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  1. Content type: Research article

    Amyloid-beta (Aβ) accumulation is a hallmark of Alzheimer’s disease (AD) that can lead to neuronal dysfunction and apoptosis. Tumor necrosis factor, alpha-induced protein 1 (TNFAIP1) is an apoptotic protein th...

    Authors: Ning Liu, Zhanyang Yu, Yu Xun, Miaomiao Li, Xiaoning Peng, Ye Xiao, Xiang Hu, Yi Sun, Manjun Yang, Shiquan Gan, Shishan Yuan, Xiaoying Wang, Shuanglin Xiang and Jian Zhang

    Citation: BMC Neuroscience 2016 17:51

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  2. Content type: Research article

    Polymorphisms in the gene for phosphatidylinositol binding clathrin assembly protein (PICALM), an endocytic-related protein, are associated with a small, increased risk of developing Alzheimer’s disease (AD), ...

    Authors: Rhian S. Thomas, Alex Henson, Amy Gerrish, Lesley Jones, Julie Williams and Emma J. Kidd

    Citation: BMC Neuroscience 2016 17:50

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  3. Content type: Research article

    Perivascular stromal cells (PSCs) are a recently identified cell type that comprises a small percentage of the platelet derived growth factor receptor-β+ cells within the CNS perivascular space. PSCs are activ...

    Authors: Kathleen K. Kelly, Amber M. MacPherson, Himmat Grewal, Frank Strnad, Jace W. Jones, Jianshi Yu, Keely Pierzchalski, Maureen A. Kane, Paco S. Herson and Julie A. Siegenthaler

    Citation: BMC Neuroscience 2016 17:49

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  4. Content type: Methodology article

    In many functional magnetic resonance imaging (fMRI) studies, experimental design often depends on the eye state (i.e., whether the participants had their eyes open or closed). Closed eyes during an fMRI is th...

    Authors: Stefan Brodoehl, Otto W. Witte and Carsten M. Klingner

    Citation: BMC Neuroscience 2016 17:48

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  5. Content type: Research article

    Peripheral neuropathy is a common and dose-limiting side effect of many cancer chemotherapies. The taxane agents, including paclitaxel (Taxol®), are effective chemotherapeutic drugs but cause degeneration of pred...

    Authors: Aniqa Tasnim, Zoe Rammelkamp, Amy B. Slusher, Krystyna Wozniak, Barbara S. Slusher and Mohamed H. Farah

    Citation: BMC Neuroscience 2016 17:47

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  6. Content type: Research article

    We previously reported the production of transgenic rats (APP21 line) that over-express human amyloid precursor protein (APP) containing Swedish and Indiana mutations. In order to generate a better model for A...

    Authors: Cansu Agca, Diana Klakotskaia, Todd R. Schachtman, Anthony W. Chan, James J. Lah and Yuksel Agca

    Citation: BMC Neuroscience 2016 17:46

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  7. Content type: Research article

    Recent research has documented structural brain abnormalities in various criminal offenders. However, there have been few brain imaging studies of sex offenders, and none on white matter integrity. The curren...

    Authors: Chiao-Yun Chen, Adrian Raine, Kun-Hsien Chou, I-Yun Chen, Daisy Hung and Ching-Po Lin

    Citation: BMC Neuroscience 2016 17:45

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  8. Content type: Research article

    Murine models of Alzheimer’s disease (AD) are mainly based on overexpression of pathologic amyloid precursor protein and/or presenilins. Those genes resemble underlying cause of early onset type of AD while ab...

    Authors: Kristina Endres, Sven Reinhardt, Anastasia Geladaris, Julia Knies, Marcus Grimm, Tobias Hartmann and Ulrich Schmitt

    Citation: BMC Neuroscience 2016 17:44

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  9. Content type: Research article

    MCT14 (SLC16A14) is an orphan member of the monocarboxylate transporter (MCT) family, also known as the SLC16 family of secondary active transmembrane transporters. Available expression data for this transport...

