Phase-locking in electrically coupled spiking neurons: the influence of intrinsic properties of neurons
BMC Neuroscience volume 8, Article number: P59 (2007)
Electrical coupling between groups of inhibitory interneurons appears to be ubiquitous in the cortex. Because inhibitory interneurons are thought to play a fundamental role in generating cortical oscillations, phase-locking dynamics of electrical coupled interneurons has received considerable interest. A recent experimental study showed that electrically coupled neocortical interneurons have the ability to robustly synchronize over a broad range of frequencies and an inability to phase-lock in anti-phase . How electrical coupling interacts with the intrinsic properties of neurons to generate stable phase-locked states remains unclear. Using the theory of weakly coupled oscillators and phase-response curves (PRC) from both real and model interneurons, I identify some of the intrinsic properties of neurons that determine the stability of phase-locked states and describe the underlying dynamical mechanisms. In the real and model interneurons that are examined, wide spikes and shallow action potential afterhyperpolarizations promote synchronous behavior; however, this property depends critically on the shape of the PRC. I discuss the combinations of PRC shapes and membrane potential time-courses required for stable synchrony and for stable anti-phase activity. I then use these results as a framework to examine how specific ionic conductances alter stability of phase-locked states.
Mancilla JG, Lewis TJ, Pinto DJ, Rinzel J, Connors BW: Firing dynamics of coupled pairs of inhibitory interneurons in neocortex. J Neurosci. 2007, 27: 2058-2073. 10.1523/JNEUROSCI.2715-06.2007.
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Lewis, T.J. Phase-locking in electrically coupled spiking neurons: the influence of intrinsic properties of neurons. BMC Neurosci 8 (Suppl 2), P59 (2007). https://doi.org/10.1186/1471-2202-8-S2-P59
- Intrinsic Property
- Dynamical Mechanism
- Inhibitory Interneuron
- Electrical Coupling
- Recent Experimental Study