Dysfunctional GABAergic inhibition in the prefrontal cortex leading to "psychotic" hyperactivation
© Tanaka; licensee BioMed Central Ltd. 2008
Received: 06 September 2007
Accepted: 25 April 2008
Published: 25 April 2008
The GABAergic system in the brain seems to be dysfunctional in various psychiatric disorders. Many studies have suggested so far that, in schizophrenia patients, GABAergic inhibition is selectively but consistently reduced in the prefrontal cortex (PFC).
This study used a computational model of the PFC to investigate the dynamics of the PFC circuit with and without chandelier cells and other GABAergic interneurons. The inhibition by GABAergic interneurons other than chandelier cells effectively regulated the PFC activity with rather low or modest levels of dopaminergic neurotransmission. This activity of the PFC is associated with normal cognitive functions and has an inverted-U shaped profile of dopaminergic modulation. In contrast, the chandelier cell-type inhibition affected only the PFC circuit dynamics in hyperdopaminergic conditions. Reduction of chandelier cell-type inhibition resulted in bistable dynamics of the PFC circuit, in which the upper stable state is associated with a hyperactive mode. When both types of inhibition were reduced, this hyperactive mode and the conventional inverted-U mode merged.
The results of our simulation suggest that, in schizophrenia, a reduction of GABAergic inhibition increases vulnerability to psychosis by (i) producing the hyperactive mode of the PFC with hyperdopaminergic neurotransmission by dysfunctional chandelier cells and (ii) increasing the probability of the transition to the hyperactive mode from the conventional inverted-U mode by dysfunctional GABAergic interneurons.
A number of studies have suggested alterations of the gamma-aminobutyric acid (GABA) system in the brains of patients with schizophrenia (for reviews: [1–5]). The alteration of GABAergic neurotransmission in the cortex seems to be selective for subpopulations of the interneurons [4–7]. Postmortem studies by Benes and colleagues reported decreased densities of interneurons in layer II of the prefrontal cortex (PFC) and layers II-IV of the cingulate cortex of patients with schizophrenia [8, 9]. Possibly owing to its compensation, GABAA receptors were observed to be upregulated in layers II, III, V and VI in the PFC and layers II and III in the cingulate cortex [10, 11]. Decreased densities of the interneurons in the PFC and the cingulate cortex might be restricted to the interneurons expressing calbindin; whether the densities of calretinin (CR)- or parvalbumin (PV)-interneurons are reduced or not is still uncertain [6, 12–14].
Analyses of postmortem brains of patients with schizophrenia have shown consistent reduction of reelin, PV, and GAD67, the 67-kilodalton isoform of glutamic acid decarboxylase [15–17]. Reelin is secreted preferentially by cortical GABAergic interneurons in layers I, II and IV and binds to integrin receptors on dendritic spines of pyramidal neurons or on GABAergic interneurons in layers III-V expressing the disabled-1 gene product (DAB1) [15, 18]. The expression of reelin mRNA was decreased in GABAergic interneurons in layers I, II and IV of schizophrenia patients . Because reelin plays a role in neuronal migration and synaptic plasticity in the cerebral cortex [18, 20, 21], the reduction of reelin in schizophrenia would indicate a neurodevelopmental abnormality that induces a GABAergic deficit in schizophrenia [1, 21]. Reduced levels of mRNA for GAD67 in the dorsolateral prefrontal cortex (DLPFC) of patients with schizophrenia suggest that GABA synthesis is reduced in schizophrenia [22–25]. The reduction was detected in about 25-30% of the GABAergic interneurons in the DLPFC [25, 26]. Among many subtypes of GABAergic interneurons in the cortex, the PV-interneurons contain basket cells and chandelier cells, which constitute 20-25% of GABAergic interneurons in the primate DLPFC . The GABAergic interneurons that show GAD67 mRNA reduction express PV , suggesting that the reduction is selective. Lewis and coworkers suggested that the density of the GABA membrane transporter (GAT1)-immunoreactive axon cartridges of chandelier cells was decreased by 40% in schizophrenic subjects compared to both normal controls and subjects with other psychotic disorders [29, 30]. They argued that the reduction was due to a decrease in the number of axon terminals rather than the number of chandelier cells [29, 30]. In contrast, the CR-positive GABAergic interneurons, which constitute about 50%, were unaffected .