    Authors: Sahar Roshanbin, Frida A. Lindberg, Emilia Lekholm, Mikaela M. Eriksson, Emelie Perland, Johan Åhlund, Amanda Raine and Robert Fredriksson

    Citation: BMC Neuroscience 2016 17:43

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  10. Content type: Research article

    After spinal cord (SC)-injury, a non-modulated immune response contributes to the damage of neural tissue. Protective autoimmunity (PA) is a T cell mediated, neuroprotective response induced after SC-injury. ...

    Authors: Susana Martiñón, Elisa García-Vences, Diana Toscano-Tejeida, Adrian Flores-Romero, Roxana Rodriguez-Barrera, Manuel Ferrusquia, Rolando E. Hernández-Muñoz and Antonio Ibarra

    Citation: BMC Neuroscience 2016 17:42

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  11. Content type: Research article

    Anticipatory and compensatory balance responses are used by the central nervous system (CNS) to preserve balance, hence they significantly contribute to the understanding of physiological mechanisms of postura...

    Authors: Andresa M. C. Germano, Daniel Schmidt and Thomas L. Milani

    Citation: BMC Neuroscience 2016 17:41

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  12. Content type: Methodology article

    Various strategies have been used for inferring brain functions from stroke lesions. We explored a new mathematical approach based on game theory, the so-called multi-perturbation Shapley value analysis (MSA),...

    Authors: Melissa Zavaglia, Nils D. Forkert, Bastian Cheng, Christian Gerloff, Götz Thomalla and Claus C. Hilgetag

    Citation: BMC Neuroscience 2016 17:40

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  13. Content type: Research article

    Regression of myelinated peripheral nerve fibers in the lower extremities contributes to sarcopenia and balance dysfunction in normal aging. This subclinical regression of myelinated fibers (MFs) is heavily in...

    Authors: Masahiro Sakita, Shinichiro Murakami and Hidemi Fujino

    Citation: BMC Neuroscience 2016 17:39

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  14. Content type: Research article

    Resiniferatoxin (RTX) is a potent analog of capsaicin and activates transient receptor potential (TRP) vanilloid type (TRPV) 1. In the current study, we investigated the preventive effect of perineural RTX on ...

    Authors: Won Uk Koh, Seong-Soo Choi, Ji Hyun Kim, Hye Joo Yoon, Ho-Soo Ahn, Sun Kyung Lee, Jeong Gil Leem, Jun Gol Song and Jin Woo Shin

    Citation: BMC Neuroscience 2016 17:38

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  15. Content type: Research article

    Glucagon-like peptide 1 (GLP-1) analogs protect a variety of cell types against oxidative damage and vascular and neuronal injury via binding to GLP-1 receptors. This study aimed to investigate the effects of ...

    Authors: Ping-Chia Li, Li-Fen Liu, Ming-Jia Jou and Hao-Kuang Wang

    Citation: BMC Neuroscience 2016 17:37

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  16. Content type: Research article

    The potential adverse effect of mobile phone radiation is currently an area of great concern in the field of public health. In the present study, we aimed to investigate the effect of mobile phone radiation (9...

    Authors: Zien Zhou, Jiehui Shan, Jinyan Zu, Zengai Chen, Weiwei Ma, Lei Li and Jianrong Xu

    Citation: BMC Neuroscience 2016 17:36

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  17. Content type: Research article

    Aristaless-related homeobox (ARX) is a paired-like homeodomain transcription factor that functions primarily as a transcriptional repressor and has been implicated in neocortical interneuron specification and mig...

    Authors: Eric D. Marsh, MacLean Pancoast Nasrallah, Caroline Walsh, Kaitlin A. Murray, C. Nicole Sunnen, Almedia McCoy and Jeffrey A. Golden

    Citation: BMC Neuroscience 2016 17:35

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  18. Content type: Research article

    Previously, we have shown that transgenic cells bearing the GDNF gene with deleted pre- and pro-regions (mGDNF) can release transgenic GDNF. The medium conditioned by transgenic cells with mGDNF induced axonal...

