Selkoe DJ: Alzheimer's disease: genes, proteins, and therapy. Physiol Rev. 2001, 81: 741-766.
CAS
PubMed
Google Scholar
Davies P: A very incomplete comprehensive theory of Alzheimer's disease. Ann N Y Acad Sci. 2000, 924: 8-16. 10.1111/j.1749-6632.2000.tb05553.x.
Article
CAS
PubMed
Google Scholar
Goedert M, Spillantini MG: Tau mutations in frontotemporal dementia FTDP-17 and their relevance for Alzheimer's disease. Biochim Biophys Acta. 2000, 1502: 110-121.
Article
CAS
PubMed
Google Scholar
Hardy J, Selkoe DJ: The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. Science. 2002, 297: 353-356. 10.1126/science.1072994.
Article
CAS
PubMed
Google Scholar
Marambaud P, Robakis NK: Genetic and molecular aspects of Alzheimer's disease shed light on new mechanisms of transcriptional regulation. Genes Brain Behav. 2005, 4: 134-146. 10.1111/j.1601-183X.2005.00086.x.
Article
CAS
PubMed
Google Scholar
Marambaud P, Shioi J, Serban G, Georgakopoulos A, Sarner S, Nagy V, Baki L, Wen P, Efthimiopoulos S, Shao Z, et al: A presenilin-1/gamma-secretase cleavage releases the E-cadherin intracellular domain and regulates disassembly of adherens junctions. EMBO J. 2002, 21: 1948-1956. 10.1093/emboj/21.8.1948.
Article
PubMed Central
CAS
PubMed
Google Scholar
Marambaud P, Wen PH, Dutt A, Shioi J, Takashima A, Siman R, Robakis NK: A CBP binding transcriptional repressor produced by the PS1/epsilon-cleavage of N-cadherin is inhibited by PS1 FAD mutations. Cell. 2003, 114: 635-645. 10.1016/j.cell.2003.08.008.
Article
CAS
PubMed
Google Scholar
Harrison T, Churcher I, Beher D: gamma-Secretase as a target for drug intervention in Alzheimer's disease. Curr Opin Drug Discov Devel. 2004, 7: 709-719.
CAS
PubMed
Google Scholar
Tanzi RE, Moir RD, Wagner SL: Clearance of Alzheimer's Abeta peptide: the many roads to perdition. Neuron. 2004, 43: 605-608.
CAS
PubMed
Google Scholar
Turner AJ, Fisk L, Nalivaeva NN: Targeting amyloid-degrading enzymes as therapeutic strategies in neurodegeneration. Ann N Y Acad Sci. 2004, 1035: 1-20. 10.1196/annals.1332.001.
Article
CAS
PubMed
Google Scholar
Collen D: Ham-Wasserman lecture: role of the plasminogen system in fibrin-homeostasis and tissue remodeling. Hematology (Am Soc Hematol Educ Program). 2001, 1-9.
Google Scholar
Ertekin-Taner N, Ronald J, Feuk L, Prince J, Tucker M, Younkin L, Hella M, Jain S, Hackett A, Scanlin L, et al: Elevated amyloid beta protein (Abeta42) and late onset Alzheimer's disease are associated with single nucleotide polymorphisms in the urokinase-type plasminogen activator gene. Hum Mol Genet. 2005, 14: 447-460. 10.1093/hmg/ddi041.
Article
CAS
PubMed
Google Scholar
Melchor JP, Pawlak R, Strickland S: The tissue plasminogen activator-plasminogen proteolytic cascade accelerates amyloid-beta (Abeta) degradation and inhibits Abeta-induced neurodegeneration. J Neurosci. 2003, 23: 8867-8871.
CAS
PubMed
Google Scholar
Luchsinger JA, Mayeux R: Dietary factors and Alzheimer's disease. Lancet Neurol. 2004, 3: 579-587. 10.1016/S1474-4422(04)00878-6.
Article
PubMed
Google Scholar
Orgogozo JM, Dartigues JF, Lafont S, Letenneur L, Commenges D, Salamon R, Renaud S, Breteler MB: Wine consumption and dementia in the elderly: a prospective community study in the Bordeaux area. Rev Neurol (Paris). 1997, 153: 185-192.
