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Functional connectivity of brain network during character imagery
BMC Neuroscience volume 9, Article number: P157 (2008)
Previous results indicate cognitive processes of brain areas usually activate during visual mental imagery , however, few studies address the functional connectivity between these active regions. In the present study, a low-frequency (0–0.15 Hz) coherence method was used to analyze the event-related fMRI data from a task in which participants visualized digits and letters (termed as character imagery). The coherence method was discussed in detail in Sun et al . A band-averaged coherence of 1 would indicate strong functional interaction between areas, and a coherence of 0 would indicate the total absence of such a relationship . The brain networks include left IFG (inferior frontal gyrus), left FUS (fusiform gyrus), left CUN (cuneus) and left SPL (superior parietal lobule). All of the four ROIs (Regions of Interest) were selected based on previous studies [1, 3]. Nine right-handed subjects participated in this study. The materials of the character imagery task were based on a subset of those used by Kosslyn et al . Statistical parametric mapping analysis was performed using SPM2 running under Matlab 6.5.
Results and conclusion
All of the four ROIs were activated during character imagery in the present study as anticipated. The schematic locations of the four ROIs and the results of low-frequency (0–0.15 Hz) coherence analysis are shown in Figure 1. Our results indicated that the left IFG, the left SPL and the left CUN had strong functional connectivity, whereas the functional connectivity between the left FUS and any one of the other three ROIs was weak. These results suggested that the four ROIs were not equally associated during character imagery.
Thompson WL, Kosslyn SM: Neural systems activated during visual mental imagery: A review and meta-analyses. Brain mapping II: The systems. Edited by: Mazziotta J, Toga A. 2000, New York: Academic Press, 535-560.
Sun FT, Miller LM, D'Esposito M: Measuring interregional functional connectivity using coherence and partial coherence analyses of fMRI data. Neuroimage. 2004, 21: 647-658.
James KH, Gauthier I: Letter processing automatically recruits a sensory-motor brain network. Neuropsychologia. 2006, 44 (14): 2937-2949.
Kosslyn SM, Thompson WL, Shephard JM, Ganis G, Bell D, Danovitch J, Wittenberg LA, Alpert NM: Brain rCBF and performance in visual imagery tasks: Common and distinct processes. The European Journal of Cognitive Psychology. 2004, 16 (5): 696-716. [http://dx.doi.org/10.1080/09541440340000475]
We thank Drs. Stephen M Kosslyn, William L Thompson, Giorgio Ganis at Harvard University for generously providing imaging data and insightful comments. We thank Dr. Lee M. Miller for helpful suggestions about the low-frequency coherence analysis method. This work was supported in part by National Natural Science Foundation of China Grant 30670699, Ministry of Education Grant NCET-06-0277 and 021010.
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Yu, Q., Tang, YY. Functional connectivity of brain network during character imagery. BMC Neurosci 9, P157 (2008). https://doi.org/10.1186/1471-2202-9-S1-P157
- Functional Connectivity
- Parietal Lobule
- Functional Interaction
- Inferior Frontal Gyrus
- Brain Network