    Authors: A. Revishchin, L. Moiseenko, N. Kust, N. Bazhenova, P. Teslia, D. Panteleev, V. Kovalzon and G. Pavlova

    Citation: BMC Neuroscience 2016 17:34

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  19. Content type: Research article

    Kainic acid (KA)-induced excitotoxicity promotes cytoplasmic calcium accumulation, oxidative stress, and apoptotic signaling, leading to hippocampal neuronal death. Mitochondria play a critical role in neuroin...

    Authors: Hwajin Kim, Jong Youl Lee, Keon Jae Park, Won-Ho Kim and Gu Seob Roh

    Citation: BMC Neuroscience 2016 17:33

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    The Erratum to this article has been published in BMC Neuroscience 2017 18:16

  20. Content type: Research article

    Retinal inflammation can cause retinal neural disorders. In particular, functional disorder in the cone photoreceptor system influences visual acuity. However, the underlying mechanism is not yet fully underst...

    Authors: Mamoru Kamoshita, Kaoru Fujinami, Eriko Toda, Kazuo Tsubota and Yoko Ozawa

    Citation: BMC Neuroscience 2016 17:32

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  21. Content type: Research article

    Canine intervertebral disc πherniation causes a naturally-occurring spinal cord injury (SCI) that bears critical similarities to human SCI with respect to both injury pathomechanisms and treatment. As such, it...

    Authors: Rae L. Russell, Jonathan M. Levine, Nick D. Jeffery, Colin Young, Armando Mondragon, Bryan Lee, C. Elizabeth Boudreau, C. Jane Welsh and Gwendolyn J. Levine

    Citation: BMC Neuroscience 2016 17:31

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  22. Content type: Methodology article

    Conducting research on the molecular biology, immunology, and physiology of brain tumors (BTs) and primary brain tissues requires the use of viably dissociated single cells. Inadequate methods for tissue diss...

    Authors: Ilan Volovitz, Netanel Shapira, Haim Ezer, Aviv Gafni, Merav Lustgarten, Tal Alter, Idan Ben-Horin, Ori Barzilai, Tal Shahar, Andrew Kanner, Itzhak Fried, Igor Veshchev, Rachel Grossman and Zvi Ram

    Citation: BMC Neuroscience 2016 17:30

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  23. Content type: Research article

    The magnitude of multimodal enhancement in the brain is believed to depend on the stimulus intensity and timing. Such an effect has been found in many species, but has not been previously investigated in insects.

    Authors: Anna Balkenius and Christian Balkenius

    Citation: BMC Neuroscience 2016 17:29

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  24. Content type: Research article

    In the current study, a transient cerebral ischemia producing selective cell death was designated a mild ischemic insult. A comparable insult in humans is a transient ischemic attack (TIA) that is associated with...

    Authors: Ursula I. Tuor, Zonghang Zhao, Philip A. Barber and Min Qiao

    Citation: BMC Neuroscience 2016 17:28

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  25. Content type: Methodology article

    Functional connectivity analyses of multiple neurons provide a powerful bottom-up approach to reveal functions of local neuronal circuits by using simultaneous recording of neuronal activity. A statistical met...

    Authors: Shigeyuki Oba, Ken Nakae, Yuji Ikegaya, Shunsuke Aki, Junichiro Yoshimoto and Shin Ishii

    Citation: BMC Neuroscience 2016 17:27

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  26. Content type: Research article

    Anorexia can occur as a serious complication of disease. Increasing evidence suggests that inflammation plays a major role, along with a hypothalamic dysregulation characterized by locally elevated serotonin l...

    Authors: J. T. Dwarkasing, R. F. Witkamp, M. V. Boekschoten, M. C. Ter Laak, M. S. Heins and K. van Norren

    Citation: BMC Neuroscience 2016 17:26

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  27. Content type: Research article

    To get a broader view of global ischemia-induced cerebral disorders at the metabolic level, a nuclear magnetic resonance-based metabolomic study was performed to evaluate the metabolic profile changes on regio...

