de Jong PT: Age-related macular degeneration. N Engl J Med. 2006, 355 (14): 1474-1485. 10.1056/NEJMra062326.
Article
CAS
PubMed
Google Scholar
Hageman GS, Gehrs K, Johnson LV, Anderson D: Age-Related Macular Degeneration (AMD). Edited by: Kolb H, Fernandez E, Nelson R. 2008, Webvision: The Oragnization of the Retina and Visual System, Salt Lake City (UT): University of Utah Health Sciences Center, 1995, [http://www.ncbi.nlm.nih.gov/books/NBK27323/]
Google Scholar
Kaarniranta K, Salminen A, Haapasalo A, Soininen H, Hiltunen M: Age-Related Macular Degeneration (AMD): Alzheimer's Disease in the Eye?. J Alzheimers Dis. 2011, 24 (4): 615-631.
CAS
PubMed
Google Scholar
Luibl V, Isas JM, Kayed R, Glabe CG, Langen R, Chen J: Drusen deposits associated with aging and age-related macular degeneration contain nonfibrillar amyloid oligomers. J Clin Invest. 2006, 116 (2): 378-385. 10.1172/JCI25843.
Article
CAS
PubMed Central
PubMed
Google Scholar
Dentchev T, Milam AH, Lee VM, Trojanowski JQ, Dunaief JL: Amyloid-beta is found in drusen from some age-related macular degeneration retinas, but not in drusen from normal retinas. Mol Vis. 2003, 9: 184-190.
CAS
PubMed
Google Scholar
Isas JM, Luibl V, Johnson LV, Kayed R, Wetzel R, Glabe CG, Langen R, Chen J: Soluble and mature amyloid fibrils in drusen deposits. Invest Ophthalmol Vis Sci. 2010, 51 (3): 1304-1310. 10.1167/iovs.09-4207.
Article
PubMed Central
PubMed
Google Scholar
Johnson LV, Leitner WP, Rivest AJ, Staples MK, Radeke MJ, Anderson DH: The Alzheimer's A beta -peptide is deposited at sites of complement activation in pathologic deposits associated with aging and age-related macular degeneration. Proc Natl Acad Sci USA. 2002, 99 (18): 11830-11835. 10.1073/pnas.192203399.
Article
CAS
PubMed Central
PubMed
Google Scholar
Liu B, Rasool S, Yang Z, Glabe CG, Schreiber SS, Ge J, Tan Z: Amyloid-peptide vaccinations reduce {beta}-amyloid plaques but exacerbate vascular deposition and inflammation in the retina of Alzheimer's transgenic mice. Am J Pathol. 2009, 175 (5): 2099-2110. 10.2353/ajpath.2009.090159.
Article
CAS
PubMed Central
PubMed
Google Scholar
Malek G, Johnson LV, Mace BE, Saloupis P, Schmechel DE, Rickman DW, Toth CA, Sullivan PM, Bowes Rickman C: Apolipoprotein E allele-dependent pathogenesis: a model for age-related retinal degeneration. Proc Natl Acad Sci USA. 2005, 102 (33): 11900-11905. 10.1073/pnas.0503015102.
Article
CAS
PubMed Central
PubMed
Google Scholar
Ding JD, Lin J, Mace BE, Herrmann R, Sullivan P, Bowes Rickman C: Targeting age-related macular degeneration with Alzheimer's disease based immunotherapies: anti-amyloid-beta antibody attenuates pathologies in an age-related macular degeneration mouse model. Vision Res. 2008, 48 (3): 339-345. 10.1016/j.visres.2007.07.025.
Article
CAS
PubMed Central
PubMed
Google Scholar
Ding JD, Johnson LV, Herrmann R, Farsiu S, Smith SG, Groelle M, Mace BE, Sullivan P, Jamison JA, Kelly U, Harrabi O, Bollini SS, Dilley J, Kobayashi D, Kuang B, Li W, Pons J, Lin JC, Rickman CB: Anti-amyloid therapy protects against retinal pigmented epithelium damage and vision loss in a model of age-related macular degeneration. Proc Natl Acad Sci USA. 2011, 108 (28): E279-E287. 10.1073/pnas.1100901108.
Article
CAS
PubMed Central
PubMed
Google Scholar
Thornton J, Edwards R, Mitchell P, Harrison RA, Buchan I, Kelly SP: Smoking and age-related macular degeneration: a review of association. Eye (Lond). 2005, 19 (9): 935-944. 10.1038/sj.eye.6701978.
Article
CAS
Google Scholar
Tomany SC, Cruickshanks KJ, Klein R, Klein BE, Knudtson MD: Sunlight and the 10-year incidence of age-related maculopathy: the Beaver Dam Eye Study. Arch Ophthalmol. 2004, 122 (5): 750-757. 10.1001/archopht.122.5.750.
