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Table 2 Scoring system of inflammation and demyelination [21]

From: Does physical exercise improve or deteriorate treatment of multiple sclerosis with mitoxantrone? Experimental autoimmune encephalomyelitis study in rats

Inflammatory score

0

No inflammatory cells

1

Few scattered inflammatory cells

2

Organization of inflammatory infiltrates around blood vessels

3

Extensive perivascular cuffing with extension into adjacent parenchyma

Demyelination score

0

Normal

1

One small focal area of demyelination

2

Two or three areas of demyelination

3

One to two large areas of demyelination

4

Extensive demyelination involving ≥ 20% of the white matter