CAS
Google Scholar
Truelsen T, Thudium D, Gronbaek M: Amount and type of alcohol and risk of dementia: the Copenhagen City Heart Study. Neurology. 2002, 59: 1313-1319.
Article
PubMed
Google Scholar
Luchsinger JA, Tang MX, Siddiqui M, Shea S, Mayeux R: Alcohol intake and risk of dementia. J Am Geriatr Soc. 2004, 52: 540-546. 10.1111/j.1532-5415.2004.52159.x.
Article
PubMed
Google Scholar
Lindsay J, Laurin D, Verreault R, Hebert R, Helliwell B, Hill GB, McDowell I: Risk factors for Alzheimer's disease: a prospective analysis from the Canadian Study of Health and Aging. Am J Epidemiol. 2002, 156: 445-453. 10.1093/aje/kwf074.
Article
PubMed
Google Scholar
Wang J, Ho L, Zhao Z, Seror I, Humala N, Dickstein DL, Thiyagarajan M, Percival SS, Talcott ST, Pasinetti GM: Moderate consumption of Cabernet Sauvignon attenuates Abeta neuropathology in a mouse model of Alzheimer's disease. FASEB J. 2006, 20: 2313-2320. 10.1096/fj.06-6281com.
Article
CAS
PubMed
Google Scholar
Wenzel E, Somoza V: Metabolism and bioavailability of trans-resveratrol. Mol Nutr Food Res. 2005, 49: 472-481. 10.1002/mnfr.200500010.
Article
CAS
PubMed
Google Scholar
Walle T, Hsieh F, DeLegge MH, Oatis JE, Walle UK: High absorption but very low bioavailability of oral resveratrol in humans. Drug Metab Dispos. 2004, 32: 1377-1382. 10.1124/dmd.104.000885.
Article
CAS
PubMed
Google Scholar
Baur JA, Sinclair DA: Therapeutic potential of resveratrol: the in vivo evidence. Nat Rev Drug Discov. 2006, 5: 493-506. 10.1038/nrd2060.
Article
CAS
PubMed
Google Scholar
Lagouge M, Argmann C, Gerhart-Hines Z, Meziane H, Lerin C, Daussin F, Messadeq N, Milne J, Lambert P, Elliott P, et al: Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha. Cell. 2006, 127: 1109-1122. 10.1016/j.cell.2006.11.013.
Article
CAS
PubMed
Google Scholar
Dasgupta B, Milbrandt J: Resveratrol stimulates AMP kinase activity in neurons. Proc Natl Acad Sci USA. 2007, 104 (17): 7217-7222. 10.1073/pnas.0610068104.
Article
PubMed Central
CAS
PubMed
Google Scholar
Baur JA, Pearson KJ, Price NL, Jamieson HA, Lerin C, Kalra A, Prabhu VV, Allard JS, Lopez-Lluch G, Lewis K, et al: Resveratrol improves health and survival of mice on a high-calorie diet. Nature. 2006, 444: 337-342. 10.1038/nature05354.
Article
CAS
PubMed
Google Scholar
Pervaiz S: Resveratrol: from grapevines to mammalian biology. FASEB J. 2003, 17: 1975-1985. 10.1096/fj.03-0168rev.
Article
CAS
PubMed
Google Scholar
Sun AY, Chen YM, James-Kracke M, Wixom P, Cheng Y: Ethanol-induced cell death by lipid peroxidation in PC12 cells. Neurochem Res. 1997, 22: 1187-1192. 10.1023/A:1021968526696.
Article
CAS
PubMed
Google Scholar
Draczynska-Lusiak B, Doung A, Sun AY: Oxidized lipoproteins may play a role in neuronal cell death in Alzheimer disease. Mol Chem Neuropathol. 1998, 33: 139-148. 10.1007/BF02870187.
Article
CAS
PubMed
Google Scholar
Han YS, Zheng WH, Bastianetto S, Chabot JG, Quirion R: Neuroprotective effects of resveratrol against beta-amyloid-induced neurotoxicity in rat hippocampal neurons: involvement of protein kinase C. Br J Pharmacol. 2004, 141: 997-1005. 10.1038/sj.bjp.0705688.