The regulation of GABAergic neurotransmission is critical for proper information processing in the brain. For example, Goldman-Rakic and coworkers demonstrated that iontophoretic application of bicuculline methiodide, a competitive antagonist of GABAA receptors, into the DLPFC of monkeys performing an oculomotor delayed response task resulted in the destruction of spatial tuning of both pyramidal neurons and GABAergic interneurons . This has been reproduced in computational studies, which suggests that isodirectional intracortical inhibition contributes to the stability of the cortical circuit and cross-directional inhibition contributes to the spatial tuning or selectivity of working memory to represent [32–34]. Therefore, the alteration of GABAergic neurotransmission in the cortex would cause dysregulation of the circuit dynamics, resulting in the impairment of working memory and other cognitive functions.
A recent neurophysiological study of rats  suggests that chandelier cells, whose spontaneous activity is fairly low, are reserved to prevent excessive firing of neurons in the circuit. Chandelier cells are characterized by their synapses on the axonal initial segment of pyramidal neurons and the reduction of GABAergic neurotransmission in cortical circuits by this type of interneurons might lead to disinhibitory overactivation of the cortex, such as epileptic activity . Given that the density of the axon terminals of chandelier cells is reduced in schizophrenia, as suggested by postmortem studies [30, 37], one of the consequences of the circuit abnormality in schizophrenia would be hyperexcitability of the cortex.
Early functional imaging studies reported reduced responses of the DLPFC or hypofrontality in patients with schizophrenia [38–41]. Many recent studies suggest overactivation of the DLPFC during performing working memory tasks [42–45] or both greater and less activation of subareas in the DLPFC [46, 47]. The DLPFC would be basically hypodopaminergic, according to the dopamine (DA) hypothesis of schizophrenia . In this situation, the GABAergic inhibition in the DLPFC is not strong. Increasing the DA release in the DLPFC increases glutamatergic neurotransmission through N-methyl-D-aspartate (NMDA) receptors by D1 receptor stimulation. Then, the activity of the DLPFC increases with the DA release in the DLPFC. Under hyperdopaminergic conditions, the GABAergic inhibition becomes so strong that it highly suppresses noisy signal neurotransmission in the DLPFC circuit . The DLPFC activity thus shows an inverted-U shaped profile of the dopaminergic modulation [50, 51]. The profile would be sensitive to the strength of the GABAergic inhibition because the decreasing phase of the inverted-U shaped curve critically depends on the GABAergic inhibition in the DLPFC [49–51]. Therefore, if the GABAergic inhibition in the DLPFC is weakened, as has been observed in schizophrenia, the activity of the DLPFC would be significantly different. In this case, neurons in the DLPFC would exhibit hyperexcitation due to high NMDA currents under hyperdopaminergic conditions [49, 52].
