The authors would like to clarify the following sentence from the abstract, “The cat sequence for Tas2r38 contains 3 major amino acid residues known to confer the taster phenotype (PAI), which is associated with sensitivity to the bitter compounds PROP and PTC.” Although P, A, and I are major amino acid residue sites known to mediate sensitivity to PROP and PTC, PAI is a rare human haplotype. In cellular assays, PAI shows identical behavior to PAV, the common taster haplotype in humans (B. Bufe et al., The molecular basis of individual differences in phenylthiocarbamide and propylthiouracil bitterness perception. Curr Biol 15, 322–327 (2005).).
Abstract correction
8 July 2015
The authors would like to clarify the following sentence from the abstract, “The cat sequence for Tas2r38 contains 3 major amino acid residues known to confer the taster phenotype (PAI), which is associated with sensitivity to the bitter compounds PROP and PTC.” Although P, A, and I are major amino acid residue sites known to mediate sensitivity to PROP and PTC, PAI is a rare human haplotype. In cellular assays, PAI shows identical behavior to PAV, the common taster haplotype in humans (B. Bufe et al., The molecular basis of individual differences in phenylthiocarbamide and propylthiouracil bitterness perception. Curr Biol 15, 322–327 (2005).).
Competing interests
None declared