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Volume 9 Supplement 2

Proceedings of the 8th International Conference on Alzheimer's Disease Drug Discovery

Reviews

Edited by Howard Fillit

The publication of this supplement was made possible by the generous support of the conference sponsors: Forest Laboratories, Inc.; Bellus Health Inc.; Elan Pharmaceuticals, Inc.; Eli Lilly and Company; Esai, Inc., Ortho-McNeil Neurologics, Inc.; Sanofi-Aventis US, Inc.; Schering-Plough; Accera, Inc.; Acumen Pharmaceuticals, Inc.; Pfizer Inc.; and Wyeth Research.

8th International Conference on Alzheimer's Disease Drug Discovery. Go to conference site.

New York, NY, USA15-16 October 2007

  1. Many studies have highlighted the pathological involvement of iron accumulation and iron-related oxidative stress (OS) in Alzheimer's disease (AD). Iron was further demonstrated to modulate expression of the A...

    Authors: Yael Avramovich-Tirosh, Tamar Amit, Orit Bar-Am, Orly Weinreb and Moussa BH Youdim
    Citation: BMC Neuroscience 2008 9(Suppl 2):S2
  2. There are no effective interventions that significantly forestall or reverse neurodegeneration and cognitive decline in Alzheimer's disease. In the past decade, the generation of new neurons has been recognize...

    Authors: Juan Sanchez-Ramos, Shijie Song, Chuanhai Cao and Gary Arendash
    Citation: BMC Neuroscience 2008 9(Suppl 2):S3
  3. The amyloid-β peptide (Aβ), implicated in the pathogenesis of Alzheimer's disease (AD), is produced through sequential proteolysis of the Aβ precursor protein (APP) by β- and γ-secretases. Thus, blocking eithe...

    Authors: Michael S Wolfe
    Citation: BMC Neuroscience 2008 9(Suppl 2):S4
  4. Central to the pathogenesis of Alzheimer's disease (AD) is the conversion of normal, soluble β-amyloid (sAβ) to oligomeric, fibrillar Aβ. This process of conformational conversion can be influenced by interact...

    Authors: Thomas Wisniewski and Martin Sadowski
    Citation: BMC Neuroscience 2008 9(Suppl 2):S5
  5. Several epidemiological studies indicate that moderate consumption of red wine is associated with a lower incidence of dementia and Alzheimer's disease. Red wine is enriched in antioxidant polyphenols with pot...

    Authors: Valérie Vingtdeux, Ute Dreses-Werringloer, Haitian Zhao, Peter Davies and Philippe Marambaud
    Citation: BMC Neuroscience 2008 9(Suppl 2):S6
  6. Protein kinases of the MARK family phosphorylate tau protein in its repeat domain and thereby regulate its affinity for microtubules and affect the aggregation of tau into Alzheimer paired helical filaments. W...

    Authors: Thomas Timm, Alexander Marx, Saravanan Panneerselvam, Eckhard Mandelkow and Eva-Maria Mandelkow
    Citation: BMC Neuroscience 2008 9(Suppl 2):S9
  7. Factors that regulate intracellular calcium concentration are known to play a critical role in brain function and neural development, including neural plasticity and neurogenesis. We previously demonstrated th...

    Authors: Jun Ming Wang and Roberta Diaz Brinton
    Citation: BMC Neuroscience 2008 9(Suppl 2):S11
  8. Protein kinases are critical modulators of a variety of cellular signal transduction pathways, and abnormal phosphorylation events can be a cause or contributor to disease progression in a variety of disorders...

    Authors: Aaron S Borders, Lucia de Almeida, Linda J Van Eldik and D Martin Watterson
    Citation: BMC Neuroscience 2008 9(Suppl 2):S12
  9. Alzheimer's disease (AD) is a neurodegenerative disease characterized by the accumulation of intracellular and extracellular aggregates. According to the amyloid beta (Aβ) hypothesis, amyloidosis occurring in ...

    Authors: John R Cashman, Senait Ghirmai, Kenneth J Abel and Milan Fiala
    Citation: BMC Neuroscience 2008 9(Suppl 2):S13
  10. The peptides angiotensin IV and LVV-hemorphin 7 were found to enhance memory in a number of memory tasks and reverse the performance deficits in animals with experimentally induced memory loss. These peptides ...

    Authors: Siew Yeen Chai, Holly R Yeatman, Michael W Parker, David B Ascher, Philip E Thompson, Hayley T Mulvey and Anthony L Albiston
    Citation: BMC Neuroscience 2008 9(Suppl 2):S14
  11. Angiotensin IV is a derivative of the potent vasoconstrictor angiotensin II and it has been shown to enhance acquisition, consolidation and recall in animal models of learning and memory when administered cent...

    Authors: Paul R Gard
    Citation: BMC Neuroscience 2008 9(Suppl 2):S15
  12. The pathology of Alzheimer's disease (AD) is characterized by cerebral atrophy in frontal, temporal, and parietal regions, with senile plaques, dystrophic neurites, and neurofibrillar tangles within defined ar...

    Authors: Lauren C Costantini, Linda J Barr, Janet L Vogel and Samuel T Henderson
    Citation: BMC Neuroscience 2008 9(Suppl 2):S16

Annual Journal Metrics

  • 2022 Citation Impact
    2.4 - 2-year Impact Factor
    3.3 - 5-year Impact Factor
    0.824 - SNIP (Source Normalized Impact per Paper)
    0.688 - SJR (SCImago Journal Rank)

    2023 Speed
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