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  1. Review

    Linoleic acid: Is this the key that unlocks the quantum brain? Insights linking broken symmetries in molecular biology, mood disorders and personalistic emergentism

    In this paper we present a mechanistic model that integrates subneuronal structures, namely ion channels, membrane fatty acids, lipid rafts, G proteins and the cytoskeleton in a dynamic system that is finely t...

    Massimo Cocchi, Chiara Minuto, Lucio Tonello, Fabio Gabrielli, Gustav Bernroider, Jack A. Tuszynski, Francesco Cappello and Mark Rasenick

    BMC Neuroscience 2017 18:38

    Published on: 19 April 2017

  2. Research article

    Transcriptional signatures of steroid hormones in the striatal neurons and astrocytes

    The mechanisms of steroids actions in the brain mainly involve the binding and nuclear translocation of specific cytoplasmic receptors. These receptors can act as transcription factors and regulate gene expres...

    Marcin Piechota, Michał Korostynski, Slawomir Golda, Joanna Ficek, Danuta Jantas, Ziolkowska Barbara and Ryszard Przewlocki

    BMC Neuroscience 2017 18:37

    Published on: 5 April 2017

  3. Research article

    Effectiveness of conservative interventions for sickness and pain behaviors induced by a high repetition high force upper extremity task

    Systemic inflammation is known to induce sickness behaviors, including decreased social interaction and pain. We have reported increased serum inflammatory cytokines in a rat model of repetitive strain injury ...

    D. L. Xin, J. Hadrévi, M. E. Elliott, M. Amin, M. Y. Harris, A. E. Barr-Gillespie and M. F. Barbe

    BMC Neuroscience 2017 18:36

    Published on: 29 March 2017

  4. Research article

    An immunohistochemical, enzymatic, and behavioral study of CD157/BST-1 as a neuroregulator

    Recent rodent and human studies provide evidence in support of the fact that CD157, well known as bone marrow stromal cell antigen-1 (BST-1) and a risk factor in Parkinson’s disease, also meaningfully acts in ...

    Haruhiro Higashida, Mingkun Liang, Toru Yoshihara, Shirin Akther, Azam Fakhrul, Cherepanov Stanislav, Tae-Sik Nam, Uh-Hyun Kim, Satoka Kasai, Tomoko Nishimura, Naila Al Mahmuda, Shigeru Yokoyama, Katsuhiko Ishihara, Maria Gerasimenko, Alla Salmina, Jing Zhong…

    BMC Neuroscience 2017 18:35

    Published on: 24 March 2017

  5. Research article

    A receptor-based analysis of local ecosystems in the human brain

    As a complex system, the brain is a self-organizing entity that depends on local interactions among cells. Its regions (anatomically defined nuclei and areas) can be conceptualized as cellular ecosystems, but ...

    Skirmantas Janušonis

    BMC Neuroscience 2017 18:33

    Published on: 20 March 2017

  6. Research article

    Hypertonic saline attenuates expression of Notch signaling and proinflammatory mediators in activated microglia in experimentally induced cerebral ischemia and hypoxic BV-2 microglia

    Ischemic stroke is a major disease that threatens human health in ageing population. Increasing evidence has shown that neuroinflammatory mediators play crucial roles in the pathophysiology of cerebral ischemi...

    Wen-Xin Zeng, Yong-Li Han, Gao-Feng Zhu, Lin-Qiang Huang, Yi-Yu Deng, Qiao-Sheng Wang, Wen-Qiang Jiang, Miao-Yun Wen, Qian-Peng Han, Di Xie and Hong-Ke Zeng

    BMC Neuroscience 2017 18:32

    Published on: 14 March 2017

  7. Research article

    Effect of skilled reaching training and enriched environment on generation of oligodendrocytes in the adult sensorimotor cortex and corpus callosum

    Increased motor activity or social interactions through enriched environment are strong stimulators of grey and white matter plasticity in the adult rodent brain. In the present study we evaluated whether spe...

    Silke Keiner, Fanny Niv, Susanne Neumann, Tanja Steinbach, Christian Schmeer, Katrin Hornung, Yvonne Schlenker, Martin Förster, Otto W. Witte and Christoph Redecker

    BMC Neuroscience 2017 18:31

    Published on: 9 March 2017

  8. Research article

    Effect of Spp1 on nerve degeneration and regeneration after rat sciatic nerve injury

    Wallerian degeneration (WD) in injured peripheral nerves is associated with a large number of up- or down-regulated genes, but the effects of these changes are poorly understood. In our previous studies, we re...

    Xingyu Liu, Yuhua Sun, Huaiqin Li, Yuting Li, Meiyuan Li, Ying Yuan, Shusen Cui and Dengbing Yao

    BMC Neuroscience 2017 18:30

    Published on: 7 March 2017

  9. Research article

    Experience-dependent modulation of alpha and beta during action observation and motor imagery

    EEG studies investigating the neural networks that facilitate action observation (AO) and kinaesthetic motor imagery (KMI) have shown reduced, or desynchronized, power in the alpha (8–12 Hz) and beta (13–30 Hz...

