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Memory deficits in amyotrophic lateral sclerosis are not exclusively caused by executive dysfunction: a comparative neuropsychological study of amnestic mild cognitive impairment

Abstract

Background

Recent work suggests that ALS and frontotemporal dementia can occur together and share at least in part the same underlying pathophysiology. However, it is unclear at present whether memory deficits in ALS stem from a temporal lobe dysfunction, or are rather driven by frontal executive dysfunction. In this study we sought to investigate the nature of memory deficits by analyzing the neuropsychological performance of 40 ALS patients in comparison to 39 amnestic mild cognitive impairment (aMCI) patients and 40 healthy controls (HC). The neuropsychological battery tested for impairment in executive functions, as well as memory and visuo-spatial skills, the results of which were compared across study groups. In addition, we calculated composite scores for memory (learning, recall, recognition) and executive functions (verbal fluency, cognitive flexibility, working memory). We hypothesized that the nature of memory impairment in ALS will be different from those exhibited by aMCI patients.

Results

Patient groups exhibited significant differences in their type of memory deficit, with the ALS group showing impairment only in recognition, whereas aMCI patients showed short and delayed recall performance deficits as well as reduced short-term capacity. Regression analysis revealed a significant impact of executive function on memory performance exclusively for the ALS group, accounting for one fifth of their memory performance. Interestingly, merging all sub scores into a single memory and an executive function score obscured these differences.

Conclusion

The presented results indicate that the interpretation of neuropsychological scores needs to take the distinct cognitive profiles in ALS and aMCI into consideration. Importantly, the observed memory deficits in ALS were distinctly different from those observed in aMCI and can be explained only to some extent in the context of comorbid (coexisting) executive dysfunction. These findings highlight the qualitative differences in temporal lobe dysfunction between ALS and aMCI patients, and support temporal lobe dysfunction as a mechanism underlying the distinct cognitive impairments observed in ALS.

Background

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder, characterized by hallmark motor neuron and corticospinal tract degeneration. It is well-established that ALS shares clinical [1], pathological [2] and genetic [3] characteristics with frontotemporal dementia (FTD), and this overlap has led some studies to assert the existence of a single continuum on which both ALS and FTD lie [4, 5]. Recent studies indicate a global neuropsychological deficit wherein impairment of executive functions is reported the most [614]. However, there is increasing evidence that other cognitive domains such as language and memory are also affected [7, 10, 1519]. Especially memory impairment has been somewhat neglected and often seen as a failure of encoding as an executive component of memory [8, 17, 20]. However, there are reports on memory dysfunction in ALS, often tested with picture recall, word list learning, pair association learning or story recall [12, 14, 18, 2130]. Most of them support an encoding or short recall deficit with relatively sparing of consolidation performance but the findings are inconsistent and have not been related to temporal lobe dysfunction. Recently, there has been growing postmortem and in vivo evidence of temporal lobe involvement in ALS, based on hippocampal TDP-43 pathology [31, 32] and volume loss [3335]. Temporal lobe pathology is also a key feature of Alzheimer's Disease (AD) with hippocampal atrophy even in early stages [36]. Based on the shared hippocampal involvement in both ALS and AD, we sought to investigate whether there are distinctive differences between the sort of memory deficits in ALS and AD. However, the extent of hippocampal pathology in AD is, up to current knowledge, far more progressed and widespread than in ALS making a direct comparison between ALS and AD patients very difficult if not impossible. Therefore we decided to compare ALS patients to a group of patients that suffer from an AD prodromal stage, amnestic mild cognitive impairment (aMCI) [37]. Patients with aMCI have overt deficits in cognition, especially in the memory domain, but are still largely independent in daily activities. They have a far higher risk of developing dementia than cognitively normal persons, but at the individual patient level the prognosis might be variable [38]. The temporal lobe pathology as hippocampal atrophy is also a hallmark in aMCI but it occurs to a much smaller extent than in AD [39]. Therefore this group of patients is comparable to patients with ALS in terms of hippocampal degeneration. In the current work we focussed on verbal memory performance and hypothesized a qualitative difference between patients with ALS and aMCI.

Methods

Subjects

40 ALS patients were recruited from the outpatient clinics of the Departments of Neurology at the Otto-von-Guericke University of Magdeburg and Hannover Medical School between 04/2011 and 03/2012. ALS patients were diagnosed according to the revised El Escorial Criteria [40], and the Amyotrophic Lateral Sclerosis Functional Rating Scale - Revised (ALSFRS-R, [41]) was used to evaluate their functional status. Three ALS patients fulfilled the Rascovsky criteria for behavioural variant frontotemporal dementia (ALS-FTD, [42]), and were included in the analysis to represent the full spectrum of cognitive impairment in ALS. ALS Patients with a history of other neurological conditions that could affect cognition (major hemispheric stroke, traumatic brain injury), severe active mental illness, or alcohol abuse were excluded.

