Huang W, Chengxuan Q, von Strauss E, Winblad B, Fratiglioni L: APOE genotype, family history of dementia, and Alzheimer Disease risk. Arch Neurol. 2004, 61: 1930-1934. 10.1001/archneur.61.12.1930.
Article
PubMed
Google Scholar
Semchuk KM, Love EJ, Lee RG: Parkinson's disease: a test of the multifactorial etiologic hypothesis. Neurol. 1993, 43: 1171-1180.
Article
Google Scholar
Doolittle TH, Myers RH, Lehrich JR, Birnbaum G, Sheremata W, Franklin GM, Nelson LM, Hauser SL: Multiple sclerosis sibling pairs: clustered onset and familial disposition. Neurol. 1990, 40: 1546-1552.
Article
Google Scholar
Shacka JJ, Roth KA: Regulation of neuronal cell death and neurodegeneration by members of the Bcl-2 family: therapeutic implications. Curr Drug Targets CNS Neurol Disorders. 2005, 4: 25-39. 10.2174/1568007053005127.
Article
Google Scholar
Ekshyyan O, Aw TY: Apoptosis: a key in neurodegenerative disorders. Curr Neurovasc Res. 2004, 1: 355-371. 10.2174/1567202043362018.
Article
PubMed
Google Scholar
Tian J, Shi J, Bailey K, Harris JM, Pritchard A, Lambert JC, Chartier-Harlin MC, Pickering-Brown SM, Lendon CL, Mann DM: A polymorphism in the angiotensin 1-converting enzyme gene is associated with damage to cerebral cortical white matter in Alzheimer's disease. Neurosci Lett. 2004, 354: 103-106. 10.1016/j.neulet.2003.09.072.
Article
PubMed
Google Scholar
Li L, Fan M, Icton CD, Chen N, Leavitt BR, Hayden MR, Murphy TH, Raymond LA: Role of NR2B-type NMDA receptors in selective neurodegeneration in Huntington disease. Neurobiol Aging. 2003, 24: 1113-1121. 10.1016/j.neurobiolaging.2003.04.003.
Article
PubMed
Google Scholar
Kruger R, Fischer C, Schulte T, Strauss KM, Muller T, Woitalla D, Berg D, Hungs M, Gobbele R, Berger K, Epplen JT, Riess O, Schols L: Mutation analysis of the neurofilament M gene in Parkinson's disease. Neurosci Lett. 2003, 351: 125-129. 10.1016/S0304-3940(03)00903-0.
Article
PubMed
Google Scholar
Kigerl KA, McGaughy VM, Popovich PG: Comparative analysis of lesion development and intraspinal inflammation in four strains fo mice following spinal contusion injury. J Comp Neurol. 2006, 494: 578-594. 10.1002/cne.20827.
Article
PubMed
PubMed Central
Google Scholar
Cook R, Lu L, Gu J, Williams RW, Smeyne RJ: Identification of a single QTL, Mptp1, for susceptibility to MPTP-induced substantia nigra pars compacta neuron loss in mice. Mol Brain Res. 2003, 110: 279-288. 10.1016/S0169-328X(02)00659-9.
Article
PubMed
Google Scholar
Sedelis M, Hofele K, Schwarting RKW, JHuston JP, Belknap JK: Chromosomal loci influencing the susceptibility to the Parkinsonian neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. J Neurosci. 2003, 23: 8247-8253.
PubMed
Google Scholar
Netland PA, Wiggs JL, Dreyer EB: Inheritance of glaucoma and genetic counseling of glaucoma patients. Int Ophthalmol Clin. 1993, 33: 101-120. 10.1097/00004397-199303320-00011.
Article
PubMed
Google Scholar
Tielsch JM, Katz J, Sommer A, Quigley HA, Javitt JC: Family history and risk of primary open angle glaucoma: The Baltimore Eye Survey. Arch Ophthalmol. 1994, 112: 69-73.