    Paula M. Di Nota, Julie M. Chartrand, Gabriella R. Levkov, Rodrigo Montefusco-Siegmund and Joseph F. X. DeSouza

    BMC Neuroscience 2017 18:28

    Published on: 6 March 2017

  10. Research article

    Upregulation of the endothelin A (ETA) receptor and its association with neurodegeneration in a rodent model of glaucoma

    Primary open angle glaucoma is a heterogeneous group of optic neuropathies that results in optic nerve degeneration and a loss of retinal ganglion cells (RGCs) ultimately causing blindness if allowed to progre...

    Nolan R. McGrady, Alena Z. Minton, Dorota L. Stankowska, Shaoqing He, Hayden B. Jefferies and Raghu R. Krishnamoorthy

    BMC Neuroscience 2017 18:27

    Published on: 1 March 2017

  11. Research article

    EEG correlates of working memory performance in females

    The study investigates oscillatory brain activity during working memory (WM) tasks. The tasks employed varied in two dimensions. First, they differed in complexity from average to highly demanding. Second, we ...

    Yuri G. Pavlov and Boris Kotchoubey

    BMC Neuroscience 2017 18:26

    Published on: 13 February 2017

  12. Research article

    Quantitative analysis of axon collaterals of single pyramidal cells of the anterior piriform cortex of the guinea pig

    The role of the piriform cortex (PC) in olfactory information processing remains largely unknown. The anterior part of the piriform cortex (APC) has been the focus of cortical-level studies of olfactory codin...

    Junli Yang, Gerhard Litscher, Zhongren Sun, Qiang Tang, Kiyoshi Kishi, Satoko Oda, Masaaki Takayanagi, Zemin Sheng, Yang Liu, Wenhai Guo, Ting Zhang, Lu Wang, Ingrid Gaischek, Daniela Litscher, Irmgard Th. Lippe and Masaru Kuroda

    BMC Neuroscience 2017 18:25

    Published on: 8 February 2017

  13. Research article

    Early start of progressive motor deficits in Line 61 α-synuclein transgenic mice

    Synucleinopathies such as Parkinson’s disease or multiple system atrophy are characterized by Lewy bodies in distinct brain areas. These aggregates are mainly formed by α-synuclein inclusions, a protein crucia...

    R. Rabl, C. Breitschaedel, S. Flunkert, S. Duller, D. Amschl, J. Neddens, V. Niederkofler, E. Rockenstein, E. Masliah, H. Roemer and B. Hutter-Paier

    BMC Neuroscience 2017 18:22

    Published on: 31 January 2017

  14. Research article

    Evoked potentials and behavioral performance during different states of brain arousal

    Previous studies compared evoked potentials (EPs) between several sleep stages but only one uniform wake state. However, using electroencephalography (EEG), several arousal states can be distinguished before s...

    Jue Huang, Tilman Hensch, Christine Ulke, Christian Sander, Janek Spada, Philippe Jawinski and Ulrich Hegerl

    BMC Neuroscience 2017 18:21

    Published on: 25 January 2017

  15. Research article

    TDP-43 protein variants as biomarkers in amyotrophic lateral sclerosis

    TDP-43 aggregates accumulate in individuals affected by amyotrophic lateral sclerosis (ALS) and other neurodegenerative diseases, representing potential diagnostic and therapeutic targets. Using an atomic forc...

    Stephanie M. Williams, Galam Khan, Brent T. Harris, John Ravits and Michael R. Sierks

    BMC Neuroscience 2017 18:20

    Published on: 25 January 2017

  16. Research article

    Selenium suppresses glutamate-induced cell death and prevents mitochondrial morphological dynamic alterations in hippocampal HT22 neuronal cells

    Previous studies have indicated that selenium supplementation may be beneficial in neuroprotection against glutamate-induced cell damage, in which mitochondrial dysfunction is considered a major pathogenic fea...

    Yan-Mei Ma, Gordon Ibeanu, Li-Yao Wang, Jian-Zhong Zhang, Yue Chang, Jian-Da Dong, P. Andy Li and Li Jing

    BMC Neuroscience 2017 18:15

    Published on: 19 January 2017

  17. Research Article

    Poly(ADP-ribose) polymerase inhibitors activate the p53 signaling pathway in neural stem/progenitor cells

    Poly(ADP-ribose) polymerase 1 (PARP-1), which catalyzes poly(ADP-ribosyl)ation of proteins by using NAD+ as a substrate, plays a key role in several nuclear events, including DNA repair, replication, and transcri...

    Akiko Okuda, Suguru Kurokawa, Masanori Takehashi, Aika Maeda, Katsuya Fukuda, Yukari Kubo, Hyuma Nogusa, Tomoka Takatani-Nakase, Shujiro Okuda, Kunihiro Ueda and Seigo Tanaka

    BMC Neuroscience 2017 18:14

    Published on: 17 January 2017

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