R, Banducci K, Caccavello RJ, Barbour R, Huang J, Kling K, Lee M, et al: Phosphorylation of Ser-129 is the dominant pathological modification of alpha-synuclein in familial and sporadic Lewy body disease. J Biol Chem. 2006, 281: 29739-29752. 10.1074/jbc.M600933200.
Article
CAS
PubMed
Google Scholar
Chen L, Feany MB: Alpha-synuclein phosphorylation controls neurotoxicity and inclusion formation in a Drosophila model of Parkinson disease. Nat Neurosci. 2005, 8: 657-663. 10.1038/nn1443.
Article
CAS
PubMed
Google Scholar
Paleologou KE, Oueslati A, Shakked G, Rospigliosi CC, Kim HY, Lamberto GR, Fernandez CO, Schmid A, Chegini F, Gai WP, et al: Phosphorylation at S87 is enhanced in synucleinopathies, inhibits alpha-synuclein oligomerization, and influences synuclein-membrane interactions. J Neurosci. 2010, 30: 3184-3198. 10.1523/JNEUROSCI.5922-09.2010.
Article
PubMed Central
CAS
PubMed
Google Scholar
Jinno S, Aika Y, Fukuda T, Kosaka T: Quantitative analysis of GABAergic neurons in the mouse hippocampus, with optical disector using confocal laser scanning microscope. Brain Res. 1998, 814: 55-70. 10.1016/S0006-8993(98)01075-0.
Article
CAS
PubMed
Google Scholar
Neddens J, Fish KN, Tricoire L, Vullhorst D, Shamir A, Chung W, Lewis DA, McBain CJ, Buonanno A: Conserved interneuron-specific ErbB4 expression in frontal cortex of rodents, monkeys, and humans: implications for schizophrenia. Biol Psychiatry. 2011, 70: 636-645. 10.1016/j.biopsych.2011.04.016.
Article
CAS
PubMed
Google Scholar
Neddens J, Buonanno A: Selective populations of hippocampal interneurons express ErbB4 and their number and distribution is altered in ErbB4 knockout mice. Hippocampus. 2010, 20: 724-744.
PubMed Central
CAS
PubMed
Google Scholar
Vullhorst D, Neddens J, Karavanova I, Tricoire L, Petralia RS, McBain CJ, Buonanno A: Selective expression of ErbB4 in interneurons, but not pyramidal cells, of the rodent hippocampus. J Neurosci. 2009, 29: 12255-12264. 10.1523/JNEUROSCI.2454-09.2009.
Article
PubMed Central
CAS
PubMed
Google Scholar
Anton ES, Ghashghaei HT, Weber JL, McCann C, Fischer TM, Cheung ID, Gassmann M, Messing A, Klein R, Schwab MH, et al: Receptor tyrosine kinase ErbB4 modulates neuroblast migration and placement in the adult forebrain. Nat Neurosci. 2004, 7: 1319-1328. 10.1038/nn1345.
Article
CAS
PubMed
Google Scholar
Flames N, Long JE, Garratt AN, Fischer TM, Gassmann M, Birchmeier C, Lai C, Rubenstein JL, Marin O: Short- and long-range attraction of cortical GABAergic interneurons by neuregulin-1. Neuron. 2004, 44: 251-261. 10.1016/j.neuron.2004.09.028.
Article
CAS
PubMed
Google Scholar
Ghashghaei HT, Weber J, Pevny L, Schmid R, Schwab MH, Lloyd KC, Eisenstat DD, Lai C, Anton ES: The role of neuregulin-ErbB4 interactions on the proliferation and organization of cells in the subventricular zone. Proc Natl Acad Sci USA. 2006, 103: 1930-1935. 10.1073/pnas.0510410103.
Article
PubMed Central
CAS
PubMed
Google Scholar
Magavi SS, Leavitt BR, Macklis JD: Induction of neurogenesis in the neocortex of adult mice. Nature. 2000, 405: 951-955. 10.1038/35016083.
Article
CAS
PubMed
Google Scholar
Okamoto M, Hojo Y, Inoue K, Matsui T, Kawato S, McEwen BS, Soya H: Mild exercise increases dihydrotestosterone in hippocampus providing evidence for androgenic mediation of neurogenesis. Proc Natl Acad Sci USA. 2012, 109: 13100-13105. 10.1073/pnas.1210023109.
Article
PubMed Central
CAS
PubMed
Google Scholar
Ubhi K, Rockenstein E, Mante M, Inglis C, Adame A, Patrick C, Whitney K, Masliah E: Neurodegeneration in a transgenic mouse model of multiple system atrophy is associated with altered expression of oligodendroglial-derived neurotrophic factors. J Neurosci. 2010, 30: 6236-6246. 10.1523/JNEUROSCI.0567-10.2010.
Article
PubMed Central
CAS
PubMed
Google Scholar
Scalzo P, Kummer A, Bretas TL, Cardoso F, Teixeira AL: Serum levels of brain-derived neurotrophic factor correlate with motor impairment in Parkinson’s disease. J Neurol. 2010, 257: 540-545. 10.1007/s00415-009-5357-2.
