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  1. Precise regulation of neural precursor cell (NPC) proliferation and differentiation is essential to ensure proper brain development and function. The HCFC1 gene encodes a transcriptional co-factor that regulates ...

    Authors: Victoria L. Castro, Joel F. Reyes, Nayeli G. Reyes-Nava, David Paz and Anita M. Quintana
    Citation: BMC Neuroscience 2020 21:27
  2. Previous studies suggest that persistent exposure to social stress in mammals may be associated with multiple physiological effects. Here, we examine the effects of social stress in rats, i.e. repeated social ...

    Authors: Dhaksshaginy Rajalingam, Ingeborg Nymoen, Daniel Pitz Jacobsen, Mina Baarnes Eriksen, Erik Dissen, Morten Birkeland Nielsen, Ståle Valvatne Einarsen and Johannes Gjerstad
    Citation: BMC Neuroscience 2020 21:25
  3. Cerebral stroke occurs following ischemic and hemorrhagic lesions in the brain. Survival and recovery of stroke patients depend on the severity of the initial injury but also the therapeutic approaches applied...

    Authors: Ewen Tu, Qiong Chen, Li Tan and Yan Wang
    Citation: BMC Neuroscience 2020 21:24
  4. Alexithymia is a personality trait characterized by difficulties identifying and describing feelings, an externally oriented style of thinking, and a reduced inclination to imagination. Previous research has s...

    Authors: Nicole Rosenberg, Klas Ihme, Vladimir Lichev, Julia Sacher, Michael Rufer, Hans Jörgen Grabe, Harald Kugel, André Pampel, Jöran Lepsien, Anette Kersting, Arno Villringer and Thomas Suslow
    Citation: BMC Neuroscience 2020 21:23
  5. Polynitroxylated PEGylated hemoglobin (PNPH, aka SanFlow) possesses superoxide dismutase/catalase mimetic activities that may directly protect the brain from oxidative stress. Stabilization of PNPH with bound ...

    Authors: Soichiro Seno, Jun Wang, Suyi Cao, Manda Saraswati, Sharon Park, Jan Simoni, Li Ma, Bohdan Soltys, Carleton J. C. Hsia, Raymond C. Koehler and Courtney L. Robertson
    Citation: BMC Neuroscience 2020 21:22
  6. Transcranial direct current stimulation (tDCS) is a non-invasive brain modulation technique that has been proved to exert beneficial effects in the acute phase of stroke. To explore the underlying mechanism, w...

    Authors: Ke-Ying Zhang, Gang Rui, Jun-Ping Zhang, Ling Guo, Guang-Zhou An, Jia-Jin Lin, Wei He and Gui-Rong Ding
    Citation: BMC Neuroscience 2020 21:21
  7. Mental fatigue is usually caused by long-term cognitive activities, mainly manifested as drowsiness, difficulty in concentrating, decreased alertness, disordered thinking, slow reaction, lethargy, reduced work...

    Authors: Gang Li, Shan Huang, Wanxiu Xu, Weidong Jiao, Yonghua Jiang, Zhao Gao and Jianhua Zhang
    Citation: BMC Neuroscience 2020 21:20
  8. Empathy refers to the ability to recognise and share emotions with others. Several research groups have recognised observational fear in mice as a useful behavioural model for assessing their ability to empath...

    Authors: Hiroshi Ueno, Shunsuke Suemitsu, Shinji Murakami, Naoya Kitamura, Kenta Wani, Yu Takahashi, Yosuke Matsumoto, Motoi Okamoto and Takeshi Ishihara
    Citation: BMC Neuroscience 2020 21:19
  9. Neonatal hypoxic-ischemic encephalopathy (HIE) represents as a major cause of neonatal morbidity and mortality. However, the underlying molecular mechanisms in brain damage are still not fully elucidated. This...

    Authors: Ya Jiang, Xue Bai, Ting-Ting Li, Mohammed AL-Hawwas, Yuan Jin, Yu Zou, Yue Hu, Lin-Yi Liu, Ying Zhang, Qing Liu, Hao Yang, Jun Ma, Ting-Hua Wang, Jia Liu and Liu-Lin Xiong
    Citation: BMC Neuroscience 2020 21:18
  10. Vasomotor regulation of dermal blood vessels, which are critical in the function of the skin in thermoregulatory control, involves both neural and non-neural mechanisms. Whereas the role of sympathetic nerves ...

