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Resonant response of a Hodgkin-Huxley neuron to a spike train input
BMC Neurosciencevolume 10, Article number: P250 (2009)
Experiments show that neurons have a tendency to respond to signals tuned to a resonant frequency . In order to understand the general properties of a resonant response of a neuron, we study the silent Hodgkin-Huxley neuron driven by periodic input. The current arriving through the synapse consists of a set of spikes I p (t) ~ gsyn ∑(t/τ) exp(-t/τ) C(t) (V a -V syn ), where g syn is the synapse conductivity, τ is the time constant associated with the synapse conduction, Va is the maximum membrane potential and Vsyn is the reversal potential of the synapse.
Hutcheon B, Yarom Y: Resonance, oscillation and the intrinsic frequency preference of neurons. Trends Neurosci. 2000, 23: 216-222. 10.1016/S0166-2236(00)01547-2.
Hasegawa H: Responses of a Hodgkin-Huxley neuron to various types of spike-train inputs. Phys Rev E. 2000, 61: 718-726. 10.1103/PhysRevE.61.718.
Lee SG, Kim S: Bifurcation analysis of mode-locking structure in a Hodgkin-Huxley neuron under sinusoidal current. Phys Rev E. 2006, 73: 041924-10.1103/PhysRevE.73.041924.
Part of the numerical computation was performed in the Computer Center of the Tri-city Academic Computer Network in Gdansk, Poland.