Article
CAS
PubMed
Google Scholar
Haaxma CA, Bloem BR, Borm GF, Oyen WJ, Leenders KL, Eshuis S, Booij J, Dluzen DE, Horstink MW: Gender differences in Parkinson’s disease. J Neurol Neurosurg Psychiatry. 2007, 78: 819-824. 10.1136/jnnp.2006.103788.
Article
PubMed Central
PubMed
Google Scholar
Deacon RM, Croucher A, Rawlins JN: Hippocampal cytotoxic lesion effects on species-typical behaviours in mice. Behav Brain Res. 2002, 132: 203-213. 10.1016/S0166-4328(01)00401-6.
Article
PubMed
Google Scholar
Szczypka MS, Kwok K, Brot MD, Marck BT, Matsumoto AM, Donahue BA, Palmiter RD: Dopamine production in the caudate putamen restores feeding in dopamine-deficient mice. Neuron. 2001, 30: 819-828. 10.1016/S0896-6273(01)00319-1.
Article
CAS
PubMed
Google Scholar
Gaffori O, Le Moal M: Disruption of maternal behavior and appearance of cannibalism after ventral mesencephalic tegmentum lesions. Physiol Behav. 1979, 23: 317-323. 10.1016/0031-9384(79)90373-1.
Article
CAS
PubMed
Google Scholar
Nelson EE, Panksepp J: Brain substrates of infant-mother attachment: contributions of opioids, oxytocin, and norepinephrine. Neurosci Biobehav Rev. 1998, 22: 437-452. 10.1016/S0149-7634(97)00052-3.
Article
CAS
PubMed
Google Scholar
Sandyk R, Iacono RP, Bamford CR: The hypothalamus in Parkinson disease. Ital J Neurol Sci. 1987, 8: 227-234. 10.1007/BF02337479.
Article
CAS
PubMed
Google Scholar
Rinne UK, Rinne JK, Rinne JO, Laakso K, Tenovuo O, Lonnberg P, Koskinen V: Brain enkephalin receptors in Parkinson’s disease. J Neural Transm Suppl. 1983, 19: 163-171.
CAS
PubMed
Google Scholar
Klucken J, Poehler AM, Ebrahimi-Fakhari D, Schneider J, Nuber S, Rockenstein E, Schlotzer-Schrehardt U, Hyman BT, McLean PJ, Masliah E, et al: Alpha-synuclein aggregation involves a bafilomycin A 1-sensitive autophagy pathway. Autophagy. 2012, 8: 754-766. 10.4161/auto.19371.
Article
PubMed Central
CAS
PubMed
Google Scholar
Mak SK, McCormack AL, Langston JW, Kordower JH, Di Monte DA: Decreased alpha-synuclein expression in the aging mouse substantia nigra. Exp Neurol. 2009, 220: 359-365. 10.1016/j.expneurol.2009.09.021.
Article
CAS
PubMed
Google Scholar
Adamczyk A, Solecka J, Strosznajder JB: Expression of alpha-synuclein in different brain parts of adult and aged rats. J Physiol Pharmacol. 2005, 56: 29-37.
CAS
PubMed
Google Scholar
Sasahara M, Fries JW, Raines EW, Gown AM, Westrum LE, Frosch MP, Bonthron DT, Ross R, Collins T: PDGF B-chain in neurons of the central nervous system, posterior pituitary, and in a transgenic model. Cell. 1991, 64: 217-227. 10.1016/0092-8674(91)90223-L.
Article
CAS
PubMed
Google Scholar
Sasahara A, Kott JN, Sasahara M, Raines EW, Ross R, Westrum LE: Platelet-derived growth factor B-chain-like immunoreactivity in the developing and adult rat brain. Brain Res Dev Brain Res. 1992, 68: 41-53.
Article
CAS
PubMed
Google Scholar
Neumann M, Kahle PJ, Giasson BI, Ozmen L, Borroni E, Spooren W, Muller V, Odoy S, Fujiwara H, Hasegawa M, et al: Misfolded proteinase K-resistant hyperphosphorylated alpha-synuclein in aged transgenic mice with locomotor deterioration and in human alpha-synucleinopathies. J Clin Invest. 2002, 110: 1429-1439.
Article
PubMed Central
CAS
PubMed
Google Scholar
Winner B, Rockenstein E, Lie DC, Aigner R, Mante M, Bogdahn U, Couillard-Despres S, Masliah E, Winkler J: Mutant alpha-synuclein exacerbates age-related decrease of neurogenesis. Neurobiol Aging. 2008, 29: 913-925. 10.1016/j.neurobiolaging.2006.12.016.
Article
PubMed Central
CAS
PubMed
Google Scholar
Fleming SM, Salcedo J, Fernagut PO, Rockenstein E, Masliah E, Levine MS, Chesselet MF: Early and progressive sensorimotor anomalies in mice overexpressing wild-type human alpha-synuclein. J Neurosci. 2004, 24: 9434-9440. 10.1523/JNEUROSCI.3080-04.2004.
Article
CAS
PubMed
Google Scholar
Deacon RM: Assessing nest building in mice. Nat Protoc. 2006, 1: 1117-1119. 10.1038/nprot.2006.170.
Article
PubMed
Google Scholar