Article
PubMed
Google Scholar
Libby RT, Gould DB, Anderson MG, John SWM: Complex genetics of glaucoma susceptibility. Ann Rev Genomics Hum Genet. 2005, 6: 15-44. 10.1146/annurev.genom.6.080604.162209.
Article
Google Scholar
Quigley HA: The number of persons with glaucoma worldwide. Br J Ophthalmol. 1996, 80: 389-393.
Article
PubMed
PubMed Central
Google Scholar
Quigley HA: Open-angle glaucoma. New Engl J Med. 1993, 328: 1097-1106. 10.1056/NEJM199304153281507.
Article
PubMed
Google Scholar
Nickells RW, Jampel H, Zack DJ: Glaucoma. Principles and Practice of Medical Genetics. Edited by: Rimion DL, Connor JM, Pyeritz RE and Korf BR. 2002, New York, Churchill Livingstone, III: 3491-3512. 4
Google Scholar
Nickells RW: The molecular biology of retinal ganglion cell death: caveats and controversies. Brain Res Bull. 2004, 62: 439-446. 10.1016/j.brainresbull.2003.07.007.
Article
PubMed
Google Scholar
Quigley HA, Enger C, Katz J, Sommer A, Scott R, Gilbert D: Risk factors for the development of glaucomatous visual field loss in ocular hypertension. Arch Ophthalmol. 1994, 112: 644-649.
Article
PubMed
Google Scholar
Kass MA, Heuer DK, Higginbotham EJ, Johnson CA, Keltner JL, Miller JP, Parrish II RK, Wilson MR, Gordon MO: The ocular hypertension study: A randomized trial determines that topical ocular hypertensive medication delays of prevents the onset of primary open-angle glaucoma. Arch Ophthalmol. 2002, 120: 701-713.
Article
PubMed
Google Scholar
Heijl A, Leske MC, Bengtsson B, Hyman L, Bengtsson B, Hussein M: Reduction of intraocular pressure and glaucoma progression. Arch Ophthalmol. 2002, 120: 1268-1279.
Article
PubMed
Google Scholar
Leske MC, Heijl A, Hussein M, Bengtsson B, Hyman L, Komaroff E: Factors for glaucoma progression and the effect of treatment. Arch Ophthalmol. 2003, 121: 48-56.
Article
PubMed
Google Scholar
Mosinger Ogilvie J, Deckwerth TL, Knudson CM, Korsmeyer SJ: Suppression of developmental retinal cell death but not photoreceptor degeneration in Bax-deficient mice. Invest Ophthalmol Vis Sci. 1998, 39: 1713-1720.
PubMed
Google Scholar
Li Y, Schlamp CL, Poulsen KP, Nickells RW: Bax-dependent and independent pathways of retinal ganglion cell death induced by different damaging stimuli. Exp Eye Res. 2000, 71: 209-213. 10.1006/exer.2000.0873.
Article
PubMed
Google Scholar
Libby RT, Li Y, Savinova OV, Barter J, Smith RS, Nickells RW, John SWM: Susceptibility to neurodegeneration in glaucoma is modified by Bax gene dosage. PLoS Genet. 2005, 1: 17-26. 10.1371/journal.pgen.0010004.
Article
PubMed
Google Scholar
Li Y, Schlamp CL, Nickells RW: Experimental induction of retinal ganglion cell death in adult mice. Invest Ophthalmol Vis Sci. 1999, 40: 1004-1008.
PubMed
Google Scholar
Lander ES, Botstein D: Mapping Mendelian factors underlying quantitative traits using RFLP linkage maps. Genetics. 1989, 121: 185-199.
PubMed
PubMed Central
Google Scholar
Doerge RW: Mapping and analysis of quantitative trait loci in experimental populations. Nat Rev Genet. 2001, 3: 43-52. 10.1038/nrg703.
Article
Google Scholar
Deckwerth TL, Elliot JL, Knudson CM, Johnson Jr. EM, Snider WD, Korsmeyer SJ: BAX is required for neuronal death after trophic factor deprivation and during development. Neuron. 1996, 17: 401-411. 10.1016/S0896-6273(00)80173-7.
