Hirsch E, Graybiel AM, Agid YA: Melanized dopaminergic neurons are differentially susceptible to degeneration in Parkinson's disease. Nature. 1988, 334 (6180): 345-348. 10.1038/334345a0.
Article
CAS
PubMed
Google Scholar
Hirsch EC: Does oxidative stress participate in nerve cell death in Parkinson's disease?. Eur Neurol. 1993, 33 (Suppl 1): 52-59. 10.1159/000118538.
Article
PubMed
Google Scholar
Jenner P: Oxidative mechanisms in nigral cell death in Parkinson's disease. Mov Disord. 1998, 13 (Suppl 1): 24-34.
PubMed
Google Scholar
Graham DG: Oxidative pathways for catecholamines in the genesis of neuromelanin and cytotoxic quinones. Mol Pharmacol. 1978, 14 (4): 633-643.
CAS
PubMed
Google Scholar
Lotharius J, Brundin P: Pathogenesis of Parkinson's disease: dopamine, vesicles and alpha-synuclein. Nat Rev Neurosci. 2002, 3 (12): 932-942. 10.1038/nrn983.
Article
CAS
PubMed
Google Scholar
Ito S, Kato T, Fujita K: Covalent binding of catechols to proteins through the sulphydryl group. Biochem Pharmacol. 1988, 37 (9): 1707-1710. 10.1016/0006-2952(88)90432-7.
Article
CAS
PubMed
Google Scholar
Hastings TG, Lewis DA, Zigmond MJ: Role of oxidation in the neurotoxic effects of intrastriatal dopamine injections. Proc Natl Acad Sci USA. 1996, 93 (5): 1956-1961. 10.1073/pnas.93.5.1956.
Article
PubMed Central
CAS
PubMed
Google Scholar
LaVoie MJ, Hastings TG: Dopamine quinone formation and protein modification associated with the striatal neurotoxicity of methamphetamine: evidence against a role for extracellular dopamine. J Neurosci. 1999, 19 (4): 1484-1491.
CAS
PubMed
Google Scholar
Spillantini MG, Schmidt ML, Lee VM, Trojanowski JQ, Jakes R, Goedert M: Alpha-synuclein in Lewy bodies. Nature. 1997, 388 (6645): 839-840. 10.1038/42166.
Article
CAS
PubMed
Google Scholar
Spillantini MG, Crowther RA, Jakes R, Hasegawa M, Goedert M: alpha-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with lewy bodies. Proc Natl Acad Sci USA. 1998, 95 (11): 6469-6473. 10.1073/pnas.95.11.6469.
Article
PubMed Central
CAS
PubMed
Google Scholar
Polymeropoulos MH, Lavedan C, Leroy E, Ide SE, Dehejia A, Dutra A, Pike B, Root H, Rubenstein J, Boyer R, et al.: Mutation in the alpha-synuclein gene identified in families with Parkinson's disease. Science. 1997, 276 (5321): 2045-2047. 10.1126/science.276.5321.2045.
Article
CAS
PubMed
Google Scholar
Kruger R, Kuhn W, Muller T, Woitalla D, Graeber M, Kosel S, Przuntek H, Epplen JT, Schols L, Riess O: Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease. Nat Genet. 1998, 18 (2): 106-108. 10.1038/ng0298-106.
Article
CAS
PubMed
Google Scholar
Zarranz JJ, Alegre J, Gomez-Esteban JC, Lezcano E, Ros R, Ampuero I, Vidal L, Hoenicka J, Rodriguez O, Atares B, et al.: The new mutation, E46K, of alpha-synuclein causes Parkinson and Lewy body dementia. Ann Neurol. 2004, 55 (2): 164-173. 10.1002/ana.10795.
Article
CAS
PubMed
Google Scholar
Singleton AB, Farrer M, Johnson J, Singleton A, Hague S, Kachergus J, Hulihan M, Peuralinna T, Dutra A, Nussbaum R, et al.: alpha-Synuclein locus triplication causes Parkinson's disease. Science. 2003, 302 (5646): 841-10.1126/science.1090278.
Article
CAS
PubMed
Google Scholar
Nakajo S, Shioda S, Nakai Y, Nakaya K: Localization of phosphoneuroprotein 14 (PNP 14) and its mRNA expression in rat brain determined by immunocytochemistry and in situ hybridization. Brain Res Mol Brain Res. 1994, 27 (1): 81-86. 10.1016/0169-328X(94)90187-2.
Article
CAS
PubMed
Google Scholar
Iwai A, Masliah E, Yoshimoto M, Ge N, Flanagan L, de Silva HA, Kittel A, Saitoh T: The precursor protein of non-A beta component of Alzheimer's disease amyloid is a presynaptic protein of the central nervous system. Neuron. 1995, 14 (2): 467-475. 10.1016/0896-6273(95)90302-X.
Article
CAS
PubMed
Google Scholar
Weinreb PH, Zhen W, Poon AW, Conway KA, Lansbury PT: NACP, a protein implicated in Alzheimer's disease and learning, is natively unfolded. Biochemistry. 1996, 35 (43): 13709-13715. 10.1021/bi961799n.
