- Poster presentation
- Open Access
Measuring spike train synchrony and reliability
BMC Neuroscience volume 8, Article number: P79 (2007)
Estimating the degree of synchrony or reliability between two or more spike trains is a frequent task in both experimental and computational neuroscience. In recent years, many different methods have been proposed that typically compare the timing of spikes on a certain time scale to be fixed beforehand. In this study , we propose the ISI-distance, a simple complementary approach that extracts information from the interspike intervals by evaluating the ratio of the instantaneous frequencies. The method is parameter free, time scale independent and easy to visualize as illustrated by an application to real neuronal spike trains obtained in vitro from rat slices (cf. ). We compare the method with six existing approaches (two spike train metrics [3, 4], a correlation measure [2, 5], a similarity measure , and event synchronization ) using spike trains extracted from a simulated Hindemarsh-Rose network . In this comparison the ISI-distance performs as well as the best time-scale-optimized measure based on spike timing, without requiring an externally determined time scale for interaction or comparison.
Kreuz T, Haas JS, Morelli A, Abarbanel HDI, Politi A: Measuring spike train synchronization. [http://arxiv.org/abs/physics/0701261]
Haas JS, White JA: Frequency selectivity of layer II stellate cells in the medial entorhinal cortex. J Neurophysiol. 2002, 88: 2422-2429. 10.1152/jn.00598.2002.
Victor J, Purpura K: Nature and precision of temporal coding in visual cortex: A metric-space analysis. J Neurophysiol. 1996, 76: 1310-
van Rossum MCW: A novel spike distance. Neural Computation. 2001, 13: 751-10.1162/089976601300014321.
Schreiber S, Fellous JM, Whitmer JH, Tiesinga PHE, Sejnowski TJ: A new correlation-based measure of spike timing reliability. Neurocomputing. 2003, 52: 925-
Hunter JD, Milton G: Amplitude and frequency dependence of spike timing: implications for dynamic regulation. J Neurophysiol. 2003, 90: 387-10.1152/jn.00074.2003.
Quian Quiroga R, Kreuz T, Grassberger P: Event synchronization: A simple and fast method to measure synchronicity and time delay patterns. Phys Rev E. 2002, 66: 041904-10.1103/PhysRevE.66.041904.
Morelli A, Grotto RL, Arecchi FT: Neural coding for the retrieval of multiple memory patterns. Biosystems. 2006, 86: 100-10.1016/j.biosystems.2006.03.011.
TK has been supported by the Marie Curie Individual Intra-European Fellowship "DEAN", project No 011434. JSH acknowledges financial support by the San Diego Foundation.
About this article
Cite this article
Kreuz, T., Haas, J.S., Morelli, A. et al. Measuring spike train synchrony and reliability. BMC Neurosci 8, P79 (2007) doi:10.1186/1471-2202-8-S2-P79
- Animal Model
- Similarity Measure
- Spike Train
- Instantaneous Frequency
- Complementary Approach