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  1. The Period Circadian Regulator 2 (Per2) gene is important for the modulation of circadian rhythms that influence biological processes. Circadian control of the hypothalamus-pituitary-adrenal (HPA) axis is critica...

    Authors: Ashley L. Russell, Lauren Miller, Hannah Yi, Rita Keil, Robert J. Handa and T. John Wu
    Citation: BMC Neuroscience 2021 22:5
  2. Astrocytes are responsible for a broad range of functions that maintain homeostasis in the brain. However, their response to the pro-inflammatory cytokines released by activated microglia in various neurologic...

    Authors: Emilia Zgórzyńska, Dawid Stulczewski, Barbara Dziedzic, Kuan-Pin Su and Anna Walczewska
    Citation: BMC Neuroscience 2021 22:4
  3. Status epilepticus (SE) is a life-threatening neurological disorder. The hippocampus, as an important area of the brain that regulates cognitive function, is usually damaged after SE, and cognitive deficits of...

    Authors: Xin-Ming Luo, Jing Zhao, Wen-Yue Wu, Jie Fu, Zheng-Yu Li, Ming Zhang and Jie Lu
    Citation: BMC Neuroscience 2021 22:2
  4. A common problem in neurophysiological signal processing is the extraction of meaningful information from high dimension, low sample size data (HDLSS). We present RoLDSIS (regression on low-dimension spanned i...

    Authors: Adrielle C. Santana, Adriano V. Barbosa, Hani C. Yehia and Rafael Laboissière
    Citation: BMC Neuroscience 2021 22:1
  5. Conditioned pain modulation (CPM) evaluates the effect of a painful conditioning stimulus (CS) on a painful test stimulus (TS). Using painful cutaneous electrical stimulation (PCES) as TS and painful cold wate...

    Authors: A. T. L. Do, E. K. Enax-Krumova, Ö. Özgül, L. B. Eitner, S. Heba, M. Tegenthoff, C. Maier and O. Höffken
    Citation: BMC Neuroscience 2020 21:53
  6. Ventromedial hypothalamic nucleus (VMN) gluco-regulatory transmission is subject to sex-specific control by estradiol. The VMN is characterized by high levels of aromatase expression.

    Authors: Md. Main Uddin, Mostafa M. H. Ibrahim and Karen P. Briski
    Citation: BMC Neuroscience 2020 21:51
  7. Transcription factor 4 (TCF4) has been linked to human neurodevelopmental disorders such as intellectual disability, Pitt-Hopkins Syndrome (PTHS), autism, and schizophrenia. Recent work demonstrated that TCF4 par...

    Authors: Katharina Braun, Benjamin M. Häberle, Marie-Theres Wittmann and D. Chichung Lie
    Citation: BMC Neuroscience 2020 21:50
  8. Previous studies have demonstrated that individuals with autism spectrum disorder (ASD) exhibit dysfunction in the three attention systems (i.e., alerting, orienting, and executive control) as well as atypical re...

    Authors: Sayaka Yoshimura, Kei Kobayashi, Tsukasa Ueno, Takashi Miyagi, Naoya Oishi, Toshiya Murai and Hironobu Fujiwara
    Citation: BMC Neuroscience 2020 21:49
  9. To identify mechanisms of cortical plasticity of the visual cortex and to quantify their significance, sensitive parameters are warranted. In this context, multifocal visual evoked potentials (mfVEPs) can make...

    Authors: Robert Kolbe, Aykut Aytulun, Ann-Kristin Müller, Marius Ringelstein, Orhan Aktas, Alfons Schnitzler, Hans-Peter Hartung, Stefan Jun Groiss and Philipp Albrecht
    Citation: BMC Neuroscience 2020 21:48
  10. We present first-time evidence for the immediate neural and behavioral effects of bifocal emotional processing via visualized tapping for two different types of negative emotions (fear and disgust) in a sample...

    Authors: Dina Wittfoth, Antonia Pfeiffer, Michael Bohne, Heinrich Lanfermann and Matthias Wittfoth
    Citation: BMC Neuroscience 2020 21:47
  11. As a noninvasive perfusion-weighted MRI technique, arterial spin-labeling (ASL) was becoming increasingly used to evaluate cerebral hemodynamics in many studies. The relation between ASL-MRI and crossed cerebe...