Article
PubMed
Google Scholar
Klein R, Peto T, Bird A, Vannewkirk MR: The epidemiology of age-related macular degeneration. Am J Ophthalmol. 2004, 137 (3): 486-495. 10.1016/j.ajo.2003.11.069.
Article
PubMed
Google Scholar
Organisciak DT, Vaughan DK: Retinal light damage: mechanisms and protection. Prog Retin Eye Res. 2010, 29 (2): 113-134. 10.1016/j.preteyeres.2009.11.004.
Article
PubMed Central
PubMed
Google Scholar
Wenzel A, Grimm C, Samardzija M, Reme CE: Molecular mechanisms of light-induced photoreceptor apoptosis and neuroprotection for retinal degeneration. Prog Retin Eye Res. 2005, 24 (2): 275-306. 10.1016/j.preteyeres.2004.08.002.
Article
CAS
PubMed
Google Scholar
Duncan JL, LaVail MM: Intense cyclic light-induced retinal degeneration in rats. Arch Ophthalmol. 2010, 128 (2): 244-245. 10.1001/archophthalmol.2009.399.
Article
PubMed
Google Scholar
Albert DM, Neekhra A, Wang S, Darjatmoko SR, Sorenson CM, Dubielzig RR, Sheibani N: Development of choroidal neovascularization in rats with advanced intense cyclic light-induced retinal degeneration. Arch Ophthalmol. 2010, 128 (2): 212-222. 10.1001/archophthalmol.2009.395.
Article
PubMed Central
PubMed
Google Scholar
Imamura Y, Noda S, Hashizume K, Shinoda K, Yamaguchi M, Uchiyama S, Shimizu T, Mizushima Y, Shirasawa T, Tsubota K: Drusen, choroidal neovascularization, and retinal pigment epithelium dysfunction in SOD1-deficient mice: a model of age-related macular degeneration. Proc Natl Acad Sci USA. 2006, 103 (30): 11282-11287. 10.1073/pnas.0602131103.
Article
CAS
PubMed Central
PubMed
Google Scholar
Cousins SW, Espinosa-Heidmann DG, Alexandridou A, Sall J, Dubovy S, Csaky K: The role of aging, high fat diet and blue light exposure in an experimental mouse model for basal laminar deposit formation. Exp Eye Res. 2002, 75 (5): 543-553. 10.1006/exer.2002.2047.
Article
CAS
PubMed
Google Scholar
Hollborn M, Francke M, Iandiev I, Buhner E, Foja C, Kohen L, Reichenbach A, Wiedemann P, Bringmann A, Uhlmann S: Early activation of inflammation- and immune response-related genes after experimental detachment of the porcine retina. Invest Ophthalmol Vis Sci. 2008, 49 (3): 1262-1273. 10.1167/iovs.07-0879.
Article
PubMed
Google Scholar
Weber BH, Schrewe H, Molday LL, Gehrig A, White KL, Seeliger MW, Jaissle GB, Friedburg C, Tamm E, Molday RS: Inactivation of the murine X-linked juvenile retinoschisis gene, Rs1h, suggests a role of retinoschisin in retinal cell layer organization and synaptic structure. Proc Natl Acad Sci USA. 2002, 99 (9): 6222-6227. 10.1073/pnas.092528599.
Article
CAS
PubMed Central
PubMed
Google Scholar
Ning A, Cui J, To E, Ashe KH, Matsubara J: Amyloid-beta deposits lead to retinal degeneration in a mouse model of Alzheimer disease. Invest Ophthalmol Vis Sci. 2008, 49 (11): 5136-5143. 10.1167/iovs.08-1849.
Article
PubMed Central
PubMed
Google Scholar
Cai Z, Zhao B, Ratka A: Oxidative stress and beta-Amyloid protein in Alzheimer's disease. Neuromolecular Med. 2011, 13 (4): 223-250. 10.1007/s12017-011-8155-9.
Article
CAS
PubMed
Google Scholar
Bressler SB: Introduction: understanding the role of angiogenesis and antiangiogenic agents in age-related macular degeneration. Ophthalmology. 2009, 116 (10 Suppl): S1-S7.
Article
PubMed
Google Scholar
Bird AC: Therapeutic targets in age-related macular disease. J Clin Invest. 2010, 120 (9): 3033-3041. 10.1172/JCI42437.
Article
CAS
PubMed Central
PubMed
Google Scholar
Cruickshanks KJ, Klein R, Klein BE, Nondahl DM: Sunlight and the 5-year incidence of early age-related maculopathy: the beaver dam eye study. Arch Ophthalmol. 2001, 119 (2): 246-250.