Article
PubMed
Google Scholar
Semaan SJ, Li Y, Babcic V, John SWM, Nickells RW: Differential regulation of the pro-apoptotic gene Bax in DBA/2J and 129B6 inbred mice affects retinal ganglion cell death after optic nerve crush. Invest Ophthalmol Vis Sci. 2005, 46: E-Abstract 1279.
Google Scholar
Kipnis J, Yoles E, Schori H, Hauben E, Shaked I, Schwartz M: Neuronal survival after CNS injury is determined by a genetically encoded autoimmune response. J Neurosci. 2001, 21: 4564-4571.
PubMed
Google Scholar
Miller TM, Moulder KL, Knudson CM, Creedon DJ, Deshmukh M, Korsmeyer SJ, Johnson Jr. EM: Bax deletion further orders the cell death pathway in cerebellar granule cells and suggests a caspase-independent pathway to cell death. J Cell Biol. 1997, 139: 205-217. 10.1083/jcb.139.1.205.
Article
PubMed
PubMed Central
Google Scholar
Yoshida K, Behrens A, Le-Niculescu H, Wagner EF, Harada T, Imaki J, Ohno S, Karin M: Amino-terminal phosphorylation of c-Jun regulates apoptosis in the retinal ganglion cells by optic nerve transection. Invest Ophthalmol Vis Sci. 2002, 43: 1631-1635.
PubMed
Google Scholar
Lingor P, Koeberle P, Kügler S, Bähr M: Down-regulation of apoptosis mediators by RNAi inhibits axotomy-induced retinal ganglion cell death in vivo. Brain. 2005, doi:10.1093/brain/awh382.
Google Scholar
Wakabayshi T, Kosaka J, Oshika T: JNK inhibitory kinase is up-regulated in retinal ganglion cells after axotomy and enhances BimEL expression levels in neuronal cells. J Neurochem. 2005, 95: 526-536. 10.1111/j.1471-4159.2005.03389.x.
Article
Google Scholar
Li Y, Schlamp CL, Poulsen G, Jackson M, Griep A, Nickells RW: p53 regulates apoptotic ganglion cell death induced by N-methyl-D-aspartate. Mol Vis. 2002, 8: 341-350, http://www.molvis.org/molvis/v8/a41.
PubMed
Google Scholar
Näpänkangas U, Lindqvist N, Lindholm D, Hallböök F: Rat retinal ganglion cells upregulate the pro-apoptotic BH3-only protein Bim after optic nerve transection. Mol Brain Res. 2003, 120: 30-37. 10.1016/j.molbrainres.2003.09.016.
Article
PubMed
Google Scholar
Weise J, Isenmann S, Bähr M: Increased expression and activation of poly(ADP-ribose) polymerase (PARP) contribute to retinal ganglion cell death following rat optic nerve transection. Cell Death Differ. 2001, 8: 801-807. 10.1038/sj.cdd.4400872.
Article
PubMed
Google Scholar
McKinnon SJ, Lenhman DM, Kerrigan-Baumrind LA, Merges CA, Pease ME, Kerrigan DF, Ransom NL, Tahzib NG, Reitsamer HA, Levkovitch-Verbin H, Quigley HA, Zack DJ: Caspase activation and amyloid precursor protein cleavage in rat ocular hypertension. Invest Ophthalmol Vis Sci. 2002, 43: 1077-1087.
PubMed
Google Scholar
Kermer P, Klöcker N, Labes M, Bähr M: Inhibition of CPP32-like proteases rescues axotomized retinal ganglion cells from secondary death in vivo. J Neurosci. 1998, 18: 4656-4662.
PubMed
Google Scholar
Kermer P, Klocker N, Labes M, Thomsen S, Srinivasan A, Bähr M: Activation of caspase-3 in axotomized rat retinal ganglion cells in vivo. FEBS Lett. 1999, 25: 361-364. 10.1016/S0014-5793(99)00747-4.
