Biophysical cortical column model for optical signal analysis
© Chemla et al; licensee BioMed Central Ltd. 2007
Published: 6 July 2007
We propose a biological cortical column model, at a mesoscopic scale, in order to explain and interpret biological sources of voltage-sensitive dye imaging signal. The mesoscopic scale, corresponding to a micro-column, is about 50 μm. The proposed model takes into account biological and electrical neural parameters of the laminar cortical layers. Thus we choose a model based on a cortical microcircuit, whose synaptic connections are made only between six specific populations of neurons, excitatory and inhibitory neurons in three main layers, following  and . For each neuron, we use a conductance-based single compartment Hodgkin-Huxley neuron model .
We claim that our model will reproduce qualitatively the same results as the optical imaging signal based on voltage-sensitive dyes, which represents the summed intracellular membrane potential changes of all the neuronal elements at a given cortical site . Furthermore, this voltage-sensitive dye imaging has a submillisecond temporal resolution that allows us to explore the dynamics of cortical processing. An example of data of V1 dye-signal in a cat, after a visual local stimulation, is shown in Figure 1. Therefore, the temporal dynamics of the measured signal will be carefully studied as being of primary interest for the proposed model identification.
- Haeusler S, Maass W: A statistical analysis of information-processing properties of lamina-specific cortical microcircuit models. Cerebral Cortex. 2006Google Scholar
- Jancke D, Chavane F, Naaman S, Grinvald A: Imaging cortical correlates of illusion in early visual cortex. Nature. 2004, 428: 423-426. 10.1038/nature02396.PubMedView ArticleGoogle Scholar
- Dextexhe A, Rudolph M, Fellous J-M, Sejnowski TJ: Fluctuating synaptic conductances recreate in vivo-like activity in neocortical neurons. Neuroscience. 2001, 107: 13-24. 10.1016/S0306-4522(01)00344-X.View ArticleGoogle Scholar
- Shoham D, Glaser DE, Arielli A, Kenet T, Wijnbergen C, Toledo Y, Hidesheim R, Grinvald A: Imaging cortical dynamics at high spatial and temporal resolution with novel blue voltage-sensitive dyes. Neuron. 1999, 24: 791-802. 10.1016/S0896-6273(00)81027-2.PubMedView ArticleGoogle Scholar
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