    Authors: Tao Zhang, Jiahui Niu, Yaxian Wang, Junying Yan, Wen Hu and Daguo Mi
    Citation: BMC Neuroscience 2020 21:15

    The Correction to this article has been published in BMC Neuroscience 2020 21:17

  11. Patients positive for anti-glutamic acid decarboxylase 65 (GAD65) antibodies have attracted increasing attention. Their clinical manifestations are highly heterogeneous and can be comorbid with tumors. Current...

    Authors: Tao-Ran Li, Yu-Di Zhang, Qun Wang, Xiao-Qiu Shao, Zhi-Mei Li and Rui-Juan Lv
    Citation: BMC Neuroscience 2020 21:13
  12. Medium spiny neurons (MSNs) comprise the main body (95% in mouse) of the dorsal striatum neurons and represent dopaminoceptive GABAergic neurons. The cAMP (cyclic Adenosine MonoPhosphate)—mediated cascade of e...

    Authors: Vladimir N. Babenko, Anna G. Galyamina, Igor B. Rogozin, Dmitry A. Smagin and Natalia N. Kudryavtseva
    Citation: BMC Neuroscience 2020 21:12
  13. Pyridoxine (PDX; vitamin B6), is an essential vitamin. PDX deficiency induces various symptoms, and when PDX is misused it acts as a neurotoxicant, inducing severe sensory neuropathy.

    Authors: Sumin Yun, Woosuk Kim, Min Soo Kang, Tae Hyeong Kim, Yoonhwan Kim, Jin-Ok Ahn, Jung Hoon Choi, In Koo Hwang and Jin-Young Chung
    Citation: BMC Neuroscience 2020 21:11
  14. Following the publication of this article [1], it has been noted by the authors that an image of the same cell nuclei has been used in error twice, in Fig. 8, parts A and B. These images are redundant in this ...

    Authors: Claudie Hooper, Ricardo Sainz-Fuertes, Steven Lynham, Abdul Hye, Richard Killick, Alice Warley, Cecilia Bolondi, Jennifer Pocock and Simon Lovestone
    Citation: BMC Neuroscience 2020 21:10

    The original article was published in BMC Neuroscience 2012 13:144

  15. Neuromyelitis optica (NMO) is a demyelinating disease primarily affecting the optic nerves and spinal cord. It is distinguished from other demyelinating conditions by the presence of AQP4-IgG and serum aquapor...

    Authors: Etedal Ahmed AbuElbasher Ibrahim, Fatima Gammer and Alsadig Gassoum
    Citation: BMC Neuroscience 2020 21:9
  16. There has been much discussion recently about the occurrence of neuropsychological complications during the perioperative period. Diabetes is known to be one of the metabolic risk factors. Although the number ...

    Authors: Momoka Nishimura, Yuki Nomura, Moritoki Egi, Norihiko Obata, Makoto Tsunoda and Satoshi Mizobuchi
    Citation: BMC Neuroscience 2020 21:8
  17. It is a crucial task of brain science researches to explore functional connective maps of Biological Neural Networks (BNN). The maps help to deeply study the dominant relationship between the structures of the...

    Authors: Mei-jia Zhu, Chao-yi Dong, Xiao-yan Chen, Jing-wen Ren and Xiao-yi Zhao
    Citation: BMC Neuroscience 2020 21:7
  18. Synaptic degeneration and accumulation of amyloid β-peptides (Aβ) are hallmarks of the Alzheimer diseased brain. Aβ is synaptotoxic and produced by sequential cleavage of the amyloid precursor protein (APP) by...

    Authors: Jolanta L. Lundgren, Lina Vandermeulen, Anna Sandebring-Matton, Saheeb Ahmed, Bengt Winblad, Monica Di Luca, Lars O. Tjernberg, Elena Marcello and Susanne Frykman
    Citation: BMC Neuroscience 2020 21:6
  19. Opioids are the most effective drugs commonly prescribed to treat pain. Due to their addictive nature, opioid pain relievers are now second to marijuana, ahead of cocaine with respect to dependence. Ours and o...

    Authors: Ruping Fan, Lisa M. Schrott, Stephen Snelling, John Felty, Derrel Graham, Patrick L. McGauly, Thomas Arnold and Nadejda L. Korneeva
    Citation: BMC Neuroscience 2020 21:4
  20. It is difficult to set up a balanced higher-order full-factorial experiment that can capture multiple intricate interactions between cognitive and psycholinguistic factors underlying bilingual speech productio...