Article
PubMed Central
CAS
PubMed
Google Scholar
Jang JH, Surh YJ: Protective effect of resveratrol on beta-amyloid-induced oxidative PC12 cell death. Free Radic Biol Med. 2003, 34: 1100-1110. 10.1016/S0891-5849(03)00062-5.
Article
CAS
PubMed
Google Scholar
Savaskan E, Olivieri G, Meier F, Seifritz E, Wirz-Justice A, Muller-Spahn F: Red wine ingredient resveratrol protects from beta-amyloid neurotoxicity. Gerontology. 2003, 49: 380-383. 10.1159/000073766.
Article
CAS
PubMed
Google Scholar
Ahn JS, Lee JH, Kim JH, Paik SR: Novel method for quantitative determination of amyloid fibrils of alpha-synuclein and amyloid beta/A4 protein by using resveratrol. Anal Biochem. 2007, 367: 259-265. 10.1016/j.ab.2007.05.023.
Article
CAS
PubMed
Google Scholar
Riviere C, Richard T, Vitrac X, Merillon JM, Valls J, Monti JP: New polyphenols active on beta-amyloid aggregation. Bioorg Med Chem Lett. 2008, 18: 828-831. 10.1016/j.bmcl.2007.11.028.
Article
CAS
PubMed
Google Scholar
Ono K, Yoshiike Y, Takashima A, Hasegawa K, Naiki H, Yamada M: Potent anti-amyloidogenic and fibril-destabilizing effects of polyphenols in vitro : implications for the prevention and therapeutics of Alzheimer's disease. J Neurochem. 2003, 87: 172-181. 10.1046/j.1471-4159.2003.01976.x.
Article
CAS
PubMed
Google Scholar
Riviere C, Richard T, Quentin L, Krisa S, Merillon JM, Monti JP: Inhibitory activity of stilbenes on Alzheimer's beta-amyloid fibrils in vitro. Bioorg Med Chem. 2007, 15: 1160-1167. 10.1016/j.bmc.2006.09.069.
Article
CAS
PubMed
Google Scholar
Guarente L: Calorie restriction and SIR2 genes – towards a mechanism. Mech Ageing Dev. 2005, 126: 923-928. 10.1016/j.mad.2005.03.013.
Article
CAS
PubMed
Google Scholar
Howitz KT, Bitterman KJ, Cohen HY, Lamming DW, Lavu S, Wood JG, Zipkin RE, Chung P, Kisielewski A, Zhang LL, et al: Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan. Nature. 2003, 425: 191-196. 10.1038/nature01960.
Article
CAS
PubMed
Google Scholar
Chen D, Steele AD, Lindquist S, Guarente L: Increase in activity during calorie restriction requires Sirt1. Science. 2005, 310: 1641-10.1126/science.1118357.
Article
CAS
PubMed
Google Scholar
Rodgers JT, Lerin C, Haas W, Gygi SP, Spiegelman BM, Puigserver P: Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1. Nature. 2005, 434: 113-118. 10.1038/nature03354.
Article
CAS
PubMed
Google Scholar
Nemoto S, Fergusson MM, Finkel T: SIRT1 functionally interacts with the metabolic regulator and transcriptional coactivator PGC-1alpha. J Biol Chem. 2005, 280: 16456-16460. 10.1074/jbc.M501485200.
Article
CAS
PubMed
Google Scholar
Kim D, Nguyen MD, Dobbin MM, Fischer A, Sananbenesi F, Rodgers JT, Delalle I, Baur JA, Sui G, Armour SM, et al: SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer's disease and amyotrophic lateral sclerosis. EMBO J. 2007, 26: 3169-3179. 10.1038/sj.emboj.7601758.
Article
PubMed Central
CAS
PubMed
Google Scholar
Patel NV, Gordon MN, Connor KE, Good RA, Engelman RW, Mason J, Morgan DG, Morgan TE, Finch CE: Caloric restriction attenuates Abeta-deposition in Alzheimer transgenic models. Neurobiol Aging. 2005, 26: 995-1000. 10.1016/j.neurobiolaging.2004.09.014.