CAS
PubMed
Google Scholar
LaVail MM, Gorrin GM, Repaci MA, Thomas LA, Ginsberg HM: Genetic regulation of light damage to photoreceptors. Invest Ophthalmol Vis Sci. 1987, 28 (7): 1043-1048.
CAS
PubMed
Google Scholar
Collier RJ, Wang Y, Smith SS, Martin E, Ornberg R, Rhoades K, Romano C: Complement deposition and microglial activation in the outer retina in light-induced retinopathy: inhibition by a 5-HT1A agonist. Invest Ophthalmol Vis Sci. 2011, 52 (11): 8108-8116. 10.1167/iovs.10-6418.
Article
CAS
PubMed
Google Scholar
Marco-Gomariz MA, Hurtado-Montalban N, Vidal-Sanz M, Lund RD, Villegas-Perez MP: Phototoxic-induced photoreceptor degeneration causes retinal ganglion cell degeneration in pigmented rats. J Comp Neurol. 2006, 498 (2): 163-179. 10.1002/cne.21028.
Article
CAS
PubMed
Google Scholar
Palop JJ, Mucke L: Amyloid-beta-induced neuronal dysfunction in Alzheimer's disease: from synapses toward neural networks. Nat Neurosci. 2010, 13 (7): 812-818. 10.1038/nn.2583.
Article
CAS
PubMed Central
PubMed
Google Scholar
Castellani RJ, Smith MA: Compounding artefacts with uncertainty, and an amyloid cascade hypothesis that is 'too big to fail'. J Pathol. 2011, 224 (2): 147-152. 10.1002/path.2885.
Article
CAS
PubMed
Google Scholar
Yoshida T, Ohno-Matsui K, Ichinose S, Sato T, Iwata N, Saido TC, Hisatomi T, Mochizuki M, Morita I: The potential role of amyloid beta in the pathogenesis of age-related macular degeneration. J Clin Invest. 2005, 115 (10): 2793-2800. 10.1172/JCI24635.
Article
CAS
PubMed Central
PubMed
Google Scholar
Perez SE, Lumayag S, Kovacs B, Mufson EJ, Xu S: Beta-amyloid deposition and functional impairment in the retina of the APPswe/PS1DeltaE9 transgenic mouse model of Alzheimer's disease. Invest Ophthalmol Vis Sci. 2009, 50 (2): 793-800.
Article
PubMed Central
PubMed
Google Scholar
Boscolo E, Folin M, Nico B, Grandi C, Mangieri D, Longo V, Scienza R, Zampieri P, Conconi MT, Parnigotto PP, Ribatti D: Beta amyloid angiogenic activity in vitro and in vivo. Int J Mol Med. 2007, 19 (4): 581-587.
CAS
PubMed
Google Scholar
Biron KE, Dickstein DL, Gopaul R, Jefferies WA: Amyloid triggers extensive cerebral angiogenesis causing blood brain barrier permeability and hypervascularity in Alzheimer's disease. PLoS One. 2011, 6 (8): e23789-10.1371/journal.pone.0023789.
Article
CAS
PubMed Central
PubMed
Google Scholar
Ni YQ, Xu GZ, Hu WZ, Shi L, Qin YW, Da CD: Neuroprotective effects of naloxone against light-induced photoreceptor degeneration through inhibiting retinal microglial activation. Invest Ophthalmol Vis Sci. 2008, 49 (6): 2589-2598. 10.1167/iovs.07-1173.
Article
PubMed
Google Scholar
Santos AM, Martin-Oliva D, Ferrer-Martin RM, Tassi M, Calvente R, Sierra A, Carrasco MC, Marin-Teva JL, Navascues J, Cuadros MA: Microglial response to light-induced photoreceptor degeneration in the mouse retina. J Comp Neurol. 2010, 518 (4): 477-492. 10.1002/cne.22227.
Article
CAS
PubMed
Google Scholar
Zhang C, Lei B, Lam TT, Yang F, Sinha D, Tso MO: Neuroprotection of photoreceptors by minocycline in light-induced retinal degeneration. Invest Ophthalmol Vis Sci. 2004, 45 (8): 2753-2759. 10.1167/iovs.03-1344.
Article
PubMed
Google Scholar
El Khoury J, Luster AD: Mechanisms of microglia accumulation in Alzheimer's disease: therapeutic implications. Trends Pharmacol Sci. 2008, 29 (12): 626-632. 10.1016/j.tips.2008.08.004.
Article
CAS
PubMed
Google Scholar
Fiala M, Zhang L, Gan X, Sherry B, Taub D, Graves MC, Hama S, Way D, Weinand M, Witte M, Lorton D, Kuo YM, Roher AE: Amyloid-beta induces chemokine secretion and monocyte migration across a human blood-brain barrier model. Mol Med. 1998, 4 (7): 480-489.