    Authors: Severin Schramm, Noriko Tanigawa, Lorena Tussis, Bernhard Meyer, Nico Sollmann and Sandro M. Krieg
    Citation: BMC Neuroscience 2020 21:3
  21. The growing abuse of amphetamine-type stimulants leads to new challenges to human health. A possible addiction mechanism has been proposed by altered functional architecture of the nucleus accumbens (NAc) duri...

    Authors: Yun Wang, Kai-Juan Yan, Chen-Xiao Fan, Xiao-Nian Luo and Yuan Zhou
    Citation: BMC Neuroscience 2019 20:66
  22. Histone deacetylase-3 (HDAC3) promotes neurodegeneration in various cell culture and in vivo models of neurodegeneration but the mechanism by which HDAC3 exerts neurotoxicity is not known. HDAC3 is known to be...

    Authors: Anto Sam Crosslee Louis Sam Titus, Dharmendra Sharma, Min Soo Kim and Santosh R. D’Mello
    Citation: BMC Neuroscience 2019 20:65
  23. Infection is an important clinical complication facing stroke-patients and triples the risk of death within 30 days post-stroke via mechanisms which are poorly understood.

    Authors: Ping Wang, Jiaqi Zhang, Feifei Guo, Shuang Wang, Yi Zhang, Defeng Li, Haiyu Xu and Hongjun Yang
    Citation: BMC Neuroscience 2019 20:64
  24. Sodium ion transportation plays a crucial role in the pathogenesis of hypoxic–ischemic brain injury. Amiodarone, a Vaughan-Williams class III antiarrhythmic drug, has been widely used to treat life-threatening...

    Authors: Masakazu Kotoda, Sohei Hishiyama, Tadahiko Ishiyama, Kazuha Mitsui and Takashi Matsukawa
    Citation: BMC Neuroscience 2019 20:62
  25. Parkinson’s disease (PD) is characterised by dopaminergic cell loss within the substantia nigra pars compacta (SNc) that leads to reduced striatal dopamine content and resulting motor deficits. Identifying new...

    Authors: Edward J. R. Fletcher, Lawrence D. F. Moon and Susan Duty
    Citation: BMC Neuroscience 2019 20:61
  26. Ketamine has been reported to cause neonatal neurotoxicity in a variety of developing animal models. Various studies have been conducted to study the mechanism of neurotoxicity for general anesthetic use durin...

    Authors: Zhanqiang Zhao, Bing Li, Yuqing Wu, Xujun Chen, Yan Guo, Yang Shen and He Huang
    Citation: BMC Neuroscience 2019 20:60
  27. The aim was to examine the impact of lipopolysaccharide-induced systemic inflammation on expression of mRNA for cocaine- and amphetamine-regulated transcript (CART) and the thyrotropin receptor (TSHR) and its ...

    Authors: Jonathan R. Burgos, Britt-Marie Iresjö, Linda Olsson and Ulrika Smedh
    Citation: BMC Neuroscience 2019 20:59
  28. The pharmacodynamic results of diazepam and ethanol administration are similar, in that each can mediate amnestic and sedative-hypnotic effects. Although each of these molecules effectively reduce the activity...

    Authors: Matthias Kreuzer, Paul S. García, Verena Brucklacher-Waldert, Rebecca Claassen, Gerhard Schneider, Bernd Antkowiak and Berthold Drexler
    Citation: BMC Neuroscience 2019 20:58
  29. Mammalian Shc (Src homology and collagen) proteins comprise a family of four phosphotyrosine adaptor molecules which exhibit varied spatiotemporal expression and signaling functions. ShcD is the most recently ...

    Authors: Hannah N. Robeson, Hayley R. Lau, Laura A. New, Jasmin Lalonde, John N. Armstrong and Nina Jones
    Citation: BMC Neuroscience 2019 20:57
  30. Non-motor symptoms are common aspects of Parkinson’s disease (PD) occurring even at the prodromal stage of the disease and greatly affecting the quality of life. Here, we investigated whether non-motor symptom...

    Authors: Flavia Niccolini, Heather Wilson, Beniamino Giordano, Konstantinos Diamantopoulos, Gennaro Pagano, Kallol Ray Chaudhuri and Marios Politis
    Citation: BMC Neuroscience 2019 20:55
  31. The pathogenesis of medication overuse headache (MOH) involves hyperexcitability of cortical and trigeminal neurons. Derangement of the brainstem modulating system, especially raphe nuclei may contribute to th...