    Authors: Juan Wang, Li-Jun Pan, Bin Zhou, Jin-Yan Zu, Yi-Xu Zhao, Yang Li, Wan-Qiu Zhu, Lei Li, Jian-Rong Xu and Zeng-Ai Chen
    Citation: BMC Neuroscience 2020 21:46
  12. Cardiac arrest (CA) is the most common cause of acute neurologic insult in children. Many survivors have significant neurocognitive deficits at 1 year of recovery. Epoxyeicosatrienoic acids (EETs) are multifun...

    Authors: Caitlin E. O’Brien, Polan T. Santos, Ewa Kulikowicz, Jennifer K. Lee, Raymond C. Koehler and Lee J. Martin
    Citation: BMC Neuroscience 2020 21:43
  13. Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative fatal disease that can affect the neurons of brain and spinal cord. ALS genetics has identified various genes to be associated with diseas...

    Authors: Surinder Pal, Abha Tiwari, Kaushal Sharma and Suresh Kumar Sharma
    Citation: BMC Neuroscience 2020 21:42
  14. During voluntary muscle contraction, sensory information induced by electrostimulation of the nerves supplying the contracting muscle is inhibited and the somatosensory evoked potentials (SEPs) amplitude decre...

    Authors: Terumasa Takahara, Hidetaka Yamaguchi, Kazutoshi Seki and Sho Onodera
    Citation: BMC Neuroscience 2020 21:41
  15. Serotonin is a neurotransmitter that has been linked to a wide variety of behaviors including feeding and body-weight regulation, social hierarchies, aggression and suicidality, obsessive compulsive disorder, ...

    Authors: Janet Best, William Duncan, Farrah Sadre-Marandi, Parastoo Hashemi, H. Frederik Nijhout and Michael Reed
    Citation: BMC Neuroscience 2020 21:40
  16. ADHD is one of the most common psychiatric disorders in children and adolescents. Altered functional connectivity has been associated with ADHD symptoms. This study aimed to investigate abnormal changes in the...

    Authors: Huayu Zhang, Yue Zhao, Weifang Cao, Dong Cui, Qing Jiao, Weizhao Lu, Hongyu Li and Jianfeng Qiu
    Citation: BMC Neuroscience 2020 21:39
  17. Glucose fluctuation promotes neuronal apoptosis, which plays a central role in diabetic encephalopathy (DE). Nerve growth factor (NGF), and its interaction with high-affinity (TrkA) and low-affinity (p75NTR) r...

    Authors: Ting Yan, Zhihui Zhang and Danqing Li
    Citation: BMC Neuroscience 2020 21:38
  18. Although previous studies have shown that intra-network abnormalities in brain functional networks are correlated with clinical/cognitive impairment in multiple sclerosis (MS), there is little information rega...

    Authors: Lin Wu, Muhua Huang, Fuqing Zhou, Xianjun Zeng and Honghan Gong
    Citation: BMC Neuroscience 2020 21:37
  19. Frontotemporal dementia (FTD) is the second leading cause of early onset dementia following Alzheimer’s disease. It involves atrophy of the frontal and temporal regions of the brain affecting language, memory,...

    Authors: Lalitha Venkataraman, Ping He, Galam Khan, Brent T. Harris and Michael R. Sierks
    Citation: BMC Neuroscience 2020 21:36
  20. The inter-scanner reproducibility of brain volumetry is important in multi-site neuroimaging studies, where the reliability of automated brain segmentation (ABS) tools plays an important role. This study aimed...

    Authors: Sirui Liu, Bo Hou, Yiwei Zhang, Tianye Lin, Xiaoyuan Fan, Hui You and Feng Feng
    Citation: BMC Neuroscience 2020 21:35
  21. When planning nerve conduction studies using animal models, the sciatic nerve is often used and the upper extremity nerves are not preferred due to the size of laboratory animals. This study aimed to present t...

    Authors: Basak Mansiz-Kaplan, Secil Pervane-Vural, Koray Gursoy and Baris Nacir
    Citation: BMC Neuroscience 2020 21:34
  22. Alzheimer’s disease (AD) is a progressive neuro-degenerative disease with a major manifestation of dementia. MicroRNAs were reported to regulate the transcript expression in patients with Alzheimer’s disease (...