In addition, 39 aMCI patients were recruited from the memory outpatient clinic in Magdeburg and classified according to the revised Peterson Criteria for mild cognitive impairment [37]. A group of 40 healthy age- and gender- matched controls without a prior history of neurological or psychiatric illness was also recruited. In the healthy control group, only subjects who performed within the normal range of the Montreal Cognitive Assessment (MoCA; cut-off 26/30) were included. The local ethics committee of Otto-von-Guericke University approved the study and all participants gave their written informed consent prior to their inclusion.

Neuropsychological assessment and data analysis

All participants underwent a detailed neuropsychological assessment in conjunction with their clinical examination. The battery of tests included a range of standardized neuropsychological instruments and was designed based on the ALS literature suggesting an early decline of frontally-mediated executive functions in ALS patients [68, 10]. To assess the executive domain, the Regensburger verbal fluency test [43] was used to survey phonemic verbal fluency (letter “K”) and flexibility (alteration between letters “G” and “R”). Additionally, we tested for cognitive flexibility with the Trail Making Test (the ratio between part B and A was computed to account for motor impairment) [44] and for verbal working memory performance (Wechsler Memory scale-revised (WMS-R), digit span backwards) [45]. The battery also tested for impairment in non-executive cognitive domains. To assess memory functions, the German version of the Rey Auditory Verbal Learning Test (RAVLT) [46], and the forward digit span task from the revised Wechsler Memory Scale [45] was used. Visuo-spatial abilities were evaluated using the Rey Complex Figure Test (RCFT) [47]. Mood was assessed using Beck Depression Inventory-II [48]. Neuropsychological performance between the study groups was compared by one-way analysis of variance (ANOVA) with group as a main factor (ALS/aMCI/HC). Because of some physical disabilities in the ALS cohort, not all patients completed all tests. The missing data strategy was to exclude them from individual analyses but the cases were retained in the dataset. All tests were two-tailed and the statistical significance threshold was set at p < 0.05. Bonferroni correction was applied to adjust the α-value for post hoc analysis where applicable.

To determine whether the patient groups could be differentiated based on group level with less refined neuropsychological measures, we computed composite scores for “Memory” and “Executive function” by transforming the raw values into Z-scores that were referenced by mean and standard deviation of the healthy controls on the corresponding test. Composite “Memory” scores incorporated the following parameters: learning (sum of trials 1–5 of the RAVLT), immediate verbal recall (difference between trial 5 and trial 6), delayed verbal recall (difference between trial 5 and trial 7) and recognition (corrected for false positive and interference items). “Executive function” score included measures of verbal fluency, cognitive flexibility and verbal working memory. These scores were compared across patient groups (ALS/aMCI) using t-tests for non-dependent samples, but also used to conduct a regression analysis to estimate the influence of executive function on memory performance in each of the three groups.

All statistical analyses were carried out using SPSS for Windows, Version 21.0 (IBM SPSS Statistics, Armonk, NY, USA; RRID:rid_000042).

Results

Demographic and clinical characteristics

Demographic and clinical data are summarized in Table 1. An analysis of variance indicated no difference in age (F2,116 = 1.92, p = 0.15) and a trend in gender distribution (Χ2 = 5.53, p = 0.06). There was also a trend toward higher self-reported depression scores in ALS patients (F2,103 = 2.94, p = 0.06). However, none of the three groups scored within the range of clinically relevant depressive symptoms (Beck Depression Inventory-II <13 points). There was a difference between groups regarding their completed educational years (F2,114 = 4.28, p = 0.02). Patients with ALS (13.0 ± 2.5) have less educational years than aMCI (14.6 ± 2.8), but both patient groups did not differ from healthy controls (14.0 ± 2.1).

