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  1. The pathology of Alzheimer's disease (AD) is characterized by cerebral atrophy in frontal, temporal, and parietal regions, with senile plaques, dystrophic neurites, and neurofibrillar tangles within defined ar...

    Authors: Lauren C Costantini, Linda J Barr, Janet L Vogel and Samuel T Henderson
    Citation: BMC Neuroscience 2008 9(Suppl 2):S16
    Content type: Review Published on:

    This article is part of a Supplement: Volume 9 Supplement 2

  3. The peptides angiotensin IV and LVV-hemorphin 7 were found to enhance memory in a number of memory tasks and reverse the performance deficits in animals with experimentally induced memory loss. These peptides ...

    Authors: Siew Yeen Chai, Holly R Yeatman, Michael W Parker, David B Ascher, Philip E Thompson, Hayley T Mulvey and Anthony L Albiston
    Citation: BMC Neuroscience 2008 9(Suppl 2):S14
    Content type: Review Published on:

    This article is part of a Supplement: Volume 9 Supplement 2

  4. Alzheimer's disease (AD) is a neurodegenerative disease characterized by the accumulation of intracellular and extracellular aggregates. According to the amyloid beta (Aβ) hypothesis, amyloidosis occurring in ...

    Authors: John R Cashman, Senait Ghirmai, Kenneth J Abel and Milan Fiala
    Citation: BMC Neuroscience 2008 9(Suppl 2):S13
    Content type: Review Published on:

    This article is part of a Supplement: Volume 9 Supplement 2

  5. Protein kinases are critical modulators of a variety of cellular signal transduction pathways, and abnormal phosphorylation events can be a cause or contributor to disease progression in a variety of disorders...

    Authors: Aaron S Borders, Lucia de Almeida, Linda J Van Eldik and D Martin Watterson
    Citation: BMC Neuroscience 2008 9(Suppl 2):S12
    Content type: Review Published on:

    This article is part of a Supplement: Volume 9 Supplement 2

  6. Factors that regulate intracellular calcium concentration are known to play a critical role in brain function and neural development, including neural plasticity and neurogenesis. We previously demonstrated th...

    Authors: Jun Ming Wang and Roberta Diaz Brinton
    Citation: BMC Neuroscience 2008 9(Suppl 2):S11
    Content type: Review Published on:

    This article is part of a Supplement: Volume 9 Supplement 2

  7. Tau aggregation is one of the major features in Alzheimer's disease and in several other tauopathies, including frontotemporal dementia with Parkinsonism linked to chromosome 17 (FTDP-17), and progressive supr...

    Authors: Jianhua Zhou, Qingming Yu and Tie Zou
    Citation: BMC Neuroscience 2008 9(Suppl 2):S10
    Content type: Review Published on:

    This article is part of a Supplement: Volume 9 Supplement 2

  8. Protein kinases of the MARK family phosphorylate tau protein in its repeat domain and thereby regulate its affinity for microtubules and affect the aggregation of tau into Alzheimer paired helical filaments. W...

    Authors: Thomas Timm, Alexander Marx, Saravanan Panneerselvam, Eckhard Mandelkow and Eva-Maria Mandelkow
    Citation: BMC Neuroscience 2008 9(Suppl 2):S9
    Content type: Review Published on:

    This article is part of a Supplement: Volume 9 Supplement 2

  10. Both malignant transformation and neurodegeneration, as it occurs in Alzheimer's disease, are complex and lengthy multistep processes characterized by abnormal expression, post-translational modification, and ...

    Authors: Wenjie Luo, Anna Rodina and Gabriela Chiosis
    Citation: BMC Neuroscience 2008 9(Suppl 2):S7
    Content type: Review Published on:

    This article is part of a Supplement: Volume 9 Supplement 2

  11. Several epidemiological studies indicate that moderate consumption of red wine is associated with a lower incidence of dementia and Alzheimer's disease. Red wine is enriched in antioxidant polyphenols with pot...

