Dominant inheritance of retinal ganglion cell resistance to optic nerve crush in mice

BMC Neuroscience

Table 1 Matrix of P values of the mean cell counts from all inbred lines

Strain	DBA/2J	129X1/SvJ	C57BL/10J	DBA/1J	C57BL/6J	MRL/MpJ	A/J	FVB/NJ	CBA/CaJ	LG/J	SJL/J	NZB/BINJ	NOD/LtJ	C3H/HeJ
BALB/cByJ	0.00012	0.00017	0.0002	0.00001	0.0008	0.0005	0.0008	0.0001	0.00003	0.0004	0.01	0.015	0.003	0.339
C3H/HeJ	0.001	0.0017	0.0022	0.0005	0.006	0.005	0.007	0.002	0.001	0.005	0.048	0.066	0.05
NOD/LtJ	0.001	0.004	0.004	0.0007	0.015	0.014	0.019	0.0065	0.003	0.013	0.18	0.29
NZB/BINJ	0.0096	0.025	0.033	0.024	0.069	0.08	0.095	0.077	0.07	0.126	0.35
SJL/J	0.022	0.06	0.07	0.08	0.138	0.17	0.189	0.189	0.194	0.265
LG/J	0.04	0.138	0.162	0.187	0.28	0.344	0.36	0.398	0.42
CBA/CaJ	0.034	0.138	0.166	0.209	0.3	0.386	0.4	0.46
FVB/NJ	0.045	0.165	0.197	0.258	0.336	0.42	0.436
A/J	0.087	0.239	0.276	0.359	0.407	0.489
MRL/MpJ	0.079	0.236	0.275	0.365	0.413
C57BL/6J	0.125	0.322	0.363	0.476
DBA/1J	0.088	0.308	0.354
C57BL/10J	0.194	0.458
129X1/SvJ	0.214

A table showing head-to-head statistical comparisons of the mean cells remaining of each strain of inbred mice. P values (t-test) shown in bold font indicate a significant difference in the mean values between the compared mice. Based on the criterion of cell loss in the ganglion cell layer 2 weeks after crush, DBA/2J mice exhibited the greatest resistance to optic nerve crush, while BALB/cByJ mice exhibited the greatest susceptibility.

ISSN: 1471-2202