    Authors: Jin Miao, Jin Jing, Yixiang Shao and Huaichang Sun
    Citation: BMC Neuroscience 2020 21:33
  23. Recent research has revealed that the community of microorganisms inhabiting the gut affects brain development, function and behaviour. In particular, disruption of the gut microbiome during critical developme...

    Authors: Katerina V. A. Johnson and Philip W. J. Burnet
    Citation: BMC Neuroscience 2020 21:32
  24. Parkinson’s disease (PD) is a disease of the central nervous system that progressively affects the motor system. Epidemiological studies have provided evidence that exposure to agriculture-related occupations ...

    Authors: Rodney C. P. Go, Michael J. Corley, G. Webster Ross, Helen Petrovitch, Kamal H. Masaki, Alika K. Maunakea, Qimei He and Maarit I. Tiirikainen
    Citation: BMC Neuroscience 2020 21:31
  25. One of the most basic human traits is language. Linguistic ability, and disability, have been shown to have a strong genetic component in family and twin studies, but molecular genetic studies of language phen...

    Authors: Ron Nudel, Camilla A. J. Christiani, Jessica Ohland, Md Jamal Uddin, Nicoline Hemager, Ditte Ellersgaard, Katrine S. Spang, Birgitte K. Burton, Aja N. Greve, Ditte L. Gantriis, Jonas Bybjerg-Grauholm, Jens Richardt M. Jepsen, Anne A. E. Thorup, Ole Mors, Thomas Werge and Merete Nordentoft
    Citation: BMC Neuroscience 2020 21:30
  26. Hypoxia inhibits the uptake of glutamate (a major neurotransmitter in the brain closely related to cognitive function) into brain cells, and the initial response of cells to cortical hypoxia depends on glutama...

    Authors: Young-Sung Kim, Young Ju Won, Byung Gun Lim, Too Jae Min, Yeon-Hwa Kim and Il Ok Lee
    Citation: BMC Neuroscience 2020 21:29
  27. Precise regulation of neural precursor cell (NPC) proliferation and differentiation is essential to ensure proper brain development and function. The HCFC1 gene encodes a transcriptional co-factor that regulates ...

    Authors: Victoria L. Castro, Joel F. Reyes, Nayeli G. Reyes-Nava, David Paz and Anita M. Quintana
    Citation: BMC Neuroscience 2020 21:27
  28. Previous studies suggest that persistent exposure to social stress in mammals may be associated with multiple physiological effects. Here, we examine the effects of social stress in rats, i.e. repeated social ...

    Authors: Dhaksshaginy Rajalingam, Ingeborg Nymoen, Daniel Pitz Jacobsen, Mina Baarnes Eriksen, Erik Dissen, Morten Birkeland Nielsen, Ståle Valvatne Einarsen and Johannes Gjerstad
    Citation: BMC Neuroscience 2020 21:25
  29. Cerebral stroke occurs following ischemic and hemorrhagic lesions in the brain. Survival and recovery of stroke patients depend on the severity of the initial injury but also the therapeutic approaches applied...

    Authors: Ewen Tu, Qiong Chen, Li Tan and Yan Wang
    Citation: BMC Neuroscience 2020 21:24
  30. Alexithymia is a personality trait characterized by difficulties identifying and describing feelings, an externally oriented style of thinking, and a reduced inclination to imagination. Previous research has s...

    Authors: Nicole Rosenberg, Klas Ihme, Vladimir Lichev, Julia Sacher, Michael Rufer, Hans Jörgen Grabe, Harald Kugel, André Pampel, Jöran Lepsien, Anette Kersting, Arno Villringer and Thomas Suslow
    Citation: BMC Neuroscience 2020 21:23
  31. Polynitroxylated PEGylated hemoglobin (PNPH, aka SanFlow) possesses superoxide dismutase/catalase mimetic activities that may directly protect the brain from oxidative stress. Stabilization of PNPH with bound ...

    Authors: Soichiro Seno, Jun Wang, Suyi Cao, Manda Saraswati, Sharon Park, Jan Simoni, Li Ma, Bohdan Soltys, Carleton J. C. Hsia, Raymond C. Koehler and Courtney L. Robertson
    Citation: BMC Neuroscience 2020 21:22
  32. Transcranial direct current stimulation (tDCS) is a non-invasive brain modulation technique that has been proved to exert beneficial effects in the acute phase of stroke. To explore the underlying mechanism, w...