    Authors: Valérie Vingtdeux, Ute Dreses-Werringloer, Haitian Zhao, Peter Davies and Philippe Marambaud
    Citation: BMC Neuroscience 2008 9(Suppl 2):S6
    Content type: Review Published on:

    This article is part of a Supplement: Volume 9 Supplement 2

  12. Central to the pathogenesis of Alzheimer's disease (AD) is the conversion of normal, soluble β-amyloid (sAβ) to oligomeric, fibrillar Aβ. This process of conformational conversion can be influenced by interact...

    Authors: Thomas Wisniewski and Martin Sadowski
    Citation: BMC Neuroscience 2008 9(Suppl 2):S5
    Content type: Review Published on:

    This article is part of a Supplement: Volume 9 Supplement 2

  13. There are no effective interventions that significantly forestall or reverse neurodegeneration and cognitive decline in Alzheimer's disease. In the past decade, the generation of new neurons has been recognize...

    Authors: Juan Sanchez-Ramos, Shijie Song, Chuanhai Cao and Gary Arendash
    Citation: BMC Neuroscience 2008 9(Suppl 2):S3
    Content type: Review Published on:

    This article is part of a Supplement: Volume 9 Supplement 2

  14. Many studies have highlighted the pathological involvement of iron accumulation and iron-related oxidative stress (OS) in Alzheimer's disease (AD). Iron was further demonstrated to modulate expression of the A...

    Authors: Yael Avramovich-Tirosh, Tamar Amit, Orit Bar-Am, Orly Weinreb and Moussa BH Youdim
    Citation: BMC Neuroscience 2008 9(Suppl 2):S2
    Content type: Review Published on:

    This article is part of a Supplement: Volume 9 Supplement 2

  15. The neurotophin signaling network is critical to the development and survival of many neuronal populations. Especially sensitive to imbalances in the neurotrophin system, cholinergic neurons in the basal foreb...

    Authors: Nicholas JG Webster and Michael C Pirrung
    Citation: BMC Neuroscience 2008 9(Suppl 2):S1
    Content type: Review Published on:

    This article is part of a Supplement: Volume 9 Supplement 2

  16. The main olfactory epithelium (MOE) in the nasal cavity detects a variety of air borne molecules that provide information regarding the presence of food, predators and other relevant social and environmental f...

    Authors: Weihong Lin, Ejiofor AD Ezekwe Jr, Zhen Zhao, Emily R Liman and Diego Restrepo
    Citation: BMC Neuroscience 2008 9:114
    Content type: Research article Published on:

  17. We have recorded responses from single neurons in murine visual cortex to determine the effectiveness of the input from the two murine cone photoreceptor mechanisms and whether there is any unique selectivity ...

    Authors: Björn Ekesten and Peter Gouras
    Citation: BMC Neuroscience 2008 9:113
    Content type: Research article Published on:

  18. The Kv2.1 delayed-rectifier K+ channel regulates membrane excitability in hippocampal neurons where it targets to dynamic cell surface clusters on the soma and proximal dendrites. In the past, Kv2.1 has been assu...

    Authors: Patrick D Sarmiere, Cecile M Weigle and Michael M Tamkun
    Citation: BMC Neuroscience 2008 9:112
    Content type: Research article Published on:

  19. With the advent of functional magnetic resonance imaging (fMRI) in awake animals it is possible to resolve patterns of neuronal activity across the entire brain with high spatial and temporal resolution. Synch...

    Authors: Craig F Ferris, Tara Stolberg, Praveen Kulkarni, Murali Murugavel, Robert Blanchard, D Caroline Blanchard, Marcelo Febo, Mathew Brevard and Neal G Simon
    Citation: BMC Neuroscience 2008 9:111
    Content type: Research article Published on:

  20. "Type II"/Receptor cells express G protein-coupled receptors (GPCRs) for sweet, umami (T1Rs and mGluRs) or bitter (T2Rs), as well as the proteins for downstream signalling cascades. Transduction downstream of ...

