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Loss of synchrony in an inhibitory network of type-I oscillators
BMC Neuroscience volume 9, Article number: P149 (2008)
Understanding the dynamics and synchronization of inhibitory neurons is a question of fundamental importance in neuroscience, since inhibitory networks play a crucial role in rhythmogenesis, both in invertebrate motor pattern generators  and in the mammalian hippocampus and neocortex . Invertebrate CPGs in particular often contain simple two-cell inhibitory sub-networks that play a crucial role in the control of rhythmic motor behaviors. Therefore, characterizing the dynamics of two-cell inhibitory networks is relevant for a better understanding of the rhythmic dynamic activity produced by central pattern generators and other inhibitory circuits.
Here we describe the activity states in a network of two cells with type-I excitability coupled by reciprocal inhibition. Weak coupling analysis is very successful in the study of phase-locked activity in such a network, and predicts synchronous or anti-synchronous dynamics, depending on the time scale of inhibition and the intrinsic cell properties . However, it is known that an increase in coupling strength can destabilize synchrony in many neural circuits . In particular, recent work by Maran and Canavier  has shown that non-weak coupling leads to alternating-order firing (termed "leap-frog" spiking by G.B. Ermentrout) in an inhibitory network of two Wang-Buzsáki model neurons, whereby the order of spiking of the two cells alternates in each cycle of the oscillation. Here we show that such activity is a generic property of an inhibitory network of oscillators of type-I excitability class. In particular, we demonstrate that leap-frog spiking can also be obtained in a two-cell network of simpler Morris-Lecar model cells, as shown in Figure 1.
We examine the phase-plane geometry of such order non-preserving dynamics, and find that it arises when the inhibition is sufficiently strong to allow a presynaptic cell to transiently suppress the postsynaptic cell below its excitability threshold (saddle-node on an invariant cycle bifurcation) in each cycle of the oscillation. Therefore, non-zero synaptic decay time is crucial for obtaining leap-frog spiking in a continuous system. However, we show that alternating-order spiking can also be obtained in an appropriately modified pulse-coupled integrate-and-fire network. Following the approach of Maran and Canavier , we show that the entire activity state bifurcation profile of the two-cell Morris-Lecar network can be completely characterized using the phase-resetting properties of each of the two cells, and describe the conditions on the phase resetting curve that lead to the loss of synchrony and the emergence of leap-frog spiking.
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This work is partially supported by the National Science Foundation grant DMS-0417416
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Oh, M., Matveev, V. Loss of synchrony in an inhibitory network of type-I oscillators. BMC Neurosci 9, P149 (2008). https://doi.org/10.1186/1471-2202-9-S1-P149
- Central Pattern Generator
- Reciprocal Inhibition
- Inhibitory Circuit
- Inhibitory Network
- Rhythmic Motor