Table 1 Baseline characteristics

Neuropsychological performance of ALS, aMCI patients, and control subjects

A significant group effect was identified in the memory domain for the following variables: Digit span (F2,114 = 8.58, p < 0.001), immediate verbal recall (F2,115 = 5.91, p = 0.004), delayed verbal recall (F2,115 = 6.97, p = 0.001) and recognition (F2,116 = 3.69, p = 0.028). Significant group effects were also revealed for tests of executive function: Phonemic fluency (F2,112 = 11.00, p < 0.001) and flexibility (F2,112 = 18.47, p < 0.001) and working memory performance (F2,114 = 10.48, p < 0.001). Visuo-spatial performance was also significantly different between the three groups (F2,104 = 6.42, p = 0.002). No differences were observed for verbal learning (F2,116 = 2.67, p = 0.074). Mean values and standard deviations for neuropsychological subtests are presented in Table 2. Figure 1 illustrates the percentage of aMCI patients and ALS patients that fell more than 1.5 standard deviations below the performance of healthy controls in each neuropsychological subtests.

Table 2 Post-hoc test results in neuropsychological tests for patients and controls: raw scores and p - values
Figure 1
figure1

Neuropsychological profile of patients with ALS and aMCI. Profile lines display the percentage of ALS patients and aMCI patients <1.5 SD below the mean of healthy controls for subtests within each cognitive domain.

The analysis of composite scores for each cognitive domain revealed no main effect for overall “Memory” and “Executive function”. Within-group comparisons in the form of regression analysis revealed no significant impact of “Executive function” on “Memory” for neither the aMCI group (r = 0.25, p = 0.13) nor the healthy control group (r = -0.02, p = 0.88). In ALS patients there was a significant relationship between the two domains (r = 0.45, p = 0.003) with “Executive function” accounting for 20.5% of the variance in “Memory” performance.

Discussion

This cross-sectional study of neuropsychological performance in controls, ALS and aMCI patients revealed a significant deficit in verbal memory function in both patient groups relative to controls. In patients with ALS we observed additional dominant executive deficits including the impairment of verbal fluency, which is a consistent, well-documented finding in motor neuron disease [7, 8, 11, 14]. This deficit also has an impact on disease progression [6] and survival [49]. In contrast, reports on memory dysfunction are more inconsistent. When evaluating overall memory impairment as a composite parameter of several memory subdomains, there were no differences between aMCI and ALS patients. However, examining the nature of amnestic deficits based on more predefined sub-functions revealed disease-group specific patterns of impairment. Patients with aMCI had overt deficits in short and delayed recall, whereas ALS patients were mainly impaired in verbal memory recognition. Recall deficits in aMCI are a hallmark feature of this patient group and support the notion of being a pre-Alzheimer's Disease stage [37]. Recall performance in patients with ALS was not affected. Previous studies, that took verbal memory into account, have reported both, impaired and preserved recall performance on word-list learning tests, depicting the inconsistency among observed memory deficits in ALS. One study reported long-delay recall impairment but no impairment on short-term recall or recognition [23], while others report deficits in short recall performance but preserved delayed recall performance [12], or impairment in both, short and delayed recall [18]. Based on the high variability regarding cognitive deficits between patients, recent population-based studies propose a neuropsychological classification into subgroups with focus on executive impairment or non-executive impairment [7] and a novel screening tool has taken into account ALS specific and non-specific tests [15]. However, given the results yielded in the present study, memory deficits in ALS seem to be disease specific and can be differentiated from other neurodegenerative diseases such as AD when assessed specifically. Recognition deficits in patients with ALS were found the most obvious memory deficit and have been reported before [17, 50], although such deficits have been mostly associated with executive dysfunction [17, 29]. In our cohort, executive impairment could only account for 20.5% of memory performance in ALS, which supports the emerging notion that executive function is only one of several cognitive domains impaired in ALS [7, 16]. Moreover, executive dysfunction in frontotemporal dementia has been related to failure in source memory but not recognition performance [51], which leads to the assumption that the recognition deficit reported here cannot be caused solely by executive dysfunction. Impairment in recognition can emerge from either insufficient encoding as a temporal lobe function or from deficient prefrontal cortical function. However, both assumptions would lead to a higher amount of errors and interference biases, which was more pronounced in patients with ALS than with aMCI. In experimental psychology, recognition memory is understand as a 'dual-process’ model that incorporates the product of two different memory functions, namely familiarity and recollection [52]. Thus, recognition judgements can be based on the recollection of details about previous events or on the assessment of stimulus familiarity [53]. In ALS, only one study so far investigated recognition memory and its underlying neuronal mechanisms [50]. The paradigm consisted of a verbal recognition task, where the subjects had to decide whether a word was presented before or not. Although this was an experimental set up, results can be compared to the recognition test that was used in this study (RAVLT). Similar to our observations, Muente et al. [50] reported a recognition deficit in patients with ALS that was related to an absent recognition associated event-related potential. Interestingly, this effect was not observed in patients with Alzheimer's Disease which completed a comparable task [54]. These results support the different qualities of memory impairment in ALS and AD observed in the current study.

