Volume 7 Supplement 1
Problems and tools in the systems biology of the neuronal cell
Reviews
Edited by Sergio Nasi, Ivan Arisi, Antonino Cattaneo, Marta Cascante
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Citation: BMC Neuroscience 2006 7(Suppl 1):S1
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The modular systems biology approach to investigate the control of apoptosis in Alzheimer's disease neurodegeneration
Apoptosis is a programmed cell death that plays a critical role during the development of the nervous system and in many chronic neurodegenerative diseases, including Alzheimer's disease (AD). This pathology, ...
Citation: BMC Neuroscience 2006 7(Suppl 1):S2 -
Rules of engagement promote polarity in RNA trafficking
Many cell biological pathways exhibit overall polarity (net movement of molecules in one direction) even though individual molecular interactions in the pathway are freely reversible. The A2 RNA trafficking pa...
Citation: BMC Neuroscience 2006 7(Suppl 1):S3 -
Synaptic proteins as multi-sensor devices of neurotransmission
Neuronal communication is tightly regulated in time and space. Following neuronal activation, an electrical signal triggers neurotransmitter (NT) release at the active zone. The process starts by the signal re...
Citation: BMC Neuroscience 2006 7(Suppl 1):S4 -
Non coding RNA and brain
Small non coding RNAs are a group of very different RNA molecules, present in virtually all cells, with a wide spectrum of regulatory functions which include RNA modification and regulation of protein synthesi...
Citation: BMC Neuroscience 2006 7(Suppl 1):S5 -
Parameter estimate of signal transduction pathways
The "inverse" problem is related to the determination of unknown causes on the bases of the observation of their effects. This is the opposite of the corresponding "direct" problem, which relates to the predic...
Citation: BMC Neuroscience 2006 7(Suppl 1):S6 -
Integration of enzyme kinetic models and isotopomer distribution analysis for studies of in situcell operation
A current trend in neuroscience research is the use of stable isotope tracers in order to address metabolic processes in vivo. The tracers produce a huge number of metabolite forms that differ according to the nu...
Citation: BMC Neuroscience 2006 7(Suppl 1):S7 -
Computational framework for the prediction of transcription factor binding sites by multiple data integration
Control of gene expression is essential to the establishment and maintenance of all cell types, and its dysregulation is involved in pathogenesis of several diseases. Accurate computational predictions of tran...
Citation: BMC Neuroscience 2006 7(Suppl 1):S8 -
Mathematical modelling and numerical simulation of the morphological development of neurons
The morphological development of neurons is a very complex process involving both genetic and environmental components. Mathematical modelling and numerical simulation are valuable tools in helping us unravel ...
Citation: BMC Neuroscience 2006 7(Suppl 1):S9 -
Mathematical modeling of intracellular signaling pathways
Dynamic modeling and simulation of signal transduction pathways is an important topic in systems biology and is obtaining growing attention from researchers with experimental or theoretical background. Here we...
Citation: BMC Neuroscience 2006 7(Suppl 1):S10 -
Model storage, exchange and integration
The field of Computational Systems Neurobiology is maturing quickly. If one wants it to fulfil its central role in the new Integrative Neurobiology, the reuse of quantitative models needs to be facilitated. Th...
Citation: BMC Neuroscience 2006 7(Suppl 1):S11
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2022 Citation Impact
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3.3 - 5-year Impact Factor
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