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Figure 4 | BMC Neuroscience

Figure 4

From: Cyclic intensive light exposure induces retinal lesions similar to age-related macular degeneration in APPswe/PS1 bigenic mice

Figure 4

Expression of VEGF in RPE/choroid of mice. (A-C) Immunohistochemistry using a specific antibody for VEGF visualized by 3-Amino-9-ethylcarbazole (AEC, red) staining and microscopy reveals increased immunoreactivity of VEGF in the region of outer retina in mice received CILE (C) compared with both non-transgenic (non-Tg) and the bigenic control (B). Scale bar = 20 μm. (D) Quantification of VEGF immunoreactivity Bars depict mean ± SEM. *: P < 0.001 (N = 6). (E) Western blots using the same antibody for VEGF confirms increased immunoreactivity of VEGF in the retina of mice following 6-month CILE.

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BMC Neuroscience

ISSN: 1471-2202

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