    Authors: Marco Tizzano, Gennady Dvoryanchikov, Jennell K Barrows, Soochong Kim, Nirupa Chaudhari and Thomas E Finger
    Citation: BMC Neuroscience 2008 9:110
    Content type: Research article Published on:

  21. Proteolytic degradation has emerged as a key pathway involved in controlling levels of the Alzheimer's disease (AD)-associated amyloid-β (Aβ) peptide in the brain. The endopeptidase, neprilysin, has been impli...

    Authors: Brian Spencer, Robert A Marr, Edward Rockenstein, Leslie Crews, Anthony Adame, Rewati Potkar, Christina Patrick, Fred H Gage, Inder M Verma and Eliezer Masliah
    Citation: BMC Neuroscience 2008 9:109
    Content type: Research article Published on:

  22. The polysialylated neuronal cell adhesion molecule (PSA-NCAM) is considered a marker of developing and migrating neurons and of synaptogenesis in the immature vertebrate nervous system. However, it persists in...

    Authors: Marina Quartu, Maria Pina Serra, Marianna Boi, Viviana Ibba, Tiziana Melis and Marina Del Fiacco
    Citation: BMC Neuroscience 2008 9:108
    Content type: Research article Published on:

  23. The aim of this study was to determine if changes in latencies and amplitudes of the major waves of Auditory Event-Related Potentials (AERP), correlate with memory status of patients with mild cognitive impair...

    Authors: Vasileios Papaliagkas, Vasileios Kimiskidis, Magda Tsolaki and George Anogianakis
    Citation: BMC Neuroscience 2008 9:107
    Content type: Research article Published on:

  24. Multi-sensory integration is necessary for organisms to discriminate different environmental stimuli and thus determine behavior. Caenorhabditis elegans has 12 pairs of amphid sensory neurons, which are involved ...

    Authors: Ryota Adachi, Hiroshi Osada and Ryuzo Shingai
    Citation: BMC Neuroscience 2008 9:106
    Content type: Research article Published on:

  25. The soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) complex, comprised of SNAP-25, syntaxin 1A, and VAMP-2, has been shown to be responsible for action potential (AP)-dependent, c...

    Authors: Lawrence CR Tafoya, C William Shuttleworth, Yuchio Yanagawa, Kunihiko Obata and Michael C Wilson
    Citation: BMC Neuroscience 2008 9:105
    Content type: Research article Published on:

  26. Redistribution of nuclear TAR DNA binding protein 43 (TDP-43) to the cytoplasm and ubiquitinated inclusions of spinal motor neurons and glial cells is characteristic of amyotrophic lateral sclerosis (ALS) path...

    Authors: Bradley J Turner, Dirk Bäumer, Nicholas J Parkinson, Jakub Scaber, Olaf Ansorge and Kevin Talbot
    Citation: BMC Neuroscience 2008 9:104
    Content type: Research article Published on:

  27. Transcranial direct current stimulation (tDCS) is a non-invasive technique that has been found to modulate the excitability of neurons in the brain. The polarity of the current applied to the scalp determines ...

    Authors: Bradley W Vines, Carlo Cerruti and Gottfried Schlaug
    Citation: BMC Neuroscience 2008 9:103
    Content type: Research article Published on:

  28. Lesion studies in human and non-human primates have linked several different regions of prefrontal cortex (PFC) with the ability to inhibit inappropriate motor responses. However, recent functional neuroimagin...

    Authors: Diane Swick, Victoria Ashley and And U Turken
    Citation: BMC Neuroscience 2008 9:102
    Content type: Research article Published on:

  29. CART (cocaine- and amphetamine-regulated transcript) peptide and cholecystokinin (CCK) are neuromodulators involved in feeding behavior. This study is based on previously found synergistic effect of leptin and...