Psychostimulants generally increase DA release from dopaminergic neurons . Psychotic states induced by psychostimulants are accompanied by the focal activation of the PFC, and the activity has a positive correlation with a psychotic symptom [54, 55]. Therefore, hyperdopaminergic neurotransmission and hyperactivity would characterize the PFC in acute psychotic states. The conventional inverted-U shape characteristic of dopaminergic modulation of the PFC activity , however, does not predict this. It rather predicts hypoactivity of the PFC with hyperdopaminergic neurotransmission. This unresolved issue would be an obstacle for advancing our understanding of the circuit mechanisms of schizophrenia. Recently, the circuit dynamics of the PFC under dopaminergic modulation has been studied using a computational model of the PFC circuit [34, 56–59]. This model predicts how the circuit dynamics of the PFC varies with D1 receptor activation. The stability of the PFC circuit varies with the D1 receptor activation when the operating point of the circuit moves along the inverted-U shaped curve. Using this model, Tanaka and coworkers extended the range of the D1 receptor activation to extremely high levels, and showed that hyperactivation of the PFC can occur under hyperdopaminergic conditions (they termed this the 'H mode') . Our study in this article uses essentially the same model and will explore the roles of GABAergic inhibition in the regulation of such dynamics of the PFC circuit. The result will show that 'chandelier cell-type inhibition' controls the H mode activity. GABAergic interneurons other than chandelier cells do not regulate this hyperactive mode effectively. Instead, these GABAergic interneurons regulate the conventional inverted-U shape mode of PFC activity. With these results, we will discuss the roles of GABAergic inhibition in the regulation and dysregulation of PFC circuit dynamics. The aim of this article is to investigate how the GABAergic abnormalities observed in the patients with schizophrenia alter the PFC circuit dynamics. Preliminary results have been published in an abstract form .
Mode diagram of the PFC
The above equation does not contain the term for the chandelier cells (or W cp = 0) because we first see the circuit dynamics of the PFC without chandelier cells. The relationship between x p and z in the above equation gives the mode diagram, which is identical to the curves for the equilibrium states in Figure 1. The equilibrium state has two typical modes of the PFC activity in the different range of D1 receptor activation, z. One is the inverted-U mode (1.0 <z < 4.3) and the other is the H mode (z > 6). There is a gap between these modes (4.3 <z < 6), in which the activity of the PFC is suppressed. Beyond z = 6, the PFC has two branches of activity. The upper branch is stable while the lower branch is unstable, as shown below, meaning that the dynamics of the PFC circuit is bistable. Therefore, once the PFC activity becomes higher than the unstable branch, the activity increases to reach the upper stable branch, whereas PFC activity that is lower than the unstable branch decreases to zero.
These are the equilibrium conditions for the two populations of neurons. The intersections of these nullclines indicate, therefore, the equilibrium states of the whole circuit or the fixed points. The figure shows three different conditions, mentioned above; i.e., the inverted-U mode (Figure 2A), the inactive state (Figure 2B), and the H mode (Figure 2C). The inverted-U mode has a single stable fixed point, indicated by a circle in Figures 2A and 2A1. The inactive state has no intersection between the two nullclines, so that only the state x p = x n = 0 is stable. In the H mode condition, there are two intersections of the nullclines or fixed points. Among these, the lower fixed point, indicated by a cross, is unstable, whereas the higher fixed point, indicated by a circle, is stable. This stable fixed point characterizes the H mode by hyperactivity of the PFC neurons.
Roles of GABAergic inhibition
A summary of the variations of the parameter values of the two different types of GABAergic inhibition used in the simulation.
Other GABA neurons
Chandelier cells vs other GABAergic interneurons
Our computational studies suggest that the dopaminergic modulation profile of PFC activity is complex rather than just an inverted U. A remarkable thing is the possibility of the existence of the H mode or hyperactive mode of the PFC with hyperdopaminergic neurotransmission. Both this mode and the conventional inverted-U mode activity of the PFC under the dopaminergic modulation would be regulated by GABAergic neurotransmission. However, the simulation in this article suggests that these modes have different sensitivities to different types of GABAergic inhibition. The H mode is sensitive to the GABAergic inhibition by chandelier cells, whereas the inverted-U mode is sensitive to the inhibition by GABAergic interneurons other than chandelier cells. The emergence of the H mode is, therefore, critically dependent on the strength of the chandelier cell-type inhibition. Stronger inhibition of this type puts the H mode away from the inverted-U mode. This means that, when the GABAergic inhibition by chandelier cells is reduced, as suggested in schizophrenia, the H mode is considered to be closer to the inverted-U mode than in healthy controls. On the other hand, the profile of the inverted-U mode is critically dependent on the inhibition by GABAergic interneurons other than chandelier cells. If this type of inhibition is stronger, the inverted-U mode easily disappears. With weaker inhibition of this type, in contrast, the profile of the inverted-U mode becomes larger. If both types of inhibition are reduced, therefore, the inverted-U mode and the H mode would merge into a single mode. As a result, the state of the PFC would be able to move to the H mode from the inverted-U mode.
