- Oral presentation
- Open Access
Short term synaptic depression with stochastic vesicle dynamics imposes a high-pass filter on presynaptic information
© Rosenbaum et al; licensee BioMed Central Ltd. 2012
- Published: 16 July 2012
- Spike Train
- High Fidelity
- Synaptic Response
- Neural Code
- Synaptic Depression
The filtering properties of synapses are modulated by a form of short term depression arising from the depletion of neurotransmitter vesicles. The uptake and release of these vesicles is stochastic in nature, but a widely used model of synaptic depression does not take this stochasticity into account. While this model of synaptic depression accurately captures the trial-averaged synaptic response to a presynaptic spike train , it fails to capture variability introduced by stochastic vesicle dynamics . Our goal is to understand the impact of stochastic vesicle dynamics on filtering and information transfer in depressing synapses.
- Tsodyks MV, Markram H: The neural code between neocortical pyramidal neurons depends on neurotransmitter release probability. Proc Natl Acad Sci USA. 1997, 94: 719-723. 10.1073/pnas.94.2.719.PubMed CentralView ArticlePubMedGoogle Scholar
- de la Rocha J, Parga N: Short-term synaptic depression causes a non-monotonic response to correlated stimuli. J Neurosci. 2005, 25: 8416-8431. 10.1523/JNEUROSCI.0631-05.2005.View ArticlePubMedGoogle Scholar
- Lindner B, Gangloff D, Longtin A, Lewis JE: Broadband Coding with Dynamic Synapses. J Neurosci. 2009, 29: 2076-2087. 10.1523/JNEUROSCI.3702-08.2009.View ArticlePubMedGoogle Scholar
- Merkel M, Lindner B: Synaptic filtering of rate-coded information. Phys Rev E. 2010, 81: 041921-View ArticleGoogle Scholar
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.