    Authors: Tianshu Zhang, Wei Wang, Jin Huang, Xia Liu, Haiyan Zhang and Naixia Zhang

    Citation: BMC Neuroscience 2016 17:25

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  28. Content type: Research article

    Epilepsy is a common neurological disorder characterized by recurrent unprovoked seizures. Seizure-induced TLR4/MYD88 signaling plays a critical role in activating microglia and triggering neuron apoptosis. SA...

    Authors: Qing-Peng Hu and Ding-An Mao

    Citation: BMC Neuroscience 2016 17:22

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  29. Content type: Research article

    Red/near-infrared light therapy (R/NIR-LT) has been developed as a treatment for a range of conditions, including injury to the central nervous system (CNS). However, clinical trials have reported variable or ...

    Authors: Bethany Eve Ashworth, Emma Stephens, Carole A. Bartlett, Stylianos Serghiou, Marcus K. Giacci, Anna Williams, Nathan S. Hart and Melinda Fitzgerald

    Citation: BMC Neuroscience 2016 17:21

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  30. Content type: Research article

    Patients with Parkinson’s disease (PD) often suffer from cognitive impairments, including set-shifting deficits, in addition to the characteristic motor symptoms. It is hypothesized that the striatal dopamine ...

    Authors: Corine C. de Bondt, Niels J. H. M. Gerrits, Dick J. Veltman, Henk W. Berendse, Odile A. van den Heuvel and Ysbrand D. van der Werf

    Citation: BMC Neuroscience 2016 17:20

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  31. Content type: Research article

    We recently reported that poly-arginine peptides have neuroprotective properties both in vitro and in vivo. In cultured cortical neurons exposed to glutamic acid excitotoxicity, we demonstrated that neuroprote...

    Authors: Diego Milani, Vince W. Clark, Jane L. Cross, Ryan S. Anderton, Neville W. Knuckey and Bruno P. Meloni

    Citation: BMC Neuroscience 2016 17:19

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  32. Content type: Research article

    Deception can distort psychological tests on socially sensitive topics. Understanding the cerebral processes that are involved in such faking can be useful in detection and prevention of deception. Previous re...

    Authors: Wanja Wolff, Sebastian Schindler, Christoph Englert, Ralf Brand and Johanna Kissler

    Citation: BMC Neuroscience 2016 17:18

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  33. Content type: Methodology article

    Regeneration of new myelin is impaired in persistent multiple sclerosis (MS) lesions, leaving neurons unable to function properly and subject to further degeneration. Current MS therapies attempt to ameliorate...

    Authors: Karen D. Lariosa-Willingham, Elen S. Rosler, Jay S. Tung, Jason C. Dugas, Tassie L. Collins and Dmitri Leonoudakis

    Citation: BMC Neuroscience 2016 17:16

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  34. Content type: Research article

    Glutamate carboxypeptidase II (GCPII) inactivates the peptide co-transmitter N-acetylaspartylglutamate following synaptic release. Inhibition of GCPII elevates extracellular levels of the peptide, inhibits glutam...

    Authors: Yang Cao, Yang Gao, Siyi Xu, Jingang Bao, Yingying Lin, Xingguang Luo, Yong Wang, Qizhong Luo, Jiyao Jiang, Joseph H. Neale and Chunlong Zhong

    Citation: BMC Neuroscience 2016 17:15

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  35. Content type: Research article

    It has been demonstrated that the zebrafish model of pentylenetetrazole (PTZ)-evoked seizures and the well-established rodent models of epilepsy are similar pertaining to behavior, electrographic features, and c-

    Authors: Patrícia Gonçalves Barbalho, Iscia Lopes-Cendes and Claudia Vianna Maurer-Morelli

    Citation: BMC Neuroscience 2016 17:12

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  36. Content type: Research article

    Prenatal maternal lipopolysaccharide (LPS) exposure leads to behavioral deficits such as depression, anxiety, and schizophrenia in the adult lives. LPS-exposure resulted in the production of cytokines and oxid...