Article
Google Scholar
Kermer P, Ankerhold R, Klocker N, Krajewski S, Reed JC, Bähr M: Caspase-9 involvement in secondary death of axotomized rat retinal ganglion cells in vivo. Brain Res Mol Brain Res. 2000, 28: 144-150. 10.1016/S0169-328X(00)00256-4.
Article
Google Scholar
Ressiniotis T, Griffiths PG, Birch M, Keers S, Chinnery PF: Primary open angle glaucoma is associated with a specific p53 gene haplotype. J Med Genet. 2004, 41: 296-298. 10.1136/jmg.2003.016089.
Article
PubMed
PubMed Central
Google Scholar
Levin LA, Schlamp CL, Spieldoch RL, Geszvain KM, Nickells RW: Identification of bcl-2 family genes in the rat retina. Invest Ophthalmol Vis Sci. 1997, 38: 2545-2553.
PubMed
Google Scholar
Kretz A, Kügler S, Happold C, Bähr M, Isenmann S: Excess BclXL increases the intrinsic growth potential of adult CNS neurons in vitro. Mol Cell Neurosci. 2004, 26: 63-74. 10.1016/j.mcn.2004.01.007.
Article
PubMed
Google Scholar
Bonfanti L, Strettoi E, Chierzi S, Cenni MC, Liu XH, Martinou JC, Maffei L, Rabacchi SA: Protection of retinal ganglion cells from natural and axotomy-induced cell death in neonatal transgenic mice overexpressing bcl-2. J Neurosci. 1996, 16: 4186-4194.
PubMed
Google Scholar
Cenni MC, Bonfanti L, Martinou JC, Ratto GM, Strettoi E, Maffei L: Long-term survival of retinal ganglion cells following optic nerve section in adult bcl-2 transgenic mice. Eur J Neurosci. 1996, 8: 1735-1745. 10.1111/j.1460-9568.1996.tb01317.x.
Article
PubMed
Google Scholar
Schlamp CL, Johnson EC, Li Y, Morrison JC, Nickells RW: Changes in Thy1 gene expression associated with damaged retinal ganglion cells. Mol Vis. 2001, 7: 192-201<http://www.molvis.org/molvis/v7/a27>.
PubMed
Google Scholar
Weishaupt JH, Klocker N, Bahr M: Axotomy-induced early down-regulation of POU-IV class transcription factors Brn-3a and Brn-3b in retinal ganglion cells. J Mol Neurosci. 2005, 26: 17-25. 10.1385/JMN:26:1:017.
Article
PubMed
Google Scholar
Park KH, Cozier F, Ong OC, Caprioli J: Induction of heat shock protein 72 protects retinal ganglion cells in a rat glaucoma model. Invest Ophthalmol Vis Sci. 2001, 42: 1522-1530.
PubMed
Google Scholar
Krueger-Naug AM, Emsley JG, Myers TL, Currie RW, Clarke DB: Injury to retinal ganglion cells induces expression of the small heat shock protein Hsp27 in the rat visual system. Neurosci. 2002, 110: 653-665. 10.1016/S0306-4522(01)00453-5.
Article
Google Scholar
Levin LA, Geszvain KM: Expression of ceruloplasmin in the retina: induction after optic nerve crush. Invest Ophthalmol Vis Sci. 1998, 39: 157-163.
PubMed
Google Scholar
Farkas RH, Chowers I, Hackam AS, Kageyama M, Nickells RW, Otteson D, Duh E, Wang C, Valenta D, Gunatilaka T, Pease ME, Quigley HA, Zack DJ: Increased expression of iron-regulating genes in monkey and human glaucoma. Invest Ophthalmol Vis Sci. 2004, 45: 1410-1417. 10.1167/iovs.03-0872.
Article
PubMed
Google Scholar
Green DR, Reed JC: Mitochondria and apoptosis. Science. 1998, 281: 1309-1312. 10.1126/science.281.5381.1309.
Article
PubMed
Google Scholar
Bellezza AJ, Rintalan CJ, Thompson HW, Downs JC, Hart RT, Burgoyne CF: Deformation of the lamina cribrosa and anterior scleral canal wall in early experimental glaucoma. Invest Ophthalmol Vis Sci. 2003, 44: 623-637. 10.1167/iovs.01-1282.