Article
CAS
PubMed
Google Scholar
Wang J, Ho L, Qin W, Rocher AB, Seror I, Humala N, Maniar K, Dolios G, Wang R, Hof PR, et al: Caloric restriction attenuates beta-amyloid neuropathology in a mouse model of Alzheimer's disease. FASEB J. 2005, 19: 659-661. 10.1096/fj.04-2370com.
Article
PubMed
Google Scholar
Qin W, Chachich M, Lane M, Roth G, Bryant M, de Cabo R, Ottinger MA, Mattison J, Ingram D, Gandy S, et al: Calorie restriction attenuates Alzheimer's disease type brain amyloidosis in Squirrel monkeys (Saimiri sciureus). J Alzheimers Dis. 2006, 10: 417-422.
CAS
PubMed
Google Scholar
Qin W, Yang T, Ho L, Zhao Z, Wang J, Chen L, Zhao W, Thiyagarajan M, MacGrogan D, Rodgers JT, et al: Neuronal SIRT1 activation as a novel mechanism underlying the prevention of Alzheimer disease amyloid neuropathology by calorie restriction. J Biol Chem. 2006, 281: 21745-21754. 10.1074/jbc.M602909200.
Article
CAS
PubMed
Google Scholar
Marambaud P, Zhao H, Davies P: Resveratrol promotes clearance of Alzheimer's disease amyloid-beta peptides. J Biol Chem. 2005, 280: 37377-37382. 10.1074/jbc.M508246200.
Article
CAS
PubMed
Google Scholar
Abou-Agag LH, Aikens ML, Tabengwa EM, Benza RL, Shows SR, Grenett HE, Booyse FM: Polyphyenolics increase t-PA and u-PA gene transcription in cultured human endothelial cells. Alcohol Clin Exp Res. 2001, 25: 155-162. 10.1111/j.1530-0277.2001.tb02193.x.
Article
CAS
PubMed
Google Scholar
Yang SH, Kim JS, Oh TJ, Kim MS, Lee SW, Woo SK, Cho HS, Choi YH, Kim YH, Rha SY, et al: Genome-scale analysis of resveratrol-induced gene expression profile in human ovarian cancer cells using a cDNA microarray. Int J Oncol. 2003, 22: 741-750.
CAS
PubMed
Google Scholar
Nicholas SB, Kawano Y, Wakino S, Collins AR, Hsueh WA: Expression and function of peroxisome proliferator-activated receptor-gamma in mesangial cells. Hypertension. 2001, 37: 722-727.
Article
CAS
PubMed
Google Scholar
Yan Q, Zhang J, Liu H, Babu-Khan S, Vassar R, Biere AL, Citron M, Landreth G: Anti-inflammatory drug therapy alters beta-amyloid processing and deposition in an animal model of Alzheimer's disease. J Neurosci. 2003, 23: 7504-7509.
CAS
PubMed
Google Scholar
d'Abramo C, Massone S, Zingg JM, Pizzuti A, Marambaud P, Dalla Piccola B, Azzi A, Marinari UM, Pronzato MA, Ricciarelli R: Role of peroxisome proliferator-activated receptor gamma in amyloid precursor protein processing and amyloid beta-mediated cell death. Biochem J. 2005, 391: 693-698. 10.1042/BJ20050560.
Article
PubMed Central
PubMed
Google Scholar
Camacho IE, Serneels L, Spittaels K, Merchiers P, Dominguez D, De Strooper B: Peroxisome-proliferator-activated receptor gamma induces a clearance mechanism for the amyloid-beta peptide. J Neurosci. 2004, 24: 10908-10917. 10.1523/JNEUROSCI.3987-04.2004.
Article
CAS
PubMed
Google Scholar
Heneka MT, Sastre M, Dumitrescu-Ozimek L, Hanke A, Dewachter I, Kuiperi C, O'Banion K, Klockgether T, Van Leuven F, Landreth GE: Acute treatment with the PPARgamma agonist pioglitazone and ibuprofen reduces glial inflammation and Abeta1–42 levels in APPV717I transgenic mice. Brain. 2005, 128: 1442-1453. 10.1093/brain/awh452.
Article
PubMed
Google Scholar