Article
CAS
PubMed
Google Scholar
Bisaglia M, Mammi S, Bubacco L: Structural insights on physiological functions and pathological effects of {alpha}-synuclein. Faseb J. 2008, 23 (2): 329-40. 10.1096/fj.08-119784.
Article
PubMed
Google Scholar
Abeliovich A, Schmitz Y, Farinas I, Choi-Lundberg D, Ho WH, Castillo PE, Shinsky N, Verdugo JM, Armanini M, Ryan A, et al.: Mice lacking alpha-synuclein display functional deficits in the nigrostriatal dopamine system. Neuron. 2000, 25 (1): 239-252. 10.1016/S0896-6273(00)80886-7.
Article
CAS
PubMed
Google Scholar
Murphy DD, Rueter SM, Trojanowski JQ, Lee VM: Synucleins are developmentally expressed, and alpha-synuclein regulates the size of the presynaptic vesicular pool in primary hippocampal neurons. J Neurosci. 2000, 20 (9): 3214-3220.
CAS
PubMed
Google Scholar
Cabin DE, Shimazu K, Murphy D, Cole NB, Gottschalk W, McIlwain KL, Orrison B, Chen A, Ellis CE, Paylor R, et al.: Synaptic vesicle depletion correlates with attenuated synaptic responses to prolonged repetitive stimulation in mice lacking alpha-synuclein. J Neurosci. 2002, 22 (20): 8797-8807.
CAS
PubMed
Google Scholar
Lotharius J, Barg S, Wiekop P, Lundberg C, Raymon HK, Brundin P: Effect of mutant alpha-synuclein on dopamine homeostasis in a new human mesencephalic cell line. J Biol Chem. 2002, 277 (41): 38884-38894. 10.1074/jbc.M205518200.
Article
CAS
PubMed
Google Scholar
Yavich L, Tanila H, Vepsalainen S, Jakala P: Role of alpha-synuclein in presynaptic dopamine recruitment. J Neurosci. 2004, 24 (49): 11165-11170. 10.1523/JNEUROSCI.2559-04.2004.
Article
CAS
PubMed
Google Scholar
Larsen KE, Schmitz Y, Troyer MD, Mosharov E, Dietrich P, Quazi AZ, Savalle M, Nemani V, Chaudhry FA, Edwards RH, et al.: Alpha-synuclein overexpression in PC12 and chromaffin cells impairs catecholamine release by interfering with a late step in exocytosis. J Neurosci. 2006, 26 (46): 11915-11922. 10.1523/JNEUROSCI.3821-06.2006.
Article
CAS
PubMed
Google Scholar
Perez RG, Waymire JC, Lin E, Liu JJ, Guo F, Zigmond MJ: A role for alpha-synuclein in the regulation of dopamine biosynthesis. J Neurosci. 2002, 22 (8): 3090-3099.
CAS
PubMed
Google Scholar
Tehranian R, Montoya SE, Van Laar AD, Hastings TG, Perez RG: Alpha-synuclein inhibits aromatic amino acid decarboxylase activity in dopaminergic cells. J Neurochem. 2006, 99 (4): 1188-1196. 10.1111/j.1471-4159.2006.04146.x.
Article
CAS
PubMed
Google Scholar
Lee FJ, Liu F, Pristupa ZB, Niznik HB: Direct binding and functional coupling of alpha-synuclein to the dopamine transporters accelerate dopamine-induced apoptosis. Faseb J. 2001, 15 (6): 916-926. 10.1096/fj.00-0334com.
Article
CAS
PubMed
Google Scholar
Wersinger C, Prou D, Vernier P, Sidhu A: Modulation of dopamine transporter function by alpha-synuclein is altered by impairment of cell adhesion and by induction of oxidative stress. Faseb J. 2003, 17 (14): 2151-2153.
CAS
PubMed
Google Scholar
Fountaine TM, Wade-Martins R: RNA interference-mediated knockdown of alpha-synuclein protects human dopaminergic neuroblastoma cells from MPP(+) toxicity and reduces dopamine transport. J Neurosci Res. 2007, 85 (2): 351-363. 10.1002/jnr.21125.
Article
CAS
PubMed
Google Scholar
Ostrerova-Golts N, Petrucelli L, Hardy J, Lee JM, Farer M, Wolozin B: The A53T alpha-synuclein mutation increases iron-dependent aggregation and toxicity. J Neurosci. 2000, 20 (16): 6048-6054.
CAS
PubMed
Google Scholar
Blum D, Torch S, Nissou MF, Benabid AL, Verna JM: Extracellular toxicity of 6-hydroxydopamine on PC12 cells. Neurosci Lett. 2000, 283 (3): 193-196. 10.1016/S0304-3940(00)00948-4.
