Dense gap-junction connections support dynamic Turing structures in the cortex
© Steyn-Ross et al; licensee BioMed Central Ltd. 2007
Published: 6 July 2007
The recent report by Fukuda et al  provides convincing evidence for dense gap-junction connectivity between inhibitory neurons in the cat visual cortex, each neuron making 60 +/- 12 gap-junction dendritic connections with neurons in both the same and adjoining orientation columns. These resistive connections provide a source of diffusive current to the receiving neuron, supplementing the chemical-synaptic currents generated by incoming action-potential spike activity. Fukuda et al describe how the gap junctions form a dense and homogeneous electrical coupling of interneurons, and propose that this diffusion-coupled network provides the substrate for synchronization of neuronal populations.
- Kosaka T, Singer W, Galuske RAW: Gap junctions among dendrites of cortical GABAergic neurons establish a dense and widespread intercolumnar network. J Neurosci. 2006, 26: 3434-3443. 10.1523/JNEUROSCI.4076-05.2006.PubMedView ArticleGoogle Scholar
- Steyn-Ross DA, Steyn-Ross ML, Sleigh JW, Wilson MT, Gillies IP, Wright JJ: The sleep cycle modelled as a cortical phase transition. J Biol Phys. 2005, 31: 547-569. 10.1007/s10867-005-1285-2.PubMedPubMed CentralView ArticleGoogle Scholar
- Fox MD, Snyder AZ, Vincent JL, Corbetta M, van Essen DC, Raichle ME: The human brain is intrinsically organized into dynamic, anticorrelated functional networks. Proc Nat Acad Sci USA. 102: 9673-9678. 10.1073/pnas.0504136102.Google Scholar
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