|
Demographic variable
|
ALS
|
N
|
Amnestic MCI
|
N
|
Healthy controls
|
N
|
p-value
|
|---|
|
Age at time of assessment
|
60.4 (12.2)
|
40
|
64.5 (5.4)
|
39
|
62.7 (10.2)
|
40
|
0.152
|
|
Male sex
|
65.0% (-)
|
40
|
45.0% (-)
|
39
|
69.2% (-)
|
40
|
0.063
|
|
Education (years)*
|
13.0 (2.5)
|
40
|
14.6 (2.8)
|
37
|
14.0 (2.1)
|
40
|
0.016
|
|
BDI-II (estimated depression scores)
|
7.9 (6.6)
|
34
|
6.8 (4.7)
|
35
|
4.7 (4.9)
|
40
|
0.057
|
|
ALSFRS-R
|
38.4 (7.8)
|
40
|
n.a.
|
n.a.
|
n.a.
|
|
Disease duration (in months; from symptom onset)
|
22.16 (19.5)
|
40
|
n.a.
|
n.a.
|
n.a.
|
|
Disease progression
|
0.54 (0.36)
|
40
|
n.a.
|
n.a.
|
n.a.
|
- Values are mean (SD). Two-tailed p-values of <0.05 are considered significant, shown in bold.
- ALS, amyotrophic lateral sclerosis; MCI, mild cognitive impairment; BDI-II, Beck Depression Inventory-II; ALSFRS-R, ALS Functional Rating Scale Revised; n.a., not applicable; disease duration, time from symptom onset to assessment; disease progression, estimated using decline in ALS Functional Rating Scale (ALSFRS-R) score since symptom onset (48-ALSFRS-R/disease duration [38]); *Years of education include: Years attended in school plus years of the longest, completed education.
