Converting a globus pallidus neuron model from 585 to 6 compartments using an evolutionary algorithm
© Hendrickson et al; licensee BioMed Central Ltd. 2007
Published: 6 July 2007
Biologically realistic neuron models are useful tools for understanding the behavior and mechanisms of neurons, but they are computationally expensive due to their fine granularity. This makes them unattractive for use in network simulations and generally leads to their replacement by simpler "integrate and fire" or black box models which are computationally cheaper, but further removed from biology. An attractive alternative is to replace a biologically realistic model with a 'reduced' version containing fewer compartments. This reduced model should largely preserve biological realism while limiting complexity and computational cost.
Methods and results
Parameter sets which yield good matches to the full model.
This article is published under license to BioMed Central Ltd.