Transition to the H mode
Functional magnetic resonance imaging (fMRI) studies of patients with schizophrenia using a verbal fluency task showed that increasing task demand produced greater activation of the PFC with higher error rates in psychotic states compared with remission . A recent fMRI study suggested an association between reality distortion and hyperactivity of the medial PFC of patients with schizophrenia or schizoaffective disorders . Besides these, 'it is postulated that before experiencing psychosis, patients [with schizophrenia] develop an exaggerated release of DA, independent of and out of synchrony with the context' . Downregulation of GABAergic neurotransmission in the PFC has consistently been associated with schizophrenia [1–5, 15]. These support our theory that psychotic states are induced by the transition to the H mode due to reduced GABAergic inhibition in the PFC with hyperdopaminergic neurotransmission.
Ketamine and amphetamines induced focal activation of the PFC in healthy subjects [54, 63, 64] and in patients with schizophrenia . In either schizophrenia or drug addiction, therefore, psychosis is associated with selective or focal activation of the cortex [54, 63–65]. NMDA antagonists, such as phencyclidine and ketamine, increase the extracellular DA concentration in the PFC [66–68]. It has been suggested that acute administration of psychostimulants, such as amphetamines and cocaine, increases the extracellular DA level significantly not only in the subcortical areas but in the PFC [69, 70]. A microdialysis study reported that intraperitoneal administration of 2 mg/kg of amphetamine to rats induced six-fold increase in the baseline DA concentration in the PFC , which could activate D1 receptors in the PFC. Recent studies reported that ketamine, an NMDA antagonist, decreased the expression of PV and GAD67 in mice [71, 72], suggesting reduced GABAergic inhibition in the PFC. Therefore, the underlying circuit mechanism of substance-induced psychosis might be the same with schizophrenic psychosis; that is, the transition to the H mode due to reduced GABAergic inhibition in the PFC with hyperdopaminergic neurotransmission.
Upregulation of D1 receptors
In contrast to acute administration, chronic administration of psychostimulants lowers the extracellular concentration of DA in the PFC [73, 74], which would induce sensitization of DA receptors. Similarly, the sensitization of DA receptors would be expected in patients with schizophrenia. A positron emission tomography (PET) study, using [11C]NNC 112 as a radiotracer, observed an increase in the binding potential of D1 receptors in the PFC of schizophrenia patients . This would reflect a chronically reduced extracellular DA concentration and an increase in the density of D1 receptors. Upregulation or sensitization of D1 receptors might be involved in schizophrenia. An increase in the DA releasability or the responsivity of dopaminergic neurons has also been suggested [76, 77]. These situations would increase the z value in the model, thereby increasing susceptibility to the H mode.
Acute stress increases DA turnover in the PFC, which leads to the impairment of cognitive functions [78, 79]. It seems that metabolic activity of dopaminergic neurons innervating the PFC is increased selectively in the PFC . The administration of the stressor FG 7142 also increases DA turnover in the PFC [81, 82]. Chronic stress induced hypodopaminergic states, and, again, impaired cognitive functions . In this case, Bmax or the density of D1 receptors in rat PFC was significantly increased (from 14.5 with 2.9 SD to 22.3 with 3.5 SD). Interestingly, either the hyperdopaminergic state or the hypodopaminergic state with D1 upregulation could lead to the H mode, according to the above arguments.