    Authors: Ke-Ying Zhang, Gang Rui, Jun-Ping Zhang, Ling Guo, Guang-Zhou An, Jia-Jin Lin, Wei He and Gui-Rong Ding
    Citation: BMC Neuroscience 2020 21:21
  33. Mental fatigue is usually caused by long-term cognitive activities, mainly manifested as drowsiness, difficulty in concentrating, decreased alertness, disordered thinking, slow reaction, lethargy, reduced work...

    Authors: Gang Li, Shan Huang, Wanxiu Xu, Weidong Jiao, Yonghua Jiang, Zhao Gao and Jianhua Zhang
    Citation: BMC Neuroscience 2020 21:20
  34. Empathy refers to the ability to recognise and share emotions with others. Several research groups have recognised observational fear in mice as a useful behavioural model for assessing their ability to empath...

    Authors: Hiroshi Ueno, Shunsuke Suemitsu, Shinji Murakami, Naoya Kitamura, Kenta Wani, Yu Takahashi, Yosuke Matsumoto, Motoi Okamoto and Takeshi Ishihara
    Citation: BMC Neuroscience 2020 21:19
  35. Neonatal hypoxic-ischemic encephalopathy (HIE) represents as a major cause of neonatal morbidity and mortality. However, the underlying molecular mechanisms in brain damage are still not fully elucidated. This...

    Authors: Ya Jiang, Xue Bai, Ting-Ting Li, Mohammed AL-Hawwas, Yuan Jin, Yu Zou, Yue Hu, Lin-Yi Liu, Ying Zhang, Qing Liu, Hao Yang, Jun Ma, Ting-Hua Wang, Jia Liu and Liu-Lin Xiong
    Citation: BMC Neuroscience 2020 21:18
  36. Vasomotor regulation of dermal blood vessels, which are critical in the function of the skin in thermoregulatory control, involves both neural and non-neural mechanisms. Whereas the role of sympathetic nerves ...

    Authors: Tao Zhang, Jiahui Niu, Yaxian Wang, Junying Yan, Wen Hu and Daguo Mi
    Citation: BMC Neuroscience 2020 21:15

    The Correction to this article has been published in BMC Neuroscience 2020 21:17

  37. Patients positive for anti-glutamic acid decarboxylase 65 (GAD65) antibodies have attracted increasing attention. Their clinical manifestations are highly heterogeneous and can be comorbid with tumors. Current...

    Authors: Tao-Ran Li, Yu-Di Zhang, Qun Wang, Xiao-Qiu Shao, Zhi-Mei Li and Rui-Juan Lv
    Citation: BMC Neuroscience 2020 21:13
  38. Medium spiny neurons (MSNs) comprise the main body (95% in mouse) of the dorsal striatum neurons and represent dopaminoceptive GABAergic neurons. The cAMP (cyclic Adenosine MonoPhosphate)—mediated cascade of e...

    Authors: Vladimir N. Babenko, Anna G. Galyamina, Igor B. Rogozin, Dmitry A. Smagin and Natalia N. Kudryavtseva
    Citation: BMC Neuroscience 2020 21:12
  39. Pyridoxine (PDX; vitamin B6), is an essential vitamin. PDX deficiency induces various symptoms, and when PDX is misused it acts as a neurotoxicant, inducing severe sensory neuropathy.

    Authors: Sumin Yun, Woosuk Kim, Min Soo Kang, Tae Hyeong Kim, Yoonhwan Kim, Jin-Ok Ahn, Jung Hoon Choi, In Koo Hwang and Jin-Young Chung
    Citation: BMC Neuroscience 2020 21:11
  40. Following the publication of this article [1], it has been noted by the authors that an image of the same cell nuclei has been used in error twice, in Fig. 8, parts A and B. These images are redundant in this ...

    Authors: Claudie Hooper, Ricardo Sainz-Fuertes, Steven Lynham, Abdul Hye, Richard Killick, Alice Warley, Cecilia Bolondi, Jennifer Pocock and Simon Lovestone
    Citation: BMC Neuroscience 2020 21:10

    The original article was published in BMC Neuroscience 2012 13:144

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