    Authors: Prangtip Potewiratnanond, Supang Maneesri le Grand, Anan Srikiatkhachorn and Weera Supronsinchai
    Citation: BMC Neuroscience 2019 20:54
  32. Neuroactive steroids seem to be implicated in a variety of neurophysiological and behavioral processes, such as sleep, learning, memory, stress, feeding and aging. Numerous studies have also addressed this imp...

    Authors: Jan Martin, Eva Plank, Bettina Jungwirth, Alexander Hapfelmeier, Armin Podtschaske and Simone M. Kagerbauer
    Citation: BMC Neuroscience 2019 20:53
  33. Neurological complications may occur in patients with acute or chronic renal failure; however, in cases of acute renal failure, the signs and symptoms are usually more pronounced, and progressed rapidly. Oxida...

    Authors: Fatemeh Sharifi, Parham Reisi and Maryam Malek
    Citation: BMC Neuroscience 2019 20:52
  34. We aimed to study the role of amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor (AMPAR) glutamate receptor 2 (GluR2) subunit trafficking, and activity changes in short-term neuroprotection provided b...

    Authors: Chenxu Wang, Ying Wei, Yuan Yuan, Yonghao Yu, Keliang Xie, Beibei Dong, Yuan Shi and Guolin Wang
    Citation: BMC Neuroscience 2019 20:51
  35. Movement performance depends on the synaptic interactions generated by coherent parallel sensorimotor cortical outputs to different downstream targets. The major outputs of the neocortex to subcortical structu...

    Authors: Rafael Olivares-Moreno, Mónica López-Hidalgo, Alain Altamirano-Espinoza, Adriana González-Gallardo, Anaid Antaramian, Verónica Lopez-Virgen and Gerardo Rojas-Piloni
    Citation: BMC Neuroscience 2019 20:50
  36. In animal research, authorities require a classification of anticipated pain levels and a perioperative analgesia protocol prior to approval of the experiments. However, data on this topic is rare and so is th...

    Authors: Irina Staib-Lasarzik, Nadine Nagel, Anne Sebastiani, Eva-Verena Griemert and Serge C. Thal
    Citation: BMC Neuroscience 2019 20:49
  37. Electrical stimulation is widely used in experimental pain research but it lacks selectivity towards small nociceptive fibers. When using standard surface patch electrodes and rectangular pulses, large fibers ...

    Authors: Rosa Hugosdottir, Carsten Dahl Mørch, Ole Kæseler Andersen, Thordur Helgason and Lars Arendt-Nielsen
    Citation: BMC Neuroscience 2019 20:48
  38. There is a need for new approaches to increase the knowledge of the membrane excitability of small nerve fibers both in healthy subjects, as well as during pathological conditions. Our research group has previ...

    Authors: Rosa Hugosdottir, Carsten Dahl Mørch, Cecilia Klitgaard Jørgensen, Camilla Winther Nielsen, Mathias Vassard Olsen, Mads Jozwiak Pedersen and Jenny Tigerholm
    Citation: BMC Neuroscience 2019 20:47
  39. The Pde6brd1 (Rd1) mouse is widely used as a murine model for human retinitis pigmentosa. Understanding the spatio-temporal patterns of cone degeneration is important for evaluating potential treatments. In th...

    Authors: Daniel S. Narayan, Jack Ao, John P. M. Wood, Robert J. Casson and Glyn Chidlow
    Citation: BMC Neuroscience 2019 20:46
  40. Systemic inflammation is an important risk factor for neurodevelopmental impairments in preterm infants. Premyelinating oligodendrocytes are main building blocks of white matter in preterm infants and vulnerab...

    Authors: Seung Han Shin, Ee-Kyung Kim, Kyung-yup Lee and Han-Suk Kim
    Citation: BMC Neuroscience 2019 20:45
  41. Traumatic brain injury (TBI) is a widespread public health problem and a signature injury of our military in modern conflicts. Despite the long-term effects of even mild brain injuries, an effective treatment ...

    Authors: Whitney A. Ratliff, Jessica N. Saykally, Ronald F. Mervis, Xiaoyang Lin, Chuanhai Cao and Bruce A. Citron
    Citation: BMC Neuroscience 2019 20:44

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