Article
PubMed
Google Scholar
Ethier CR: Scleral biomechanics and glaucoma - a connection?. Can J Ophthalmol. 2006, 41: 9-11.
Article
PubMed
Google Scholar
Quigley HA, Addicks EM, Green WR, Maumenee AE: Optic nerve damage in human glaucoma: II. The site of injury and susceptibility to damage. Arch Ophthalmol. 1981, 99: 635-649.
Article
PubMed
Google Scholar
Quigley HA, Addicks EM: Regional differences in the structure of the lamina cribrosa and their relation to glaucomatous optic nerve damage. Arch Ophthalmol. 1981, 99: 137-143.
Article
PubMed
Google Scholar
Pease ME, McKinnon SJ, Quigley HA, Kerrigan-Baumrind LA, Zack DJ: Obstructed axonal transport of BDNF and its receptor TrkB in experimental glaucoma. Invest Ophthalmol Vis Sci. 2000, 41: 764-774.
PubMed
Google Scholar
Jakobs TC, Libby RT, Ben Y, John SWM, Masland RH: Retinal ganglion cell degeneration is topological but not cell type specific in DBA/2J mice. J Cell Biol. 2005, 171: 313-325. 10.1083/jcb.200506099.
Article
PubMed
PubMed Central
Google Scholar
Schlamp CL, Li Y, Dietz JA, Janssen KT, Nickells RW: Progressive ganglion cell loss and optic nerve degeneration in DBA/2J mice is variable and asymmetric. BMC Neurosci. 2006, 7: 66-10.1186/1471-2202-7-66.
Article
PubMed
PubMed Central
Google Scholar
John SWM, Smith RS, Savinova OV, Hawes NL, Chang B, Turnbull D, Davisson M, Roderick TH, Heckenlively JR: Essential iris atrophy, pigment dispersion, and glaucoma in DBA/2J mice. Invest Ophthalmol Vis Sci. 1998, 39: 951-962.
PubMed
Google Scholar
Chang B, Smith RS, Hawes NL, Anderson MG, Zabaleta A, Savinova O, Roderick TH, Heckenlively JR, Davisson MT, John SWM: Interacting loci cause severe iris atrophy and glaucoma in DBA/2J mice. Nature Genet. 1999, 21: 405-409. 10.1038/7741.
Article
PubMed
Google Scholar
Anderson MG, Smith RS, Hawes NL, Zabaleta A, Chang B, Wiggs JL, John SWM: Mutations in genes encoding melanosomal proteins cause pigmentary glaucoma in DBA/2J mice. Nat Genet. 2002, 30: 81-85. 10.1038/ng794.
Article
PubMed
Google Scholar
Libby RT, Anderson MG, Pang IH, Robinson Z, Savinova OV, Cosma IM, Snow A, Wilson LA, Smith RS, Clark AF, John SWM: Inherited glaucoma in DBA/2J mice: pertinent disease features for studying the neurodegeneration. Vis Neurosci. 2005, 22: 637-648.
Article
PubMed
Google Scholar
Stone J: The Wholemount Handbook. A Guide to the Preparation and Analysis of Retinal Wholemounts. 1981, Sydney, Maitland Publishing Pty. Ltd., 3-23.
Google Scholar
Bancroft JD, Stevens A: Bielschowsky's silver stain for axons in frozen and paraffin sections (modified). Theory and Practice of Histological Techniques. Edited by: Bancroft JD and Stevens A. 1990, New York, Churchill Livingstone, 347-348. 3rd
Google Scholar
Dräger UC, Olsen JF: Ganglion cell distribution in the retina of the mouse. Invest Ophthalmol Vis Sci. 1981, 20: 285-293.
PubMed
Google Scholar
Jeon CJ, Strettoi E, Masland RH: The major cell populations of the mouse retina. J Neurosci. 1998, 18: 8936-8946.
PubMed
Google Scholar