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Fig. 2 | BMC Neuroscience

Fig. 2

From: Biaryl scaffold-focused virtual screening for anti-aggregatory and neuroprotective effects in Alzheimer’s disease

Fig. 2

The heatmaps based on binding scores compounds with multitarget binding efficiency. The heatmap was generated using chemmines numerical clustering tool based on binding scores. A heat map analysis of binding constants of 107 in vivo tested compounds screened against acetylcholinesterase (4EY7), beta-secretase cleavage enzyme (2HM1), monoamine oxidase (2Z5X), N-methyl-D-aspartate receptor receptor (1PBQ) by AutoDock tool. In the gradient ruler, blue colour indicated strong binding (Docking score − 11), while red colour indicate weak binding (Docking score − 6)

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BMC Neuroscience

ISSN: 1471-2202

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