    Authors: Md. Mamun Al-Amin, Rabeya Sultana, Sharmin Sultana, Md. Mahbubur Rahman and Hasan Mahmud Reza

    Citation: BMC Neuroscience 2016 17:11

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  37. Content type: Research article

    Spinal cord edema is a serious complication and pathophysiological change after ischemia reperfusion (IR) injury. It has been demonstrated closely associated with bimodal disruption of blood–spinal cord barrie...

    Authors: Xiao-Qian Li, Bo Fang, Wen-Fei Tan, Zhi-Lin Wang, Xi-Jia Sun, Zai-Li Zhang and Hong Ma

    Citation: BMC Neuroscience 2016 17:10

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  38. Content type: Research article

    Smartphone use while walking is becoming a public concern owing to an increased risk of falling that can result from cognitive-motor interference. We evaluated prefrontal cortex (PFC) activity in participants ...

    Authors: Naoyuki Takeuchi, Takayuki Mori, Yoshimi Suzukamo, Naofumi Tanaka and Shin-Ichi Izumi

    Citation: BMC Neuroscience 2016 17:9

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  39. Content type: Research article

    Speech-related disorders may refer to impairment of temporal analysis in the human auditory system. By the advance of non-invasive brain stimulation new forms of therapy arise. In the present study, we examine...

    Authors: Kai Heimrath, Anna Fischer, Hans-Jochen Heinze and Tino Zaehle

    Citation: BMC Neuroscience 2016 17:8

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  40. Content type: Methodology article

    The decline of remyelination in chronic multiple sclerosis (MS) is in part attributed to inadequate oligodendrocyte precursor cell (OPC) migration, a process governed by the extracellular matrix (ECM). Elucida...

    Authors: Ryan W. O’Meara, Sarah E. Cummings, John-Paul Michalski and Rashmi Kothary

    Citation: BMC Neuroscience 2016 17:7

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  41. Content type: Research article

    Bilateral subthalamic nucleus deep brain stimulation (STN-DBS) of parkinson’s disease (PD) patients has demonstrated to improve motor performance and to reduce dopa-induced dyskinesia. An association between t...

    Authors: Massiva Sayad, Mohamed Zouambia, Malika Chaouch, Farida Ferrat, Mustapha Nebbal, Mohamed Bendini, Suzanne Lesage, Alexis Brice, Mohamed Brahim Errahmani and Boualem Asselah

    Citation: BMC Neuroscience 2016 17:6

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  42. Content type: Research article

    A major area of unmet need is the development of strategies to restore neuronal network systems and to recover brain function in patients with neurological disease. The use of cell-based therapies remains an a...

    Authors: Jaime Belkind-Gerson, Ryo Hotta, Michael Whalen, Naema Nayyar, Nandor Nagy, Lily Cheng, Aaron Zuckerman, Allan M. Goldstein and Jorg Dietrich

    Citation: BMC Neuroscience 2016 17:5

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  43. Content type: Research article

    Depression is one of the most prevalent mood disorders, and is known to be associated with abnormal functional connectivity in neural networks of the brain. Interestingly, a significant proportion of patients ...

    Authors: Arshi Khalid, Byung Sun Kim, Bo Am Seo, Soon-Tae Lee, Keun-Hwa Jung, Kon Chu, Sang Kun Lee and Daejong Jeon

    Citation: BMC Neuroscience 2016 17:4

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  44. Content type: Research article

    In highly complex social settings, an animal’s motivational drive to pursue an object depends not only on the intrinsic properties of the object, but also on whether the decision-making animal perceives an ob...

    Authors: Fang Li, Wen-Yu Cao, Fu-Lian Huang, Wen-Jing Kang, Xiao-Lin Zhong, Zhao-Lan Hu, Hong-Tao Wang, Juan Zhang, Jian-Yi Zhang, Ru-Ping Dai, Xin-Fu Zhou and Chang-Qi Li

    Citation: BMC Neuroscience 2016 17:3

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