Biologically plausible statistics from a Markov model of spiking cortical networks
© Benayoun et al; licensee BioMed Central Ltd. 2008
Published: 11 July 2008
Understanding the spatio-temporal correlations observed in nervous tissue is a major challenge in computational neuroscience. We approach this challenge by modeling the global network state as a single Markov process [1, 2]. Each neuron is modeled as a two (active or inactive) – or three-state (active, inactive, or refractory) random variable, with each neuron's spike probability a function of its input current and internal threshold, updated at time steps dependent upon the current network state. Using the stochastic simulation algorithm , we simulate the network model with excitatory and inhibitory neurons and with random connectivity tuned so that each spike triggers on average one new spike, i.e. in the critical regime.
In order to study the model analytically, we recast the model in the language of statistical field theory . The result is a moment-generating functional which permits the calculation of correlation functions and critical exponents. Analytical calculation of the first moment produces a form of the Wilson-Cowan equations . The analytical and simulation results can be compared to those obtained from cortical slice recordings .
This work was supported in part by the Falk Foundation and the Linn family. Also, we would like to thank Dr. John Beggs, Dr. Alan Litke, and Aonan Tang for providing the experimental data on critical exponents and Figure 3.
- Cowan JD: Stochastic neurodynamics. Proc of the 1990 conf on adv in neural inf process sys 3. 1990, 62-69.Google Scholar
- Buice MA, Cowan JD: Field-theoretic approach to fluctuation effects in neural networks. Phys Rev E. 2007, 75 (5): 051919-10.1103/PhysRevE.75.051919.View ArticleGoogle Scholar
- Gillespie DT: Exact stochastic simulation of coupled chemical reactions. J Phys Chem. 1977, 81 (25): 2340-2361. 10.1021/j100540a008.View ArticleGoogle Scholar
- Wilson HR, Cowan JD: Excitatory and inhibitory interactions in localized populations of model neurons. Biophys J. 1972, 12 (1): 1-24.PubMed CentralView ArticlePubMedGoogle Scholar
- Beggs JM, Plenz D: Neuronal avalanches in neocortical circuits. J Neurosci. 2003, 23 (35): 11167-11177.PubMedGoogle Scholar
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