Figure 5

Effect of calpain and caspase inhibitors on glutamate-induced cell death in primary cortical cells as assessed by phase contrast microscopy (20×). Primary cortical cells were isolated and treated as described under Figure 4. Normal cells are depicted by arrows and degenerated cells by arrowheads. A = untreated control cells; B = glutamate lone; C = glutamate + ALLN; D = glutamate + z-DEVD.