People with epilepsy are susceptible to schizophrenia-like psychosis [84–86]. The association between epilepsy and schizophrenia-like psychosis has long attracted much attention [87, 88], and would be interesting to know the commonalities between epilepsy and schizophrenia and the mechanisms underlying both diseases. Epilepsy is accompanied by excessive excitation of neuronal circuits in the brain [89, 90]. Many studies have suggested selective alterations in GABAA receptor subtypes in patients with epilepsy [91, 92]. DeFelipe proposed the hypothesis that the chandelier cell is a key component of cortical circuits in the establishment of epilepsy . Links to dopaminergic mechanisms have also been suggested [93, 94]. Using whole-cell recording and voltage-sensitive dye imaging techniques in the rat PFC, Bandyopadhyay et al.  demonstrated that bath application of SKF 81297, a selective D1 receptor agonist, enhanced spatiotemporal spread of activity in response to weak stimulation and previously subthreshold stimulation resulted in epileptiform activity that spread across the whole cortex. This result indicates that DA, via a D1 receptor-mediated mechanism, enhances spatiotemporal spread of neuronal activity and lowers the threshold for epileptiform activity in local circuits within the PFC. A rat study suggested that the supersensitivity of the DA systems, which was developed in the chronic phase of the kainate-induced temporal lobe epilepsy, was responsible for the genesis of epileptic psychosis . The H mode hypothesis is consistent with all of these results.
Enhanced cortical inputs
Because of the bistable nature of the H mode, the occurrence of the H mode critically depends on the strength of inputs. They are mediated by corticocortical or thalamocortical afferents to the PFC, and would be modulated by several ways, including dopaminergic modulation. It has also been suggested that DA has a sensorimotor gating function in PFC and subcortical circuits [96–99]. In fact, many studies have reported deficits in the sensorimotor gating function in patients with schizophrenia (for reviews: [98, 100, 101]) and, interestingly, also in amphetamine-sensitized animals . When a dysregulated or unfiltered input is given to the PFC, the PFC would respond to it with hyperactivity. Recent neurophysiological study in monkey reported an enhancement of the response-period activity of DLPFC neurons, but no effect on delay-period activity, by the stimulation of the D2 receptors in the DLPFC . This may suggest that D2 receptors are involved in gating afferent input to the DLPFC circuit for working memory and other cognitive functions. Moreover, if D2 receptors are supersensitive [104, 105], the H mode would more readily emerge because hyperactivation of D2 receptors could contribute to the enhancement of the input to the PFC.
We have investigated how GABAergic inhibition by chandelier cells and other GABAergic interneurons contribute to the regulation of neuronal activity in the PFC circuit. The results show that the roles of the two different types of GABAergic inhibition on PFC circuit dynamics are markedly different. The inhibition by GABAergic interneurons other than chandelier cells effectively regulates the PFC activity with rather low or modest levels of dopaminergic neurotransmission, which has an inverted-U shaped profile of dopaminergic modulation and is associated with normal cognitive functions. In contrast, the chandelier cell-type inhibition regulates the PFC activity with hyperdopaminergic neurotransmission. Therefore, dysfunction of chandelier cells in the PFC would produce the H mode, a "psychotic" hyperactive state with hyperdopaminergic neurotransmission. Reduction of the inhibition by other GABAergic interneurons would make the transition to the H mode more readily occur, thereby increasing vulnerability to psychosis.
Prefrontal Cortical Circuit Model
where fmax is the maximum firing rate. The activation function for the chandelier cell population will be given below. The simulation used the values of the parameters in the above equations as: fmax = 100 sp/s, τ p = 20.0, τ c (0) = τ n (0) = 5.0, W pp (0) = 0.00055, W pc (0) = W pn (0) = 0.00035, W cp = 0.0002, and W np = 0.0005.
Dopaminergic Modulation via D1 Receptors
where a, b and c are constants (a = 0.2, b = 0.4, c = 0.3).
This work was supported partly by the Sophia University Open Research Center grant. The author acknowledges the discussions with Hiroaki Ebi toward the construction of the computational model used in this study.
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