In addition to detailed neuropsychological testing and/or neurophysiological measures, imaging studies could provide more information about the specific anatomical structures involved. A number of studies correlated cognitive performance with white or grey matter integrity [4, 30, 55, 56], but only two focused on word list learning and structural integrity. The results however seem inconsistent since one reported a relationship between memory performance in ALS and uncinate fasciculus (UF) integrity [30], whereas the other study found no such association [55]. Since both studies had relatively small sample sizes, further structural-functional correlations are needed to draw more definite conclusions on the relationship between memory impairment and cerebral pathology in ALS. Given that the uncinate fasciculus connects temporal lobe structures such as the hippocampus with frontal lobe areas, its involvement highlights the contribution of structures other than the frontal lobe in memory performance in ALS. Hippocampal and parahippocampal pathology in ALS are well-described in post mortem studies [32, 34, 35], and lesions have been related to memory deficits. Interestingly, those lesions were different from those found in Alzheimer's Disease [34], which underlines the distinct neuropsychological profiles between patients with ALS and aMCI in the present study. There is further evidence from structural imaging, that the hippocampus, a key structure in memory function, is affected in ALS. Both hippocampal volume reduction [33] and parahippocampal surface alterations [57, 58] are sites of ALS pathology, but these changes have not been related in-vivo to patients’ memory performance to date. Overall, imaging data support the notion that memory impairment in ALS is not caused exclusively by executive dysfunction. Further research needs to establish the relationship of temporal lobe involvement and memory impairment in ALS.

This study measured a wide range of cognitive domains, including verbal memory, executive functions and visuo-spatial skills with standardized neuropsychological tests. Tests of verbal memory revealed substantial recognition deficits in patients with ALS. However, there are some limitations to take into account. Initially we did not have a specific hypothesis which sub-function of memory would differ between ALS and aMCI and therefore chose a memory test that covers several sub-functions (RAVLT). With the results presented here, further research should focus on recognition memory, both verbal and visual, and investigate if the observed deficits are caused by deficient familiarity or recollection performance. It would be of interest to relate it to prefrontal lobe dysfunction as well, either measured by behavioural or imaging parameters in order to identify correlates of impaired recognition in ALS.

Conclusions

In conclusion, the current investigation suggests that memory impairment in ALS is different from that observed in Alzheimer's disease, but also that there is considerable overlap in verbal memory performance between these conditions. The differentiation between the distinct cognitive profiles of the two patient groups can only be captured with detailed subdomain specific neuropsychological testing, and composite scores of domain level performance proved insufficient. Moreover, this study further underscores on the considerable extramotor deficits in ALS that extends well beyond executive dysfunction. Emerging cognitive screening tests in ALS, which are increasingly used in clinical trials and specialist clinics should take the unique memory deficits of ALS into consideration. The pragmatic implications of memory impairment in ALS in relation to compliance with medications and assistive devices are currently also understudied. At present there is a growing consensus that cognitive impairment in ALS is not solely dominated by executive dysfunction, but language and amnestic deficits are equally important.

Abbreviations

ALS:

Amyotrophic lateral sclerosis

aMCI:

Amnestic mild cognitive impairment

FTD:

Frontotemporal dementia

TDP-43:

TAR DNA-binding protein 43

AD:

Alzheimer's disease

ALSFRS-R:

ALS functional rating scale-revised.

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Acknowledgement

The authors are grateful to the patients and their families for their kind support of this research project and they also thank all of the healthy controls and Christa Sobetzko for organizing the examinations.

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Correspondence to Judith Machts.

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The authors declare that they have no competing interest.

Authors’ contributions

JM carried out data collection and analysis and drafted the manuscript. VB carried out data collection and analysis and revised the manuscript for intellectual content. EK, CS and SA participated in data collection and analysis. JP, KK, SP, RD and HH conceived of the study and participated in its design and coordination. SV supervised all clinical aspects of the study and participated in its design and coordination and revised the manuscript for intellectual content. MS participated in study design and coordination and helped drafting the manuscript. DB conceived of the study, and participated in its design and coordination and helped to draft the manuscript. All authors read and approved the final manuscript.

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Machts, J., Bittner, V., Kasper, E. et al. Memory deficits in amyotrophic lateral sclerosis are not exclusively caused by executive dysfunction: a comparative neuropsychological study of amnestic mild cognitive impairment. BMC Neurosci 15, 83 (2014). https://doi.org/10.1186/1471-2202-15-83

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Keywords

  • Cognitive neuropsychology
  • ALS
  • Episodic memory