    Authors: Lenka Maletínská, Jana Maixnerová, Resha Matyšková, Renata Haugvicová, Zdeno Pirník, Alexander Kiss and Blanka Železná
    Citation: BMC Neuroscience 2008 9:101
    Content type: Research article Published on:

  31. Pseudoephedrine is a drug commonly prescribed as a nasal decongestant and bronchodilator and is also freely available in cold remedies and medications. The structural and pharmacological similarity of pseudoep...

    Authors: Nootchanart Ruksee, Walaiporn Tongjaroenbuangam, Stefano O Casalotti and Piyarat Govitrapong
    Citation: BMC Neuroscience 2008 9:99
    Content type: Research article Published on:

  32. The present paper examines the visual processing speed of complex objects, here faces, by mapping the relationship between object physical properties and single-trial brain responses. Measuring visual processi...

    Authors: Guillaume A Rousselet, Cyril R Pernet, Patrick J Bennett and Allison B Sekuler
    Citation: BMC Neuroscience 2008 9:98
    Content type: Research article Published on:

  33. GPR125 belongs to the family of Adhesion G protein-coupled receptors (GPCRs). A single copy of GPR125 was found in many vertebrate genomes. We also identified a Drosophila sequence, DmCG15744, which shares a comm...

    Authors: Chris Pickering, Maria Hägglund, Joanna Szmydynger-Chodobska, Fernanda Marques, Joana A Palha, Linn Waller, Adam Chodobski, Robert Fredriksson, Malin C Lagerström and Helgi B Schiöth
    Citation: BMC Neuroscience 2008 9:97
    Content type: Research article Published on:

  34. Anatomical tracing of neural circuits originating from specific subsets of taste receptor cells may shed light on interactions between taste cells within the taste bud and taste cell-to nerve interactions. It ...

    Authors: Sami Damak, Bedrich Mosinger and Robert F Margolskee
    Citation: BMC Neuroscience 2008 9:96
    Content type: Research article Published on:

  35. The pre-Bötzinger complex (preBötC) is a central pattern generator within the ventrolateral medulla oblongata's ventral respiratory group that is important for the generation of respiratory rhythm. Activation ...

    Authors: Richard J VanDam, Edward J Shields and Jonathan D Kelty
    Citation: BMC Neuroscience 2008 9:95
    Content type: Research article Published on:

  36. The Fgf2 gene is expressed in the brain neuroepithelium during embryonic development and in astroglial cells throughout life. Previous knockout studies suggested that FGF2 plays a role in the proliferation of neu...

    Authors: Kesi Chen, Yasushi Ohkubo, Dana Shin, Thomas Doetschman, L Philip Sanford, Hongqi Li and Flora M Vaccarino
    Citation: BMC Neuroscience 2008 9:94
    Content type: Research article Published on:

  37. The nonhuman primate model of glaucomatous optic neuropathy most faithfully reproduces the human disease. We used high-density oligonucleotide arrays to investigate whole genome transcriptional changes occurri...

    Authors: Kenneth S Kompass, Olga A Agapova, Wenjun Li, Paul L Kaufman, Carol A Rasmussen and M Rosario Hernandez
    Citation: BMC Neuroscience 2008 9:93
    Content type: Research article Published on:

  38. Alpha-Synuclein (α-syn), a 140 amino acid protein associated with presynaptic membranes in brain, is a major constituent of Lewy bodies in Parkinson's disease (PD). Three missense mutations (A30P, A53T and E46...

    Authors: Sabine Wislet-Gendebien, Naomi P Visanji, Shawn N Whitehead, Diana Marsilio, Weimin Hou, Daniel Figeys, Paul E Fraser, Steffany AL Bennett and Anurag Tandon
    Citation: BMC Neuroscience 2008 9:92
    Content type: Research article Published on:

    The Retraction Note to this article has been published in BMC Neuroscience 2021 22:40

  39. The therapeutic capacity of human umbilical cord blood mononuclear cells (HUCB-MNC) and stem cells derived thereof is documented in animal models of focal cerebral ischemia, while mechanisms behind the reducti...