Article
CAS
PubMed
Google Scholar
Colapinto M, Mila S, Giraudo S, Stefanazzi P, Molteni M, Rossetti C, Bergamasco B, Lopiano L, Fasano M: alpha-Synuclein protects SH-SY5Y cells from dopamine toxicity. Biochem Biophys Res Commun. 2006, 349 (4): 1294-1300. 10.1016/j.bbrc.2006.08.163.
Article
CAS
PubMed
Google Scholar
Hillion JA, Takahashi K, Maric D, Ruetzler C, Barker JL, Hallenbeck JM: Development of an ischemic tolerance model in a PC12 cell line. J Cereb Blood Flow Metab. 2005, 25 (2): 154-162. 10.1038/sj.jcbfm.9600003.
Article
PubMed Central
CAS
PubMed
Google Scholar
Chen L, Ding Y, Cagniard B, Van Laar AD, Mortimer A, Chi W, Hastings TG, Kang UJ, Zhuang X: Unregulated cytosolic dopamine causes neurodegeneration associated with oxidative stress in mice. J Neurosci. 2008, 28 (2): 425-433. 10.1523/JNEUROSCI.3602-07.2008.
Article
PubMed
Google Scholar
Conway KA, Rochet JC, Bieganski RM, Lansbury PT: Kinetic stabilization of the alpha-synuclein protofibril by a dopamine-alpha-synuclein adduct. Science. 2001, 294 (5545): 1346-1349. 10.1126/science.1063522.
Article
CAS
PubMed
Google Scholar
Martinez-Vicente M, Talloczy Z, Kaushik S, Massey AC, Mazzulli J, Mosharov EV, Hodara R, Fredenburg R, Wu DC, Follenzi A, et al.: Dopamine-modified alpha-synuclein blocks chaperone-mediated autophagy. J Clin Invest. 2008, 118 (2): 777-788.
PubMed Central
CAS
PubMed
Google Scholar
Tabrizi SJ, Orth M, Wilkinson JM, Taanman JW, Warner TT, Cooper JM, Schapira AH: Expression of mutant alpha-synuclein causes increased susceptibility to dopamine toxicity. Hum Mol Genet. 2000, 9 (18): 2683-2689. 10.1093/hmg/9.18.2683.
Article
CAS
PubMed
Google Scholar
Xu J, Kao SY, Lee FJ, Song W, Jin LW, Yankner BA: Dopamine-dependent neurotoxicity of alpha-synuclein: a mechanism for selective neurodegeneration in Parkinson disease. Nat Med. 2002, 8 (6): 600-606. 10.1038/nm0602-600.
Article
CAS
PubMed
Google Scholar
Moussa CE, Wersinger C, Tomita Y, Sidhu A: Differential cytotoxicity of human wild type and mutant alpha-synuclein in human neuroblastoma SH-SY5Y cells in the presence of dopamine. Biochemistry. 2004, 43 (18): 5539-5550. 10.1021/bi036114f.
Article
CAS
PubMed
Google Scholar
Orth M, Tabrizi SJ, Tomlinson C, Messmer K, Korlipara LV, Schapira AH, Cooper JM: G209A mutant alpha synuclein expression specifically enhances dopamine induced oxidative damage. Neurochem Int. 2004, 45 (5): 669-676. 10.1016/j.neuint.2004.03.029.
Article
CAS
PubMed
Google Scholar
Moussa CE, Mahmoodian F, Tomita Y, Sidhu A: Dopamine differentially induces aggregation of A53T mutant and wild type alpha-synuclein: insights into the protein chemistry of Parkinson's disease. Biochem Biophys Res Commun. 2008, 365 (4): 833-839. 10.1016/j.bbrc.2007.11.075.
Article
CAS
PubMed
Google Scholar
Mosharov EV, Staal RG, Bove J, Prou D, Hananiya A, Markov D, Poulsen N, Larsen KE, Moore CM, Troyer MD, et al.: Alpha-synuclein overexpression increases cytosolic catecholamine concentration. J Neurosci. 2006, 26 (36): 9304-9311. 10.1523/JNEUROSCI.0519-06.2006.
Article
CAS
PubMed
Google Scholar
Mosharov EV, Larsen KE, Kanter E, Phillips KA, Wilson K, Schmitz Y, Krantz DE, Kobayashi K, Edwards RH, Sulzer D: Interplay between cytosolic dopamine, calcium, and alpha-synuclein causes selective death of substantia nigra neurons. Neuron. 2009, 62 (2): 218-229. 10.1016/j.neuron.2009.01.033.
Article
PubMed Central
CAS
PubMed
Google Scholar
Bisaglia M, Mammi S, Bubacco L: Kinetic and structural analysis of the early oxidation products of dopamine: analysis of the interactions with alpha-synuclein. J Biol Chem. 2007, 282 (21): 15597-15605. 10.1074/jbc.M610893200.
Article
CAS
PubMed
Google Scholar
Cuervo AM, Stefanis L, Fredenburg R, Lansbury PT, Sulzer D: Impaired degradation of mutant alpha-synuclein by chaperone-mediated autophagy. Science. 2004, 305 (5688): 1292-1295. 10.1126/science.1101738.
Article
CAS
PubMed
Google Scholar