CAS
PubMed Central
PubMed
Google Scholar
Davis JB, McMurray HF, Schubert D: The amyloid beta-protein of Alzheimer's disease is chemotactic for mononuclear phagocytes. Biochem Biophys Res Commun. 1992, 189 (2): 1096-1100. 10.1016/0006-291X(92)92317-Q.
Article
CAS
PubMed
Google Scholar
Harada T, Harada C, Kohsaka S, Wada E, Yoshida K, Ohno S, Mamada H, Tanaka K, Parada LF, Wada K: Microglia-Muller glia cell interactions control neurotrophic factor production during light-induced retinal degeneration. J Neurosci. 2002, 22 (21): 9228-9236.
CAS
PubMed
Google Scholar
Jankowsky JL, Slunt HH, Ratovitski T, Jenkins NA, Copeland NG, Borchelt DR: Co-expression of multiple transgenes in mouse CNS: a comparison of strategies. Biomol Eng. 2001, 17 (6): 157-165. 10.1016/S1389-0344(01)00067-3.
Article
CAS
PubMed
Google Scholar
Bruban J, Glotin AL, Dinet V, Chalour N, Sennlaub F, Jonet L, An N, Faussat AM, Mascarelli F: Amyloid-beta(1-42) alters structure and function of retinal pigmented epithelial cells. Aging Cell. 2009, 8 (2): 162-177. 10.1111/j.1474-9726.2009.00456.x.
Article
CAS
PubMed
Google Scholar
Li J, Dong Z, Liu B, Zhuo Y, Sun X, Yang Z, Ge J, Tan Z: Hypoxia induces beta-amyloid in association with death of RGC-5 cells in culture. Biochem Biophys Res Commun. 2011, 410 (1): 40-44. 10.1016/j.bbrc.2011.05.101.
Article
CAS
PubMed
Google Scholar
Hoh Kam J, Lenassi E, Jeffery G: Viewing ageing eyes: diverse sites of amyloid Beta accumulation in the ageing mouse retina and the up-regulation of macrophages. PLoS One. 2010, 5 (10): pii: e13127
Google Scholar
Martin LJ, Sisodia SS, Koo EH, Cork LC, Dellovade TL, Weidemann A, Beyreuther K, Masters C, Price DL: Amyloid precursor protein in aged nonhuman primates. Proc Natl Acad Sci USA. 1991, 88 (4): 1461-1465. 10.1073/pnas.88.4.1461.
Article
CAS
PubMed Central
PubMed
Google Scholar
Thakker DR, Weatherspoon MR, Harrison J, Keene TE, Lane DS, Kaemmerer WF, Stewart GR, Shafer LL: Intracerebroventricular amyloid-beta antibodies reduce cerebral amyloid angiopathy and associated micro-hemorrhages in aged Tg2576 mice. Proc Natl Acad Sci USA. 2009, 106 (11): 4501-4506. 10.1073/pnas.0813404106.
Article
CAS
PubMed Central
PubMed
Google Scholar
Ito D, Imai Y, Ohsawa K, Nakajima K, Fukuuchi Y, Kohsaka S: Microglia-specific localisation of a novel calcium binding protein, Iba1. Brain Res Mol Brain Res. 1998, 57 (1): 1-9.
Article
CAS
PubMed
Google Scholar
Wakisaka Y, Chu Y, Miller JD, Rosenberg GA, Heistad DD: Spontaneous intracerebral hemorrhage during acute and chronic hypertension in mice. J Cereb Blood Flow Metab. 2010, 30 (1): 56-69. 10.1038/jcbfm.2009.183.
Article
CAS
PubMed Central
PubMed
Google Scholar
Zhang B, Veasey SC, Wood MA, Leng LZ, Kaminski C, Leight S, Abel T, Lee VM, Trojanowski JQ: Impaired rapid eye movement sleep in the Tg2576 APP murine model of Alzheimer's disease with injury to pedunculopontine cholinergic neurons. Am J Pathol. 2005, 167 (5): 1361-1369. 10.1016/S0002-9440(10)61223-0.
Article
CAS
PubMed Central
PubMed
Google Scholar
Pratico D, Uryu K, Leight S, Trojanoswki JQ, Lee VM: Increased lipid peroxidation precedes amyloid plaque formation in an animal model of Alzheimer amyloidosis. J Neurosci. 2001, 21 (12): 4183-4187.
CAS
PubMed
Google Scholar
Bowes C, Li T, Frankel WN, Danciger M, Coffin JM, Applebury ML, Farber DB: Localization of a retroviral element within the rd gene coding for the beta subunit of cGMP phosphodiesterase. Proc Natl Acad Sci USA. 1993, 90 (7): 2955-2959. 10.1073/pnas.90.7.2955.
Article
CAS
PubMed Central
PubMed
Google Scholar