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Volume 9 Supplement 2

Proceedings of the 8th International Conference on Alzheimer's Disease Drug Discovery

Reviews

Edited by Howard Fillit

The publication of this supplement was made possible by the generous support of the conference sponsors: Forest Laboratories, Inc.; Bellus Health Inc.; Elan Pharmaceuticals, Inc.; Eli Lilly and Company; Esai, Inc., Ortho-McNeil Neurologics, Inc.; Sanofi-Aventis US, Inc.; Schering-Plough; Accera, Inc.; Acumen Pharmaceuticals, Inc.; Pfizer Inc.; and Wyeth Research.

8th International Conference on Alzheimer's Disease Drug Discovery. Go to conference site.

New York, NY, USA15-16 October 2007

  1. Many studies have highlighted the pathological involvement of iron accumulation and iron-related oxidative stress (OS) in Alzheimer's disease (AD). Iron was further demonstrated to modulate expression of the A...

    Authors: Yael Avramovich-Tirosh, Tamar Amit, Orit Bar-Am, Orly Weinreb and Moussa BH Youdim

    Citation: BMC Neuroscience 2008 9(Suppl 2):S2

    Content type: Review

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  2. There are no effective interventions that significantly forestall or reverse neurodegeneration and cognitive decline in Alzheimer's disease. In the past decade, the generation of new neurons has been recognize...

    Authors: Juan Sanchez-Ramos, Shijie Song, Chuanhai Cao and Gary Arendash

    Citation: BMC Neuroscience 2008 9(Suppl 2):S3

    Content type: Review

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  3. The amyloid-β peptide (Aβ), implicated in the pathogenesis of Alzheimer's disease (AD), is produced through sequential proteolysis of the Aβ precursor protein (APP) by β- and γ-secretases. Thus, blocking eithe...

    Authors: Michael S Wolfe

    Citation: BMC Neuroscience 2008 9(Suppl 2):S4

    Content type: Review

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  4. Several epidemiological studies indicate that moderate consumption of red wine is associated with a lower incidence of dementia and Alzheimer's disease. Red wine is enriched in antioxidant polyphenols with pot...

    Authors: Valérie Vingtdeux, Ute Dreses-Werringloer, Haitian Zhao, Peter Davies and Philippe Marambaud

    Citation: BMC Neuroscience 2008 9(Suppl 2):S6

    Content type: Review

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  5. Protein kinases of the MARK family phosphorylate tau protein in its repeat domain and thereby regulate its affinity for microtubules and affect the aggregation of tau into Alzheimer paired helical filaments. W...

    Authors: Thomas Timm, Alexander Marx, Saravanan Panneerselvam, Eckhard Mandelkow and Eva-Maria Mandelkow

    Citation: BMC Neuroscience 2008 9(Suppl 2):S9

    Content type: Review

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  6. Factors that regulate intracellular calcium concentration are known to play a critical role in brain function and neural development, including neural plasticity and neurogenesis. We previously demonstrated th...

    Authors: Jun Ming Wang and Roberta Diaz Brinton

    Citation: BMC Neuroscience 2008 9(Suppl 2):S11

    Content type: Review

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  7. Protein kinases are critical modulators of a variety of cellular signal transduction pathways, and abnormal phosphorylation events can be a cause or contributor to disease progression in a variety of disorders...

    Authors: Aaron S Borders, Lucia de Almeida, Linda J Van Eldik and D Martin Watterson

    Citation: BMC Neuroscience 2008 9(Suppl 2):S12

    Content type: Review

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  8. Alzheimer's disease (AD) is a neurodegenerative disease characterized by the accumulation of intracellular and extracellular aggregates. According to the amyloid beta (Aβ) hypothesis, amyloidosis occurring in ...

    Authors: John R Cashman, Senait Ghirmai, Kenneth J Abel and Milan Fiala

    Citation: BMC Neuroscience 2008 9(Suppl 2):S13

    Content type: Review

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  9. The peptides angiotensin IV and LVV-hemorphin 7 were found to enhance memory in a number of memory tasks and reverse the performance deficits in animals with experimentally induced memory loss. These peptides ...

    Authors: Siew Yeen Chai, Holly R Yeatman, Michael W Parker, David B Ascher, Philip E Thompson, Hayley T Mulvey and Anthony L Albiston

    Citation: BMC Neuroscience 2008 9(Suppl 2):S14

    Content type: Review

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  10. Angiotensin IV is a derivative of the potent vasoconstrictor angiotensin II and it has been shown to enhance acquisition, consolidation and recall in animal models of learning and memory when administered cent...

    Authors: Paul R Gard

    Citation: BMC Neuroscience 2008 9(Suppl 2):S15

    Content type: Review

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  11. The pathology of Alzheimer's disease (AD) is characterized by cerebral atrophy in frontal, temporal, and parietal regions, with senile plaques, dystrophic neurites, and neurofibrillar tangles within defined ar...

    Authors: Lauren C Costantini, Linda J Barr, Janet L Vogel and Samuel T Henderson

    Citation: BMC Neuroscience 2008 9(Suppl 2):S16

    Content type: Review

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