    Authors: Doreen M Reich, Susann Hau, Tobias Stahl, Markus Scholz, Wilfried Naumann, Frank Emmrich, Johannes Boltze and Manja Kamprad
    Citation: BMC Neuroscience 2008 9:91
    Content type: Research article Published on:

  40. Insect neuropeptides are distributed in stereotypic sets of neurons that commonly constitute a small fraction of the total number of neurons. However, some neuropeptide genes are expressed in larger numbers of...

    Authors: Dick R Nässel, Lina E Enell, Jonathan G Santos, Christian Wegener and Helena AD Johard
    Citation: BMC Neuroscience 2008 9:90
    Content type: Research article Published on:

  41. The generation of saccades is influenced by the level of "preparatory set activity" in cortical oculomotor areas. This preparatory activity can be examined using the gap-paradigm in which a temporal gap is int...

    Authors: M Nagel, A Sprenger, R Lencer, D Kömpf, H Siebner and W Heide
    Citation: BMC Neuroscience 2008 9:89
    Content type: Research article Published on:

  43. Previous reports have demonstrated that short durations of vibrotactile stimuli (less than or equal to 2 sec) effectively and consistently modify both the perceptual response in humans as well as the neurophys...

    Authors: Stephen E Folger, Vinay Tannan, Zheng Zhang, Jameson K Holden and Mark Tommerdahl
    Citation: BMC Neuroscience 2008 9:87
    Content type: Research article Published on:

  44. Delirium increases morbidity, mortality and healthcare costs especially in the elderly. Serum anticholinergic activity (SAA) is a suggested biomarker for anticholinergic burden and delirium risk, but the assoc...

    Authors: Christine Thomas, Ute Hestermann, Juergen Kopitz, Konstanze Plaschke, Peter Oster, Martin Driessen, Christoph Mundt and Matthias Weisbrod
    Citation: BMC Neuroscience 2008 9:86
    Content type: Research article Published on:

  45. MEK1/2 is a serine/threonine protein that phosphorylates extracellular signal-regulated kinase (ERK1/2). Cerebral ischemia results in enhanced expression of cerebrovascular contractile receptors in the middle ...

    Authors: Aida Maddahi and Lars Edvinsson
    Citation: BMC Neuroscience 2008 9:85
    Content type: Research article Published on:

  46. It is generally believed that activation in functional magnetic resonance imaging (fMRI) is restricted to gray matter. Despite this, a number of studies have reported white matter activation, particularly when...

    Authors: Erin L Mazerolle, Ryan CN D'Arcy and Steven D Beyea
    Citation: BMC Neuroscience 2008 9:84
    Content type: Research article Published on:

  47. Matrix metalloproteinase-28 (MMP-28) is a poorly understood member of the matrix metalloproteinase family. Metalloproteinases are important mediators in the development of the nervous system and can contribute...

    Authors: Sean R Werner, Joseph E Dotzlaf and Rosamund C Smith
    Citation: BMC Neuroscience 2008 9:83
    Content type: Research article Published on:

  49. Several transgenic animal models genetically predisposed to develop Alzheimer's disease (AD)-like pathology have been engineered to facilitate the study of disease pathophysiology and the vetting of potential ...

    Authors: Michael A Mastrangelo and William J Bowers
    Citation: BMC Neuroscience 2008 9:81
    Content type: Research article Published on:

  50. Visual, tactile and auditory information is processed from the periphery to the cortical level through separate channels that target primary sensory cortices, from which it is further distributed to functional...

    Authors: Ye Wang, Simona Celebrini, Yves Trotter and Pascal Barone
    Citation: BMC Neuroscience 2008 9:79
    Content type: Research article Published on:
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