Figure 2From: Dopamine presynaptically and heterogeneously modulates nucleus accumbens medium-spiny neuron GABA synapses in vitroDifferential run down of autaptic vs . synaptic responses. A. Control responses are presented from two experiments done on sister cultures recorded a day apart. While the synaptic response was stable for the duration of the experiment, the autaptic response showed significant run-down. B. In some recordings (see Figure 7) there was a second autaptic response (Component 2) riding on top of the initial response (Component 1), Component 1 ran down, while Component 2 did not, suggesting that Component 2 was mediated by autaptic connections made on more distal dendrites.Back to article page